1. Polycystic Kidney Disease - Nephrologychannel An overview of Cystic kidney disease, including a description, the types, causes, diagnoses and treatment.Category Health Conditions and Diseases polycystic kidney...... Incidence and Prevalence polycystic kidney disease (PKD) is the most frequently inheriteddisease; it affects approximately 600,000 people in the United States http://www.nephrologychannel.com/polycystic/

Home Search SiteMap Ask the Dr. ... Medical Store advertisement advertisement POLYCYSTIC KIDNEY DISEASE Overview Types Causes Diagnosis ... Treatment CONDITIONS Acute Glomerulonephritis (AGN) Acute Interstitial Nephritis (AIN) Acute Renal Failure (ARF) Acute Tubular Necrosis (ATN) Chronic Renal Failure Diabetic Nephropathy Hematuria Ischemic Nephropathy ... Nephrotic Syndrome (NS) Polycystic Kidney Disease Microalbuminuria Renal Artery Stenosis (RAS) Renal Vascular Hypertension (RVH) TREATMENT OPTIONS Hemodialysis Peritoneal Dialysis Kidney Transplant RELATED CONDITIONS Electrolyte Imbalance Hemolytic Uremic Syndrome (HUS) Thrombotic Thrombocytopenic Purpura (TTP) RESOURCES Anatomy Links Clinical Trials Videos ABOUT US Healthcommunities.com Pressroom Testimonial Bibliography Overview Cystic kidney disease describes several conditions in which fluid-filled cysts form in the kidneys. Cysts generally develop in weak segments of the tubules that carry urine from the glomeruli. The cyst's growth displaces healthy kidney tissue. The kidneys expand to accommodate the cyst, which can weigh as much as 20 pounds. Three factors determine cyst classification: its cause (acquired, inherited), its features (complicated, simple, multiple, single), and its location (outer [cortical] or inner [medullary] kidney tissue).

2. Polycystic Kidney Disease In depth look at this disease and its symptoms, treatment and diagnosis. http://www.niddk.nih.gov/health/kidney/pubs/polycyst/polycyst.htm

Autosomal Dominant PKD Autosomal Recessive PKD Acquired Cystic Kidney Disease The Search for PKD Genes ... Additional Resources Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys. The cysts are filled with fluid. PKD cysts can slowly replace much of the mass of the kidneys, reducing kidney function and leading to kidney failure. The kidneys are two organs, each about the size of a fist, located in the upper part of a person's abdomen, toward the back. The kidneys filter wastes from the blood to form urine. They also regulate amounts of certain vital substances in the body. When PKD causes kidneys to failwhich usually happens only after many yearsthe patient requires dialysis or kidney transplantation. About one-half of people with the major type of PKD progress to kidney failure, i.e., end-stage renal disease (ESRD). PKD can cause cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain. These complications help doctors distinguish PKD from the usually harmless "simple" cysts that often form in the kidneys in later years of life. In the United States, about 500,000 people have PKD, and it is the fourth leading cause of kidney failure. Medical professionals describe two major inherited forms of PKD and a noninherited form:

3. The Polycystic Kidney Disease Information Page For people with PKD who wish to look up research about this disease, ask each other questions and Category Health Conditions and Diseases polycystic kidney......This page is about polycystic kidney Disease. It has links to other sites, a chatroom and a message board. The polycystic kidney Disease Information Page. http://www.geocities.com/HotSprings/Spa/3265/

The Polycystic Kidney Disease Information Page Health News Reuter's Medical Articles Re: Kidneys Message Board Sign/View Guestbook ...  Low Protein Diet Page Click here for the text only version of this page. Old PKD Poll Results You are not alone! Polycystic Kidney Disease affects 600,000 people in the U.S. alone, and 12.5 million world wide. There are more people with PKD than cystic fibrosis, muscular dystrophy, hemophilia, Downs syndrome and sickle cell anemia combined. There are a lot of us out there! My father died of PKD in 1981 when very little information was available about this disease, even to the doctors. The nephrologist ( kidney doctor) thought he got it from his grandfather who had had medical problems and it had skipped a generation that I've since found out isn't possible. He was also never told that limiting his protein would help reduce the symptoms of uremia ( blood poisoning from kidney failure) which I think would have made his life much more comfortable. This is a big part of why I've put up this web page. I want people with PKD to be able to look up research about this disease, talk to each other, ask each other questions and be there to encourage one another. If you have PKD, please contact the

4. Nephrology - Polycystic Kidney Disease A good, though brief (less than 1024 chars), description of your site. polycystic kidney DISEASE. polycystic kidney disease in children may be divided into two disorders with distinct http://www.mc.vanderbilt.edu/peds/pidl/nephro/polykidn.htm

PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Nephrology POLYCYSTIC KIDNEY DISEASE The overall incidence of polycystic kidney disease in the pediatric population is unknown. Autopsy series have identified polycystic kidneys in 1.3 - 5.9/1000 pediatric patients. Autosomal dominant polycystic kidney disease is far more common than the recessive form. The incidence of the dominant condition in patients of all ages has been estimated from autopsy studies at 1/220 to 1/1100. As anticipated with autosomal inheritance, the male:female ratio of both disorders is approximately 1:1. Patients with autosomal recessive polycystic kidney disease usually follow one of two different clinical courses, suggesting variable expression among affected individuals. The disease most often presents in the neonatal period, frequently after a pregnancy remarkable for oligohydramnios. The newborn may have physical manifestations of the Potter syndrome and massively enlarged, poorly functioning kidneys. Neonatal death due to pulmonary hypoplasia occurs in 84% of children with recessive polycystic kidney disease. However, a small number of affected patients follow a milder clinical course. In these children, the diagnosis may be made when enlarged kidneys are palpated at birth or in infancy. Hepatosplenomegaly may also be noted.

5. Polycystic Kidney Disease National Center for Biotechnology Information a division of the National Library of Medicine at the National Institutes of Health gives a description of this disease. http://www.ncbi.nlm.nih.gov/disease/PKD.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View on chromosome 16 Databases PubMed the literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information Fact sheet from the National Institute of Diabetes and Digestive and Kidney Diseases, NIH ADULT POLYCYSTIC kidney disease (APKD) is characterized by large cysts in one or both kidneys and a gradual loss of normal kidney tissue which can lead to chronic renal failure. The role of the kidneys in the body is to filter the blood, excreting the end-products of metabolism in the form of urine and regulating the concentrations of hydrogen, sodium, potassium, phosphate and other ions in the extracellular fluid. In 1994 the European Polycystic Kidney Disease Consortium isolated a gene from chromosome 16 that was disrupted in a family with APCD. The protein encoded by the PKD1 gene is an integral membrane protein involved in cell-cell interactions and cell-matrix interactions. The role of PKD1 in the normal cell may be linked to microtubule-mediated functions, such as the placement of Na(+), K(+)-ATPase ion pumps in the membrane. Programmed cell death, or apoptosis, may also be invoked in APKD. Further clarification of the pathogenesis of the disease await further research. The so-called 'cpk mouse' is a well known model for the human disease. Studying the molecular basis of the disease in the mouse is expected to provide a better understanding of the human disease, and is hoped to lead to more effective therapies.

6. The PKD Foundation Discusses the inherited kidney disease in persian cats, including how it affects the animal. Autosomal Dominant polycystic kidney Disease in Persian Cats. polycystic kidney Disease Seminar http://www.pkdcure.org/

7. Our Polycystic Kidney Disease Page A personal site about polycystic kidney disease with chat room for sharing and support.Category Health Conditions and Diseases polycystic kidney......You are the . person to view this page since 1/1/99. This site is a better placeto be because ofMy Mom! Thanks Mom!!! Last modified 1/1/99. Guestbook by Lpage. http://www.geocities.com/HotSprings/5291/

Sign My Guestbook View My Guestbook You are the . person to view this page since 1/1/99 This site is a better place to be because of-My Mom! Thanks Mom!!! Last modified 1/1/99 This PKD Ring site is owned by Mary Elizabeth Jones

8. GENES INVOLVED IN POLYCYSTIC KIDNEY DISEASE SCIENCE NEWS DIGEST FOR PHYSICIANS AND SCIENTISTS GENES INVOLVED IN polycystic kidney DISEASE polycystic kidney disease is an autosomal dominant disorder. http://www.bioscience.org/news/scientis/urine.htm

SCIENCE NEWS DIGEST FOR PHYSICIANS AND SCIENTISTS GENES INVOLVED IN POLYCYSTIC KIDNEY DISEASE Polycystic kidney disease is an autosomal dominant disorder. Worldwide, this disease accounts for 8-10% of end stage kidney disease and results in chronic renal failure in about 45% of the affected individuals by the age of 60. The patients with the disease develop cysts in both kidneys that gradually enlarge over the lifetime of the individual and ultimately lead to chronic renal failure and hypertension. At least two loci are known to exist for this disease. One locus was designated PKD4. By analysis of a genomic cosmid clone and cDNA, Lisowsky et al identified a new human gene on chromosome 16 (16p13.3) in the locus for polycystic kidney disease (PKD1). The gene contains at least one intron and is actively transcribed in tissues from kidney and brain. The predicted protein was homologous (42%) to the yeast scERV1 protein which is essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell-division cycle. A second locus is present on chromosome 4q (4q21-23). In the May 31, 1996 issue of Science, Mochizuki et al describe identification of a second gene by positional cloning, whose nonsense mutation leads to this disease. The predicted protein consists of 968 amino acids and contains six transmembrane spans with both amino- and carboxyl termini residing in the cytoplasm. This protein shows amino acid similarity to the previously described PKD1 as well as the C elegans homolog of PKD1. The protein contains one potential calcium binding site and it is interesting that there is amino acid identity between this protein and the members of the family of voltage-activated calcium and sodium channels.

9. Polycystic Kidney Disease An article on the symptoms, causes, diagnosis and treatment of polycystic kidney disease. http://www.med-help.com/PolycysticKidneyDisease.html

Polycystic Kidney Disease Polycystic Kidney Disease: Characterized by multiple, bilateral, grape-like clusters of fluid filled cysts that grossly enlarge the kidneys, compressing and eventually replacing functioning renal tissue. This disorder is inherited. It appears in two distinct forms. The infantile form causes stillbirth or early neonatal death. Infants with this disease may survive for 2 years and then develop fatal renal, congestive heart, or respiratory failure. Onset of the adult form is insidious but commonly becomes obvious between ages 30 and 50. Rarely, polycystic kidney disease doesn't cause symptoms during an individual's life-time, and may only be found during autopsy. Renal deterioration in the adult form of this disorder is slower than in the infantile form, but often leads to renal failure. Cause: The infantile form appears to be inherited as an autosomal recessive trait. The adult form appears to be autosomal dominant trait. Symptoms: Infantile: Pronounced epicanthal folds (a vertical fold of skin on either side of the nose) Pointed nose Small chin Floppy, low set ears

10. Polycystic Kidney Disease polycystic kidney Disease, what it is, they types , symptoms and statistics. http://www.mamashealth.com/poly.asp

Mamashealth.com Home Category Links About Us Allergies Cancers Types of Diabetes ... Buy Health Books Links Add Mamashealth to your favorites Email Mama Floral Gift for your Loved Ones Tell A Friend about MAMA! ... Join Mamas Mailing List Donate $$$ and help support Mamashealth.com What is Polycystic Kidney Disease? Polycystic kidney disease (PKD) is an inherited disease characterized by the growth of numerous cysts filled with fluid in the kidneys. PKD cysts can slowly replace much of the mass of the kidneys, reducing kidney function and leading to kidney failure. PKD can also cause cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain. The cysts may also cause pain or may get infected. There are two types of PKD ( autosomal dominant and autosomal recessive Types? Autosomal dominant PKD is inherited. This kind of PKD accounts for about 90 percent of all PKD cases. The term "Autosomal dominant" means that if one parent has the disease, there is a 50 percent chance that the disease will pass to a child. Autosomal recessive PKD is also inherited. This type of PKD is rare. Parents that do not have the disease can have a child with the disease. How can this happen? Ib both parents carry the recessive gene and pass the recessive gene to their child, the child will have two recessive genes and develop the disease.(inherited).

11. Melanie's PKD Page The personal story of experiences with polycystic kidney disease and resources. http://victorian.fortunecity.com/ferndale/686/pkd.html

web hosting domain names email addresses related sites Melanie's PKD Page This page is all about PKD (Polycystic Kidney Disease). Even though very few people have heard of it, Polycystic Kidney Disease affects 600,000 people in the U.S. alone, and 12.5 million world wide. There are more people with PKD than cystic fibrosis, muscular dystrophy, hemophilia, Downs syndrome and sickle cell anemia combined. Many PKD patients find it useful to have access to the same information as their doctors because many doctors are unfortunately pretty unfamiliar with the disease. I will try to bring you as much information and sources about the disease as possible. If you have any questions about PKD for any reason, or if you know of anyone who has the disease and is looking for more information or for support groups I encourage you to contact any of the sources I have listed here, or to ask me a question . I would also appreciate an email if you have any pertinent information I should add to this page. PKD has been a profound part of my life so far, and will only continue to become more so. Likewise, the information on this page is just the beginning, and will continue to grow as time and research allows. If there is just one person out there that this page might help, I will be grateful for having the opportunity to make a difference. How to help PKD Resources My personal experience with PKD How to help One woman and her dog are traveling across the country by car to raise awareness of PKD and money to help find a cure. You can use the

12. The PKD Foundation The PKD Foundation is the only organization, worldwide, devoted to improving clinicaltreatment and discovering a cure for polycystic kidney Disease (PKD). http://www.pkdcure.org/home.htm

The PKD Foundation is the only organization, worldwide, devoted to improving clinical treatment and discovering a cure for Polycystic Kidney Disease (PKD). We're happy you found us on the internet. We've structured this site to answer your questions, provide resources and allow opportunities for you to become more involved in our organization and our mission to END PKD Our Vision: No one suffers the full effects of PKD. Our Mission: Promote research to find a cure for PKD and improve the care and treatment of those it affects. Spring 2003 The Really Grand Parents. Grandparents of a teenager with PKD rally to support research. ARPKD Patient Profile - Carley's Cause Although her life was too short, Carley’s legacy lives on. Medical News Ovarian cysts and PKD, Growth Hormones and ARPKD, and Bone Density After Transplantation. In the News Effects of Caffeine, PKD Foundation's Report Card, and Save the Date for the 14th Annual Conference on PKD. A Timely Reminder Get Your Limited Edition PKD Foundation watch today! Make a Donation to help fund PKD research Become a Member of the PKD Foundation Request an Information Packet on Polycystic Kidney Disease Attend the PKD Conference June 27 - 29, 2003

13. Polycystic Kidney Disease Chat & Community A place where people with PKD, friends and family members can go for support. With many links for dialysis information and offers weekly chats and message boards. http://beta.communities.msn.com/PolycysticKidneydiseasechatcommunity

MSN Home My MSN Hotmail Search ... Money Groups PolycysticKidneydiseasechatcommunity@beta.communities.msn.com Groups Home My Groups Language Help ... Tools SPONSORED SITES: Recommend This Group to a Friend Welcome to our PKD (Polycystic Kidney Disease) Support Group You're not Alone!!! some clipart courtesy of New Messages View all Hi Lin Hi Lin Nice to hear from you. The thought of dialysis does frighten... Destiny Hi Bridget Hi Lin Hi, I'm sorry that you're not having such a good day; hoping that tomorrow will be better! Well, you've gone through the change, and I'm going through dialysis so ... Lin Hi Lin Hi Lin Thanx for your email. I try to laugh about my illness and try to dismiss it to the... Destiny Tools Join This Group Recommend This Group ... Group Settings New Photos View all tulips Hans pot of gold rainbow ... Easter Bunny Albums with New Photos Hans ? manager's album? Hi Bridget/ Willy Notice: Microsoft has no responsibility for the content featured in this Group. Click here for more info. MSN - More Useful Everyday MSN Home My MSN ... GetNetWise

14. Polycystic Kidney page dedicated to Autosomal Recessive polycystic kidney Disease (ARPKD) survivors, victims and their families. http://www.foundhealth.com/Health/Conditions_and_Diseases/P/Polycystic_Kidney

Advertisement Foundhealth.com Search All Terms Any Term Tips Browse foundhealth.com Health calculators Fast Food Database Speakers Bureau How to evaluate sites Submit a site Contact us Home - main directory Top Health Conditions and Diseases P : Polycystic Kidney Joey's Page - A page dedicated to Autosomal Recessive Polycystic Kidney Disease (ARPKD) survivors, victims and their families. Polycystic Kidney Disease - Cecilia Maida is working to increase public awareness of the disease. Contact information and related links. The Polycystic Kidney Research Foundation - A site for patients, medical professionals, and researchers of Polycystic Kidney Disease, the world's most common life-threatening genetic disorder. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the Open Directory made available on foundhealth.com have been modified. Home Health Tools Fast Food Database Vitamins and Minerals ... foundhealth.com

15. MayoClinic A description of the disease as well as how to detect and treat it. http://www.mayoclinic.com/home?id=5.1.1.16.23

16. Acute Pyelonephritis Of The Kidney polycystic kidney of the Kidney From the Virtual Pathology Museum, Department of Pathology, University of Connecticut Health Center ©1997 . Feed Back . polycystic kidney, Kidney. Infantile polycystic kidney http://radiology.uchc.edu/Code/641.htm

Acute pyelonephritis, Kidney Acute Pyelonephritis Secondary to Obstruction •This is a posterior view of kidneys. The specimen includes metastatic colon carcinoma (T) involving the hilar and proximal peri-ureteral soft tissues on the right. •Although not demonstated by this photograph, the tumor growth in this region has led to secondary hydronephrosis and pyelonephritis of the right kidney. Image Contrib. by: UCHC Description by: H. Yamase, M.D. ( 294-6024) More Information

17. Page Moved polycystic kidney Research Foundation has Moved. Pleaseupdate your bookmarks now. http//www/pkdcure.org. http://www.kumc.edu/pkrf/

Polycystic Kidney Research Foundation has Moved Please update your bookmarks now http://www/pkdcure.org

18. Adult Polycystic Kidney Disease - General Practice Notebook Clinicallyoriented information. http://www.gpnotebook.co.uk/MedwebPage.cfm?ID=-1945763840

19. Polycystic Kidney Disease Image that's a link to Genetics Education Center Support Page polycystic kidneyDisease Segregation analysis of autosomal dominant polycystic kidney disease. http://www.kumc.edu/gec/support/polycyst.html

Polycystic Kidney Disease PKD Foundation (Polycystic Kidney Disease Foundation) Phone: 1-800-PKD-CURE (800.753.2873) or 816.931.2600 Fax: 816.931.8655 E-mail: pkdcure@pkdcure.org Web site: www.pkdcure.org/home.htm National Kidney Foundation 30 East 33rd Street New York, NY 10016 Phone: 800.622.9010 Web site: www.kidney.org/ Also See: National organizations - information on genetic conditions or birth defects Creating a Healthy Menu , Computer Program for Kidney Patients and Others Kidney Foundation of Canada Kidney Transplant/Dialysis Association, Inc. Australian Kidney Foundation National Kidney Research Fund , United Kingdom Other kidney disease organizations Polycystic Kidney Disease information National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIDDK) Renal Family Cookbook World Kidney Fund for families in developing countries International Nephrology: Australian and New Zealand Society of Nephrology Brazilian Society of Nephrology International Society of Nephrology (ISN) International Society for Peritoneal Dialysis (ISPD) ... Renal Association (United Kingdom), for families developing countries, who have little or no access to healthcare facilities

20. Polycystic Kidney Disease polycystic kidney Disease. by Colleen Power. The cat likely had a progressive kidneydisease that they didnt know much about, called polycystic kidney Disease. http://www.netcat.org/pkd.html

$nbsp; Polycystic Kidney Disease by Colleen Power Is your cat drinking a lot of water? Does it visit the litter pan a bit too often? In 1978, my three year old white Persian stud began exhibiting these symptoms one day. Each time I passed the bathroom, there he was in the litter pan. After the third time past the door, with him back in the litter pan, I immediately thought, renal blockage. Whipped him up and over to the vet. That was not the problem. He was simply urinating too frequently. So frequently in fact that the vet called it "Polyuria." There was no blockage, no crystal formations in the bladder. He was simply urinating frequently, to the extent that within six hours, he had become dehydrated. The vet pumped him full of fluids, peritoneally(through the abdominal wall) He did x-rays to look for tumors. He then gave me the bad news. The cat likely had a progressive kidney disease that they didnt know much about, called Polycystic Kidney Disease. The cats would experience episodes of polyuria over a one year period before succumbing to the disease. Upon autopsy, they would find lesions on the kidneys, the cause was not known, but the disease was progressive, and the diagnosis: incurable. However, my cat could go home, live a happy, but short life, with increasingly frequent episodes, before he would eventually die. Supportively he received renal tablets(Renaseptic), and of course, some antibiotics. Apollo was fine for six months. I did not stress him with breedings. In fact, I was in the middle of moving and had placed nearly all of the cats, except Apollo and my two folds.

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