81. ClinicalTrials.gov - Linking Patients To Medical Research: Study Details Purpose This study will try to identify mutations in the genes responsible for primaryimmunodeficiency disorders (inherited diseases of the immune system) and http://www.clinicaltrials.gov/ct/gui/show/NCT00006319?order=14

82. P1 Prescription Drug Assistance Programs. primary Biliary Cirrhosis. primaryImmune disorders. Prion Diseases. Probability and Statistics. Progeria. http://www.ability.org.uk/p1.html

Our Aims Services Stats ... Z P Prayer An SAS Soldier's Prayer Pain Pain Chronic Pain Pancreatic Cancer ... Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

83. IPOPI - International Patient Organisation For Primary Immunodeficiencies Some disorders such as Selective IgA Deficiency can be quite Untreated primary immunedeficiencies are characterized by frequent lifethreatening infections http://www.ipopi.org/pidinfo/

The World Health Organization recognizes approximately 70 primary immune deficiencies including X-Linked Agammaglobulinemia (Bruton's Disease), Common Variable Immune Deficiency (also called Hypogammaglobulinemia), Selective IgA Deficiency, and Severe Combined Immune Deficiency (boy-in-the-bubble disease). Some disorders such as Selective IgA Deficiency can be quite common, occurring as often as 1/500 to 1/1000 individuals. Others may be as rare as 1 individual affected per million. Untreated primary immune deficiencies are characterized by frequent life-threatening infections and debilitating illnesses. Because of advances in our medical understanding and treatment of primary immune deficiency diseases, many patients who in the past would not have survived childhood are now able to live nearly normal lives. Most primary immune deficient patients require life long therapies including intravenous gammaglobulin infusion, aggressive antibiotic therapies, or bone marrow transplantation. Five classes of primary immunodeficiency diseases have been identified: T-lymphocyte disorders (such as the DiGeorge anomaly and chronic mucocutaneous candidiasis);

84. Primary Immunodeficiency program. NIAID primary immune Deficiency Fact Sheet from the NationalInstitute of Allergy and Infectious Diseases (US). National http://rarediseases.about.com/cs/primaryimmunodef/

zfp=-1 About Rare/Orphan Diseases Search in this topic on About on the Web in Products Web Hosting Rare/Orphan Diseases with Mary Kugler Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects BUYER'S GUIDE Before You Buy Top Picks Sites for Online Specialty Shopping ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement Primary Immunodeficiency Guide picks An inherited problem with, or lack of, some or all of the body's immune system. NICHD: Primary Immunodeficiency Immune Deficiency Foundation Site offers information, literature, "ask the expert" section, advocacy, insurance help, and consulting immunologist program. NIAID: Primary Immune Deficiency Fact Sheet from the National Institute of Allergy and Infectious Diseases (U.S.). National Primary Immunodeficiency Resource Center Site offers resources for both physicians and patients including a research library, information, and K.I.D.S Korner. JMF: Primary Immunodeficiency Information about the disorder from the Jeffrey Modell Foundation. Site also offers other resources including message board. Severe Combined Immunodeficiency A severe defect in both parts of the body's immune system, which leaves the person open to infection.

85. Infusion Network Systems: Physicians Clinical Warning Signs of primary immune Deficiency 8 Warning Signs Disordersof Host Defense Immunologist's rule of thumb for determining immunodeficiency, http://www.infusionsystems.net/physicians.html

Infusion Network Systems, Inc. 3401 Enterprise Parkway # 340 Beachwood, Ohio 44122 phone: 877.442.7009 email: ClinicInfo@infusionsystems.net Other Resources About INS On Line Consult Form On Line Infusion Log Patients Physicians Nurses Partners Services INS Clinic Locations ... Physician's Clinical Signs Infusion Network Systems is dedicated to expanding the knowledge base of the medical community to increase awareness of primary immune deficiency. This is accomplished through lectures, grand rounds, consultations, formal and informal meetings, and medical journal submissions. Our Medical Director, Dr. Robert W. Hostoffer , is a leading immunologist and expert in the field of treating primary immune deficiency. Dr. Hostoffer has been a contributing author in various publications and actively involved as PI in numerous studies in the administration of intravenous immune globulin (IVIG). Physicians and Healthcare Professionals Questions concerning immune deficiency?

86. Support - KIDS Foundation Of NZ - Everybody.co.nz OUR ORGANISATION Free seminars on primary immune Deficiency DisordersEarly Diagnosis 10 warning signs. NZ, February 2003. Leading http://www.everybody.co.nz/support/kids.html

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87. The Dangers Of Smallpox It is believed that about 1 person in 500,000 has this form of primaryimmune deficiency. Other immune disorders are far more common. http://www.tucsoncitizen.com/living/2_3_03smallpox.html

88. OUP USA: ToC: Primary Immunodeficiency Diseases Inherited disorders with Autoimmunity and Defective Lymphocyte Assessment of the ImmuneSystem, Helen M Genetic Aspects of primary Immunodeficiencies, Jennifer M http://www.oup-usa.org/toc/tc_0195104862.html

Primary Immunodeficiency Diseases A Molecular and Genetic Approach Edited by Hans D. Ochs, C.I. Edvard Smith, and Jennifer M. Puck CONTENTS Part I: Overview 1. Genetically Determined Immunodeficiency Diseases: A Perspective, C.I. Edvard Smith, Hans D. Ochs, and Jennifer M. Puck 2. Genetic Principles and Technologies in the Study of Immune Disorders, Jennifer M. Puck and Robert L. Nussbaum 3. Mammalian Hematopoietic Development and Function, Gerald J. Sprangrude 4. T Cell Development, Rae S.M. Yeung, Joseph M. Penninger, and Tak W. Mak 5. Molecular Mechanisms Guiding B Cell Development, Antonius Rolink, Jan Andersson, Paolo Ghia, Ulf Grawunder, et al. 6. Signal Transduction by T and B Lymphocyte Antigen Receptors, Arthur Weiss, Anthony L. DeFranco 7. Phagocytic System, Kuender D. Yang, Harry R. Hill, Paul G. Quie Part II: Syndromes 8. X-linked Severe Combined Immunodeficiency, Jennifer M. Puck 9. Severe Combined Immune Deficiency Due to Defects of the JAK3 Tyrosine Kinase, Fabio Candotti and Luigi D. Notarangelo 10. Immunodeficiency Disease Due to Deficiency of Adenosine Deaminase (ADA)

89. NORD - National Organization For Rare Disorders, Inc. immune Deficiency Foundation 40 West Chesapeake Avenue Patient Organization for PrimaryImmunodeficiencies Web National Organization for Rare disorders, Inc. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Granulomatous

90. MediVibe.com - Welcome To Your Everyday Medical Resource Obstetrics/Gynecology Oncology Ophthalmology Orthopedics Pediatrics Podiatry PrimaryCare Psychiatry HealthPortal Diseases and Conditions immune disorders http://medivibe.subportal.com/health/Diseases_and_Conditions/Immune_Disorders/

l Home About Us Member Login Contact Us ... Advertise With Us Email Login Password New users sign up Web Page Search Main Search by Specialty Anesthesiology Cardiology Dermatology Emergency Medicine ... Urology Search by Topic Alternative Medicine Health Care Infectious Diseases Pharmaceuticals ... Diseases and Conditions Immune Disorders News: A New Wimp Factor? Immune systems weaker in Clark Kent types Sneeze on My Child, Please Early exposure to germs might boost kids' immunity A Winter Break for Immune System? Hamster research sheds light on that possibility And a Side of Algae, Please Blue-green plant may boost immune system Fear and Self-Loathing in Your Immune System Autoimmune diseases result of mutations and infection, study suggests Stress Dampens Immunity That frazzled feeling may make it easier to get sick New Drug Stalls Rheumatoid Arthritis Heralded as major breakthrough in treatment Don't Worry, Stay Well Study shows immune systems are weaker in neurotic types Scientists Think They Can Suppress MS Animal tests offer hope for future treatment 'AIDS Battle Fatigue' Survey finds HIV patients have trouble sticking to tough drug regimen Can a Woman's Immune System Kill Her Fetus?

91. Te Puna Web Directory > NZ > Health > Children And Young People's Health KIDS Foundation of New Zealand Inc. Offers support to children and adults withprimary immune deficiencies, immune defects and related blood disorders. http://webdirectory.natlib.govt.nz/dir/en/nz/health/children-and-young-peoples-h

Web Directory NZ Health Children and Young People's Health See also: Children and Young People@ Brainwave : build a lifetime in the first three years Aims to inform people about what is happening inside baby's brains in the first critical years, and how this impacts on adulthood. CanTeen The national support network for teenage cancer patients. Child Cancer Foundation Support and information for child cancer patients and their families. Children's Issues Centre = Manawa Rangahau Tamariki Research and information centre for issues involving children, with local and international links, publications and current activities. Cloud 9 Children's Foundation (New Zealand) : helping you understand children with Asperger's Syndrome and helping them understand you Aim is "Helping you understand children with Asperger's Syndrome and helping them understand you." Drug Abuse Resistance Education (New Zealand) Fifty D.A.R.E. Support Committees have been established in New Zealand, made up of parents, teachers, and concerned citizens, determined to do their part in making our communities healthy and safe environments for our children to prosper in. Includes contact details. Everybody Health information which has been written for New Zealanders, by New Zealanders. Covers health conditions, healthy living, the New Zealand health scene, tests and treatments.

92. KIDS Foundation - Medical Advisory Panel Dr Ameratunga has a special interest in primary immune deficiencydisorders. Dr Ameratunga has received a PhD for genetic studies http://www.pidsnz.co.nz/panel/panel.htm

Medical Advisory Panel Operating as a sub-committee of the KIDS Foundation Board, the Medical Advisory Panel is comprised of eight medical professionals specialising in immunology-related illnesses. Two of the Panelists, Dr Rohan Ameratunga and Dr Jan Sinclair will also strengthen the link with the Foundation by becoming fully-fledged Board directors with voting rights. Dr Ameratunga will cover adult patient issues while Dr Sinclair will advocate for child patient issues. The Panel will provide the Foundation with medical advice, review scientific advances, prepare written articles for 'In Touch' magazine and assist in providing talks or lectures about Primary Immune Deficiency and related conditions. Panelists will also endorse Foundation activities as appropriate and update the Board on any medical service issues and concerns. KIDS Foundation general manager, Janet Simons, says the confirmation of the Medical Advisory Panel signals a new and exciting era for the Foundation. "We see the Panel as the key to building a stronger Foundation team dedicated to achieving more for the immunology service providers as well as PID patients around New Zealand. Having leading medical specialists working closely with the Foundation also enhances our reputation and credibility - an essential cornerstone if we are to raise awareness about PID".

93. Primary Immunodeficiency primary immunodeficiencies are complex diseases them is according to the part of theimmune system that In some disorders, the B cells make almost no antibodies http://156.40.88.3/publications/pubs/primaryimmunobooklet.htm

Home Search Sitemap Contact ... Publications Primary Immunodeficiency C O N T E N T S Introduction What is Primary Immunodeficiency? The Immune Defenses Genes and PI ... Glossary I N T R O D U C T I O N M There are over 70 different types of PIs. Each type has somewhat different symptoms, depending on which parts of the immune defense system are deficient. Some deficiencies are deadly, while some are mild. But they all have one thing in common: they may open the door to multiple infections. In the more severe forms of PI, germs which cause only mild infections in people with healthy immune systems may cause severe or life-threatening infections. Although infections are the hallmark of PIs, they are not always the only health problem, or even the main one. Some PIs are associated with other immune system disorders, such as anemia, arthritis, or autoimmune diseases. Other PIs involve more than the immune system; some, for instance, are associated with symptoms involving the heart, digestive tract, or the nervous system. Some PIs retard growth and increase the risk of cancer. Today, thanks to rapid advances in medicine, many PI diseases can be successfully treated or even cured. With proper treatment, most people with PIs are not only surviving once-deadly diseases, they are usually able to lead normal lives. Children usually can go to school, mix with playmates, and take part in sports. Most adults with PI are leading productive lives in their communities.

94. Immunopharmacology Page 5 primary and secondary serum antibody responses. induces tolerance for marrow/immunecell grafting Efficacious for managing Autoimmune disorders systemic lupus http://www.pharmacology2000.com/Hemo/Immunosupression/immuno5.htm

Immunosuppressive Cytotoxic Drugs return to main menu Azathioprine Chemistry imidazolyl derivative of mercaptopurine (6-MP; 6-mercaptopurine structural analog antimetabolite Primary use azathioprine: immunosuppression prototype: cytotoxic immunosuppressive drugs kill profilerative cells return to main menu Pharmacokinetic/Pharmacodynamics: azathioprine well absorbed from the GI tract metabolized to mercaptopurine (primarily) xanthine oxidase converts azathioprine to 6-thiouric acid patients on xanthine oxidase inhibitors (allopurinol for management of hyperuricemia) dosage reduction required to prevent toxicity urinary excretion small amounts of mercaptopurine and unchanged drug also renally excreted return to main menu Mechanism of Immunosuppression Action:azathioprine interference with nucleic acid metabolism

95. SRBI.COM - Market Research Projects - Primary Immune Deficiency Diseases In Amer DISEASES IN AMERICA The First National Survey of Patients and Specialists Primaryimmune deficiency diseases represent a class of disorders in which there is http://www.srbi.com/immune_dificiency.html

SRBI TODAY LINKS PRIMARY IMMUNE DEFICIENCY DISEASES IN AMERICA: The First National Survey of Patients and Specialists Primary immune deficiency diseases represent a class of disorders in which there is an intrinsic defect in the human immune system (as distinct from immune disorder that are secondary to infection, chemotherapy, or some other external agent). In some cases, the body fails to produce any or enough antibodies to fight infection. In other cases, the cellular defenses against infection fail to work properly. The first medical recognition of primary immune deficiency diseases was only fifty years ago. Today, the World Health Organization recognizes more than 80 different primary immune deficiency diseases. Although primary immune deficiency diseases are often described as rare disorders, the true population prevalence of these diseases, either individually or collectively, is not well established. The major health surveys conducted by the U.S. government, the National Health Interview Survey and the National Health and Nutrition Examination Survey, do not collect information on primary immune deficiency diseases. No national population survey has ever been undertaken in the United States to estimate the prevalence or the population characteristics of the disease. Hence, although the diseases are clinically described in the medical literature, there is no comprehensive portrait available of the patient with primary immune deficiency diseases.

96. NIH Study Category Listing (7): Immunology/Infectious Diseases Inhibitor Conta. Evaluation of Antibody Production in primary ImmuneDisorders. Cryptococcosis in Previously Normal Adults. Treatment http://www.centerwatch.com/patient/nih/nihcat7.html

About the NIH Clinical Center NIH Clinical Trials Search Page Return to NIH Listings Menu Non-NIH Trial Listings ... Additional resources in this illness area NIH Studies: Immunology/Infectious Diseases Below is a listing of government-funded clinical trials in Immunology/Infectious Diseases, being conducted by the various National Institutes of Health at the Warren Grant Magnuson Clinical Center in Bethesda, MD. Click on a study summary to view the study description and contact information directly from the NIH's web site. Epidemiology, Infectivity and Natural History of Hepatitis C Virus Infection in a Blood Donor Population Prospective Evaluation of the Significance of Anti-HIV Antibody in Asymptomatic Blood Donors A Phase II Study of Liposomal Doxorubicin and Interleukin-12 in AIDS-Associated Kaposi's Sarcoma Followed by Chronic Administration of Interleukin-12 Immunologic and Virologic Studies of Intermittent Versus Continuous HAART in the Treatment of HIV Disease ... A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients with Suspected Chronic Lyme Infection and Selected Control Populations Last updated: March 28, 2003 at 2:41:17 PM Patient Resources: [ Trial Listing Notification Services Drug Directories About Clinical Research ... Patient Bookstore Professional Resources: [ Research Center Profiles Industry Provider Profiles Industry News Professional Resources ... Professional Bookstore General: [ Search Site Map Your Privacy CW World ... Home This site was developed in association with

97. Clinical Study: 01-HG-0226, Evaluation Of Antibody Production In Primary Immune Clinical Study Summary Sheet for 01HG-0226 http://clinicalstudies.info.nih.gov/detail/A_2001-HG-0226.html

Protocol Number: 01-HG-0226 Title: Evaluation of Antibody Production in Primary Immune Disorders Number: 01-HG-0226 Summary: This study will evaluate immune function in people with a known or suspected immune disorder. It will determine participants' immune response to vaccines by measuring blood antibody levels after vaccination. Patients enrolled in a NIH protocol involving immune reconstitution (bone marrow transplantation or gene therapy) for a known or suspected primary immune disorder may be eligible for this study. Participants may be asked to have more than one vaccine, based on their age, use of IVIG, past immunization history and underlying immune problem. The possible vaccinations include: The diphtheria, tetanus, pneumococcus and rabies vaccines are approved by the Food and Drug Administration (FDA) and used routinely to protect against disease. Bacteriophage PhiX174 is approved for research purposes to test immune status. Study participants will have a blood sample drawn before vaccination. The number of additional samples collected will vary according to the vaccines administered-8 for bacteriophage PhiX174; 1 for rabies; 1 for tetanus; and 1 to 2 for the pneumococcal vaccines. Each sample will be up to 5 teaspoonfuls. Participation in the study may last up to a year, depending on the blood sampling scheduling Sponsoring Institute: National Human Genome Research Institute (NHGRI) Recruitment Detail Type: Active Accrual Of New Subjects Gender: Referral Letter Required: Yes

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