1. STEVENS JOHNSON SYNDROME SUPPORT NETWORK A type of hypersensitivity (allergic) reaction that occurs in response to medications, infections, or illness. In stevensjohnson syndrome, the systemic symptoms are severe and the lesions are extensive, involving multiple body areas (especially the mucous membranes). Toxic epidermal necrolysis (TEN syndrome, or Lyell's syndrome) involves multiple large blisters (bullae) that coalesce, followed by sloughing of all or most of the skin and mucous membranes. http://www.interlog.com/~zzzz/

Stevens Johnson Syndrome Toxic Epidermal Necrolysis Syndrome Support Network SJS/TENS sjssuport@interlog.com TORONTO ONTARIO CANADA The Stevens Johnson Syndrome and Toxic Epidermal Necrolysis Syndrome Support Network is dedicated to providing people with emotional support, providing information and to building a network of contacts for people to access. If you have something to add to this site, or if you have any suggestions for this site, I would love to hear them PLEASE BE SURE TO JOIN OUR STEVENS JOHNSON SYNDROME TOXIC EPIDERMAL NECROLYSIS SYNDROME MAILING LIST. WE NOW HAVE 133 PEOPLE ON THE LIST! To Join please enter your e-mail address in the box below and press "Join group" Subscribe to Stevens Johnson Syndrome tens archive Hosted by eGroups.com PRESS BUTTON FOR MORE INFORMATION LAST UPDATE Oct. Oct. 23, 1999

2. Stevens Johnson Syndrome Foundation See an overview of the condition's origins, history, diagnosis, treatment and incidence of occurrence. Background stevensjohnson syndrome (SJS) is an immune-complexmediated hypersensitivity complex that is a severe http://www.sjsupport.org/

Stevens Johnson Syndrome Foundation sjs, stevens johnson, Stevens Johnson, steven johnson, sjsupport, sjs foundation, sjs colorado, Stevens Johnson Syndrome, drug reaction, reaction, rash, allergic reaction, The Stevens Johnson Syndrome Foundation (Julie Foundation for allergic drug reactions) a non profit organization. The purpose of the foundation is to provide the public and medical communities with information on adverse allergic drug reactions. Enter Here NameZero.com - Register your domain name.

3. Arava Injury Attorney: Health Alert Provides information about the inflammatory skin disorder, Stevens Johnson Syndrome, and its relation to the rheumatoid arthritistreatment drug, Arava. 3. stevens-johnson syndrome A type of hypersensitivity (allergic) reaction that occurs in response to medications and http://www.arava-stevens-johnson-syndrome.com/

Arava Submission Form ARAVA HEALTH ALERT Arava Health Risks Arava Side Effects Dangers of Arava Arava Public Warnings Statements from doctors Arava Alternatives How did this happen? Arava Law What are my rights? Details of Arava law. Get legal help Locate an attorney. Home Legal Compensation for Arava Damages On March 28th, 2002 Public Citizen, a consumer protection group started by Ralph Nader, urged regulators to immediately ban the rheumatoid arthritis drug Arava, saying it had linked the product to 12 fatal cases of liver damage. According to the petition, there have been at least 130 cases of severe liver toxicity reported to the FDA, including 56 hospitalizations and 22 deaths. Liver toxicity induced by Arava is a suspected cause in 12 of these deaths. If you have taken Arava you may be entitled to legal compensation for pain and suffering.

4. Expert Advice -- Stevens-Johnson Syndrome stevensjohnson syndrome is an illness which causes severe swelling and destruction of the skin and mucous membranes. The first signs of stevens-johnson syndrome generally do not develop until about two to three weeks after being exposed http://www.parentsoup.com/experts/ped/qas/0%2C7813%2C200533_417049%2C00.html

var cimsCid = ''; var cimsUid = '417049'; main COMMUNITY Message Boards Chats ... Community Challenges find on iVillage on astrology on babies on beauty on books on food on health on lamaze.com on money on parenting on pets on relationships on women.com on work MAGAZINES on Cosmopolitan on Country Living on Good Housekeeping on House Beautiful on Marie Claire on Redbook on Victoria you are here: iVillage parent soup experts pediatrician ... Talent Test more centers iMaternity RECOMMENDED Find Out What Your Child's Name Means Top Children's Names by Decade Birthday Parties Made Easy Best Ways to Discipline Your Child ... 4 Things Every Stay-at-Home Mom Needs to Know WHAT'S NEW 10 Best Travel Games 10 Steps to Potty Training Your Toddler 40 Ways to Balance Work and Family TOPICS Activities and fun Ages and stages Behavior problems Child health ... Parenting A-Z FEATURES Boards Chats Debates Experts ... Workshops FREE NEWSLETTERS Parent Soup ParentsPlace more newsletters Stevens-Johnson Syndrome My son was diagnosed with Stevens-Johnson Syndrome recently. Could you provide me with information regarding this disease? Robert Steele, M.D.

5. EMedicine - Stevens-Johnson Syndrome : Article By Steven Parrillo, DO, FACOEP, F stevensjohnson syndrome. Last Updated November 26, 2002, FULL DISCLAIMER.stevens-johnson syndrome excerpt. © Copyright 2002, eMedicine.com, Inc. http://www.emedicine.com/EMERG/topic555.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Emergency Medicine Allergy And Immunology Stevens-Johnson Syndrome Last Updated: November 26, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: SJS, erythema multiforme major AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Steven Parrillo, DO, FACOEP, FACEP , Assistant Professor, Department of Internal Medicine, Thomas Jefferson University; Chair, Emergency Preparedness Committee, Department of Emergency Medicine, Albert Einstein Medical Center Coauthor(s): Catherine V Parrillo, DO, FACOP, FAAP , Clinical Assistant Professor, Director of Pediatric Student Clinical Rotation, Department of Pediatrics, Philadelphia College of Osteopathic Medicine Steven Parrillo, DO, FACOEP, FACEP, is a member of the following medical societies: Society for Academic Emergency Medicine Editor(s): Daniel J Dire, MD, FACEP, FAAEM

6. EMedicine - Erythema Multiforme (Stevens-Johnson Syndrome) : Article By Don R Re Erythema Multiforme (stevensjohnson syndrome). Last Updated January 20, 2003, FULLDISCLAIMER. Erythema Multiforme (stevens-johnson syndrome) excerpt. http://www.emedicine.com/MED/topic727.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Infectious Diseases Erythema Multiforme (Stevens-Johnson Syndrome) Last Updated: January 20, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: erythema multiforme major, erythema multiforme bullosum, bullous erythema multiforme, erythema multiform exudativum, SJS, toxic epidermal necrolysis, TEN, SJS/TEN overlap, target lesions, iris lesions, herpes simplex virus, HSV, Epstein-Barr virus, histoplasmosis, keratinocyte necrosis AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Don R Revis, Jr, MD , Consulting Staff, Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Florida College of Medicine Don R Revis, Jr, MD, is a member of the following medical societies: American College of Surgeons , and American Medical Association Editor(s): Jeffrey Lee Kishiyama, MD

7. Treatment Of Severe Drug Reactions: Stevens-Johnson Syndrome, Toxic Epidermal Ne Treatment of severe drug reactions stevensjohnson syndrome, Toxic EpidermalNecrolysis and Hypersensitivity syndrome Pierre-Dominique Ghislain MD, Jean http://dermatology.cdlib.org/DOJvol8num1/reviews/drugrxn/ghislain.html

DOJ Contents Treatment of severe drug reactions: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis and Hypersensitivity syndrome Pierre-Dominique Ghislain M.D., Jean-Claude Roujeau, M.D. Dermatology Online Journal 8(1): 5 Department of Dermatology, H6pital Henri Mondor, Universit6 Paris XII, Cr6teil, France Abstract Severe skin adverse drug reactions can result in death. Toxic epidermal necrolysis (TEN) has the highest mortality (30-35%); Stevens-Johnson syndrome and transitional forms correspond to the same syndrome, but with less extensive skin detachment and a lower mortality (5-15%). Hypersensitivity syndrome, sometimes called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), has a mortality rate evaluated at about 10%. Drug reactions are self-limited diseases and therefore, generally treatment is symptomatic. Prompt diagnosis, identification of, and early withdrawal of all suspect drugs are the most important preliminaries. The management of the patients must be undertaken in specialized intensive care units, with the same main types of therapy as for burns: warming of the enviromnent, correction of electrolyte disturbances, administration of a high caloric enteral intake, and prevention of sepsis. Efficacy of drugs used in some case reports is difficult to evaluate: intravenous immunoglobulins, cyclosporin, cyclophosphamide, pentoxyfilline, and thalidomide have all been tried. Corticosteroid use is debated and is probably deleterious in late forms of TEN. For DRESS, corticoids are used in cases of life-threatening systemic impairment. Specific nursing care and adequate topical management reduce associated morbidity and allow a more rapid re-epithelialization of skin lesions.

8. Nursing Continuing Education With Wild Iris Medical Education. stevensjohnson syndrome Just the Facts. Author Stephen Byrnes, ND,RNCP 1 contact hour contact hour What is Stevens Johnson Syndrome? http://www.nursingceu.com/NCEU/courses/stevens/

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9. Menu.html SJS stevensjohnson syndrome a skin detachment less than 10% of thebody surface area with widespread spots or flat atypical targets . http://www.b3e.jussieu.fr/euroscar2/menu.html

10. Stevens-Johnson Syndrome & Herpes stevensjohnson syndrome Herpes What is the relationship betweenherpes and stevens-johnson syndrome? ME. Harold Oster Dr. Oster http://www.ivillagehealth.com/experts/infectious/qas/0,11816,166233_128716,00.ht

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11. Stevens-Johnson Syndrome stevensjohnson syndrome When I was a teenager, I had something called Stevens-Johnsonsyndrome. It affected all of my mucous membranes and caused what they http://www.ivillagehealth.com/experts/ent/qas/0,11816,166233_191599,00.html

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12. Eye Conditions > Stevens-Johnson Syndrome -- EyeMDLink.com Last Updated 9/25/2001. stevensjohnson syndrome. stevens-johnson syndromeis a potentially life-threatening, immune-mediated, illness http://www.eyemdlink.com/Condition.asp?ConditionID=420

13. I Only Had Sore Throat But Allergy Caused This... - FEB 6, 2003 The medicines had apparently triggered a rare drug allergy called StevensJohnsonsyndrome. This stevens-johnson syndrome couldn't have come at a worse time.'. http://newpaper.asia1.com.sg/top/story/0,4136,15438,00.html

MARCH 31, 2003 MON SEARCH I only had sore throat but allergy caused this... Mother of three lands in hospital burns unit for 17 days after reacting to medicine By Michael Lee YOU have a sore throat and a few pimples, so you go to a doctor. You are given some common medicines. Suddenly, you get blisters so bad, it's like half your body has been burnt. That is the unusual ordeal that Madam Norhayati Khalid has just been through. She suffered from an allergic reaction to her medication, which left her barely conscious and in severe pain. It could also have killed her. On Dec 14, the 32-year-old security officer was admitted to hospital. Her body was 'burnt' with blisters from the waist up. The medicines had apparently triggered a rare drug allergy called Stevens-Johnson syndrome. (See report below.) She was so badly affected that she had to spend more than two weeks at the burns unit of the Singapore General Hospital (SGH). And, though much better now, she says she still looks like she has been 'stung by a nest of hornets'. Her problems started with a routine visit to the Bukit Merah polyclinic for acne, sore throat and sore eyes, on Dec 10.

14. Arava Stevens Johnson Sydrome Side Effects In recent studies Arava has been linked with Stevens Johnson Syndrome.stevensjohnson syndrome is a potentially life-threatening http://www.yourlawyer.com/practice/overview.htm?topic=Arava

15. Arava Injury Attorney: Health Alert 1998. The rheumatoid arthritis drug has also been linked to lymphoma,high blood pressure, and stevensjohnson syndrome. From September http://www.arava-stevens-johnson-syndrome.com/side-effects.html

Arava Submission Form ARAVA HEALTH ALERT Arava Health Risks Arava Side Effects Dangers of Arava Arava Public Warnings Statements from doctors Arava Alternatives How did this happen? Arava Law What are my rights? Details of Arava law. Get legal help Locate an attorney. Home Side effects Arava has been associated to at least 130 cases of severe liver problems (hepatoxicity) and 22 deaths since its arrival to the market in 1998. The rheumatoid arthritis drug has also been linked to lymphoma, high blood pressure, and Stevens-Johnson syndrome. From September 1998, when Arava debuted in the United States, to September 2001, the FDA received 130 reports of severe liver reactions in patients taking Arava, Public Citizen said. For 12 cases that were fatal, liver damage from Arava "appears to be the most plausible explanation," the group said. Public Citizen said it also found reports of many side effects from Arava: Liver damage : The purpose of the liver is to process harmful substances, aid in the digestive process, and produce cholesterol. Liver failure, or hepatoxicity, mostly occurs when a large part of the liver has become damaged beyond repair. Prescription drugs can cause liver failure, and Arava has been associated to this serious condition. Most instances of liver failure require a liver transplant in order to avoid death.

16. Abstracts W, Schöpf E. Incidence of stevensjohnson syndrome (SJS) and toxic epidermalnecrolysis (TEN) in West-Germany and Berlin among different ethnic groups. http://www.ukl.uni-freiburg.de/haut/dzh/abstrace.htm

Abstracts Baur S, Rzany B, Mockenhaupt M, Holländer N, Stocker U, Mueller J, Schröder W, Schöpf E. Incidence of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in West-Germany and Berlin among different ethnic groups. J Invest Dermatol 102: 619 (1994). Mockenhaupt M, Hamouda O, Stocker U, Holländer N, Körner M, Baur S, Rzany B, Schöpf E. Incidence of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in AIDS patients in Germany. Journal of Investigative Dermatology 100: 542 (1993). Mockenhaupt M, Rzany B, Baur S, Mueller J, Schröder W, Stocker U, Zobel K, Holländer N, Schöpf E. Drug risk for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN): Evaluation of antiepileptics based on sale numbers in defined daily doses (DDD). Pharmacoepidemiology and Drug Safety 3: 22 (1994). Mockenhaupt M, Schröder W, Höchstetter R, Rzany B, Schöpf E. Drug attributability in HIV-infected patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Pharmacoepidemiology and Drug Safety 4: 54 (1995).

17. Erythema Multiforme, Stevens-Johnson Syndrome, And Toxic Epidermal Necrolysis Erythema Multiforme, stevensjohnson syndrome, and Toxic EpidermalNecrolysis. Kate M. Petersen, Pharm.D. stevens-johnson syndrome. http://hsc.virginia.edu/cmc/pedpharm/v4n11.htm

Pediatric Pharmacotherapy A Monthly Review for Health Care Professionals of the Children's Medical Center Volume 4 Number 11, November 1998 Erythema Multiforme, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis Kate M. Petersen, Pharm.D. Introduction Erythema multiforme Stevens Johnson Syndrome Toxic epidermal necrolysis ... References Pharmacology Literature Reviews Adverse Effects from Anesthetics Frequency of Adverse Drug Reactions Grapefruit Juice with Carbemazepine Formulary Update Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis are mucocutaneous disorders that are thought to be related, constituting a spectrum of reactions. Erythema multiforme (EM) has the most benign presentation, and is followed in severity by Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Additionally, EM is generally a postinfectious process, while SJS and TEN are drug-induced reactions. As a result, SJS and TEN will therefore be discussed in greater detail than EM in this newsletter article. Erythema multiforme EM, first described in 1860 by von Hebra

18. Pediatric Pharmacotherapy, Volume 1, Number 6 Carbamazepineassociated stevens-johnson syndrome. Keating A, BlahunkaP. Carbamazepine-induced stevens-johnson syndrome in a child. http://hsc.virginia.edu/~smb4v/pedpharm/v1n6.html

Pediatric Pharmacotherapy A Monthly Review for Health Care Professionals of the Children's Medical Center Volume 1, Number 6, June 1995 Proper Storage of Vaccines to Maintain Potency Vaccine Storage Guidelines for vaccine handling and storage Vaccines that should be refrigerated, but not frozen Vaccines that should be frozen Stability of unreconstituted vaccines at room temperature ... FDA News Pharmacology Literature Reviews Carbamazepine-associated Stevens-Johnson Syndrome Carbamazepine-Cyclosporine Interaction Cost-Benefit of DNase HIV in Children ... Formulary Update Proper Storage of Vaccines to Maintain Potency The importance of proper storage conditions for vaccines and other biological medications is often overlooked. Many products, such as the measles vaccine, are inactivated at high temperatures. There is typically little physical evidence of inactivation, making visual inspection of the products an unreliable method of assuring potency. Most currently available vaccines require refrigeration, while some should be frozen until use. These storage requirements must be adhered to from the time of manufacture to the administration to the patient, a process often referred to as maintenance of the "cold chain". Standards of practice for the storage of vaccines have been established by organizations such as the World Health Organization (WHO), the Centers for Disease Control, and the American Academy of Pediatrics [1-3]. Guidelines for vaccine handling and storage Designate one person within each clinic or office to

19. Arava Recall And Injuries Lawyer Injuries Lawyer ARAVALAWSUITS LEGAL ACTIONS FOR LIVER FAILURE, LIVER COMPLICATIONS,stevens-johnson syndrome, HYPERTENSION DEATHS RELATED TO ARAVA USAGE. http://www.arava-injuries.com/

Arava Injuries Home Arava Information Arava-FDA Recall ? Arava-D ... Contact Us Provided By: Willis Law Firm 1221 McKinney Houston, Texas Call Toll Free ARAVA INJURIES - LEGAL ACTIONS ARAVA BACKGROUND: ARAVA , an arthritis drug has been linked to an alarmingly high number of severe liver problems, liver complications, including deaths, since it was first approved by the FDA for the US market in and later in in Canada. Public Citizen says that Arava should be taken off the market immediately. On March 28, 2002 a petition was filed by Public Citizen to the Food and Drug Administration (FDA). ARAVA, ( lenflunomide ), is an anti-inflammatory drug used for the treatment of rheumatoid arthritis. Patients with rheumatoid arthritis (RA) take the prescription medication to reduce the pain and swelling that occurs in joints, most notably in the hands or feet. Aventis, the maker of the drug, reports that there have been 1.5 million prescriptions written for ARAVA since 1998. FDA first approved Arava on September 10, 1998.

20. Arava - Stevens - Johnson Syndrome Arthritis Drug Arava May Cause Liver Damage, Lymphoma, High Blood Pressure stevensjohnson syndrome among Avara Users says Public Citizen. http://www.arava-injuries.com/stevens_johnson.htm

Arava Injuries Home Arava Information Arava-FDA Recall ? Arava-D ... Contact Us Provided By: Willis Law Firm 1221 McKinney Houston, Texas Call Toll Free Thu Mar 28, 4:05 PM ET By LAURAN NEERGAARD, AP Medical Writer WASHINGTON - A prescription drug for rheumatoid arthritis has been linked to dozens of serious liver injuries and 12 deaths and should be banned, a consumer advocacy group told the government Thursday. Arava began selling in 1998 as a competitor to the gold-standard treatment for rheumatoid arthritis, called methotrexate. When the Food and Drug Administration (news - web sites) approved Arava, the agency noted Arava worked no better than the older drug, but said patients needed some different options. Since then, the FDA has received at least 130 reports of severe liver toxicity linked to Arava use, including 56 hospitalizations and 12 deaths, said Dr. Sidney Wolfe of the consumer advocacy group Public Citizen. Two of the deaths were people in their 20s. Since Arava and methotrexate work equally well, and methotrexate also bears a warning about possible liver damage, Wolfe compared the two. The FDA has six times more reports of liver damage among Arava users than methotrexate users — even though thousands more people use methotrexate, he said. Citing similar reactions abroad, the European Union (news - web sites) last year warned patients and doctors about Arava's toxicity, Wolfe said. He wants the FDA to go further and ban Arava's sales.

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