41. MedWatch - BEXTRA Dear Healthcare Professional Letter of hypersensitivity reactions (ie, anaphylactic reactions and angioedema) and skinreactions, including cases of stevensjohnson syndrome, toxic epidermal http://www.fda.gov/medwatch/SAFETY/2002/bextra.htm

2002 Safety Alert - BEXTRA (valdecoxib tablets) This is the text of a letter from Pharmacia and Pfizer. Contact the companies for a copy of any referenced enclosures. Important Drug Warning November 13, 2002 Dear Healthcare Professional, (valdecoxib tablets). BEXTRA is indicated for relief of the signs and symptoms of osteoarthritis and adult rheumatoid arthritis,and for the treatment of primary dysmenorrhea. Since BEXTRA was approved by the FDA on November 16,2001,in postmarketing experience,rare spontaneous reports of hypersensitivity reactions (i.e., anaphylactic reactions and angioedema) and skin reactions, including cases of Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis and erythema multiforme, have been received for patients treated with BEXTRA. These cases, some of which were serious/life threatening,have occurred in patients with and without a history of allergic-type reactions to sulfonamides. In order to communicate this important postmarketing information to healthcare professionals, the following

42. Medicina.hr Livia Puljak. Literatura 1. DontaBakoyianni K, Mitsea AG, Deodoropoulou-PapadimitriouK. stevens-johnson syndrome case presentation. J Clin Pediatr Dent. http://www.medicina.hr/clanci/stevens_johnsonov_sindrom.htm

ISSN: 1333-994X Medicina.hr Internet Stevens Johnsonov sindrom Definicija Stevens Johnsonov sindrom je bolest ko¾e i sluznica koja se odlikuje vruæicom, erozijom u ustima, te¹kim konjunktivitisom i ko¾nim promjenama na cijelom tijelu. Promjene tipièno poèinju na licu i trupu, nepravilnog su oblika, ravne, okruglaste, crvenkaste i ponekad se javljaju mjehuri i lju¹tenje ko¾e. Vi¹e od 50% sluèajeva povezuje se s uzimanjem lijekova (njihova nuspojava). Zbrka s nazivljem u literaturi Erythema multiforme, Stevens-Johnsonov sindrom i toksièna epidermalna nekroliza se u literaturi èesto koriste kao sinonimi bez isticanja razlika meðu njima. Ferdinand von Hebra je 1860. prvi opisao multiformni eritem (erythema multiforme) kao akutno, samo-ogranièavajuæe stanje s karakteristiènim uzdignutim crvenim ko¾nim promjenama. Ove se ko¾ne promjene kasnije razvijaju u karakteristièan oblik mete ili irisa. Promjene poèinju na udovima, traju sedam dana i cijele. Odreðenu ulogu u nastanku bolesti imaju herpes simplex virus (HSV), Epstein-Barr virus i gljiva Histoplasma capsulatum.

43. Glaucoma Shunt Purpose Keratoprosthesis in cicatrizing diseases (chemical burns, ocular cicatricialpemphigoid, stevensjohnson syndrome, etc) is often complicated by severe http://www.djo.harvard.edu/meei/OA/Dohlman/

CAN A GLAUCOMA SHUNT TUBE BE SAFELY EXTENDED TO THE LACRIMAL SAC OR THE ETHMOID SINUS IN KERATOPROSTHESIS PATIENTS? Preliminary Findings Claes H Dohlman MD PhD, Cynthia Grosskreutz MD PhD, Eric J Dudenhoefer MD, and Peter A D Rubin MD From Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute and Harvard Medical School, Boston, MA Address correspondence to: Claes H. Dohlman, MD, PhD Massachusetts Eye and Ear Infirmary 243 Charles Street Boston, MA 02114 USA Tel: 617-573-3240 Fax: 617-573-4369 Key words: glaucoma shunt, keratoprosthesis Supported by a grant from the Joint Clinical Research Center, Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute Abstract Purpose: Keratoprosthesis in cicatrizing diseases (chemical burns, ocular cicatricial pemphigoid, Stevens-Johnson Syndrome, etc) is often complicated by severe glaucoma. A glaucoma shunt is often valuable but the development of an unusually thick capsule around the shunt plate can still leave the pressure unacceptably high. Theoretically, the intraocular pressure may then be lowered by connecting additional tubing from the shunt plate to a cavity with an epithelial lining where fibrous tissue may not form to block the aqueous flow, i.e. the lacrimal sac or the sinuses. In exploring this hypothesis, it must be

44. Entrez-PubMed 257) and of serious rash, 0.1% (N = 2). One mild case of stevensjohnson syndromenot requiring hospitalization occurred in a patient treated with lamotrigine. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

45. Stevens-Johnson Syndrome (www.whonamedit.com) stevensjohnson syndrome Also known as Baader's dermatostomatitisBaader's syndrome Fiessinger-Rendu syndrome Baader-Fiessinger http://www.whonamedit.com/synd.cfm/1501.html

Home List categories Eponyms A-Z Biographies by country ... Contact Stevens-Johnson syndrome Also known as: Baader's dermatostomatitis Baader's syndrome Fiessinger-Rendu syndrome Baader-Fiessinger-Stevens-Johnson syndrome Fuchs' syndrome Klauder's syndrome Neumann's syndrome (Isidor Neumann) Stevens-Baader-Fiessinger-Johnson syndrome Synonyms: Acute mucocutaneous-ocular syndrome, aphthosis generalisata, bullous malignant erythema multiforme, bullous malignant multiforme syndrome, conjunctivitis et cheilostomatitis pseudomembranacea exanthematodes, conjunctivitis et stomatitis pseudopseudomembranacea, cutaneomuco-oculoepithelial syndrome, dermatostomatitis, dry eye syndrome, ectodermosis erosiva pluroficialis, eruptive fever-stomatitis-ophthalmia syndrome, erythema exudativum multiforme majus, erythema multiforme, erythema multiforme exudativum, erythema multiforme exudativum major, fever-stomatitis-ophthalmia syndrome, mucosal-respiratory syndrome. Associated persons: Ernst Baader Noël Fiessinger Ernst Fuchs Frank Chambliss Johnson ... Albert Mason Stevens Description: A syndrome characterized by severe erythema multiforme-like eruption of the skin and lesions of the oral, genital and anal mucosa, and haemorrhagic crusting on the lips, associated with fever, headache and arthralgia. The macular eruptions are usually on extremities, appearing in successive eruptions of short duration. No itching, burning, or rheumatic pains. May appear in separate rings, concentric rings, disk-shaped patches, distributed elevations, and figured arrangements. A very long list of symptoms and signs affecting the eyes, the gastrointestinal tract, etc. It affects all ages, with highest incidence in first or third decades, rarely in infants, or adults over 50 years of age. Prevalent in men. The more severe forms of the disorder occur in boys and young adults. It can be associated with malignant disease and systemic lupus erythematosus. Attacks usually come during the spring and fall.

46. Connection Volume 5 Number 3 Page 4 ABSTRACT stevensjohnson syndrome secondary to nevirapine. Practice We reportthree cases of stevens-johnson syndrome, secondary to nevirapine. http://www.aciis.org/english/v5n3/53p4.htm

CONNECTION REPORT FROM THE ANNUAL CANAC CONFERENCE HIV Nursing for a New Millennium: Learning from our past, Preparing our future April 27 - 29, 2000 - Toronto Colony Hotel, Toronto, Ontario Once again the conference was a true success. Over 200 people were in attendance. Thank you to the organizing committee under the leadership of Cheryl Arneson and John Flannery. The social program was fun thanks to Sally Eaton and her team who managed to get us all on top of the CN Tower. She even provided some of us with elevator buddies should we feel a little unsure about the quick climb to the summit. Who said it was lonely at the top? 20 years of HIV nursing care Index of Abstracts Stevens-Johnson syndrome secondary to nevirapine Cardiac complications and HAART therapy National HIV/AIDS: The Mentorship Program HIV Nursing Information Technology of the Future The following are a selection of abstracts presented in April 2000 in Toronto for the benefit of our members who were unable to attend: ABSTRACT: Stevens-Johnson syndrome secondary to nevirapine Terry Pook; Heather Jarman; Fran Clark; Janet Gilmour; Daniel Gregson; Brenda Done; HIV Care Program, London, Ontario

47. U.S. Pharmacist Continuing Education - Stevens-Johnson Syndrome - Lesson stevensjohnson syndrome A Disease of Diagnostic and Therapeutic Controversy, 1,2Table1. Presenting Symptoms in stevens-johnson syndrome. Prodrome. http://www.uspharmacist.com/ce/stevensjohnson/lesson.cfm

Stevens-Johnson Syndrome A Disease of Diagnostic and Therapeutic Controversy U.S. Pharmacist Continuing Education ACPE Program No. 430-000-01-024-H01 This program provides 2.0 hours of credit (0.2 CEU). Lesson Expires: April 30, 2003 A complication of drug therapy, SJS is a serious and potentially life-threatening, but very rare, skin condition. C utaneous reactions are among the most common adverse drug events reported. Rashes are typically thought of as benign hypersensitivity reactions that resolve merely by discontinuing the offending agent. In most cases, this is true. However, there are some skin disorders that are dangerous and sometimes even fatal. One such disorder is Stevens-Johnson syndrome (SJS). There is great controversy over the true definitions of and distinctions between erythema multiforme, SJS, and toxic epidermal necrolysis (TEN). The terms are sometimes incorrectly used interchangeably. Erythema multiforme is most typically experienced subsequent to an infection, specifically herpes simplex virus (HSV) and mycoplasma. The skin lesions have a regular shape with a well-defined border and occur mostly on the extremities.

48. Nursing CEUs In Eye, Ear, Nose And Throat Topics Conscious Sedation, NursingCEU, 2, Jan 2004, $14. Drug Allergy StevensJohnsonSyndrome, NursingCEU, Jun 2004, $8. stevens-johnson syndrome, NursingCEU, 1, Jun2004, $8. http://www.nurseceu.com/phar.htm

The Free Directory of Online Continuing Education for Nurses Site sponsored by: Please support our advertisers. Their contributions allow us to maintain this free directory. Thank you! Pharmacology Classes Online Courses listed on this site are offered by many different online providers. NurseCEU.com does not offer any courses and is not responsible for the courses listed on this site. Click a course title to view the course material or provider's course description. Classes and charges for classes may have changed on provider sites since their posting here. Always check the provider's site for accreditation information, terms and conditions of courses offered. Title Provider Contact Hours Expires/ Updated Cost Adverse Drug Reactions Nursing Spectrum Antibiotic Resistance: VRE Vancomycin-Resistant Enterococcus NursingCEU July 2004 Antibiotic Update NursingCEU Oct 2004 Bacteria to the Future: Millennium Prevention of Multiple Drug Resistant Microorganisms NYSNA (RR) Upd. 2001

49. Skin And Connective Tissue Diseases via MedlinePlus; About Erythema Multiforme, stevensjohnson syndrome,and Toxic Epidermal Necrolysis KM Petersen, '98; Erythema http://www.mic.ki.se/Diseases/c17.html

search help staff Skin and Connective Tissue Diseases Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Alphabetical List of Diseases Search PubMed at NCBI/NLM Dermatology Issues , and an Introduction to Basic Dermatology W Piette ] from the Department of Dermatology - Univ of Iowa (US) Dermatology Online Atlas Pediatric Dermatology Online Atlas , and some Dermatology Lectures - U of Erlangen/U of Heidelberg (DE) PedsDermAtlas , including an index of diagnoses Cohen and Lehmann ] - JHU (US) Dermatlas Cohen and Lehmann ] at Johns Hopkins (US) On-line Atlas of Dermatology and Rheumatology Rondinone and Doria ] - (IT) Atlas of Inflammatory Skin Diseases Feit et al. ] - (CZ) Skin and Wound Infections: An Overview M O'Dell ] - American Family Phys, May '98 PubMed Dermatology Search - Hardin Meta Directory, U of Iowa Dermatology Education Website ] - LUMEN, Chicago (US) Matrix Dermatology Resources AC Huntley ] - UC/Davis (US) Hautkrankheiten [in German] - Medicine WorldWide Cutaneous Markers of Internal Malignancy MN Kamel ] - MediCad DermatoNet L Rousseau ; in French and English] - (FR) Kuen-kong et al ] - (HK) Dermatology Online Reference [online text book] - eMedicine Military Dermatology - Textbooks of Military Medicine 1994/Borden Institute (US) Dr. AF Hood's

50. Thalidomide Toxicity In Myeloma Thalidomide should not be resumed if the rash is exfoliative, purpuric, or bullous,or if stevensjohnson syndrome or toxic epidermal necrolysis (TEN) is http://www.clevelandclinic.org/myeloma/management_of_thalidomide_toxicity.htm

Management of Thalidomide Toxicity in Multiple Myeloma Thalidomide is active in patients with relapsed and refractory multiple myeloma. Although it is generally well tolerated at daily doses up to 400 mg, thalidomide may cause a number of different adverse effects, including sedation, constipation, rash, peripheral neuropathy, and others. By starting thalidomide at a low dose (50 mg once daily at 1 to 2 hours before bedtime) and then gradually escalating the dose in 50-mg increments each week, it is possible to minimize many of these adverse effects. In addition, other strategies may be implemented to prevent or effectively manage some adverse effects, such as using a mild laxative to manage constipation and correcting any vitamin B12 and folate deficiencies to reduce neuropathic symptoms. Nurses must be proactive in recognizing the adverse effects associated with thalidomide and then take appropriate steps to manage them in order for patients to realize the full benefits of this agent. In order to prevent potential birth defects and ensure the safe use of thalidomide, the System for Thalidomide Education and Prescribing Information (STEPS®) has been implemented in conjunction with the Food and Drug Administration (FDA) and several advocacy groups.

51. HIV+ Issue 11: Anti-HIV Drugs (more), Rash (possibly indicating lifethreatening stevens-johnson syndromein rare cases). Take with or without food. Rare stevens-johnson syndrome. http://www.aidsinfonyc.org/hivplus/issue11/departments/anti.html

Safer Sex Why Get Tested? GUIDE ANTI-HIV DRUGS NUCLEOSIDE ANALOG REVERSE TRANSCRIPTASE INHIBITORS are potent in combination with other drugs; used alone, they lead to HIV resistance. AZT , and abacavir penetrate the blood-brain barrier. Drug-class side effects: Lactic acidosis, lipodystrophy (fat redistribution). DRUG/DOSAGE SIDE EFFECTS RECOMMENDATIONS Combivir (3TC 150 mg/AZT 300 mg) See 3TC and AZT. Watch for anemia. Epivir (3TC, lamivudine) Glaxo Wellcome. 300 mg/day (Two 150 mg/day). Liquid solution for pediatric use. (more) Headache, nausea, fatigue, low white-blood-cell count, rare hair loss, neuropathy. Watch for anemia and neutropenia. Monitor triglycerides for pancreatitis, especially in children. Take with or without food. Hivid (ddC/zalcitabine) Hoffmann-La Roche. Three 0.75 mg doses/day. Approved for pediatric use. (more) Skin rashes, canker sores, inflammation of mouth, nausea, neuropathy, upset stomach, pancreatitis, liver damage. Watch for neuropathy and pancreatitis. Avoid taking with food if possible. Retrovir (AZT/ zidovudine) Glaxo Wellcome. Dose: 300-600 mg/day. Approved for pediatric use.

52. HIV+ Issue 10: Anti-HIV Drugs (more), Fever, muscle soreness, elevated liver function, rash (possiblyindicating lifethreatening stevens-johnson syndrome in rare cases). http://www.aidsinfonyc.org/hivplus/issue10/departments/anti.html

GUIDE ANTI-HIV DRUGS Nucleoside analog reverse transcriptase inhibitors are potent in combination with other drugs; used alone, they lead to HIV resistance. AZT , and abacavir penetrate the blood-brain barrier. Drug/Dosage Side Effects Recommendations Retrovir (AZT/ zidovudine) Glaxo Wellcome Dose: 300-600 mg/day Approved for pediatric use. (more) Nausea, vomiting, anemia, low white-blood-cell counts, bone-marrow damage, headaches, rash, itching, weakness, loss of appetite, muscle loss. Best on empty stomach; take AZT with food if you have stomach irritation. Take vitamin E, erythropoieitin alpha (EPO), or G-CSF to prevent possible blood-cell damage; B vitamins and manganese. Warning: A structural flaw in AZT may lead to HIV resistance. Combivir (3TC 150 mg/AZT 300 mg) See 3TC and AZT. Watch for anemia. Epivir (3TC, lamivudine) Glaxo Wellcome 300 mg/day (Two 150 mg/day) Liquid solution for pediatric use. (more) Headache, nausea, fatigue, low white-blood-cell count, rare hair loss, neuropathy. Watch for anemia and neutropenia. Monitor triglycerides for pancreatitis, especially in children. Take with or without food. Videx (ddI/didanosine) Bristol-Myers Squibb 400 mg/day Approved for pediatric use.

53. Oncology Forum - Articles stevensjohnson syndrome Secondary to Sodium Valproate. Discussion. Stevens-Johnsonsyndrome is a severe and extensive type of erythema multiforme. http://www.scientific-com.com/oncology/vol3.4/articles/article2.html

Stevens-Johnson Syndrome Secondary to Sodium Valproate Wing Tat Poon Medical House Officer Wing Ming Ho Medical Officer Department of Clinical Oncology Prince of Wales Hospital Hong Kong Case History A 52-year-old man presented 19 months prior to this episode with right-sided weakness. He was subsequently diagnosed with inoperable anaplastic astrocytoma of the left basal ganglion. He underwent radical whole brain irradiation and his symptoms were controlled until 3 months ago when he complained of increasing right-sided weakness with ipsilateral pain. Computed tomography of the brain confirmed progressive disease with a new lesion in the left frontal lobe with surrounding oedema. Four weeks prior to the current presentation, he was commenced on dexamethasone 8 mg/day plus physiotherapy. Sodium valproate was given for neuropathic pain. Figure 1 . Erythematous rash on trunk. Figure 2.

54. First Genetic Trust stevensjohnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN).First Genetic Trust is currently conducting a research study http://www.firstgenetic.net/products_current_studies.html

Overview Dynamic Informed Consent Secure Technology Platform Internal Security, Internet, Third-Party Audits Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) First Genetic Trust is currently conducting a research study of the genetics of drug-induced Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). If you would like to obtain more information about this study, please contact FGT: info@firstgenetic.net . If you live in the UK, FGT will forward your contact information to recruiting sites in Manchester or Liverpool. If you live in the US, your contact information will be forwarded to the research site nearest to you. A study researcher will contact you with additional information and answer your questions. This Study will not help you determine whether you are allergic to certain medications. IF YOU THINK YOU ARE HAVING AN ALLERGIC REACTION TO YOUR MEDICATION CONTACT YOUR HEALTH-CARE PROVIDER IMMEDIATELY Home Terms and Conditions

55. AEGiS-MMWR: APPENDIX C. Basic And Expanded HIV Postexposure Prophylaxis Regimens Disadvantages Drug is associated with rash (early onset) that canbe severe and might rarely progress to stevens-johnson syndrome. http://www.aegis.com/pubs/mmwr/2001/rr5011a4.html

Important note: Information in this article was accurate in June 2001. The state of the art may have changed since the publication date. APPENDIX C. Basic and Expanded HIV Postexposure Prophylaxis Regimens Morbidity and Mortality Weekly Report, June 29, 2001 / 50(RR11);47-52 Centers for Disease Control and Prevention BASIC REGIMEN - ZDV: 600 mg per day, in two or three divided doses, and - 3TC: 150 mg twice daily. Advantages - ZDV is associated with decreased risk of HIV transmission in the CDC case-control study of occupational HIV infection. - ZDV has been used more than the other drugs for PEP in HCP. - Serious toxicity is rare when used for PEP. - Side effects are predictable and manageable with antimotility and antiemetic agents. - Probably a safe regimen for pregnant HCP. Disadvantages - Side effects are common and might result in low adherence. - Source patient virus might have resistance to this regimen. - Potential for delayed toxicity (oncogenic/teratogenic) is unknown. ALTERNATE BASIC REGIMENS - 3TC: 150 mg twice daily, and

56. Kawasaki Syndrome by cats), juvenile rheumatoid arthritis, and a blistering and inflammation of theskin caused by reactions to certain medications (stevensjohnson syndrome). http://www.healthatoz.com/healthatoz/Atoz/ency/kawasaki_syndrome.html

Encyclopedia Index K Home Encyclopedia Encyclopedia Index K Kawasaki syndrome Definition Kawasaki syndrome is a potentially fatal inflammatory disease that affects several organ systems in the body, including the heart, circulatory system, mucous membranes, skin, and immune system. It occurs primarily in infants and children but has also been identified in adults as old as 34 years. Its cause is unknown. Description Kawasaki syndrome, also called mucocutaneous lymph node syndrome (MLNS), is an inflammatory disorder with potentially fatal complications affecting the heart and its larger arteries. Nearly twice as many males are affected as females. Although persons of Asian descent are affected more frequently than either black or white individuals, there does not appear to be a distinctive geographic pattern of occurrence. Eighty percent of cases involve children under the age of four. Although the disease usually appears in individuals, it sometimes affects several members of the same family and occasionally occurs in small epidemics. Causes and symptoms The specific cause of Kawasaki syndrome is unknown, although the disease resembles infectious illnesses in many ways. It has been suggested that Kawasaki syndrome represents an allergic reaction or other unusual response to certain types of infections. Some researchers think that the syndrome may be caused by the interaction of an immune cell, called the T cell, with certain poisons (toxins) secreted by bacteria.

57. Toxic Epidermal Necrolysis Another disease, stevensjohnson syndrome, is a drug-induced skin diseasethat some experts believe is really a milder form of TEN. http://www.healthatoz.com/healthatoz/Atoz/ency/toxic_epidermal_necrolysis.html

Encyclopedia Index T Home Encyclopedia Encyclopedia Index T Toxic epidermal necrolysis Definition Toxic epidermal necrolysis is a rare condition that causes large portions of the epidermis, the skin's outermost layer, to detach from the layers of skin below. A reaction to a medication is the primary cause. Description Toxic epidermal necrolysis (TEN) begins with fever cough , and other nonspecific symptoms, and is soon followed by purplish, bloody-looking lesions on the skin and mucous membranes. These early lesions, typically found on the head, neck, and upper chest, soon merge and blister. Sheets of epidermis then begin to detach from the skin layers below. In time, the entire surface of the skin may be involved, with detachment of 100% of the epidermis. Causes and symptoms The main cause of TEN is a severe drug reaction. Some investigators believe there may be additional infectious causes. A severe reaction in transplant patients, called graft-vs.-host disease , can also produce TEN. One study reported more than 100 different drugs as causes of TEN. The drugs most commonly implicated, however, include antibacterial sulfonamides such as sulfadiazine

58. Radiology In Ped Emerg Med, Vol 3, Case 1 medical history. His family history is significant for an older brotherwho died of stevensjohnson syndrome 3 years ago. The patient http://www.hawaii.edu/medicine/pediatrics/pemxray/v3c01.html

Myocardial Failure in a 2-Month Old Radiology Cases in Pediatric Emergency Medicine Volume 3, Case 1 James J. Matsuda, MD, PhD Kapiolani Medical Center For Women And Children University of Hawaii John A. Burns School of Medicine Return to Radiology Cases In Ped Emerg Med Case Selection Page Return to Univ. Hawaii Dept. Pediatrics Home Page Web Page Author: Loren Yamamoto, MD, MPH Associate Professor of Pediatrics University of Hawaii John A. Burns School of Medicine loreny@hawaii.edu

59. The University Hospital For 30 years, Jon Newton has lived with stevensjohnson syndrome (SJS), a rare andserious disorder that causes inflammation of the body's mucous membranes. http://www.theuniversityhospital.com/healthlink/mayjune2002/html/longs/limbal.ht

May/June For 30 years, Jon Newton has lived with Stevens-Johnson Syndrome (SJS), a rare and serious disorder that causes inflammation of the body's mucous membranes. The impact on his eyes was so severe that he became legally blind, able to count only fingers held up two feet in front of him. About 40 operations on his eyes did nothing to restore his sight. But a remarkable new procedure, in which cells from a healthy eye are harvested and transplanted, paved the way for a successful cornea transplant. Mr. Newton was 16 when he contracted SJS, an autoimmune disorder triggered by an allergic reaction to certain medications. Two weeks after he took phenobarbital and dilantin, a rash broke out on his arm. His doctor took him off phenobarbital, but the next day blood blisters broke out all over his body, and he had a high fever. "I was in an intensive care unit for three weeks," says Mr. Newton. "I had a horrific reaction that made its way throughout my body." The corneas of Mr. Newton's eyes, once clear and healthy, became clouded and scarred. His eyes were excessively dry, and eyelashes were growing into the eyelids. One surgical attempt to restore moisture in his eyes involved transplanting salivary glands to replace defective tear glands; the procedure produced only "two years of pain." Neither electrolysis nor a freezing process to remove the invading eyelashes was successful.

60. Stevens-Johnson Syndrome What is stevensjohnson syndrome ? stevens-johnson syndrome is a rareinflammatory skin disorder that can be life-threatening. Stevens http://www.arava-information-center.com/stevens-johnson-syndrome.htm

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