1. NINDS Stiff-Person Syndrome Information Page Information sheet compiled by National Institute of Neurological Disorders and Stroke.Category Health Conditions and Diseases stiff-person syndrome...... More about stiffperson syndrome, Studies with patients, Research literature, Pressreleases, NINDS stiff-person syndrome Information Page Reviewed 05-09-2002 http://www.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Stiff-Person Syndrome Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Stiff-Person Syndrome Information Page Reviewed 05-09-2002 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Stiff-Person Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Stiff-Person Syndrome? Is there any treatment? The drug diazepam, which relaxes the muscles, provides improvement in most cases. Baclofen, phenytoin, clonidine, or tizanidine may provide additional benefit. In some patients, immunomodulatory treatments such as intravenous immunoglobulin may be beneficial. Physical and rehabilitation therapy may also be needed. What is the prognosis?

2. Stiff-Person Syndrome An article about stiffperson syndrome, a rare progressive neurological disorder. http://healthlink.mcw.edu/article/921988627.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Stiff-Person Syndrome Stiff-person syndrome is a rare progressive neurological disorder characterized by constant painful contractions and spasms of voluntary muscles, particularly the muscles of the back and upper legs. Symptoms may occur gradually, spreading from the back and legs to involve the arms and neck. Symptoms may worsen when the affected individual is anxious or exposed to sudden motion or noise. Affected muscles may become twisted and contracted, resulting in bone fractures in the most severe cases. Individuals with stiff-person syndrome may have difficulty making sudden movements and may have a stiff-legged, unsteady gait. Sleep usually suppresses frequency of contractions. Stiffness may increase and patients may develop a hunched posture (kyphosis) or a swayback (lordosis). Researchers theorize that stiff-person syndrome may be an autoimmune disorder. Other autoimmune disorders such as diabetes, pernicious anemia (a chronic, progressive blood disorder), and thyroiditis (inflammation of the thyroid gland) may occur more frequently in patients with stiff-person syndrome.

3. STIFF MAN SYNDROME Web sites devoted to health, nutrition, and fitness. Most of the links below are direct links to pages on stiff person syndrome (SPS, a.k.a. http://www.stiff-man.org/

Stiff Man Syndrome is a neuromuscular condition in which a hyperactive startle reflex results in the contraction of the muscles causing violent spasms. These spasms are capable of slamming the victim into walls and furniture. The disorder's cause is unknown, although evidence is pointing increasingly to the fact that it is an autoimmune disorder. Although they appear completely normal, those afflicted with Stiff-Man Syndrome must avoid any situation where they might be exposed to sudden sounds or stimulation. Often, they remain isolated in their home and excluded from normal living. They are orphaned from society by this rare and ruthless disorder. Use this page to subscribe to the SMS discussion list to receive information and to participate in raising the health professional and public awareness of this rare disease. To Join the Stiff-Man E-mail group: Please send E-mail to: stiffman-request@gurr.org Put the words "subscribe" as the body of your message. Then to post a message: Send E-mail to: stiffman@gurr.org

4. Healthlink Template Drager Syndrome; Sleep Apnea; Soto's Syndrome; Spasticity; SpinaBifida; stiffperson syndrome; Sturge-Weber Syndrome; Sydenham Chorea; http://healthlink.mcw.edu/search/search-page.php?neurology

5. NINDS Stiff-Person Syndrome Information Page More about NINDS stiffperson syndrome Information Page. Content for thispage. NINDS stiff-person syndrome Information Page. Reviewed 05-09-2002. http://accessible.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm

Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders-you are in this section ... Find People Disorders section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury More about NINDS Stiff-Person Syndrome Information Page Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us Content for this page NINDS Stiff-Person Syndrome Information Page Reviewed 05-09-2002 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Stiff-Person Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Stiff-Person Syndrome? Is there any treatment?

6. Stiff-Person Syndrome stiffperson syndrome. What is stiff-person syndrome? Researchers theorizethat stiff-person syndrome may be an autoimmune disorder. http://www.clevelandclinic.org/health/health-info/docs/1300/1347.asp?index=6076

7. Show-documents.asp New. The Cleveland Clinic, stiffperson syndrome Written Information.Care Treatment. - stiff-person syndrome. New Search1. The http://www.clevelandclinic.org/health/search/do-query.asp?TopicId=1361

8. NEJM -- High-Dose Intravenous Immune Globulin For Stiff-Person Syndrome HighDose Intravenous Immune Globulin for stiff-person syndrome Marinos C. Dalakas,MD, Mavis Fujii, MD, Mian Li, MD, Bashar Lutfi, MD, Joan Kyhos, BSN, and http://content.nejm.org/cgi/content/short/345/26/1870

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 345:1870-1876 December 27, 2001 Number 26 Next High-Dose Intravenous Immune Globulin for Stiff-Person Syndrome Marinos C. Dalakas, M.D., Mavis Fujii, M.D., Mian Li, M.D., Bashar Lutfi, M.D., Joan Kyhos, B.S.N., and Beverly McElroy, C.N.R.N. Table of Contents Full Text of this article PDF of this article Editor's Summary ... Alert me when this article is cited ISI Web of Science Related Articles Citing Articles (9) Related Articles in Medline Articles in Medline by Author: Dalakas, M. C. McElroy, B. Medline Citation Neurologic Disease ... Related Chapters at Harrison's Online ABSTRACT Background Stiff-person syndrome is a disabling central nervous system disorder with no satisfactory treatment that is characterized by muscle rigidity, episodic muscle spasms, high titers of antibodies against glutamic acid decarboxylase (GAD65), and a frequent association with autoimmune disorders. Because stiff-person syndrome is most likely immune-mediated, we evaluated the efficacy of intravenous immune globulin.

9. NEJM -- High-Dose Intravenous Immune Globulin For Stiff-Person Syndrome December 27, 2001 HighDose Intravenous Immune Globulin for Stiff-PersonSyndrome. Patients with stiff-person syndrome, a disabling http://content.nejm.org/cgi/content-tweek/full/345/26/1861-a

December 27, 2001 High-Dose Intravenous Immune Globulin for Stiff-Person Syndrome Patients with stiff-person syndrome, a disabling central nervous system disease with no effective therapy, are plagued by muscle rigidity and episodes of muscle spasm. Patients have high titers of antibodies against glutamic acid decarboxylase (anti-GAD65), suggesting an autoimmune pathogenesis. In this study, 16 patients were randomly assigned to receive either placebo or intravenous immune globulin for three months, followed by a washout period and then three months of therapy with the other agent. Eleven of the 14 patients who completed the study had a marked improvement in their condition with active therapy. Intravenous immune globulin is a safe and effective, though costly, therapy for patients with stiff-person syndrome and anti-GAD65 antibodies.

10. ClinicalTrials.gov - Linking Patients To Medical Research: Study Details Cause, Development, and Progression of stiffperson syndrome. This studyis currently recruiting patients. Condition. stiff-person syndrome. http://www.clinicaltrials.gov/ct/gui/show/NCT00030940?order=1

11. Annals Of Internal Medicine: Abstract NIH CONFERENCES The stiffperson syndrome An Autoimmune Disorder AffectingNeurotransmission of -Aminobutyric Acid. Moderator Lucien http://www.annals.org/issues/v131n7/abs/199910050-00008.html

5 October 1999 Volume 131 Number 7 NIH CONFERENCES The Stiff-Person Syndrome: An Autoimmune Disorder Affecting Neurotransmission of -Aminobutyric Acid Moderator: Lucien M. Levy, MD, PhD; Discussants: Marinos C. Dalakas, MD; and Mary Kay Floeter, MD, PhD Pages The stiff-person syndrome, a rare and disabling disorder, is characterized by muscle rigidity and episodic spasms that involve axial and limb musculature. Continuous contraction of agonist and antagonist muscles caused by involuntary motor-unit firing at rest are the hallmark clinical and electrophysiologic signs of the disease. Except for global muscle stiffness, results of neurologic examination are usually normal. Results of conventional computed tomography and magnetic resonance imaging of the brain are also normal. The cause of the stiff-person syndrome is unknown; however, an autoimmune pathogenesis is suspected because of 1) the presence of antibodies against glutamic acid decarboxylase (GAD), the rate-limiting enzyme for the synthesis of the inhibitory neurotransmitter -aminobutyric acid (GABA); 2) the association of the disease with other autoimmune conditions; 3) the presence of various autoantibodies; and 4) a strong immunogenetic association. Anti-GAD antibodies, which are found in high titers in most patients, seem to be directed against conformational forms of GAD. New evidence suggests that these antibodies may be pathogenic because they interfere with the synthesis of GABA. In addition, a reduction in brain levels of GABA, which is prominent in the motor cortex, has been demonstrated with magnetic resonance spectroscopy in patients with the stiff-person syndrome.

12. Health Library - Stiff Person Syndrome Stiff Person Syndrome. Synonyms Disorder Subdivisions General Discussion Resources Theexact cause of stiffperson syndrome is not known.. Resources. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

13. Health Library - Stiff Person Syndrome Stiff Person Syndrome. Synonyms Disorder Subdivisions General Discussion Resources Theexact cause of stiffperson syndrome is not known.. Resources. http://www.laurushealth.com/library/healthguide/illnessconditions/topic.asp?hwid

14. WorldMedicus A description of stiffperson syndrome, the alternate names and a link to articles. http://www.worldmedicus.com/servlet/Controller/$7006040b416e0000.sj/

15. ClinicalTrials.gov - Linking Patients To Medical Research: Results Search results for stiffperson syndrome ALL-FIELDS are shown below. Show alltrials, including those no longer recruiting patients. 2 studies were found. http://clinicaltrials.gov/search/term=Stiff-Person Syndrome

Home Search Browse Resources ... About Search results for Stiff-Person Syndrome [ALL-FIELDS] are shown below. Show all trials, including those no longer recruiting patients. 2 studies were found. Recruiting Cause, Development, and Progression of Stiff-Person Syndrome Condition: Stiff-Person Syndrome Recruiting Diagnostic Evaluation of Patients with Neuromuscular Disease Condition: Neuromuscular Disease U.S. National Library of Medicine Contact NLM Customer Service National Institutes of Health Freedom of Information Act ... Accessibility

16. ACP-ASIM Online - Medicine In Quotations Online Subject stiffperson syndrome (stiff-man syndrome). Contributor Huth,Edward J. Subject stiff-person syndrome (stiff-man syndrome). http://www.acponline.org/cgi-bin/medquotes.pl?subject=Stiff-person syndrome (sti

17. Annals Of Internal Medicine: Table Of Contents The stiffperson syndrome An Autoimmune Disorder Affecting Neurotransmissionof -Aminobutyric Acid LM Levy, MC Dalakas, and MK Floeter The stiff-person http://www.acponline.org/journals/annals/05oct99/henney.htm

5 October 1999 Volume 131 Number 7 TABLE OF CONTENTS Articles Using the Berlin Questionnaire To Identify Patients at Risk for the Sleep Apnea Syndrome N.C. Netzer, R.A. Stoohs, C.M. Netzer, K. Clark, and K.P. Strohl Although sleep apnea is common, it often goes undiagnosed in primary care encounters. The Berlin Questionnaire was found to be a means of identifying patients who are likely to have sleep apnea. Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation: A Meta-Analysis R.G. Hart, O. Benavente, R. McBride, and L.A. Pearce Adjusted-dose warfarin and aspirin reduce stroke in patients with atrial fibrillation, and warfarin is substantially more efficacious than aspirin. The benefit of antithrombotic therapy was not offset by the occurrence of major hemorrhage among participants in randomized trials. Drug Resistance Patterns, Genetic Subtypes, Clinical Features, and Risk Factors in Military Personnel with HIV-1 Seroconversion S.K. Brodine, R.A. Shaffer, M.J. Starkey, S.A. Tasker, J.L. Gilcrest, M.K. Louder, A. Barile, T.C. VanCott, M.T. Vahey, F.E. McCutchan, D.L. Birx, D.D. Richman, and J.R. Mascola Brief Communications High-Dose Chemotherapy and Syngeneic Hemopoietic Stem-Cell Transplantation for Severe, Seronegative Rheumatoid Arthritis

18. 1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso Sites. MCW HealthLink An article about stiffperson syndrome, a rareprogressive neurological disorder. NORD - Stiff Person Syndrome http://www.1uphealth.com/links/muscle-diseases-stiff-person-syndrome.html

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Muscle Diseases : Stiff-Person Syndrome Description See Related Categories Health: Conditions and Diseases: Neurological Disorders: Spinal Cord Health: Conditions and Diseases: Rare Disorders Sites MCW HealthLink An article about Stiff-person syndrome, a rare progressive neurological disorder. NORD - Stiff Person Syndrome Offers synonyms, a general discussion and further resources. Stiff-Person Syndrome Information sheet compiled by National Institute of Neurological Disorders and Stroke. WorldMedicus A description of Stiff-Person syndrome, the alternate names and a link to articles. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement. Search: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites.

19. Searchalot Directory For Stiff-Person Syndrome Related Web Sites. MCW HealthLink An article about Stiff-personsyndrome, a rare progressive neurological disorder. NORD - Stiff http://www.searchalot.com/Top/Health/ConditionsandDiseases/NeurologicalDisorders

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20. GoGuides.Org Directory | Stiff-Person Syndrome Home Health Fitness Disabilities Disorders Conditions Diseases Nervous System Disorders Neuromuscular Diseases stiffperson syndrome http://www.goguides.org/index.php/viewCat/13376

Home Nervous System Disorders Neuromuscular Diseases Stiff-Person Syndrome ... URL Submission Status Sponsored Link: Sponsored Link: Advertise Here Stiff-Person Syndrome: Number of Matches: 3 eMedicine: Stiff-Person Syndrome - Presented is a clinical report authored by Nancy Rodgers-Neame, MD, assistant Professor, Department of Pharmacology and Therapeutics, University of South Florida. URL: http://author.emedicine.com/neuro/topic353.htm NINDS: Stiff-Person Syndrome - Find an information sheet about this disease which is characterized by constant painful contractions and spasms of voluntary muscles. Provided by the National Institute of Neurological Disorders and Stroke. URL: http://www.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm NORD: Stiff-Person Syndrome - Find the synonyms, a general discussion and further resources prented by the National Organization for Rare Disorders. URL: http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Stiff%20Person%20Syndrome < Previous Pages: Next >> Guide needed for this topic.

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