1. MEDLINEplus Medical Encyclopedia: Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis, a definition and a look at the causes, incidence and risk factors.Category Health Conditions and Diseases......subacute sclerosing panencephalitis. http://www.nlm.nih.gov/medlineplus/ency/article/001419.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Subacute sclerosing panencephalitis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top SSPE; Subacute sclerosing leukoencephalitis; Dawson´s encephalitis Definition Return to top SSPE is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles rubeola ) virus (a measles virus that has undergone certain genetic changes or mutations). Causes, incidence, and risk factors Return to top Measles virus usually doesn't cause brain damage, but certain mutant forms can invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, decreasing the frequency of this disease dramatically, following the nationwide measles immunization program. However, in some countries like India, over 20 cases of SSPE per million people are annually reported. SSPE tends to occur several years after having measles ( rubeola ), even though recovery from the illness appears to have been normal. More males are affected than females, and the disease generally occurs in children and adolescents.

2. Subacute Sclerosing Panencephalitis - Online Neuropathology Atlas subacute sclerosing panencephalitis Panencephalitis subacuta sclerotisans.Subacute sclerosing encephalitis, SSPE, gross image, Subacute http://www.neuropat.dote.hu/panenc.htm

Subacute sclerosing panencephalitis Panencephalitis subacuta sclerotisans Macroscopic Appearance Perivascular Infiltration Mononuclear Infiltration ... Nuclear Inclusion Click on any image for larger view. Relevant Web Sites: Baylor Neurology Case of the Month Subacute Sclerosing Pancephalitis - Kansas University Infection Internet Handbook of Neurology var site="sm5hegeduskdote" Last modified: February 17, 2001 If you have any comments, please, contact Neuroanatomy Structures Online Neuropathology Atlas Internet Handbook of Neurology

3. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Parenchymal Medical facility describes the cause of this infection of the brain and illustrates the article with a few photos. See related links. http://www.vh.org/Providers/TeachingFiles/CNSInfDisR2/Text/PInf.VSSP.html

For Providers Infectious Diseases of the Central Nervous System Parenchymal Infections: Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed Subacute sclerosing panencephalitis (SSPE) is one of three types of encephalitis that may occur secondary to measles virus. The other two types are 1) an acute encephalitis characterized by lymphocytic infiltrates in meninges and around vessels associated with the acute rash of measles, and 2) a post-measles demyelinating process which is probably an autoimmune hyperallergenic phenomenon. In this tutorial only subacute sclerosing panencephalitis will be discussed. Subacute sclerosing panencephalitis develops following the reactivation of the latent measles virus. Clinically, it is insidious in its onset, and is characterized by progressive motor and mental deterioration with myoclonus. The course usually runs from 1 to 3 years. The frequency of SSPE is about 1 in 1 million, there is a male-to-female ratio of 4:1, and 85% of the cases arise in a rural environment. The gross pathology of subacute sclerosing panencephalitis, which is shown on this slide

4. Pediatric Database - Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. DEFINITION A slow viral infection of the brain characterized by chronic http://www.icondata.com/health/pedbase/files/SUBACUTE.HTM

Pediatric Database (PEDBASE) Discipline: CNS Last Updated: 5/22/94 SUBACUTE SCLEROSING PANENCEPHALITIS DEFINITION: A slow viral infection of the brain characterized by chronic encephalitis caused by a persistent measles viral infection. EPIDEMIOLOGY: incidence: rare incidence decreased after immunization initiation in 1963 risk 8.5/million cases of natural measles infection risk 0.7/million cases after immunization age of onset: 5-15 years in 85% of cases (5-15 years after a natural measles infection or immunization) risk factors: measles before age 18 PATHOGENESIS: 1. Background pathogenesis involves the accumulation of incomplete measles virus that cannot be cleared by B or T cell mechanisms measles genomes in SSPE are larger and contain multiple mutations PATHOLOGY: 1. Intranuclear Inclusion Bodies inflammation, necrosis, gliosis, and repair panencephalitis involves cortical and subcortical grey and white matter and blood vessels with an increasing number of glial cells CLINICAL FEATURES: 1. Prodrome mild to severe measles with full recovery or immunization mean interval between immunization and SSPE: 8 years mean interval between measles and SSPE : 12 years 2. Clinical Course

5. Subacute Sclerosing Panencephalitis (SSPE) & Vaccines subacute sclerosing panencephalitis (SSPE) Vaccines. Diseases linked to vaccines http://www.whale.to/vaccines/sspe1.html

Diseases linked to vaccines "Stacey Berry, of Atherton, Manchester was 13 when she had a booster jab in November 1994. Days later she started having fits, "stopped smiling, and stared into space." She was diagnosed with the brain disease SSPE and given two years to live. She died in November 2000, aged 19. A post mortem examination concluded the disease was a "rare complication" of the vaccine"." Media "It is believe that the administration of Salk vaccine in N Zealand was related to the appearance of SSPE in the community. The idea that an unusual reaction to measles infection is the sole cause of SSPE is not consistent with the observations in N Zealand." SSPE AND SALK VACCINE Belgamwar RB, et al (1997). Measles, mumps, rubella vaccine induced subacute sclerosing panencephalitis. J Indian Med Assoc. 1997 Nov;95(11):594. No abstract available. PMID: 9567594; UI: 98229001. Halsey N. Risk of subacute sclerosing panencephalitis from measles vaccination. Pediatr Infect Dis J. 1990 Nov;9(11):857-8. No abstract available.PMID: 2263442; UI: 91088240. "Polymerase chain reaction detection of the hemagglutinin gene from an attenuated measles vaccine strain in the peripheral mononuclear cells of children with autoimmune hepatitis," Archives of Virology volume 141, 1996, pages 877-884: "The measles virus is known to be persistent in patients with subacute sclerosing panencephalitis (SSPE) and measles inclusion body encephalitis (MIBE). Since the introduction of measles vaccines, vaccine-associated SSPE has increased in the USA. Therefore, we should pay attention to SSPE after inoculation with measles vaccine, despite the decrease in the incidence of [wild] measles."

6. NORD - Subacute Sclerosing Panencephalitis Offers the synonyms, a general discussion and further resources. http://www.stepstn.com/cgi-win/nord.exe?proc=Redirect&type=rdb_sum&id=18

7. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Parenchymal Parenchymal Infections subacute sclerosing panencephalitis. In this tutorialonly subacute sclerosing panencephalitis will be discussed. http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/PInf.VSSP.html

For Providers Infectious Diseases of the Central Nervous System Parenchymal Infections: Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed Subacute sclerosing panencephalitis (SSPE) is one of three types of encephalitis that may occur secondary to measles virus. The other two types are 1) an acute encephalitis characterized by lymphocytic infiltrates in meninges and around vessels associated with the acute rash of measles, and 2) a post-measles demyelinating process which is probably an autoimmune hyperallergenic phenomenon. In this tutorial only subacute sclerosing panencephalitis will be discussed. Subacute sclerosing panencephalitis develops following the reactivation of the latent measles virus. Clinically, it is insidious in its onset, and is characterized by progressive motor and mental deterioration with myoclonus. The course usually runs from 1 to 3 years. The frequency of SSPE is about 1 in 1 million, there is a male-to-female ratio of 4:1, and 85% of the cases arise in a rural environment. The gross pathology of subacute sclerosing panencephalitis, which is shown on this slide

8. Mylifepath Offers a description of subacute sclerosing panencephalitis, including the symptoms, causes, diagnosis, treatment, prognosis and further reading. http://www.mylifepath.com/article/gale/100268292

9. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Subacute Sc subacute sclerosing panencephalitis. Gary The histology of subacute sclerosingpanencephalitis is nicely demonstrated on this slide. Note http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/229.html

For Providers Infectious Diseases of the Central Nervous System Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed The histology of subacute sclerosing panencephalitis is nicely demonstrated on this slide. Note the perivascular lymphocytic infiltrates, the intense gliosis, and the virtual lack of any normal histological features in the background. Section Top Title Page See related Provider Textbooks about Neurology or Pathology See related Provider Topics Abscesses Bacterial Infections Brain and Nervous System Brain Diseases ... Pathology or Viral Infections See related Patient Textbooks about Neurology or Pathology See related Patient Topics Bacterial Infections Brain and Nervous System Brain Diseases Creutzfeldt-Jakob Disease ... Pathology or Viral Infections Virtual Hospital Home Virtual Children's Hospital Home Site Map ... UI Health Care Home http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/229.html

10. MEDLINEplus Medical Encyclopedia: Topics Beginning With Sq-Sz see Cancer penis; Squamous cell carcinoma; Squint see Strabismus;SSPE see subacute sclerosing panencephalitis. St. Vitus dance see http://www.nlm.nih.gov/medlineplus/ency/encyclopedia_Sq-Sz.htm

Skip navigation Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Medical Encyclopedia Topics beginning with "Sq-Sz" Squamous cell cancer - mouth see Oral cancer Squamous cell cancer of the penis see Cancer - penis Squamous cell carcinoma Squint see Strabismus SSPE see Subacute sclerosing panencephalitis St. Vitus dance see Sydenham chorea Stage 1 Lyme disease see Lyme disease - primary Stage 2 Lyme disease see Lyme disease - secondary Stage 3 Lyme disease see Lyme disease - tertiary Stagnant loop see Intestinal bacterial overgrowth Stagnant loop syndrome see Blind loop syndrome Standard ophthalmic exam Staph aureus food poisoning Staph skin infection see Carbunculosis Staphylococcal meningitis see Meningitis - staphylococcal Staphylococcal scalded skin syndrome (SSS) see Scalded skin syndrome Staphylococcal toxic shock syndrome see Toxic shock syndrome Starch ingestion Starches see Carbohydrates Startle reflex see Moro reflex Startle response see Moro reflex Stasis dermatitis Stasis syndrome see Blind loop syndrome Steam iron cleaner Steely hair disease see Menkes syndrome Stein-Leventhal syndrome Stellachrome see Merbromin overdose Stem cell research Stenosis - renal artery see Renal artery stenosis Stent Stereotypic movement disorder Sterile meningitis see Aseptic meningitis Sterilization and women Sterilization surgery - female see Tubal ligation Sterilization surgery - male see Vasectomy Sternal tap see Bone marrow aspiration Sternutation see Sneezing Stevens-Johnson syndrome see Erythema multiforme Stiff heart syndrome see Cardiac amyloidosis Stiff lung see

11. Sign Up For Free Email On Medical And Health Related Topics subacute sclerosing panencephalitis factsheet http://www.rdhealth.com/kbase/nord/nord185.htm

Health Related Categories Alternative Medicine Children's Health Cosmetic Surgery Procedures Men's Health ... Women's Health Illnesses and Conditions Cancer Cardiovascular Conditions (Heart and Circulatory Conditions) Dermatological Conditions (Skin Conditions) Endocrine Conditions (Hormonal and Glandular Conditions) Gastrointestinal Conditions Hematology and Oncology (Blood, Clotting and Leukemia) Infectious Diseases Kidney and Urinary Tract Conditions Neurological Conditions (Brain and Nervous System) Ocular Conditions (Eye Conditions) Orthopedic Conditions (Bones, Joints and the Musculoskeletal System) Respiratory Conditions (Lung Conditions) Looking for a revolutionary way to track your level of health and fitness? Find out about the latest technology to help you measure and track your lean body mass, calories burned, body fat and much more! Turn your daily routine into a healthy one! Recommend this site to a friend and get a chance to win $10,000 About Us Contact Us Advertising The information that you may receive from subscribing to any MedicalMailbox.com list is for educational purposes only. In no way should it be considered as offering medical advice. MedicalMailbox.com assumes no responsibility for how this material is used. Please check with a physician if you have any questions regarding the information you receive. MedicalMailbox.com does not guarantee that you will receive email on every topic you may subscribe to. We subscribe to the HONcode principles of the

12. NINDS Subacute Sclerosing Panencephalitis Information Page subacute sclerosing panencephalitis information sheet compiled by NINDS,the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/subacute_panencephalitis.h

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Subacute Sclerosing Panencephalitis Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Subacute Sclerosing Panencephalitis Information Page Synonym(s): Dawson Disease Reviewed 11-01-2002 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Subacute Sclerosing Panencephalitis? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Subacute Sclerosing Panencephalitis? Is there any treatment? For several decades, the palliative treatment for SSPE has included anticonvulsant therapy and supportive measures (tube feedings and good nursing care especially in patients with advanced disease). Medical literature during the last decade, however, has shown stabilization of disease and delay in clinical progression after therapy with inosine pranobex (oral Isoprinosine); oral isoprinosine combined with intrathecal or intraventricular interferon alpha (up to 50% rate of remission or improvement); oral isoprinosine combined with interferon beta; and intrathecal interferon alpha combined with I.V. ribavirin. However, no controlled studies have been performed. The Food and Drug Administration has added inosine pranobex (Isoprinosine) to its List of Orphan Products Designations and Approvals (1988) for the treatment of SSPE.

13. Subacute Sclerosing Panencephalitis, A Measles Complication, In An International Dispatch subacute sclerosing panencephalitis, a Measles Complication, in an InternationallyAdopted Child. Gascon GG. subacute sclerosing panencephalitis. http://www.cdc.gov/ncidod/eid/vol6no4/bonthius.htm

Past Issue Vol. 6, No. 4 Jul–Aug 2000 Download Article PDF Help Feedback Dispatch Subacute Sclerosing Panencephalitis, a Measles Complication, in an Internationally Adopted Child Daniel J. Bonthius,* Nicholas Stanek,† and Charles Grose* *Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA; †Department of Neurology, Medical Associates Clinic, Dubuque, Iowa, USA A healthy 13-year-old boy who had spent the first 4.5 years of his life in an orphanage in Thailand before adoption by an American couple became ill with subacute sclerosing panencephalitis and died several months later. The boy had most likely contracted wild-type measles in Thailand. Measles complications are a risk in international adoptions. Undiagnosed infections in internationally adopted children have been receiving increasing attention throughout the past decade. HIV, hepatitis viruses, Treponema pallidum Mycobacterium tuberculosis , and intestinal parasites frequently complicate such adoptions ( ). Subacute sclerosing panencephalitis (SSPE), a postinfectious neurologic complication of measles, can also occur. We describe a fatal case of SSPE in an internationally adopted child 9 years after he arrived in the United States. Case Report A 13-year-old boy of Thai descent was referred to the pediatric neurology clinic at the University of Iowa Hospital with cognitive difficulties and a progressive movement disorder. The boy was born in 1984 and spent the first 4 ½ years of his life in an orphanage in Thailand before being adopted by an American couple from Dubuque, Iowa. His adoptive parents were told by the adoption agency that the boy's medical history was unremarkable. No history of measles was reported. At adoption, the child appeared healthy and well nourished, and at no time afterwards did he have an illness suggestive of measles. Shortly after arrival, he displayed a short attention span and easy distractibility, for which he was eventually diagnosed with attention deficit hyperactivity disorder. He was treated with low-dose methylphenidate for several years with good results.

14. Subacute Sclerosing Panencephalitis Factsheet subacute sclerosing panencephalitis. Download Factsheet. Not available. Feedback. http://www.ich.ucl.ac.uk/factsheets/illnesses/subacute_sclerosing/

15. Subacute Sclerosing Pancephalitis I. subacute sclerosing panencephalitis (SSPE) 1. Clinical featuresa. Onset 520 years of age, predominantly in males. The disease http://kobiljak.msu.edu/cai/pathology/CNS_Infections_F/CNS_1i.html

I. SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) Clinical features a. Onset: 5-20 years of age, predominantly in males. The disease has always been preceded by an attack of measles in the distant past or, occasionally, by measles immunization. b. Clinical presentation: personality changes, intellectual deterioration; periodic involuntary movements; decerebrate rigidity, severe dementia c. Duration: death usually in several years d. CSF changes: elevated gamma globulin; antibody titer elevated to measles Pathological changes a. Gross pathology: Cortical atrophy, demyelination and ventricular dilatation may all be present; changes are mild and are not diagnostic. b. Microscopic pathology: Inclusion bodies in oligodendroglia, neurons and astrocytes; chronic inflammatory reaction (perivascular cuffing by lymphocytes and plasma cells); some neuronal loss, gliosis and demyelination. The entire brain may be involved, but lesions are often more severe in neocortex, white matter, hippocampus, thalamus, ventral brainstem. Ultrastructural changes include paramyxovirus nucleocapsid tubules characteristic of measles virus in the inclusion bodies. This low power microscopic view shows perivascular cuffing in a case of subacute sclerosing panencephalitis, with mononuclear cells clustered around a vessel.

16. The Contact A Family Directory - SUBACUTE-SCLEROSING PANENCEPHALITIS printer friendly, SUBACUTESCLEROSING PANENCEPHALITIS, subacute sclerosing panencephalitis(SSPE) is a serious viral encephalitis of children and young adults. http://www.cafamily.org.uk/Direct/s64.html

printer friendly SUBACUTE-SCLEROSING PANENCEPHALITIS home more about us in your area conditions information ... how you can help search this site Subacute-Sclerosing Panencephalitis: SSPE Subacute Sclerosing Panencephalitis (SSPE) is a serious viral encephalitis of children and young adults. It is a late manifestation of measles virus infection, developing between usually 6 and 12 years after natural measles infection. Cases can also follow immunization with measles vaccine but at a lesser frequency than after natural measles. The annual incidence is about 1 per million. It is believed that measles immunisation significantly reduces the risk of developing SSPE. Males are more commonly affected, as are those living in rural areas. Mortality is very high. Those who survive do so with considerable intellectual and also physical impairment. The precise sequence of events that results in the development of this disease in a tiny proportion of the population is not known. The great majority of children who develop SSPE are known to have had an attack of classical measles, usually many years before. Over 50% of cases have had the disease at the unusually early age of under two years. The onset of the illness is insidious, the first signs are behavioural disturbances or a decline in school performance. Not infrequently the family are told that the cause for these behavioural or school problems is "psychological". Progression of the illness will vary from child to child but evidence that this is a more serious illness usually begins with loss of motor control and co-ordination. This often starts with characteristic jerking movements which may at first appear as clumsiness. These jerking movements are known as myoclonic seizures. Grand mal (also called tonic-clonic) seizures may also occur. As the condition worsens problems with swallowing and speech develop and vision may be impaired.

17. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. Definition. Subacute sclerosingpanencephalitis is a rare, progressive brain disorder caused http://www.healthatoz.com/healthatoz/Atoz/ency/subacute_sclerosing_panencephalit

Encyclopedia Index S Home Encyclopedia Encyclopedia Index S Subacute sclerosing panencephalitis Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Causes and symptoms Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia . The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

18. CPS CPSP Resource Article Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis in Perspective TI Fulminating subacutesclerosing panencephalitis case report and literature review. http://www.cps.ca/english/CPSP/Resources/Rsspe.htm

19. High-Dose Intravenous Ribavirin Therapy For Subacute Sclerosing Panencephalitis 943 945 DOI 10.1128/AAC.45.3.943945.2001 High-Dose Intravenous Ribavirin Therapyfor subacute sclerosing panencephalitis Mitsuaki Hosoya, 1 * Shiro Shigeta http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90399

20. Member Sign In References. subacute sclerosing panencephalitis, a Measles Complication,in an Internationally Adopted Child from Emerging Infectious Diseases http://www.medscape.com/viewarticle/414739

If you are having trouble logging in: In order to use Medscape, your browser must be set to accept "cookies." To find out how to adjust your browser settings, please click here Log In Username Password Forgot your password? Not a Member? Register Now for free access to: MEDLINE (Optimized for Physicians) 200+ Free CME Courses 25 Medical Specialty Sites 100+ Medical Journals Conference Coverage Daily Medical News About Medscape Help WebMD Health

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 1     1-20 of 94    1  | 2  | 3  | 4  | 5  | Next 20