61. MEDNEMO.it - Il Sito Noprofit Del Dott. Luigi Vicari Ofloxacin a probable cause of toxic epidermal necrolysis. Melde SL. He experienceda severe skin reaction diagnosed as toxic epidermal necrolysis. http://www.mednemo.it/abstracts/avvelenamento/anno2002/aprile/160402pois.htm

8 citations found Other Formats: Order this document Ann Pharmacother 2001 Nov;35(11):1492 Fatal hepatotoxicity associated with enalapril. Gonzalez de la Puente MA, Calderon E, Espinosa R, Rincon M, Varela JM Publication Types: Letter PMID: 11724106, UI: 21580631 Other Formats: Order this document Ann Pharmacother 2001 Nov;35(11):1490-1 Suspected tegenaria agrestis envenomation. Sadler MA, Force RW, Solbrig RM, Sommer S Department of Family Medicine, Idaho State University, Pocatello 83209-8357, USA. PMID: 11724105, UI: 21580630 Other Formats: Order this document Ann Pharmacother 2001 Nov;35(11):1388-90 Ofloxacin: a probable cause of toxic epidermal necrolysis. Melde SL Central Texas Veterans Health Care System, Pharmacy Service, Temple 76504-7493, USA. Stephen.Melde@Med.VA.Gov PMID: 11724089, UI: 21580614 Other Formats: Order this document Ann Pharmacother 2001 Nov;35(11):1364-6 Hepatotoxicity associated with carvedilol. Hagmeyer KO, Stein J College of Pharmacy, The University of Toledo, OH 43606, USA. Khagmey@utnet.utoledo.edu PMID: 11724083, UI: 21580608

62. MEDNEMO.it - Il Sito Noprofit Del Dott. Luigi Vicari Correlations between clinical patterns and causes of erythema multiforme majus,StevensJohnson syndrome, and toxic epidermal necrolysis results of an http://www.mednemo.it/abstracts/avvelenamento/anno2002/settembre/040902pois.htm

8 citations found Other Formats: Order this document Am J Psychiatry 2002 Aug;159(8):1436 Tardive dyskinesia and ziprasidone. Rosenquist KJ, Walker SS, Ghaemi SN Publication Types: Letter PMID: 12153846, UI: 22148302 Other Formats: Order this document Am J Psychiatry 2002 Aug;159(8):1435 Rhabdomyolysis, pancreatitis, and hyperglycemia with ziprasidone. Yang SH, McNeely MJ Publication Types: Letter PMID: 12153844, UI: 22148300 Other Formats: Order this document Arch Dermatol 2002 Aug;138(8):1091-6 Diffuse pustular eruption after treatment of dog bite: acute generalized exanthematous pustulosis (AGEP) due to antibiotic therapy. Pattee SF, Silvis NG, Ellsworth LG University of Arizona Health Center, Tucson, USA. PMID: 12164751, UI: 22154844 Other Formats: Order this document Arch Dermatol 2002 Aug;138(8):1019-24 Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study. Auquier-Dunant A, Mockenhaupt M, Naldi L, Correia O, Schroder W, Roujeau JC Department of Biostatistics and Epidemiology, Institut Gustave-Roussy, Villejuif, France.

63. Toxic Epidermal Necrolysis | Vhihealthe toxic epidermal necrolysis. Advances in toxic epidermal necrolysis. Seminarsin Cutaneous Medicine and Surgery 15 (December 1996) 258266. http://www2.vhihealthe.com/topic/topic100587580

You are here: Home Health A to Z Toxic Epidermal Necrolysis Camer, Richard H. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Toxic epidermal necrolysis is a rare condition that causes large portions of the epidermis, the skin's outermost layer, to detach from the layers of skin below. A reaction to a medication is the primary cause. Description Toxic epidermal necrolysis (TEN) begins with fever, cough, and other nonspecific symptoms, and is soon followed by purplish, bloody-looking lesions on the skin and mucous membranes. These early lesions, typically found on the head, neck, and upper chest, soon merge and blister. Sheets of epidermis then begin to detach from the skin layers below. In time, the entire surface of the skin may be involved, with detachment of 100% of the epidermis. Causes and symptoms The main cause of TEN is a severe drug reaction. Some investigators believe there may be additional infectious causes. A severe reaction in transplant patients, called graft-vs.-host disease, can also produce TEN. One study reported more than 100 different drugs as causes of TEN. The drugs most commonly implicated, however, include antibacterial sulfonamides such as sulfadiazine, antibiotics such as aminopenicillins and cephalosporins, and anticonvulsants like phenytoin. TEN is extremely rare. Researchers estimate that there are 0.2 cases per million users of aminopenicillins and 4.5 cases per million users of sulfonamides. Exactly what leads to detachment of the epidermis remains unclear. People with TEN seem to have difficulty metabolizing the offending drug. Some researchers suggest that certain substances that should be cleared from the body instead get deposited on the outer shell of the epidermis, causing an immune response that leads the body to "reject" the skin.

64. Fas-mediated Cell Death In Toxic Epidermal Necrolysis And Graft-versus-host Dise Translate this page French LE, Tschopp J. Fas-mediated cell death in toxic epidermal necrolysisand graft-versus-host disease potential for therapeutic inhibition. http://www.smw.ch/archive/2000/130-44-229-00.html

French LE, Tschopp J. Fas-mediated cell death in toxic epidermal necrolysis and graft-versus-host disease: potential for therapeutic inhibition. Congress report Fas-mediated cell death in toxic epidermal necrolysis and graft-versus-host disease: potential for therapeutic inhibition Department of Dermatology, Geneva University Medical School, Geneva Institute of Biochemistry, Lausanne University, Epalinges

65. Toxic Epidermal Necrolysis | Building Better Health You are here Home Health A to Z toxic epidermal necrolysisHealth Topics AZ toxic epidermal necrolysis. Camer, Richard H. http://www.buildingbetterhealth.com/topic/topic100587580

Medical Library Cool Tools Women's Health Men's Health ... Drug Dictionary You are here: Home Health A to Z Health Topics A-Z Toxic Epidermal Necrolysis Camer, Richard H. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Toxic epidermal necrolysis is a rare condition that causes large portions of the epidermis, the skin's outermost layer, to detach from the layers of skin below. A reaction to a medication is the primary cause. Description Toxic epidermal necrolysis (TEN) begins with fever, cough, and other nonspecific symptoms, and is soon followed by purplish, bloody-looking lesions on the skin and mucous membranes. These early lesions, typically found on the head, neck, and upper chest, soon merge and blister. Sheets of epidermis then begin to detach from the skin layers below. In time, the entire surface of the skin may be involved, with detachment of 100% of the epidermis. Causes and symptoms The main cause of TEN is a severe drug reaction. Some investigators believe there may be additional infectious causes. A severe reaction in transplant patients, called graft-vs.-host disease, can also produce TEN. One study reported more than 100 different drugs as causes of TEN. The drugs most commonly implicated, however, include antibacterial sulfonamides such as sulfadiazine, antibiotics such as aminopenicillins and cephalosporins, and anticonvulsants like phenytoin. TEN is extremely rare. Researchers estimate that there are 0.2 cases per million users of aminopenicillins and 4.5 cases per million users of sulfonamides.

66. Toxic Epidermal Necrolysis | AHealthyAdvantage You are here Home Health A to Z toxic epidermal necrolysis.toxic epidermal necrolysis. Camer, Richard H. http://www.ahealthyadvantage.com/topic/topic100587580

Site Search Ills and Conditions Women's Health Men's Health Senior Health ... Self-Care Centers Go To Premera Home Provider Directory Preferred Drug List Cool Tools ... Health A-Z You are here: Home Health A to Z Toxic Epidermal Necrolysis Toxic Epidermal Necrolysis Camer, Richard H. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Toxic epidermal necrolysis is a rare condition that causes large portions of the epidermis, the skin's outermost layer, to detach from the layers of skin below. A reaction to a medication is the primary cause. Description Toxic epidermal necrolysis (TEN) begins with fever, cough, and other nonspecific symptoms, and is soon followed by purplish, bloody-looking lesions on the skin and mucous membranes. These early lesions, typically found on the head, neck, and upper chest, soon merge and blister. Sheets of epidermis then begin to detach from the skin layers below. In time, the entire surface of the skin may be involved, with detachment of 100% of the epidermis. Causes and symptoms The main cause of TEN is a severe drug reaction. Some investigators believe there may be additional infectious causes. A severe reaction in transplant patients, called graft-vs.-host disease, can also produce TEN. One study reported more than 100 different drugs as causes of TEN. The drugs most commonly implicated, however, include antibacterial sulfonamides such as sulfadiazine, antibiotics such as aminopenicillins and cephalosporins, and anticonvulsants like phenytoin. TEN is extremely rare. Researchers estimate that there are 0.2 cases per million users of aminopenicillins and 4.5 cases per million users of sulfonamides.

67. Toxic Epidermal Necrolysis Dermatology toxic epidermal necrolysis from Advocate's Health Information ReferenceLibrary. toxic epidermal necrolysis. What is toxic epidermal necrolysis? http://www.advocatehealth.com/system/info/library/reference/peds/derm/necrolys.h

About Us Health Info Programs and Services Jobs and Education ... Dermatology Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction - frequently antibiotics or anticonvulsives. About one-third of all diagnosed cases of toxic epidermal necrolysis do not have an identifiable cause. What are the symptoms of toxic epidermal necrolysis? Toxic epidermal necrolysis causes the skin to peel in sheets, leaving large, raw areas. The loss of skin allows fluids and salts to ooze from the raw, damaged areas and can easily become infected. The following are the most common symptoms of toxic epidermal necrolysis. However, each child may experience symptoms differently. Symptoms may include: a painful, red area that spreads quickly the skin may peel without blistering raw areas of skin discomfort fever condition spread to eyes, mouth, and genitals The symptoms of toxic epidermal necrolysis may resemble other skin conditions. Always consult your child's physician for a diagnosis.

68. Dermatology - Toxic Epidermal Necrolysis Dermatology - Toxic toxic epidermal necrolysis What is toxic epidermal necrolysis? Toxic Whatare the symptoms of toxic epidermal necrolysis? Toxic http://www.chcsys.org/health_info_a_z/adult_html_templated/Derm/toxic.htm

Home For Physicians Health Education and Links Career Opportunities ... Add to My CHC Health Information A - Z Community Health Care Home News CHC Magazine About CHC ... Wausau Hospital Robin Quednow is the February winner of our survey drawing. You too could win a CHC polo shirt in the random drawing for this month if you Take our Site Survey Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the top layer of skin. This disorder can be caused by a drug reaction frequently antibiotics or anticonvulsives or another disease. About one-third of all diagnosed cases of toxic epidermal necrolysis are a result of unknown causes. What are the symptoms of toxic epidermal necrolysis? Toxic epidermal necrolysis can cause the skin to peel off in sheets, leaving large areas that look scalded. The loss of skin causes fluids and salts to ooze from the raw, damaged areas which can easily become infected. The following are the most common symptoms of toxic epidermal necrolysis. However, each person may experience symptoms differently: a painful, red area that spreads quickly

69. Health A-Z Being Healthy, Health AZ. toxic epidermal necrolysis What is toxic epidermalnecrolysis? What are the symptoms of toxic epidermal necrolysis? http://www.lvhhn.org/health_az/derm/toxic.shtml

Find a Doctor Being Healthy Educational Programs Calendar of Events Locations Near You About Us/Donations Employment Press Room Search Being Healthy index Vitality Plus Calendar of Events Sleep Center Women's Health ... Health Info A-Z Being Healthy Health A-Z Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction - frequently antibiotics or anticonvulsives. About one-third of all diagnosed cases of toxic epidermal necrolysis do not have an identifiable cause. What are the symptoms of toxic epidermal necrolysis? Toxic epidermal necrolysis causes the skin to peel in sheets, leaving large, raw areas exposed. The loss of skin allows fluids and salts to ooze from the raw, damaged areas and can easily become infected. The following are the other most common symptoms of toxic epidermal necrolysis. However, each individual may experience symptoms differently. Symptoms may include: a painful, red area that spreads quickly

70. Toxic Epidermal Necrolysis http://www.medigraphic.com/ingles/i-htms/i-abc/i-bc2001/i-bc01-1/im-bc011h.htm

71. EUBS4 HYPERBARIC OXYGEN TREATMENT (HBO) IN toxic epidermal necrolysis (TEN).B. Sparacia, A. Sansone toxic epidermal necrolysis is a form http://www.unipa.it/~ccare/hbo/eubs4.htm

HYPERBARIC OXYGEN TREATMENT (HBO) IN TOXIC EPIDERMAL NECROLYSIS (TEN) B. Sparacia, A. Sansone Toxic Epidermal Necrolysis is a form of cutaneomucous reaction characterized by fever, systemic toxicity, erythema, bullae followed by an extended exfoliation. Such a syndrome was described in 1956 by Lyell who outlined its clinical picture. Etiologically many factors have been indicated as etiological moments of TEN: drugs, microorganisms, food and other elements having an antigenic action. Some drugs may act as factors causing TEN; among them there are Fans, Antibiotics, Anticonvulsants (Phenobarbital, Carbomazefine) and Allopurinol. Some factors such as connective diseases or infections (29), may make it easier for TEN to arise. TEN has been also associated with morbilli, flu, vaccination, serious infections, septicemia by Clostridium Septicum, Escherichia Coli, Klebsiella Pneumoniae, Pseudomonas Aeruginosa, Streptococcus Pyogenes (7).That is the reason why during TEN pathogenesis a great number of physiopathological events occur; these events are not quite clear and various mechanisms have been hypothesized, such as: a) reaction by delayed hypersensitivity type IV b) keratinocytic cytotoxicity mediated by a lymphocytic substance c) reaction by cytotoxicity type II d) non immunologically mediated necrolysis.

72. Dermatology - Toxic Epidermal Necrolysis toxic epidermal necrolysis toxic epidermal necrolysis is a lifethreateningskin disorder characterized by a blistering and peeling of the skin. http://www.fhshealth.org/health/derm/toxic.htm

73. 1Up Health > Erythema Multiforme > Causes, Incidence, And Risk Factors Of Erythe Comprehesive information on Erythema multiforme (Lyell's syndrome,StevensJohnson syndrome, toxic epidermal necrolysis). Covers http://www.1uphealth.com/health/erythema_multiforme_info.html

1Up Health Erythema multiforme Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Erythema multiforme Information Erythema multiforme Causes, Incidence, and Risk Factors Alternative names : Lyell's syndrome, Stevens-Johnson syndrome, Toxic epidermal necrolysis Definition : Erythema multiforme is a skin disorder resulting from an allergic reaction Causes, Incidence, and Risk Factors Erythema multiforme is a type of hypersensitivity (allergic) reaction that occurs in response to medications, infections, or illness. Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include herpes simplex and mycoplasma infections. The exact cause is unknown. The disorder is believed to involve damage to the blood vessels of the skin with subsequent damage to skin tissues. Approximately 90% of erythema multiforme cases are associated with herpes simplex or Mycoplasma infections. The disorder occurs primarily in children and young adults. Erythema multiforme may present with a classic skin lesion with or without systemic (whole body) symptoms. In Stevens-Johnson syndrome, the systemic symptoms are severe and the lesions are extensive, involving multiple body areas (especially the mucous membranes). Toxic epidermal necrolysis (TEN syndrome, or Lyell's syndrome) involves multiple large

74. Dorlands Medical Dictionary toxic epidermal necrolysis, an exfoliative skin disease seen primarily in adultsas a severe cutaneous reaction to various factors, usually drugs but sometimes http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

75. StevensJohnson STEVENSJOHNSON SYNDROME/toxic epidermal necrolysis. Erythema Multiforme/StevensJohnson Syndrome and toxic epidermal necrolysis. http://www.stevensjohnsonsyndrome.com/stevensjohnson.htm

Report Adverse Drug Reaction To FDA STEVENS-JOHNSON SYNDROME/TOXIC EPIDERMAL NECROLYSIS CAUSED BY NSAIDs AND OTHER ARTHRITIC DRUGS SJS/TEN caused mostly by drugs Among the most feared complications of drug therapy are the exfoliative skin disorderserythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Both diseases, SJS and TEN, are primarily, if not solely, caused by drugs among adults, and approximately 50% are drug-related among all ages. The most common drugs associated with SJS and TEN are antibiotics, NSAIDs and anti-convulsants. Prescription NSAIDs, such as Feldene (piroxicam) and Daypro (oxaprozin), are one of the leading classes of drugs that cause SJS and TEN reactions. In many countries, increasing rates of skin eruptions are attributed to (NSAIDs). NSAIDs have played in increasing role in the etiology or cause of TEN, and it has been reported in the medical literature that some NSAIDs that have a long half-life carry a higher risk of SJS or TEN. History In 1922, Stevens and Johnson described two children with fever and stomatitis (mouth ulcers), severe disseminated conjunctivitis (eye inflammation) and cutaneous (skin) eruptions. It soon became evident that severe forms of Stevens-Johnson Syndrome (SJS) could lead to toxic epidermal necrolysis (TEN) and that both diseases could be induced by the same drugs.

76. "Stevens Johnson Syndrome Update Includes Articles About Daypro And Bextra, And Stevens Johnson Syndrome, erythema multiforme (EM), and toxic epidermal necrolysis(TEN) are the most feared complications of drug therapy resulting in http://www.stevensjohnsonsyndrome.com/

Report Adverse Drug Reaction To FDA Telephone 1-877-JBARBER (522-7237) FAX 214-821-3834 email: lojcb@aol.com Stevens Johnson Syndrome / Toxic Epidermal Necrolysis Caused By Drugs ... Parents of stricken girl sue makers of Children's Motrin Among the most feared complications of drug therapy are the exfoliative skin disorderserythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Both diseases, SJS and TEN, are primarily, if not solely, caused by drugs among adults, and approximately 50% are drug-related among all ages. The most common drugs associated with SJS and TEN are antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs) and anti-convulsants. Prescription NSAIDs, such as Bextra (valdecoxib) and Daypro (oxaprozin), are one of the leading classes of drugs that cause SJS and TEN reactions. In many countries, increasing rates of skin eruptions are attributed to (NSAIDs). NSAIDs have played in increasing role in the etiology or cause of TEN, and it has been reported in the medical literature that some NSAIDs that have a long half-life carry a higher risk of SJS or TEN. History In 1922, Stevens and Johnson described two children with fever and stomatitis (mouth ulcers), severe disseminated conjunctivitis (eye inflammation) and cutaneous (skin) eruptions. It soon became evident that severe forms of Stevens-Johnson Syndrome (SJS) could lead to toxic epidermal necrolysis (TEN) and that both diseases could be induced by the same drugs.

77. Child Health Library - Dermatology - Toxic Epidermal Necrolysis Information concerning the diagnosis and treatment of toxic epidermal necrolysisfrom the Child Health Library of Children's Hospital of Pittsburgh. http://www.chp.edu/greystone/derm/necrolys_jm.php

About Parents Providers Library ... Research Select Another Subject Adolescent Medicine Arthritis Burns Cardiovascular Disorders Craniofacial Anomalies Dermatology Eye Care Growth and Development High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Neurological Disorders Normal Newborn Oncology Orthopaedics Respiratory Disorders Surgery Terminally Ill, Care of Transplantation Urology About Pittsburgh Directions and Parking Departments and Services Neighborhood Locations ... Online Resources Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction - frequently antibiotics or anticonvulsives. About one-third of all diagnosed cases of toxic epidermal necrolysis do not have an identifiable cause. What are the symptoms of toxic epidermal necrolysis?

78. Drug Eruptions toxic epidermal necrolysis is the most serious drug eruption and isfatal in almost half of the victims. toxic epidermal necrolysis http://193.255.199.10/dermatology/Allergy-i/cdad0000.htm

79. MercyWeb.org | Health Information toxic epidermal necrolysis. Definition Advances in toxic epidermal necrolysis. Seminars in Cutaneous Medicine and Surgery 15 (December 1996) 258266. http://www.ehealthconnection.com/regions/toledo/health_information/00068540.asp?

80. First Genetic Trust StevensJohnson syndrome (SJS) and toxic epidermal necrolysis (TEN).First Genetic Trust is currently conducting a research study http://www.firstgenetic.net/products_current_studies.html

Overview Dynamic Informed Consent Secure Technology Platform Internal Security, Internet, Third-Party Audits Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) First Genetic Trust is currently conducting a research study of the genetics of drug-induced Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). If you would like to obtain more information about this study, please contact FGT: info@firstgenetic.net . If you live in the UK, FGT will forward your contact information to recruiting sites in Manchester or Liverpool. If you live in the US, your contact information will be forwarded to the research site nearest to you. A study researcher will contact you with additional information and answer your questions. This Study will not help you determine whether you are allergic to certain medications. IF YOU THINK YOU ARE HAVING AN ALLERGIC REACTION TO YOUR MEDICATION CONTACT YOUR HEALTH-CARE PROVIDER IMMEDIATELY Home Terms and Conditions

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