81. Vascular Dementia And Memantine Pharmacologic rationale for memantine in chronic cerebral hypoperfusion, especiallyvascular dementia. Mobius HJ. Merz and Co., Frankfurt, Germany. http://www.memantine.info/memantine-3.htm

Pharmacologic rationale for memantine in chronic cerebral hypoperfusion, especially vascular dementia. Mobius HJ. Merz and Co., Frankfurt, Germany. Alzheimer Dis Assoc Disord 1999 Oct-Dec;13 Suppl 3:S172-8 Abstract Memantine is a moderate-affinity, voltage-dependent, uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors. In contrast to competitive NMDA antagonists, memantine is well tolerated in humans and is being developed for the treatment of dementia. The pathogenesis of vascular dementia (VaD) is largely unknown, and is likely multifactorial, but it involves the impairment of blood circulation as a common denominator. There is broad evidence for the efficacy of memantine in several animal models of ischemia. Memantine also acts on several secondary, potentially contributing factors in VaD such as neuronal depolarization, removal of magnesium block of NMDA receptors, chronic overstimulation of these receptors, and, possibly, mitochondrial dysfunction. Among others, it also has additional positive effects on long-term potentiation and cognition in standard animal models of impaired synaptic plasticity. Recently, clinical efficacy of memantine has been shown in an etiologically mixed population of severely demented patients, including those with VaD. Given the difficulties of diagnosing VaD in clinical practice, an optimal antidementive drug should be beneficial in both Alzheimer disease and VaD. Preclinical data presented in this paper indicate that such benefits can be achieved with

82. Memantine And Vascular Dementia New approaches to clinical trials in vascular dementia memantine in smallvessel disease. Mobius HJ, Stoffler A. Merz Co. Frankfurt, Germany. http://www.memantine.info/memantine-10.htm

New approaches to clinical trials in vascular dementia: memantine in small vessel disease. Mobius HJ, Stoffler A. Frankfurt, Germany. hj.moebius@merz.de Cerebrovasc Dis 2002;13 Suppl 2:61-6 Abstract Galantamine Idebenone Pyritinol CDP Choline ... Home

83. A Z Psychiatry vascular dementia. F01 vascular dementia. Vascular (formerly arteriosclerotic suggestingAlzheimer's disease. F01.1 vascular dementia Of Acute Onset. http://www.azpsychiatry.info/icd/cognitive/vasculardementia.htm

A Z Psychiatry Ray's Web Encyclopedia of Mental Health The ICD-10 Classification of Mental and Behavioural Disorders World Health Organization, Geneva, 1992 Vascular Dementia F01 Vascular Dementia F01.1 Vascular Dementia Of Acute Onset F01.1 Multi-Infarct Dementia F01.2 Subcortical Vascular Dementia ... F01.3 Mixed Cortical And Subcortical Vascular Dementia F01 Vascular Dementia Diagnostic Guidelines The diagnosis presupposes the presence of a dementia as described above. Impairment of cognitive function is commonly uneven, so that there may be memory loss, intellectual impairment, and focal neurological signs. Insight and judgement may be relatively well preserved. An abrupt onset or a stepwise deterioration, as well as the presence of focal neurological signs and symptoms, increases the probability of the diagnosis; in some cases, confirmation can be provided only by computerized axial tomography or, ultimately, neuropathological examination. Associated features are: hypertension, carotid bruit, emotional lability with transient depressive mood, weeping or explosive laughter, and transient episodes of clouded consciousness or delirium, often provoked by further infarction. Personality is believed to be relatively well preserved, but personality changes may be evident in a proportion of cases with apathy, disinhibition, or accentuation of previous traits such as egocentricity, paranoid attitudes, or irritability.

84. Vascular Dementia Dementia Care Caregiver Burden Alzheimer Disease AlzheimerCentre. AlzheimerCentre Facing Alzheimer's disease. Alzheimer Disease Brain Disease Dementia Loss Memory . vascular dementia. http://www.apiavia.com/Alzheimer_Disease/Vascular_Dementia.html

Alzheimer Disease : AlzheimerCentre AlzheimerCentre : Facing Alzheimer's disease Alzheimer Disease Brain Disease Dementia Loss Memory ... Vascular Dementia

85. Vascular Dementia -- ECureMe.com vascular dementia, more about vascular dementia, Multiinfarct Dementia.vascular dementia Dementia. more about vascular dementia, .. About http://www.ecureme.com/emyhealth/data/Vascular_Dementia.asp

March 31, 2003 Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health Ask The Doctor Lifestyle Counseling Ask by mail My Health Chart ... Hospitals Vascular Dementia more about Vascular Dementia Multi-infarct Dementia Vascular Dementia is one of the common causes of Dementia resulting from the interruption of the blood supply to the brain. The symptoms vary depending on the location and severity of the Stroke s Patients may show a slow progression with a stepwise pattern in which the neurological deficits will deteriorate after a Stroke , then remain stable until the next Stroke Slowly progressive Dementia , characterized by memory loss, judgment impairment, impaired thinking, personality changes, mood changes, Delirium , hallucination and confusion.

86. Cognitive Functioning In Alzheimer’s Disease And Vascular Dementia: Further Evi Cognitive Functioning in Alzheimer’s Disease and vascular dementiaFurther Evidence for Similar Patterns of Deficits. Kjell Fahlander http://www.szp.swets.nl/szp/journals/jc246734.htm

Journal of Clinical and Experimental Neuropsychology 2002, Vol.24, No.6, pp. 734-744 Cognitive Functioning in Alzheimer’s Disease and Vascular Dementia: Further Evidence for Similar Patterns of Deficits Kjell Fahlander , Åke Wahlin and Lars Bäckman Karolinska Institute, Stockholm Gerontology Research Center and NEUROTEC, Division of Geriatric Epidemiology, Stockholm, Sweden HM Queen Sophia College of Nursing, Stockholm, Sweden Uppsala University, Department of Psychology, Uppsala, Sweden The purpose of the present study was to examine possible differences in patterns of cognitive performance between population-based samples of Alzheimer’s disease (AD; n = 51) and vascular dementia (VaD; n = 14) patients between 75 and 96 years of age. The two demented groups were comparable in age, years of education, gender distribution, and severity of dementia. The selection of cognitive tasks (letter and category fluency, Block design, Clock reading and setting, and episodic face recognition) was thought to address some of the inconsistencies in previous research. The main finding was that AD and VaD patients were comparable on most tasks, although robust dementia-related deficiencies were found when comparing the results of the demented participants with those of the control participants. These findings suggest that AD and VaD may affect several basic cognitive functions in an equal manner.

87. Topic 12 Vascular Dementia NINDS Search (search help). Contact us My privacy NINDS is part of the NationalInstitutes of Health Contact us . Content for this page. vascular dementia. http://accessible.ninds.nih.gov/funding/neural_environment/stroke_prg/topic12.ht

Funding - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders ... Find People Funding section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury Research funding NINDS funding strategy Funding opportunities Grant mechanisms Research contracts ... Grants policy Contact staff - you are in this section Training funding Research training and career development Special training and research funding Minorities and persons with disabilities Frequently asked questions E-mail notifications Funded grants/contracts (CRISP) ... Advisory council NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us Content for this page Vascular Dementia Get Web page suited for printing Email this to a friend or colleague Session Chairs Philip V. Gorelick

88. Meyer_4255 vascular dementia Edited by John Stirling Meyer, MD Director Reviews vascular dementia. I recommend the book for neurologists and http://www.futuraco.com/m_books/meyer_4255.htm

Published by Futura Publishing Company, Inc. Search by (first named) Author A B C D ... Z This comprehensive, multi-authored textbook provides a unique and up-to-date Vascular Dementia Edited by John Stirling Meyer, MD Director, Cerebrovascular Research Laboratory, Veterans Administration Medical Center, Baylor College of Medicine, Houston, TX Gaiane M. Rauch, MD, PhD Associate Director, Cerebrovascular Research Laboratory, Veterans Administration Medical Center, Baylor College of Medicine, Houston, TX Helmut Lechner, MD Director, Institute for Clinical Neurophysiology and Neurorehabilitation, Graz, Austria Carlo Loeb, MD Professor of Neurology, Clinical Neurologica, Universita di Genova, Genova, Italy Honorary Editor: James F. Toole, MD President, World Federation of Neurology, Director, Stroke Research Center, Wake Forest University, Winston-Salem, NC 320 pp., 36 illus., 45 tables, 6 x 9 hardcover 0-87993-425-5 October 2000 Reviews Vascular Dementia "I recommend the book for neurologists and other physicians with an interest in geriatric neurology, dementia, or cerebrovascular disease." The New England Journal of Medicine "Overall, this book provides an adequate background to the subject."

89. CyberSpace Search! SEARCH THE WEB. Results 1 through 8 of 8 for vascular dementia. http://www.cyberspace.com/cgi-bin/cs_search.cgi?Terms=vascular dementia

90. Characterization Of Risk Factors For Vascular Dementia Characterization of risk factors for vascular dementia. The Honolulu–AsiaAging Study. GW Ross, MD; H. Petrovitch, MD; LR White, MD http://diabetes-mellitus.org/haas.htm

Characterization of risk factors for vascular dementia G. W. Ross, MD; H. Petrovitch, MD; L. R. White, MD; K. H. Masaki, MD; C. Y. Li, MSc, MPH; J. D. Curb, MD; K. Yano, MD; B. L. Rodriguez, MD, PhD; D. J. Foley, MS; P. L. Blanchette, MD; R. Havlik, MD, MPH From the Department of Veterans Affairs (Drs. Ross and White), Honolulu; Department of Medicine (Drs. Ross, Petrovitch, White, Masaki, Curb, Rodriguez, and Blanchette), University of Hawaii John A. Burns School of Medicine, Honolulu; National Institute on Aging (D.J. Foley and Dr. Havlik), National Institutes of Health, Bethesda, MD; and Honolulu-Asia Aging Study (Drs. Petrovitch, White, and Masaki, C.Y. Li, and Drs. Curb, Yano, Rodriguez, and Blanchette), Kuakini Medical Center, Honolulu, HI. NEUROLOGY 1999;53:337 Background: Objective: To characterize patients with VaD by stroke subtype and to investigate risk factors for VaD in a cohort of Japanese American men, aged 71 to 93, living in Hawaii and participating in the HHP. Methods: Sixty-eight men with VaD were compared with 3,335 men without dementia or stroke (NSND). Men with VaD were also compared with 106 men with stroke who were not demented (SND). Candidate risk factors were measured prospectively.

91. Vitamins C And E May Protect Against Mental Decline in the journal Neurology. vascular dementia is typically caused byobstructed blood circulation to the brain. This can lead to a http://healthlink.mcw.edu/article/954383616.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Mental Health Nutrition/Food Senior Health Vitamins/Herbs By keywords: vitamin C vitamin e Receive Health Link via email! Subscribe now >> Vitamins C and E May Protect Against Mental Decline Supplementing diets with antioxidant vitamins C and E may boost mental ability in later life and could protect against vascular and some other forms of dementia, according to a study published in the journal Neurology Vascular dementia is typically caused by obstructed blood circulation to the brain. This can lead to a series of minor cerebrovascular accidents that may cause impairment in thinking or memory functions. "We believe antioxidants like vitamins C and E may protect against vascular dementia by limiting the amount of brain damage that persists after a stroke," said study author Kamal Masaki, MD, of the University of Hawaii in Honolulu. "The supplements may also play a role in providing protection against brain cell and membrane injury involved in many aging-related diseases, thus resulting in significantly higher scores on mental performance tests in later life." The study investigated 3,385 Japanese-American men, aged 71 to 93, participating in the Honolulu Heart Program, a prospective study of heart disease and stroke initiated in 1965. The men were interviewed or surveyed in 1982 and 1988, and were assessed for dementia and mental abilities during exams in 1991 to 1993. Of the participants, 47 were diagnosed with Alzheimer's disease, 35 with vascular dementia, 50 with other or mixed types of dementia, 254 had low cognitive test scores without diagnosed dementia, and 2,999 men showed no cognitive difficulties.

92. VASCULAR-DEMENTIA Search on This Term Main Index TopTerm Index Term Index Prev TermVALPROICACID Next Term vascular-DISEASES vascular-dementia. Broader Terms http://www.alzheimers.org/chid/00001668.htm

Search on This Term Main Index TopTerm Index Term Index Prev Term: VALPROIC-ACID Next Term: VASCULAR-DISEASES VASCULAR-DEMENTIA Broader Terms: CEREBROVASCULAR-DISORDERS DEMENTIA Narrower Terms: MULTI-INFARCT-DEMENTIA Related Terms: STROKE Subject Categories: [D] Disease, Symptoms, and Pathological Processes

93. Antiphospholipid Antibody Syndrome - New Treatments, February 5, 2003 New Treatments for Antiphospholipid Antibody Syndrome, February 5, 2003 http://redirect-west.inktomi.com/click?u=http://www.medical-library.org/journals

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