21. Boston Globe Online / Table Of Contents Date Friday, October 13, 1989 Page 3 Section NATIONAL/FOREIGN If thomas R.cech, was surprised that he won this year's nobel Prize for Chemistry, his http://www.boston.com/globe/search/stories/nobel/1989/1989j.html

Archives Big Dig Book Reviews Boston Capital ... Week in Photos Search the Globe: Today Yesterday THOMAS R. CECH Author: By Alison Bass, Globe Staff Date: Friday, October 13, 1989 Page: Section: NATIONAL/FOREIGN If Thomas R. Cech, was surprised that he won this year's Nobel Prize for Chemistry, his colleagues and mentors were not. There was reason to suspect he was headed for scientific glory while he was still a schoolboy, winning state science fairs in Iowa year after year. Cech, a lanky 41-year-old Colorado resident, reminisced about those early years while sipping champagne with colleagues at the Whitehead Institute in Cambridge yesterday. He had just spoken on the phone with a reporter from a Des Moines newspaper, who remembered that Cech won a science fair in eastern Iowa while still in junior high. When one of his colleagues asked the topic of his winning entry, Cech joked, "I don't remember. I was in so many science fairs." Cech, born in Chicago, took that all-consuming passion for science to Grinnell College in Iowa, where he received a BA in chemistry, and then to the University of California at Berkeley, where he earned a doctorate. He joined the faculty at the University of Colorado at Boulder in 1978 after doing a postdoctoral fellowship at MIT. Many of the scientists who gathered around Cech yesterday remembered him fondly from his days at MIT.

22. NIH Record-9-05-2000--Cech To Discuss 'Life At The End Of The Chromosome' that has the potential to increase the longevity of normal cells and may providenew tools to attack malignant ones, says nobel laureate Dr. thomas R. cech. http://www.nih.gov/news/NIH-Record/09_05_2000/story02.htm

Front Page Previous Story Next Story Cech To Discuss 'Life at the End of the Chromosome' By Doug Dollemore On the Front Page... Scientists are hot on the trail of an enzyme that has the potential to increase the longevity of normal cells and may provide new tools to attack malignant ones, says Nobel laureate Dr. Thomas R. Cech. The enzyme, called telomerase, synthesizes or extends chromosome endings in germ cells, and may act like a molecular "timer" to regulate how long chromosomes in non-germ cells can continue to function. Continued... Cech will discuss what is known about telomerase and its possible impact on lifespan and health when he delivers the NIH Director's Lecture on Wednesday, Sept. 20 at 3 p.m. in Masur Auditorium, Bldg. 10. His lecture, "Life at the End of the Chromosome: Telomeres and Telomerase," will include a glimpse at emerging findings about this unusual enzyme. Dr. Thomas R. Cech

23. Nobel Laureates - 7. Lectures And Nobel Laureates - NIH 1998 Almanac Content nobel Laureates. thomas cech, USA (shared with S. Altman, USA), .do, 1989,NIGMS, NCI. Stanley Cohen, USA (shared with R. LeviMontalcini, USA/Italy http://www.nih.gov/about/almanac/1998/lectures/nobel.html

NIH 1998 Almanac Lectures and Nobel Laureates Nobel Laureates Laureate Field Year Supporting Institute(s) Paul D. Boyer, U.S.A. (shared with J.C. Skou) Chemistry NIGMS, NIDDK Jens C. Skou, Denmark (shared with P.D. Boyer) ......do NINDS Stanley B. Prusiner, U.S.A. Phyisology or medicine NINDS, NIA, NCRR, NIGMS Edward B. Lewis, U.S.A. (shared with C. Nusslein-Volhard, Germany, and E.F. Wieschaus, U.S.A.) Physiology or medicine NICHD, NIGMS Eric F. Wieschaus, U.S.A. (shared with E.B. Lewis, U.S.A., and C. Nusslein-Volhard, Germany) ......do NICHD Alfred G. Gilman, U.S.A. (shared with M. Rodbell, U.S.A.) .....do NIGMS, NINDS Martin Rodbell, U.S.A. (shared with A.G. Gilman, U.S.A.) ......do NIEHS, NIDDK George A. Olah, U.S.A. Chemistry NCI, NIGMS Phillip A. Sharp, U.S.A. (shared with R. Roberts, U.K.) Physiology or medicine NIGMS, NCI, NIAID, DRS, NCRR Richard Roberts, U.K. (shared with P.A. Sharp, U.S.A.) ......do NCRR, NLM, NCHGR, NCI, NIGMS Kary B. Mullis, U.S.A. (shared with M. Smith, Canada) Chemistry NHLBI, NIAID, NIGMS

24. Premios Nobel De Química Premios nobel de Química. Año, Tema, Ganador. 1989, por su descubrimientode las propiedades catalíticas del ARN , Altman, Sidney; cech, thomas R.;. http://fai.unne.edu.ar/biologia/nobeles/nobelq~1.htm

Tema Ganador Hoff, Jacobus Henricus Van't Fischer, Hermann Emil Arrhenius, Svante August Ramsay, Sir William Baeyer, Johann Friedrich Wilhelm Von Moissan, Henri Buchner, Eduard Rutherford, Lord Ernest Ostwald, Wilhelm Wallach, Otto Curie, Marie Grignard, Victor; Sabatier, Paul Werner, Alfred Richards, Theodore William Willstatter, Richard Martin Haber, Fritz Nernst, Walther Hermann Soddy, Frederick Aston, Francis William Pregl, Fritz Zsigmondy, Richard Adolf Svedberg, The Wieland, Heinrich Otto Windaus, Adolf Otto Reinhold Euler-chelpin, Hans Karl August Von; Harden, Sir Arthur Fischer, Hans Bergius, Friedrich; Bosch, Carl Langmuir, Irving Urey, Harold Clayton Joliot, Frederic; Joliot-Curie, Irene Debye, Petrus Josephus Wilhelmus Haworth, Sir Walter Norman; Karrer, Paul Kuhn, Richard Butenandt, Adolf Friedrich Johann; Ruzicka, Leopold De Hevesy, George Hahn, Otto Virtanen, Artturi Ilmari Northrop, John Howard; Stanley, Wendell Meredith; Sumner, James Batcheller Robinson, Sir Robert

25. Encyclopædia Britannica thomas R. cech nobel Foundation Autobiography of this American scientist awardedthe nobel Prize in Chemistry in 1989, for the discovery of catalytic http://search.britannica.com/search?query=Thomas R. Marshall

26. Zeal.com - United States - New - Library - Sciences - Chemistry - Chemists - Oth 13. cech, thomas R. 1989 nobel Autobiography http//www.nobel.se/chemistry/laureates/1989/cech-autobio.ht Consult the autobiography http://www.zeal.com/category/preview.jhtml?cid=554800

27. Editorial Board Translate this page Daniel Bellus (Ciba Specialty Chemicals, Basel) thomas R. cech (University of Colorado,Boulder) nobel Prize Chemistry 1989 Robert JP Corriu (Université de http://www.wiley-vch.de/vch/journals/2002/2002_edbd.html

Editorial Board ** Chairman * Vice-Chairman Reinhart Ahlrichs Univ. Karlsruhe Karlheinz ... Diederich Fred-Robert Heiker Bayer AG , Leverkusen) Wolfgang A. Herrmann Martin Jansen ... Kessler Stefan Marcinowski BASF AG , Ludwigshafen) Rolf Univ. Freiburg Martin Quack Peter Raddatz Merck KGaA , Darmstadt) Manfred Reetz Wolfram Saenger ... Univ. Bonn Hartmut Wiezer Clariant , Sulzbach/Ts.) International Advisory Board Daniel Bellus Ciba Specialty Chemicals , Basel) Thomas R. Cech University of Colorado, Boulder Robert J. P. ... Weizmann Inst. of Science , Rehovot) Robert Langer Massachusetts Inst. of Technology Jean-Marie ... Scripps Research Inst. , La Jolla) Stephen Mann University of Bristol E. W. "Bert" ... Scripps Research Inst. , La Jolla) Ryoji Noyori Nagoya University Colin L. ... Kyushu University , Fukuoka) J. Fraser Stoddart Univ. of California, Los Angeles George M. ... Stanford University

28. Sheffield Chemdex - Autobiographies Awarded the nobel prize for chemistry in 1989 with thomas R. cech for their discoveryof catalytic properties of RNA Reviews Rate It Hits 120, Rating 0.00 http://www.chemdex.org/index.php?t=sub_pages&cat=232

29. UMBC News thomas R. cech, President of the Howard Hughes Medical Institute, to Address Classof 2000 Baltimore, Md. nobel laureate thomas R. cech, president of the http://www.umbc.edu/newsevents/releases/article.phtml?news_id=180

30. Nobel Prize Winners Support Basic Science Americans have been awarded more than onehalf of all nobel Prizes in MD, TheodoreW. Schultz, Ph.D., Steven Weinberg, Ph.D., Sc.D., thomas R. cech, Ph.D http://www.sdsc.edu/SDSCwire/v2.13/nobelists.html

Nobel Prize Winners Seek Stronger Support for Basic Science The American Institute of Physics Bulletin of Science Policy News Number 101: June 26, 1996 The letter, dated June 19, follows: "Dear President Clinton and Members of Congress: "As men and women who have helped to shape the modern scientific age and who care deeply about the future of our nation, we urge you to reaffirm the fundamental role of the federal government in supporting basic scientific research. "Americans have been awarded more than one-half of all Nobel Prizes in physics, chemistry and medicine since 1945. This impressive success is no accident, but the result of a firm and consistent commitment by the federal government to basic science research at our universities. Our nation's policymakers and public have been prudent investors because their support has paid off in tremendous ways. "America's investment in research over the last fifty years has been a vital source of our economic and political strength around the world, as well as the quality of life Americans enjoy at home. The polio vaccine, computers, jet propulsion and disease resistant grains and vegetables are some of the thousands of advances pioneered at our universities that have had dramatic benefits for our health, economy, security and quality of life. "New and equally breathtaking advances may be just around the corner. Genetic research, for example, gives promise of better treatments for Alzheimer's, cancer and other diseases. Lighter and stronger composite materials may be developed with important applications in transportation, medicine and the military. Continuing support for university-based research will not only pave the way for these important breakthroughs, but will also train the next generation of pioneers and Nobelists.

31. Nobel Prize For Chemistry nobel Prize for Chemistry Name, Year, The Work. ALTMAN, SIDNEY, USA cech,thomas R. 1989, for their discovery of catalytic properties of RNA . http://www.planet101.com/nobel_chemistry.htm

Nobel Prize for Chemistry Name Year The Work William S. Knowles , USA Ryoji Noyori, Japan K. Barry Sharpless , USA for their work on chirally catalysed hydrogenation reactions" Alan J. Heeger, Alan G. MacDiarmid and Hideki Shirakawa for the discovery and development of conductive polymers Ahmed H. Zewail For his studies of the transition states of chemical reactions using femtosecond spectroscop Walter Kohn, U.S.A John A. Pople, Great Britain "to Walter Kohn for his development of the density-functional theory and to John Pople for his development of computational methods in quantum chemistry." BOYER, PAUL D., U.S.A WALKER, JOHN E., Great Britain "for their elucidation of the enzymatic mechanism underlying the synthesis of adenosine triphosphate (ATP)" SKOU, JENS C., Denmark "for the first discovery of an ion-transporting enzyme, Na+, K+-ATPase" CURL, ROBERT F. JR., U.S.A KROTO, Sir HAROLD W, Great Britain SMALLEY, RICHARD E., U.S.A "for their discovery of fullerenes"

32. Nobel Prize In Chemistry Since 1901 cech, thomas R.;. 1990, Corey, Elias James. http://www.planet101.com/nobel_chemistry_hist.htm

Nobel Prize in Chemistry since 1901 Year Winners Hoff, Jacobus Henricus Van't Fischer, Hermann Emil Arrhenius, Svante August Ramsay, Sir William Baeyer, Johann Friedrich Wilhelm Von Moissan, Henri Buchner, Eduard Rutherford, Lord Ernest Ostwald, Wilhelm Wallach, Otto Curie, Marie Grignard, Victor; Sabatier, Paul Werner, Alfred Richards, Theodore William Willstatter, Richard Martin Haber, Fritz Nernst, Walther Hermann Soddy, Frederick Aston, Francis William Pregl, Fritz Zsigmondy, Richard Adolf Svedberg, The Wieland, Heinrich Otto Windaus, Adolf Otto Reinhold Euler-chelpin, Hans Karl August Von; Harden, Sir Arthur Fischer, Hans Bergius, Friedrich; Bosch, Carl Langmuir, Irving Urey, Harold Clayton Joliot, Frederic; Joliot-Curie, Irene Debye, Petrus Josephus Wilhelmus Haworth, Sir Walter Norman; Karrer, Paul Kuhn, Richard Butenandt, Adolf Friedrich Johann; Ruzicka, Leopold De Hevesy, George Hahn, Otto Virtanen, Artturi Ilmari Northrop, John Howard; Stanley, Wendell Meredith; Sumner, James Batcheller Robinson, Sir Robert Tiselius, Arne Wilhelm Kaurin Giauque, William Francis

33. Bioeducation.net thomas R. cech, Ph.D., is Among his many honors are the Lasker Award, the NationalMedal of Science, and the 1989 nobel Prize in chemistry. Abstract. http://www.bioeducation.net/grants/bioeducation/tomcech-sharonlong.htm

Home Agenda Plenary I Plenary II ... Thomas R. Cech, Ph.D., is President of the Howard Hughes Medical Institute. He is also American Cancer Society Professor at the University of Colorado at Boulder and Professor of Biochemistry, Biophysics, and Genetics at the University of Colorado Health Sciences Center, Denver. Among his many honors are the Lasker Award, the National Medal of Science, and the 1989 Nobel Prize in chemistry. Abstract Sharon R. Long, Ph.D. Abstract EDUCATIONAL ADVENTURES BEYOND AND BETWEEN THE SCIENTIFIC DISCIPLINES

34. Kimyaokulu - Nobel ödülü Kazanan Bilim Adamlarý nobel ÖDÜLÜ KAZANAN BILIM ADAMLARI VE YAPTIGI ÇALISMALAR. ABD ve Kanada,Yale Üniversitesi, New Haven, CT, d. 1939; ve cech, thomas R. ABD, Colorado http://kimyaokulu.com/bilimin onculeri/nobel/nobel_odulu_kazananlar02.htm

NOBEL ÖDÜLÜ KAZANAN BÝLÝM ADAMLARI VE YAPTIÐI ÇALIÞMALAR YIL YAPILAN ÇALIÞMALAR VE BÝLÝM ADAMLARI COREY, ELIAS JAMES A.B.D., Harvard Üniversitesi, Cambridge, MA, d. 1928: Organik sentez kuramýný ve metodolojisini geliþtirdiði için ALTMAN, SIDNEY A.B.D. ve Kanada, Yale Üniversitesi, New Haven, CT, d. 1939; ve CECH, THOMAS R. A.B.D., Colorado Üniversitesi, Boulder, CO, d. 1947: RNA’nýn katalitik özelliklerini keþfettikleri için DEISENHOFER, JOHANN Federal Almanya Cumhuriyeti, Howard Hughes Medical Onstitute ve Texas Üniversitesi, Southwestern Medical Center at Dallas, Biyokimya Bölümü, TX, A.B.D., d. 1943; HUBER, ROBERT Federal Almanya Cumhuriyeti, Max-Planck-Institut für Biochemie, Martinsried, d. 1937, ve MICHEL, HARTMUT Federal Almanya Cumhuriyeti, Max-Planck-Institut für Biophysik, frankfurt/Main, d. 1948: Fotosentetik tepkime merkezinin üç boyutlu yapýsýný belirlediði için CRAM, DONALD J., A.B.D. Kaliforniya Üniversitesi, Los Angeles, CA, d. 1919; LEHN, JEAN-MARIE, Fransa, Universite Lois Pateur, Strasbourg, ve College de Fransa, Paris, d. 1939; ve

35. 50/50 Reflections On The Double Helix - News cech, thomas R. President, Howard Hughes Medical Institute nobel Prize Laureatein Chemistry Chakravarti, Aravinda Director McKusickNathans Institute of http://www.bio-itworld.com/news/reflections_index.html

More Information About Home > 50/50 Reflections on the Double Helix To mark the 50th anniversary of the double helix and the genomic revolution it inspired, Bio-IT World presents in this Special Report the personal views of 50 luminaries from the world of genomics and biomedicine on the future of DNA research. Check back daily for more exclusive interviews, conducted by Senior Editor Malorye Branca. View by Name / View By Date Adams, Mark Vice President, Bioinformatics Celera Genomics Aebersold, Ruedi Founding Member, Institute for Systems Biology Boguski, Mark S. Investigator, Fred Hutchinson Cancer Research Center Califano, Andrea Chief Technology Officer, First Genetic Trust Cantor, Charles R. Chief Scientific Officer, Sequenom Inc. Cech, Thomas R. President, Howard Hughes Medical Institute Nobel Prize Laureate in Chemistry Chakravarti, Aravinda Director McKusick-Nathans Institute of Genetic Medicine Codani, Jean-Jacques Chairman and CEO, Gene-IT Cohen, Dalia VP and Global Head of Functional Genomics Novartis Pharmaceuticals Corp.

36. Nobel Prize In Chemistry - Wikipedia http//www.nobel.se/chemistry/laureates/index.html. 1988 Johann Deisenhofer, RobertHuber, Hartmut Michel 1989 Sidney Altman, thomas R. cech 1990 Elias James http://www.wikipedia.org/wiki/Nobel_Prize/Chemistry

37. Nobel Prize In Chemistry - Wikipedia J. Pedersen 1988 Johann Deisenhofer, Robert Huber, Hartmut Michel 1989 Sidney Altman,thomas R. cech 1990 Elias James Corey 1991 Richard R. Ernst 1992 http://www.wikipedia.org/wiki/Nobel_Prize_in_chemistry

38. PREMIOS NOBEL RELACIONADOS CON LA GENÉTICA Translate this page 1989, Sidney Altman thomas R. cech. nobel de Química Por su descubrimientode las propiedades catalíticas del ácido ribonucleíco. 1993, http://www.ucm.es/info/genetica/AVG/nobel/nobel.htm

Alfred Nobel La mayoría de los Premios Nobel que figuran en la siguiente lista son de Fisiología y Medicina, salvo algunos de Química y de la Paz que se indican de forma expresa en la tabla. Albrecht Kossel Por sus trabajos sobre las sustancias albuminoides, incluyendo las nucleínas, que han contribuido al conocimiento de la química de las células. Karl Landsteiner Por sus descubrimientos de los grupos sanguíneos de la especie humana. Thomas H. Morgan Por su descubrimiento sobre la función de los cromosomas como portadores de la herencia. Hermann J. Muller Por su descubrimiento de la inducción de mutaciones mediante radiación con rayos X. Linus Carl Pauling Por sus investigaciones sobre la naturaleza de los enlaces químicos y su aplicación en la elucidación de la estructura de las sustancias complejas. También recibió el Premio Nobel de la Paz en 1962 por su lucha contra el desarrollo de las armas nucleares. George W. Beadle Edward L. Tatum Por su descubrimiento de que los genes actúan regulando sucesos químicos definidos.

39. The Lasker Foundation | Lasker Awards And The Nobel Year of. Basic Award Winner, Lasker, nobel. George Wells Beadle, 1950, 1958. F.MacFarlane Burnet, 1952, 1960. thomas R. cech, 1988, 1989. Stanley Cohen, 1986,1986. http://www.laskerfoundation.org/awards/n_vs_l.html

Lasker Awards Jury Members This Year's Winners Former Winners ... Award History View Video Interviews Of select Lasker Award winners... Lasker Luminaries The Awards Society Find out how you can participate in our deferred giving program... The Awards Society Lessons Learned The making of a premier Awards Program. Find out how in... Lessons Learned Nominations Open call to... Nominate a Scientist Lasker Awards and the Nobel The Lasker Medical Science Awards in basic research, clinical research, special achievement and public service, which have been bestowed since l945, provide a chronicle of the progress of biomedical research over the last half-century. The Lasker Foundation is proud that many of the amazing discoveries and achievements of Lasker Award winners are recognized, in addition, by the prestigious Nobel Prize. As of 2002, sixty-six Lasker winners have gone on to win the Nobel. The following statistics are of interest: 47.5% of the Basic Lasker Winners go on to win the Nobel

40. DLS- Thomas Cech Biographical Sketch thomas R. cech Born in Chicago, Illinois on Dr. cech's workhas been recognized by many Medical Research Award (1988), the nobel Prize in http://www7.nationalacademies.org/opus/Thomas_Cech_Lecture.html

OPUS HOMEPAGE VISION AND MISSION STATEMENT OPUS UPDATE NAS INTERVIEWS ... Directions Dr. Thomas Cech Life at the End of Your Chromosomes: How to Stay Forever Young? (lecture given on January 20, 2000) Do you know what goes on at the ends of your chromosomes? Do you know how that activity may effect aging? You know about DNA, but do you know about the ends of your chromosomes, or telomeres? The telomeres are copied by telomerase, a molecular machine distinct from other replication machines in the chromosome. Find out how telomerase is implicated in both cellular aging and cancer. More detailed description of lecture: Life at the Ends of your Chromosomes: How to Stay Forever Young? Biographical Sketch - Thomas R. Cech Born in Chicago, Illinois on December 8, 1947, Tom Cech was raised and educated in Iowa (B. A. in Chemistry from Grinnell College). He obtained his Ph.D. in Chemistry from the University of California, Berkeley and then engaged in postdoctoral research in the Department of Biology at M. I. T. in Cambridge, Massachusetts. In 1978 he joined the faculty of the University of Colorado, Boulder. In 1982 Tom Cech and his research group announced that an RNA molecule from Tetrahymena , a single-celled pond organism, cut and rejoined chemical bonds in the complete absence of proteins. Thus RNA was not restricted to being a passive carrier of genetic information, but could have an active role in cellular metabolism. This discovery of self-splicing RNA provided the first exception to the long-held belief that biological reactions are always catalyzed by proteins. In addition, it has been heralded as providing a new, plausible scenario for the origin of life; because RNA can be both an information-carrying molecule and a catalyst, perhaps the first self-reproducing system consisted of RNA alone. Only years later was it recognized that RNA catalysts, or "ribozymes," might provide a new class of highly specific pharmaceutical agents, able to cleave and thereby inactivate viral RNAs or other RNAs involved in disease.

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