81. Thomas R. Cech HHMI INVESTIGATORS / thomas R. cech. thomas R. cech, Ph.D. President, HowardHughes Medical Institute, University of Colorado Biography http://www.hhmi.org/research/investigators/cech.html

HHMI INVESTIGATORS / Thomas R. Cech HHMI INVESTIGATORS INTERNATIONAL RESEARCH SCHOLARS HHMI-NIH RESEARCH SCHOLARS LAB SAFETY ... HHMI HOME ALSO OF INTEREST Search PubMed The Cech Lab Homepage at the University of Colorado at Boulder 1989 Nobel Prize in Chemistry Nobel Autobiography ... Ribozymes Come Ready for Action Enzymatic RNA Molecules and the Replication of Chromosome Ends Thomas R. Cech, Ph.D. President, Howard Hughes Medical Institute, University of Colorado Biography... Summary: Tom Cech and his group are working to understand the structure and function of catalytic RNA molecules and the activity and regulation of telomerase. A cell must orchestrate thousands of chemical reactions in order to live, to grow, and to respond to its environment. These chemical reactions rarely happen spontaneously but are usually catalyzed by macromolecules called enzymes. It was long thought that all enzymes were proteins. More recently we and others have found that RNA can in some cases act as an enzyme. The finding of RNA catalysis has several implications. First, it means that RNA is not solely a passive carrier of genetic information but can participate actively in directing cellular biochemistry. In particular, many RNA-processing reactions, as well as protein synthesis on ribosomes, are at least in part catalyzed by RNA. Second, the study of how RNA enzymes work may reveal hitherto unknown mechanisms of biologic catalysis. Third, RNA enzymes (ribozymes) have the potential to provide new therapeutic agents. For example, ribozymes efficiently cleave and thereby destroy viral RNAs under controlled laboratory conditions, making it plausible that ribozymes might be able to inactivate viruses in animals, including people.

82. Thomas R. Cech Tom cech thomas R. cech. Department of Chemistry and Biochemistry FacultyDirectory. Department of Molecular, Cellular, and Developmental http://petunia.colorado.edu/~nakamut/personal/cech.html

83. Thomas R. Cech - CIRS cech, thomas R. thomas.cech@Colorado.EDU. Tom cech and his group are working tounderstand the structure and function of catalytic RNA molecules and the http://www.cirs.net/researchers/Chemistry/CECH.htm

CECH, THOMAS R. thomas.cech@Colorado.EDU President of the Howard Hughes Medical Institute Distinguished Professor and Investigator at the Cech Laboratory , Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, USA. Research interests : Cech discovered that the intron in rRNA catalyzes its own excision. The discovery that RNA can function as an enzyme has changed the traditional concept of an enzyme and is of major importance in our understanding of RNA functions. His work has already led to fundamentally new ideas about the origin and evolution of cell genetics. Tom Cech and his group are working to understand the structure and function of catalytic RNA molecules and the activity and regulation of telomerase. Awards and Prizes : USPHS Research Career Development Award, 1980 Pfizer Award in Enzyme Chemistry, 1985 U.S. Steel Award in Molecular Biology, 1987 Heineken Prize, 1988 Nobel Prize in Chemistry, 1989 National Medal of Science, 1995

84. The Real Moment Of Science Episode Guide R. cech. TwentyFive The Duel Life of RNA, nobel Laureate Dr. ThomasR. cech. Twenty-Six Comet Collisions, Dr. Brian Toon. Twenty-Seven http://casa.colorado.edu/~kachun/mos/epguide.html

The Real Moment of Science Episode Guide: Episode Subject Guest One: Life on Mars Dr. Bruce Jakosky Two: Black Holes Dr. Mitch Begelman Three: Chaos Dr. John Cary Four: Arithmetic, Population, and Energy, Part I Dr. Albert Bartlett Five: Arithmetic, Population, and Energy, Part II Dr. Albert Bartlett Six: Arithmetic, Population, and Energy, Part III Dr. Albert Bartlett Eight: Arithmetic, Population, and Energy, Part IV, LIVE Dr. Albert Bartlett Seven: Microbes! Dr. Steve Schmidt Nine: Bose-Einstein Condensate, Part I Dr. Carl Wieman Ten: Bose-Einstein Condensate, Part II Dr. Carl Wieman Eleven: Venus Revealed Dr. David Grinspoon Twelve: Ozone Depletion Dr. Susan Solomon Thirteen: Evolution Dr. Michael Grant Fourteen: Airborne Astronomy and Galapagos Tortoises , a talk on Science Education John Keller Fifteen: Forensic Anthropology Katherine Hoff Sixteen: Comet Hale-Bopp Mary Urquhart and Niescja Turner Seventeen: Catalysis, Chemical, and Biochemical, Part I

85. GK- National Network Of Education Huber, Robert, 1988. Michel, Hartmut, 1988. Deisenhofer, Johann, 1988. cech, ThomasR. 1989. Altman, Sidney, 1989. Corey, Elias James, 1990. Ernst, Richard R. 1991. http://www.indiaeducation.info/infomine/nobel/nobelarchive.htm

86. General2.gif or Medicine, 1989. thomas R. cech University of Colorado, Boulder NobelPrize in Chemistry, 1989. Stanley Cohen Vanderbilt University http://www.curesnow.org/news/forty_nobel.html

April 10, 2002 FORTY NOBEL LAUREATES ANNOUNCE SUPPORT FOR `THERAPEUTIC CLONING' Rare Public Statement Opposes Brownback Bill, Highlights Its Threats to the Fight Against Deadly Diseases, Chilling Effect on Scientific Research Washington, DC Forty American Nobel Laureates, including pioneers in research on cancer and other life-threatening diseases, today released a joint statement strongly supporting nuclear transplantation technology for research and therapeutic purposes (more commonly known as therapeutic cloning.) The statement cites the critical role this research could play in the fight against the most debilitating diseases known to man, and strongly opposes legislation proposed by Senator Brownback (R-KS) that would ban nuclear transplantation technology. Senator Brownback's legislation, if it becomes law, would have a chilling effect on all scientific research in the United States, the Nobel Laureates say. "We decided to speak out to clear up the confusion that has arisen about this issue. Cloning humans and `therapeutic cloning' (or nuclear transplantation technology) are fundamentally different," said Paul Berg, who won the Nobel Prize in 1980. "The cloning of a human being should be prohibited. Nuclear transplantation technology, on the other hand, is meant to produce stem cells, not babies." "This impressive statement underlines what advocates for the 100 million Americans with life-threatening diseases have been saying: this really is a matter of life and death, said Michael Manganiello, president of the Coalition for the Advancement of Medical Research. Nuclear transplantation technology means hope. The Brownback bill would deny it."

87. The Hindu : Nobel Laureates In Chemistry: Down Memory Lane nobel Laureates in chemistry Down memory lane. 1989 SIDNEY ALTMAN and THOMASR. cech for their discovery of catalytic properties of RNA. http://www.hinduonnet.com/thehindu/2001/10/18/stories/08180002.htm

Online edition of India's National Newspaper Thursday, October 18, 2001 Front Page National Southern States Other States ... Next Nobel Laureates in chemistry: Down memory lane 2001 WILLIAM S. KNOWLES, RYOJI NOYORI and K. BARRY SHARPLESS for developing catalytic asymmetric synthesis. The achievements are of great importance for the development of new drugs and materials.2000-1991 2000 ALAN J. HEEGER, ALAN G. MACDIARMID, and HIDEKI SHIRAKAWA for the discovery and development of conductive polymers. 1999 AHMED ZEWAIL for his research and studies of transition states of chemical reactions using femtosecond spectroscopy. 1998 WALTER KOHN for his development of the density-functional theory and JOHN A. POPLE for his development of computational methods in quantum chemistry. 1997 PAUL D. BOYER and JOHN E. WALKER for their elucidation of the enzymatic mechanism underlying the synthesis of adenosine triphosphate (ATP), and JENS C. SKOU for the first discovery of an ion-transporting enzyme, Na+, K+-ATPase. 1996 ROBERT F. CURL, Jr. , SIR HAROLD W. KROTO , and RICHARD E. SMALLEY for discovering fullerenes.

88. Nobel.html Winners of the nobel Prize in Chemistry. 1989 Sidney Altman and ThomasR. cech Showed that RNA could act as a biological catalyst. http://server.ccl.net/cca/documents/dyoung/topics-framed/nobel.shtml

http://server.ccl.net/cca/documents/dyoung/topics-framed/nobel.shtml CCL nobel.html topics checkpoint.html chem_links.html compchem.html ... vib.html Winners of the Nobel Prize in Chemistry Jacobus Hendricus van't Hoff Chemical dynamics and osmotic pressure. Emil Hermann Fischer Work on carbohydrates and purines. Svante August Arrhenius Theory of electrolytic dissociation. Sir William Ramsay Discovery of helium, neon, xenon and krypton. Johann Friedrich Wilhelm Adolf von Baeyer Synthetic organic chemistry, particularily for the synthesis of indigo and triphenylmethane dyes. Preparing pure fluorine and developing the electric furnace (the Moissan furnace). Eduard Buchner Biochemical research including discovery of cell-less fermentation (fermentation in a test tube by extracting the active enzymes from yeast cells). Ernest Rutherford Study of radioactive substances. Friedrich Wilhelm Ostwald Work on catalysis, chemical equilibrium and reaction rates. Otto Wallach Work on alicyclic compounds. Marie Curie Chemistry of radioactive isotopes.

89. Tous Les Prix Nobel De Chimie Prix nobels, Alfred nobel. A. Kurt Alder. Sydney Altman. C. Melvin Calvin. ThomasCech. Elias James Corey. Walter Norman Haworth. Dudley R. Herschbach. Gerhard Herzberg. http://membres.lycos.fr/xjarnot/Chimistes/Prix_Nobel_alphabetique.html

P rix Nobels Alfred Nobel A Kurt Alder Sydney Altman ... Aston B Adolf Johann Friedrich Wilhelm von Baeyer Sir Derek Harold Barton ... Butenandt C Melvin Calvin Thomas Cech ... Curl D Peter Joseph William Debye Johann Deisenhofer ... Diels E Manfred Eigen Hans von Euler ... Chelpin F Emil Hermann Fischer Ernst Otto Fischer ... Fukui G William Francis Giauque Walter Gilbert ... Grignard H Fritz Haber Otto Hahn ... Huber J Frédéric Joliot-Curie Irène Joliot-Curie K Jérôme Karle Paul Karrer ... Kuhn L Irwing Langmuir Luis F. Leloir ... Lipscomb M Edwin M. McMillan Archer John Porter Martin ... Mulliken N Giulio Natta Hermann Walther Nernst ... Northrop O Lars Onsager Friedrich Wilhelm Ostwald P Linus Carl Pauling Charles J. Pedersen ... Prigogine R Sir William Ramsay Franck Sherwood Rowland ... Ruzicka S Paul Sabatier Frederik Sanger et Glenn T. Seaborg Nicolas Nicolaevitch Semenov ... Synge T Henry Taube Arne Wilhelm Kaurin Tiselius ... Todd U Harold Clayton Urey V Jacobus Henricus Van't Hoff Vincent du Vigneaud ... Virtanen W Otto Wallach Alfred Werner ... Woodward Y Yuan Lee Z Karl Ziegler Richard Zsigmondy Pour tous problèmes ou remarques, écrivez au webmaster

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