1. Robert F. Furchgott Winner Of The 1998 Nobel Prize In Medicine robert F. furchgott, a nobel Prize Laureate in Physiology and Medicine,at the nobel Prize Internet Archive. robert F. furchgott. http://almaz.com/nobel/medicine/1998a.html

R OBERT F F URCHGOTT 1998 Nobel Laureate in Medicine for his discovery concerning nitric oxide as a signalling molecule in the cardiovascular system. Background Born: June 4, 1916 Place of birth: Charleston, South Carolina, U.S.A. Residence: Brooklyn, NY, U.S.A. Affiliation:Department of Pharmacology, Box 29, SUNY Health Science Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA Book Store Books on Nitric Oxide Books on Viagra Featured Internet Links Prize co-recipient: Louis J. Ignarro Prize co-recipient: Ferid Murad Official award announcement and background Illustrated Presentation ... PubMedline search results for nitric oxide and cardiovascular system Search WWW Search The Nobel Prize Internet Archive Links added by Nobel Internet Archive visitors Winner of the 1991 Gairdner Foundation International Award Viagra connection Psychiatry, Psychopharmacology, Molecular Biophysics, Medical Genetics (submitted by Mekhti M. KULIEV Psychiatry, Psychopharmacology, Molecular Biophysics, Medical Genetics (submitted by Mekhti M. KULIEV

2. Robert F. Furchgott - Autobiography robert F. furchgott – Autobiography. reason for the move was that the furchgottdepartment store young physiologist who had trained with robert Chambers and http://www.nobel.se/medicine/laureates/1998/furchgott-autobio.html

Early education Within the first couple of years of high school, I knew that I would like to be a scientist. My parents were encouraging: they gave me chemistry sets and a small microscope as presents. I liked to read popular books about scientists, although there were not many available at that time. My father subscribed to the Sunday New York Times, in which there was often a column on science that I found very exciting. During the four years that I was in high school, my older brother Arthur was at the University of North Carolina at Chapel Hill. I wanted to attend college there also, but that was not possible when I finished high school in 1933 because tuition for me, as an out-of-state resident, was more than my father could afford at that time. So I spent my freshman year at the University of South Carolina , where my tuition was much less. However, by the summer of 1934, my father moved his business from Orangeburg to Goldsboro, N.C., where he felt that the local economy was better. So now, as a resident of North Carolina, I was able to register at the University at Chapel Hill as a sophomore majoring in chemistry. Northwestern University Medical School in Chicago. I was to be a graduate student of Dr Henry Bull, who had recently come to Northwestern, and whose research interests were physical chemical aspects of biochemistry.

3. Medicine 1998 Presentation robert F. furchgott Autobiography Curriculum Vitae BanquetSpeech nobel Diploma Prize Award Photo Other Resources. Louis http://www.nobel.se/medicine/laureates/1998/

The Nobel Prize in Physiology or Medicine 1998 "for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system" Robert F. Furchgott Louis J. Ignarro Ferid Murad 1/3 of the prize 1/3 of the prize 1/3 of the prize USA USA USA SUNY Health Science Center Brooklyn, NY, USA UCLA School of Medicine Los Angeles, CA, USA University of Texas Medical School at Houston Houston, TX, USA b. 1916 b. 1941 b. 1936 The Nobel Prize in Physiology or Medicine 1998 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1998 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Last modified October 17, 2000 The Official Web Site of The Nobel Foundation

4. Dr. Robert F. Furchgott, Nobel Laureate Dr. robert F. furchgott. SUNY Health Science Center at Brooklyn. Dr. furchgottwas awarded the 1998 nobel Prize in Medicine for his discoveries concerning http://www.rfsuny.org/50_anniversary/nobel_laureates/Furchgott.htm

Dr. Robert F. Furchgott SUNY Health Science Center at Brooklyn Dr. Furchgott was awarded the 1998 Nobel Prize in Medicine for his discoveries concerning "nitric oxide as a signaling molecule in the cardiovascular system." In 1980, Dr. Furchgott published his discovery of endothelium-derived relaxing factor (EDRF), a mysterious chemical in the inner linings of the arteries that controls the artery’s widening and narrowing. Six years later, he identified EDRF as nitric oxide. Dr. Furchgott’s findings opened up a new area of research, which is contributing much to our understanding of cardiovascular physiology and is helping doctors save lives.

5. Candidates SUNY Downstate Congratulates Dr. robert F. furchgott uponhis having been awarded the nobel Prize in Medicine. http://www.downstate.edu/Nobel Prize/dr._furchgott.htm

SUNY Downstate Congratulates Dr. Robert F. Furchgott upon his having been awarded the Nobel Prize in Medicine. SUNY Downstate Celebrates this historic event! In 1980, Dr. Furchgott published his discovery of endothelium-derived relaxing factor (EDRF), a mysterious chemical in the inner linings of the arteries that controls the artery's widening and narrowing. By 1986, he had worked out EDRF's nature and mechanism and, from his 6th floor lab at the SUNY Health Science Center at Brooklyn, announced that EDRF was in fact the tiny molecule nitric oxide (NO).Between those years, laboratories around the globe were detailing EDRF's importance in the body's physiology, from regulating blood pressure to preventing blood clots. Dr. Furchgott's work in the laboratory is now helping doctors save lives. Further Reading A utobiography Biography Department of Pharmacology at the SUNY Health Science Center at Brooklyn ... Congratulations letter from Governer George E. Pataki Web site design: Biomedical Communications Last updated: Tuesday, November 26, 2002

6. Nobel Celebration SUNY Downstate acknowledges Dr. robert furchgott the 1998 recipient of theNobel Prize in Medicine. Standing Room Only. Dr. robert F.furchgott. http://www.downstate.edu/nc/nobel_celebration.htm

SUNY Downstate acknowledges Dr. Robert Furchgott the 1998 recipient of the Nobel Prize in Medicine Standing Room Only Dr. Furchgott and President Feigelson Dr. Furchgott with SUNY's Chancellor John W. Ryan Chancellor John W. Ryan Warm words from Dr. Eugene Feigelson One Happy Family Professor of Pharmacology Dr.Stanley Friedman Dr. Robert F.Furchgott Chancellor John W. Ryan, Brooklyn Borough President Howard Golden, Dr. Robert F.Furchgott and SUNY Downstate President Dr.Eugene Feigelson The SUNY Downstate community comes out in mass to greet Dr. Furchgott. Return to main SUNY page Designed by the Department of Biomedical Communications

7. Nobel Prize Winner Robert Furchgott Served On School Of Medicine Faculty robert F. furchgott, Ph.D., one of three scientists to receive the 1998 nobel Prizein Physiology or Medicine, was a member of the School of Medicine faculty http://record.wustl.edu/archive/1998/10-29-98/articles/furchgott.html

Nobel Prize winner Robert Furchgott served on School of Medicine faculty Robert F. Furchgott, Ph.D., one of three scientists to receive the 1998 Nobel Prize in Physiology or Medicine, was a member of the School of Medicine faculty more than 40 years ago. Formal presentation of the awards will take place Dec. 10 in Stockholm, Sweden. Furchgott, a pharmacologist at the State University of New York (SUNY), and two other Americans, Ferid Murad, M.D., and Louis J. Ignarro, Ph.D., received the prize earlier this month for their work concerning nitric oxide as a signaling molecule in the cardiovascular system. Furchgott came to the medical school in 1949 to work in the laboratory of world-renowned researcher Oliver H. Lowry, M.D., Ph.D., who was professor and head of the Department of Pharmacology. Furchgott previously had been an assistant professor of biochemistry at Cornell University. He joined the pharmacology department here as an assistant professor and was one of six faculty members in the 1950s. He was promoted to associate professor in 1952. He studied the effects of drugs on heart rate and rhythm, and, in particular, the action of drugs on the smooth muscle of blood vessels. F. Edmund Hunter, Jr., Ph.D., professor emeritus of pharmacology, recalled that Furchgott, now 82, was one of Lowry's first recruits after being named head of pharmacology.

8. Medical News robert F. furchgott, Ph.D., one of three scientists to receive the 1998 nobel Prizein Physiology or Medicine, was a member of the School of Medicine faculty http://record.wustl.edu/archive/1998/10-29-98/medical.html

October 29, 1998 New explorations into mind-body connections Cognitive behavior therapy helps control depression and blood glucose in patients with diabetes by Jim Dryden Lustman: Diabetes researcher School of Medicine investigators have found that a form of psychotherapy called cognitive behavior therapy (CBT) is an effective treatment for depression in patients with diabetes, restoring mental health and significantly improving control of blood sugar levels. Cognitive behavior therapy treats depression by involving patients in social and physical activities, teaching problem-solving skills to resolve stressful situations, identifying distorted thought patterns that lead to depression and replacing them with more positive and useful views. The researchers report the findings of this first-ever controlled trial of CBT in diabetes in the Oct. 15, 1998 issue of Annals of Internal Medicine. They found that a 10-week program of therapy helped relieve depression in the majority of patients with diabetes. In the months after CBT, these patients also achieved better control of their blood glucose levels. Click to see entire article Nobel Prize winner Robert Furchgott served on School of Medicine faculty Robert F. Furchgott, Ph.D., one of three scientists to receive the 1998 Nobel Prize in Physiology or Medicine, was a member of the School of Medicine faculty more than 40 years ago.

9. Robert F. Furchgott In 1998, robert F. furchgott was awarded the nobel Prize in Physiology or Medicinejointly with Louis Ignarro and Ferid Murad for their discoveries concerning http://web2.ccpl.org/scienceproject/ScienceWalk/Furchgott.html

Charleston Science Walk Introduction Noisette Garden Ernest E.Just William Wells ... Credits Dr. Robert F. Furchgott (b.1916 ) Robert F. Furchgott, biochemist and pharmacologist, was born in Charleston, S.C. With two brothers, his father owned and operated the Furchgott department store in the city, until the onset of the Great Depression. In 1998, Robert F. Furchgott was awarded the Nobel Prize in Physiology or Medicine jointly with Louis Ignarro and Ferid Murad for their discoveries concerning "nitric oxide as a signalling molecule in the cardiovascular system." In 1980 Dr. Furchgott discovered a substance in the endothelium, a layer of cells at the innermost surface of blood vessels which causes the underlying smooth muscle to relax. He later discovered this was actually nitric oxide, a chemical that is a messenger molecule that mediates control of blood pressure, airway tone, gastrointestinal motility, penile erection, and in fighting cancer and infections. Furchgott's early interest in science was fostered by nature study classes and field trips to nearby beaches, marshes, and woods sponsored by the Charleston Museum. His parents encouraged his interest in science with gifts of a chemistry set and a small microscope. He was also inspired by the science columns he read in the Sunday

10. Ferid Murad - Robert Furchgott - Louis Ignarro The nobel Assembly at the Karolinska Institute has today decided to award the nobelPrize in Physiology for Medicine jointly to robert F. furchgott, Louis J http://www.dietsexercise.com/nobel-prize-arginine-Text.htm

Ferid Murad - Robert Furchgott - Louis Ignarro Press Release: The 1998 Nobel Prize in Physiology or Medicine NOBELFÖRSAMLINGEN KAROLINSKA INSTITUTET THE NOBEL ASSEMBLY AT THE KAROLINSKA INSTITUTE 12 October 1998 The Nobel Assembly at the Karolinska Institute has today decided to award the Nobel Prize in Physiology for Medicine jointly to Robert F. Furchgott, Louis J. Ignarro and Ferid Murad for their discoveries concerning "nitric oxide as a signaling molecule in the cardiovascular system." Ferid Murad, MD and pharmacologist, now in Houston, Texas, analyzed how nitroglycerin and related vasodilating compounds act and discovered in 1977 that they release nitric oxide, which relaxes smooth muscle cells. He was fascinated by the concept that a gas could regulate important cellular functions and speculated that endogenous factors such as hormones might also act through NO. However, there was no experimental evidence to support this idea at the time. Robert F. Furchgott

11. Sigma Xi: The Scientific Research Society: News Archive Four members joined this illustrious group in 1998. 1998 nobel Prizein Physiology or Medicine. robert F. furchgott and Louis J. Ignarro. http://www.sigmaxi.org/about/news/archive.19.shtml

Overview Leadership Organization News ... Contact Us News Sigma Xi Center Construction Under Way American Scientist News Sigma Xi Today Newsletters ... Archive Search: Site Map Home News Archive Four Sigma Xi Members Receive 1998 Nobel Prizes Election to Sigma Xi has been an early milestone in many distinguished careers, the first professional honor many young scientists receive in recognition of their potential to make meaningful contributions to research. Many Sigma Xi members have gone on to win major awards. In the Society's history, more than 175 members have received the Nobel Prize. Four members joined this illustrious group in 1998. 1998 Nobel Prize in Physiology or Medicine Robert F. Furchgott and Louis J. Ignarro For their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system. Robert F. Furchgott , a pharmacologist at the State University of New York Health Science Center in Brooklyn, studied the effect of drugs on blood vessels but often achieved contradictory results. The same drug sometimes caused a contraction and at other times, a dilatation. Furchgott wondered if the variation could depend on whether the surface cells (the endothelium) inside the blood vessels were intact or damaged. In 1980, he demonstrated in an ingenious experiment that acetylcholine dilated blood vessels only if the endothelium was intact. He concluded that blood vessels are dilated because the endothelial cells produce an unknown signal molecule that makes vascular smooth muscle cells relax. He called this signal molecule EDRF, the endothelium-derived relaxing factor, and his findings led to a quest to identify the factor. He was elected to membership in Sigma Xi by the Northwestern University Chapter in 1939.

12. Sigma Xi: The Scientific Research Society: Nobel Laureates About Sigma Xi » Overview » nobel Laureates 1992 Edmond Henri Fischer 1992 EdwinGerhard Krebs 1994 Alfred G. Gilman 1998 robert F. furchgott 1998 Louis J http://www.sigmaxi.org/about/overview/nobel.shtml

Overview Leadership Organization News ... Contact Us About: Overview Leadership Organization News Support Sigma Xi ... Contact Us Search: Site Map Home Overview Physics 1907 Albert Michelson 1921 Albert Einstein 1923 Robert A. Millikan 1925 James Franck 1927 Arthur H. Compton 1936 Carl D. Anderson 1937 Clinton J. Davisson 1938 Enrico Fermi 1939 Ernest O. Lawrence 1943 Otto Stern 1944 Isidor Isaac Rabi 1945 Wolfgang Pauli 1946 Percy Williams Bridgman 1952 Felix Bloch 1952 Edward M. Purcell 1955 Polykarp Kusch 1955 Willis E. Lamb, Jr. 1956 John Bardeen 1956 Walter H. Brattain 1956 William Shockley 1957 Chen Ning Yang 1958 Igor Y. Tamm 1959 Owen Chamberlain 1959 Emilio G. Segre 1960 Donald A. Glaser 1961 Robert Hofstadter 1963 Eugene P. Wigner

13. Best Deal Nutritionals - Physiology Or Medicine For 1998 - Nobel Prize October 12, 1998 The nobel Assembly at Karolinska Institutet awarded the nobel Prizein Physiology or Medicine for 1998 jointly to robert F. furchgott, Louis J http://www.bestdealnutritionals.com/shop/press.asp

The 1998 Nobel Prize in Physiology or Medicine THE NOBEL ASSEMBLY AT KAROLINSKA INSTITUTET October 12, 1998 The Nobel Assembly at Karolinska Institutet awarded the Nobel Prize in Physiology or Medicine for 1998 jointly to Robert F. Furchgott, Louis J. Ignarro and Ferid Murad for their discoveries concerning "nitric oxide (NO) as a signalling molecule in the cardiovascular system". NO has been proven to improve sexual performance in both men and women. Summary Nitric oxide (NO) is a gas that transmits signals in the organism. Signal transmission by a gas that is produced by one cell, penetrates through membranes and regulates the function of another cell represents an entirely new principle for signalling in biological systems. The discoverers of NO as a signal molecule are awarded this year's Nobel Prize. Robert F Furchgott Biography ) pharmacologist in New York, studied the effect of drugs on blood vessels but often achieved contradictory results. The same drug sometimes caused a contraction and at other occasions a dilatation. Furchgott wondered if the variation could depend on whether the surface cells (the endothelium) inside the blood vessels were intact or damaged. In 1980, he demonstrated in an ingenious experiment that acetylcholine dilated blood vessels only if the endothelium was intact. He concluded that blood vessels are dilated because the endothelial cells produce an unknown signal molecule that makes vascular smooth muscle cells relax. He called this signal molecule EDRF, the endothelium-derived relaxing factor, and his findings led to a quest to identify the factor.

14. AldeaEducativa.com | Contenidos Y Consultas Educativas Translate this page Recordando a un ganador del Premio nobel de Fisiologíay Medicina Ir al Tope. furchgott, robert F. http://www.aldeaeducativa.com/aldea/buscador9d.asp?which=Medicina

15. Jewish Nobel Prize Laureates - Biomedical Sciences Year, nobel Laureate, Country of birth. 1998, furchgott, robert F. for their discoveriesconcerning nitric oxide as a signaling molecule in the cardiovascular http://www.science.co.il/Nobel-Biomedical.asp

Israel Science and Technology Homepage HOME Search About Contact Nobel Prize Subject Biomedical Chemistry Economics Physics ... Literature Sort options Country Name Year Order A - Z Z - A Show citation Yes No Jewish Laureates of Nobel Prize in Biomedical Sciences Year Nobel Laureate Country of birth Brenner, Sydney "for their discoveries concerning genetic regulation of organ development and programmed cell death" South Africa Horvitz, H. Robert "for their discoveries concerning genetic regulation of organ development and programmed cell death" USA Greengard, Paul "signal transduction in the nervous system" USA Kandel, Eric R. "signal transduction in the nervous system" Austria Furchgott, Robert F. "for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system" USA Prusiner, Stanley B. "for his discovery of Prions - a new biological principle of infection" USA Gilman, Alfred G. "for their discovery of G-proteins and the role of these proteins in signal transduction in cells" USA Rodbell, Martin "for their discovery of G-proteins and the role of these proteins in signal transduction in cells" USA Varmus, Harold E.

16. Biolinks Files: Nobel Prize The nobel Prize winners for 1998 Medicine robert F. furchgott, Louis J. Ignarroand Ferid Murad Achievement for their discoveries concerning nitric oxide as http://www.biolinks.com/files/nobel/medicine.html

Internet Search Engine Designed by Scientists, for Scientists !!! Welcome BioBoard Email Nobel Awards ... Click Here! The Nobel Prize winners for 1998: Medicine Robert F. Furchgott, Louis J. Ignarro and Ferid Murad Achievement: for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system. Biography: Robert F. Furchgott: Professor at the University of Miami School of Medicine. He is 82. Louis J. Ignarro: Professor of UCLA School of Medicine. He is 57. Ferid Murad: Professor of the University of Texas Medical School in Houston. He is 62. Stories and related links: Official announcement U.S. discoverers of Viagra principle get Nobel Prize (CNN coverage) Cardiovascular Discoveries Earn Honors for Medical Prize (ABC News coverage) Nobel Prize for Medicine Awarded to Tripos Board Member ... Economics '); document.write(' A Monster owned company

17. Biolinks Files: Nobel Prize Medicine robert F. furchgott, Louis J. Ignarro and Ferid Murad Stories and relatedlinks Why US Dominates Science US academia has lock on scientific nobel http://www.biolinks.com/files/nobel/

Internet Search Engine Designed by Scientists, for Scientists !!! Welcome BioBoard Email Nobel Awards ... Click Here! The Nobel Prize winners for 1998 Literature: Jose Saramago Peace: John Hume and David Trimble Chemistry: Walter Kohn and John A. Pople Physics: Robert B. Laughlin, Horst L. Stormer and Daniel C. Tsui Economics: Amarthya Sen Medicine: Robert F. Furchgott, Louis J. Ignarro and Ferid Murad Stories and related links: Why U.S. Dominates Science U.S. academia has lock on scientific Nobel prizes Magnet for world's scientists, U.S. dominates Nobels '); document.write(' A Monster owned company

18. NOBEL PRIZES robert F. furchgott won nobel prize for his discovery concerning nitric oxideas a signalling molecule in the cardiovascular system. robert F. furchgott. http://www.bioscience.org/urllists/nobel.htm

FRONTIERS IN BIOSCIENCE; NOBEL PRIZES 2000 Nobel prize winner in medicine Arvid Carlsson, Paul Greengard And Eric Kandel jointly won nobel prize for their discoveries in signal transduction in the nervous system ARVID CARLSSON Born: January 25, 1923 Place of birth: Uppsala, Sweden Residence: Sweden Affiliation: Department of Pharmacology, University of Göteborg Medicine Address: Department of Pharmacology University of Göteborg Medicinaregatan 7 Box 431, SE-405 30 Göteborg, Sweden Tel: +46 31-773 34 35 Fax: +46 31-82 17 95 E-mail: arvid.carlsson@pharm.gu.se 2000 Nobel prize winner in medicine Arvid Carlsson, Paul Greengard And Eric Kandel jointly won nobel prize for their discoveries in signal transduction in the nervous system PAUL GREENGARD Born: December 11, 1925 Place of birth: New York, NY, USA Residence: New York, USA Affiliation: Laboratory of Molecular and Cellular Neuroscience, Rockefeller University Address: Laboratory of Molecular and Cellular Neuroscience The Rockefeller University 1230 York Avenue, New York, NY 10021, USA E-mail: greengd@rockvax.rockefeller.edu

19. NOBEL PRIZE: Medicine Other sites nobel Prize in Physiology or Medicine official site;robert F furchgott Department of Pharmacology at SUNY, Brooklyn; http://www.cnn.com/SPECIALS/1998/nobel/medicine/

MAIN PAGE WORLD africa americas ... news quiz CNN WEB SITES: TIME INC. SITES: Go To ... Time.com People Money Fortune EW MORE SERVICES: video on demand video archive audio on demand news email services ... pointcast DISCUSSION: message boards chat feedback SITE GUIDES: help contents search FASTER ACCESS: europe japan WEB SERVICES: Keyword Title Author MAIN PEACE CHEMISTRY ECONOMICS ... LAUREATE LOCATOR Cardiovascular discovery carries potent news Robert Furchgott Louis Ignarro Ferid Murad (CNN) The Nobel Prize in physiology and medicine went this year to three U.S. scientists whose discovery helped pave the way for the wildly popular anti-impotence drug Viagra. The $978,000 prize, awarded by Sweden's Karolinska Institute, is to be divided equally among Robert Furchgott of the State University of New York in Brooklyn; Louis Ignarro of the University of California-Los Angeles; and Ferid Murad of the University of Texas Medical School in Houston. Through collective research efforts, the trio discovered that the body uses nitric oxide a colorless gas long believed to be just a common air pollutant to regulate blood vessels. How the discovery was made In 1977, Murad, a Houston medical doctor and pharmacologist, discovered that nitroglycerin and other related compounds that dilate blood vessels release nitric oxide. The nitric oxide, or NO, relaxes smooth muscle cells, he found.

20. Press Release: The Nobel Prize In Physiology Or Medicine For 1998 The discoverers of NO as a signal molecule are awarded this year´s nobel Prize.robert F furchgott, pharmacologist in New York, studied the effect of drugs on http://www.bb.iastate.edu/~bb404/nopriz98.html

Karolinska Institutet Press Release October 12, 1998 The Nobel Assembly at the Karolinska Institute has today decided to award the 1998 Nobel Prize in Physiology or Medicine jointly to Robert F Furchgott, Louis J Ignarro and Ferid Murad for their discoveries concerning "nitric oxide as a signalling molecule in the cardiovascular system" Summary Robert F Furchgott , pharmacologist in New York, studied the effect of drugs on blood vessels but often achieved contradictory results. The same drug sometimes caused a contraction and at other occasions a dilatation. Furchgott wondered if the variation could depend on whether the surface cells (the endothelium) inside the blood vessels were intact or damaged. In 1980, he demonstrated in an ingenious experiment that acetylcholine dilated blood vessels only if the endothelium was intact. He concluded that blood vessels are dilated because the endothelial cells produce an unknown signal molecule that makes vascular smooth muscle cells relax. He called this signal molecule EDRF, the endothelium-derived relaxing factor, and his findings led to a quest to identify the factor. Ferid Murad , MD and pharmacologist now in Houston, analyzed how nitroglycerin and related vasodilating compounds act and discovered in 1977 that they release nitric oxide, which relaxes smooth muscle cells. He was fascinated by the concept that a gas could regulate important cellular functions and speculated that endogenous factors such as hormones might also act through NO. However, there was no experimental evidence to support this idea at the time.

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