1. Alfred G. Gilman Winner Of The 1994 Nobel Prize In Medicine alfred G. gilman, a nobel Prize Laureate in Physiology and Medicine,at the nobel Prize Internet Archive. alfred G. gilman. 1994 http://almaz.com/nobel/medicine/1994a.html

A LFRED G G ILMAN 1994 Nobel Laureate in Medicine for discovery of G-proteins and the role of these proteins in signal transduction in cells. Background Born: 1941 Residence: U.S.A Affiliation: University of Texas Southwestern Medical Center, Dallas, TX Featured Internet Links Prize co-recipient Martin Rodbell Search WWW Search The Nobel Prize Internet Archive Nobel News Links Two from US share Nobel Prize in Medicine 'G Proteins' seen key to cell links Links added by Nobel Internet Archive visitors Something about cell regulation by Alfred Gilman (submitted by Bill King) UT Southwestern - Impact of Nobel Prizes Winner of The Gairdner Foundation Int'l Award Genbrain Biosystem Network (submitted by Bangzhe J. Zeng Back to The Nobel Prize Internet Archive Literature Peace ... Medicine We always welcome your feedback and comments

2. Index Of Nobel Laureates In Medicine ALPHABETICAL LISTING OF nobel PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE.Name, Year Awarded. Gasser, Herbert Spencer, 1944. gilman, alfred G. 1994. http://almaz.com/nobel/medicine/alpha.html

ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Medicine We always welcome your feedback and comments

3. Alfred G. Gilman - Autobiography alfred G. gilman – Autobiography. I too was born in 1941 (in New Haven, Connecticut)and named alfred Goodman gilman. Not bad, gilman, he said, it still http://www.nobel.se/medicine/laureates/1994/gilman-autobio.html

My father, Alfred Gilman, could play almost any musical instrument and frequently did so at neighborhood parties; his father owned a music store in Bridgeport, Connecticut. My mother, Mabel Schmidt Gilman, was an excellent pianist and gave lessons; her father was a professional trombonist, also in Bridgeport. Despite this heritage, my musical career ended after a few years of mediocre performance with the Yale University Concert Band during my days in college. There were more substantial influences. My father had turned to science, receiving his Ph.D. in Physiological Chemistry from Yale in 1931 for "Chemical and Physiological Investigations on Canine Gastric Secretion". He then joined the faculty of the Department of Pharmacology at the Yale Medical School, where he and Louis S. Goodman, a young M.D., became colleagues and close friends. A major new textbook of Pharmacology The Pharmacological Basis of Therapeutics , was the fruit of the Goodman and Gilman collaboration, first published in 1941. I too was born in 1941 (in New Haven, Connecticut) and named Alfred Goodman Gilman. Perhaps my fate was sealed from that day; as my friend Michael Brown once said, I am probably the only person who was ever named after a textboook.

4. Medicine 1994 nobel Prize in Physiology or Medicine 1994. for their discovery of Gproteins andthe role of these proteins in signal transduction in cells . alfred G. gilman, http://www.nobel.se/medicine/laureates/1994/

The Nobel Prize in Physiology or Medicine 1994 "for their discovery of G-proteins and the role of these proteins in signal transduction in cells" Alfred G. Gilman Martin Rodbell 1/2 of the prize 1/2 of the prize USA USA University of Texas Southwestern Medical Center Dallas, TX, USA National Institute of Environmental Health Sciences Research Triangle Park, NC, USA b. 1941 b. 1925 d. 1998 The Nobel Prize in Physiology or Medicine 1994 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1994 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Last modified June 16, 2000 The Official Web Site of The Nobel Foundation

5. UT Southwestern Nobel Laureates: Dr. Alfred Gilman alfred G. gilman, MD, Ph.D Professor and Chairman, UT Southwestern Dept. Dr. gilmanreceived the 1994 nobel Prize in Physiology or Medicine for the http://www3.utsouthwestern.edu/library/speccol/archives/nobel/gilman.htm

Alfred G. Gilman, M.D., Ph.D Professor and Chairman, UT Southwestern Dept. of Pharmacology, Regental Professor, Holder of the Raymond and Ellen Willie Jr. Distinquished Chair in Molecular Neuropharmacology Dr. Gilman received the 1994 Nobel Prize in Physiology or Medicine for the discovery of G-proteins and the role of these proteins in signal transduction in cells. "Gilman's research, for which he was awarded the 1994 Nobel Prize in physiology or medicine, showed that an activated G protein enlists other proteins, called effector proteins, to stimulate cellular activities, such as the production of adenosine-3',5' -cyclic phosphate (cyclic AMP), a second messenger in cellular communication..." Morgan Lyons, "Cell Talk," Southwestern Medicine 1994 pgs. 19-21. (sidebar) "The Path to the Nobel Prize" (from Southwestern Medicine PDF version "Cell Talk" (from Southwestern Medicine) Community of Science Profile and List of Recent Publications Nobel Prize Press Release Illustrated Explanation of G-proteins discoveries from the Nobel poster Autobiography (from the Nobel site) Brief Biography (from UIC site) Research Interests Maintained by: Archives Updated: 4/24/2002 Nobel Home Archives Home Special Collections Library Home

6. Southwestern Medicine: The Path To The Nobel Prize: Alfred Gilman Dr. alfred G. gilman, chairman of Chair in Molecular Neuropharmacology, in Honorof Harold B. Crasilneck, Ph.D., has been following that Gprotein pathway http://www3.utsouthwestern.edu/library/speccol/archives/nobel/pathToNobel.htm

The human body is crisscrossed with pathways: neural pathways, biochemical pathways, pathways like the ones paved by G proteins through a cell's membrane to its interior. By Jennifer Donovan D r. Alfred G. Gilman , chairman of pharmacology at UT Southwestern and holder of the Raymond Willie Jr. Distinguished Chair in Molecular Neuropharmacology, in Honor of Harold B. Crasilneck, Ph.D., has been following that G-protein pathway for three decades, ever since he was an M.D./Ph.D. student. It turned out to be the path to the 1994 Nobel Prize in physiology or medicine, which was announced Oct. 10. Science got its hooks into Al Gilman early. Born in 1941 in New Haven, Conn., home of Yale University, where his father-also an Alfred Gilman- was teaching pharmacology, young Gilman cut his teeth on the thrill of scientific research. “My father never pushed me to go into science,” he said. 'He never encouraged me, and he never discouraged me. He just allowed me to see that he was having a very good time." The elder Gilman left Yale for the Army in 1943, and after World War 11 ended, the family moved to New York. Before he hit his teens, the boy who was to become a Nobel laureate was sitting in with the medical students at Columbia University College of Physicians and Surgeons, watching his father conduct demonstrations of heart, lung and kidney function.

7. Gilman, Alfred G. gilman, alfred G.,. in full alfred GOODMAN gilman (b. July 1, 1941, New Haven,Conn., US), American pharmacologist who shared the 1994 nobel Prize for http://www.britannica.com/nobel/micro/711_33.html

Gilman, Alfred G., in full ALFRED GOODMAN GILMAN (b. July 1, 1941, New Haven, Conn., U.S.), American pharmacologist who shared the 1994 Nobel Prize for Physiology or Medicine with American biochemist Martin Rodbell for their separate research in discovering molecules called G proteins, which are intermediaries in the multistep pathway cells use to react to an incoming signal, such as a hormone or neurotransmitter. Gilman attended Yale University (B.S., 1962) and Case Western Reserve University (M.D. and Ph.D., 1969), where he studied under Nobel Prize recipient Earl W. Sutherland, Jr. Gilman worked at the National Institutes of Health (1969-71) and taught at the University of Virginia (1971-81) before becoming the director of the pharmacology department at the University of Texas Southwestern Medical Center in Dallas in 1981. In the 1960s Rodbell demonstrated that a cell's response to a chemical signal involves not only a receptor for the signal at the cell's surface and an amplifier that functions within the cell, as was already known, but also an intermediary molecule that transduces, or relays, the message from receptor to amplifier. Gilman, working in the 1970s with mutant cells that were unable to send signals properly, identified the intermediary signaling molecule as a G protein, so named because it becomes activated when bound to a molecule called guanosine triphosphate (GTP). Abnormally functioning G proteins can disrupt the normal signal transduction process and play a role in diseases such as cholera, cancer, and diabetes.

8. Nobel Prize Winners G-I gilman, alfred G. 1994, physiology/medicine, US, discovery of cell signalerscalled Gproteins, Gjellerup, Karl Adolph, 1917, literature, Denmark, novelist. http://www.britannica.com/nobel/win_g-i.html

Article Year Category Country* Achievement Literary Area Gabor, Dennis physics U.K. invention of holography Gajdusek, D. Carleton physiology/medicine U.S. studies of origin and spread of infectious diseases Galsworthy, John literature U.K. novelist literature Colombia novelist, journalist, social critic peace Mexico Gasser, Herbert Spencer physiology/medicine U.S. researches on differentiated functions of nerve fibres Gell-Mann, Murray physics U.S. classification of elementary particles and their interactions Gennes, Pierre-Gilles de physics France discovery of general rules for behaviour of molecules Giaever, Ivar physics U.S. tunneling in semiconductors and superconductors Giauque, William Francis chemistry U.S. behaviour of substances at extremely low temperatures literature France novelist, essayist Gilbert, Walter chemistry U.S. development of chemical and biological analyses of DNA structure Gilman, Alfred G. physiology/medicine U.S. discovery of cell signalers called G-proteins Gjellerup, Karl Adolph literature Denmark novelist Glaser, Donald A.

9. Alfred G. Gilman alfred G. gilman Professor and Head nobel Laureate Department of PharmacologyUniversity of Texas Southwestern Medical Center Dallas, TX. http://www.uic.edu/depts/mcph/seminar gilman.html

Alfred G. Gilman Professor and Head Nobel Laureate Department of Pharmacology University of Texas Southwestern Medical Center Dallas, TX Dr. Alfred G. Gilman was born in New Haven, Connecticut in 1941. He received his B.S. (summa cum laude) in Biochemistry in 1962 from Yale University, and his M.D. and Ph.D. in Pharmacology in 1969 from Case Western Reserve University. Dr. Gilman received further training as a Pharmacology Research Associate in the Laboratory of Biochemical Genetics at the National Institutes of Health (1969-71). In 1971 Dr. Gilman began a ten-year stay at the University of Virginia in Charlottesville. His positions included Assistant Professor of Pharmacology (1971-73), Associate Professor of Pharmacology (1973-77), Professor of Pharmacology (1977-81), and Director of the Medical Scientist Training Program (1978-81). Dr. Gilman became Chairman of the Department of Pharmacology at the University of Texas Southwestern Medical Center at Dallas in 1981. He still chairs this department and was named a Regental Professor in 1995. He also holds the Raymond and Ellen Willie Distinguished Chair of Molecular Neuropharmacology.

10. Nobel Prize Recipient At NIEHS Health Sciences (NIEHS) and Dr. alfred G. gilman of University of Texas SouthwesternMedical Center at Dallas were awarded the 1994 nobel Prize in physiology http://www.niehs.nih.gov/external/nobel.htm

National Institute of Environmental Health Sciences Dr. Martin Rodbell of NIEHS - Nobel Prize Winner Nobel Prize-winner Martin Rodbell, 73, who discovered a key secret of the communications system that regulates the human body’s cellular activities, died December 7th, 1998 at University of North Carolina Hospitals in Chapel Hill, where he was being treated for cardiovascular problems. A Memorial Service and Symposium for Dr. Rodbell was held on February 12, 1999 . A booklet containing quotes listed in the "In Memory of Martin Rodbell" section below was distributed at the service. Please click on one of the links below: In Memory of Dr. Martin Rodbell Obituary Autobiography The Nobel Prize in Physiology or Medicine 1994 Press Release NIH News: Dr. Martin Rodbell of the National Institute of Environmental Health Sciences (NIEHS) and Dr. Alfred G. Gilman of University of Texas Southwestern Medical Center at Dallas were awarded the 1994 Nobel Prize in physiology and medicine. Dr. Rodbell is a scientist emeritus in the Laboratory of Cellular and Molecular Pharmacology at NIEHS and Dr. Alfred G. Gilman, an NIH grantee, is professor and chairman in the department of pharmacology at University of Texas Southwestern Medical Center. Their work focuses on G proteins, a key component of the communication system that regulates cellular activity. Click picture for full size Dr. Martin Rodbell

11. NOBEL LAUREATE MARTIN RODBELL DIES - Press Release For his pioneering work he shared the 1994 nobel Prize for Medicine and PhysiologyProfessor alfred G. gilman of the University of Texas Southwestern Medical http://www.niehs.nih.gov/oc/news/rodbel.htm

FOR IMMEDIATE RELEASE NIEHS Press Contacts: Dec 8, 1998 Bill Grigg, (301) 402-3378 NIEHS PR #24-98 Tom Hawkins (919) 541-1402 NOBEL LAUREATE MARTIN RODBELL DIES Nobel Prize-winner Martin Rodbell , 73, who discovered a key secret of the communications system that regulates the human body’s cellular activities, died yesterday morning (Dec. 7) at University of North Carolina Hospitals in Chapel Hill, where he was being treated for cardiovascular problems. Dr. Rodbell in 1970 discovered that signal transmission, or transduction, which is the way the body’s cells get their directions, requires a small intracellular molecule called GTP. His finding has had many implications for human diseases, from cancer to cholera, and their cure. For his pioneering work he shared the 1994 Nobel Prize for Medicine and Physiology Professor Alfred G. Gilman of the University of Texas Southwestern Medical Center , who identified the proteins to which GTP binds and called these the G proteins. Despite heart surgery a decade ago, Dr. Rodbell had continued to work on the signal transmission from and to cells, completing 42 years at NIEHS and other components of National Institutes of Health He had started at what was then the National Heart Institute, made his key discovery at the National Institute of Arthritis and Metabolic Diseases, and then left the Bethesda campus of NIH to continue to work on transduction as scientific director of NIEHS from 1985 to 1989 and thereafter as scientist emeritus.

12. 1999 Commencement Honorary Degree Recipient Alfred Gilman nobel laureate alfred G. gilman is receiving the honorary degree of Doctor of Sciencefor his research involving Gproteins and the role of these proteins in http://gehon.ir.miami.edu/commencements/hongilman.html

Alfred G. Gilman Honorary Doctor of Science N obel laureate Alfred G. Gilman is receiving the honorary degree of Doctor of Science for his research involving G-proteins and the role of these proteins in signal transduction in cells. His discovery, which revealed that an activated G-protein enlists other proteins, namely effector proteins, to stimulate cellular activities, garnered him the 1994 Nobel Prize in physiology or medicine. Born in New Haven, Connecticut, Gilman was fascinated with science from an early age. After receiving his first chemistry set, Gilman quickly found that the chemicals included in the set were not as active as those found in the local apothecary shop. A few days later, he and a friend secretly bought some of the more reactionary chemicals and began conducting experiments in the Gilmans' attic. Besides his natural inclination for the sciences, Gilman also came from a scientific family; his father was a professor of pharmacology at Yale University. In 1943, Gilman's father left teaching to enlist in the U.S. Army. Once World War II ended, the family moved to New York. By the time he was a teenager, Gilman had already begun sitting in with medical students at Columbia University College of Physicians and Surgeons to watch his father conduct demonstrations of heart, lung, and kidney functions. The experience would leave a lasting impression.

13. Professor Alfred Gilman guanine nucleotidebinding regulatory proteins termed G proteins. 1990); Louis S.Goodman and alfred gilman Award in of Medicine, 1990); and The nobel Prize in http://www.general.uwa.edu.au/u/raine/rvp/agilman.htm

14. Jewish Nobel Prize Laureates - Biomedical Sciences Year, nobel Laureate, Country of birth. 1994, gilman, alfred G. for their discoveryof Gproteins and the role of these proteins in signal transduction in cells http://www.science.co.il/Nobel-Biomedical.asp

Israel Science and Technology Homepage HOME Search About Contact Nobel Prize Subject Biomedical Chemistry Economics Physics ... Literature Sort options Country Name Year Order A - Z Z - A Show citation Yes No Jewish Laureates of Nobel Prize in Biomedical Sciences Year Nobel Laureate Country of birth Brenner, Sydney "for their discoveries concerning genetic regulation of organ development and programmed cell death" South Africa Horvitz, H. Robert "for their discoveries concerning genetic regulation of organ development and programmed cell death" USA Greengard, Paul "signal transduction in the nervous system" USA Kandel, Eric R. "signal transduction in the nervous system" Austria Furchgott, Robert F. "for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system" USA Prusiner, Stanley B. "for his discovery of Prions - a new biological principle of infection" USA Gilman, Alfred G. "for their discovery of G-proteins and the role of these proteins in signal transduction in cells" USA Rodbell, Martin "for their discovery of G-proteins and the role of these proteins in signal transduction in cells" USA Varmus, Harold E.

15. Nobel Prizes Relating To The Products Used In The Results Project™ Blobel's Laboratory at Rockefeller University Recent publications nobel Prize Winnersin Medicine for 1994 alfred G. gilman and MARTIN RODBELL alfred G. gilman http://www.resultsproject.net/nobel_prizes.html

Nobel Prize Winner in Medicine for 1999 DR. GÜNTER BLOBEL Official award announcement and background An interview with Dr. Blobel after he won the award. Blobel's Laboratory at Rockefeller University Recent publications Nobel Prize Winners in Medicine for 1994 ALFRED G. GILMAN and MARTIN RODBELL Two from US share Nobel Prize in Medicine - 'G Proteins' seen as key to cell links

16. Themes Geography History History Prize Winners Nobel Themes Geography History History Prize Winners nobel Prize Medicine. Year, Winners. 1994, gilman, alfred G. Rodbell, Martin. http://www.cartage.org.lb/en/themes/GeogHist/histories/prizewinners/nobelprize/m

17. Nobel Prize - Neuroscience 1994, gilman, alfred G. 7/1/1941 to, American, Discovery of Gprotein 1925 to 12/7/1998,American, Discovery of G-protein coupled Information on the 2000 nobel Prize http://faculty.washington.edu/chudler/nobel.html

Nobel Prize - Neuroscience Year of Award Name(s) Birth and Death Dates Nationality/Citizenship Field of Study Golgi, Camillo 7/7/1843 to 1/21/1926 Italian Structure of the Nervous System Ramon y Cajal, Santiago 5/1/1852 to 10/18/1934 Spanish Structure of the Nervous System Gullstrand, Allvar 6/5/1862 to 7/28/1930 Swedish Optics of the Eye Barany, Robert 5/22/1876 to 4/8/1936 Austrian Physiology and pathology of the vestibular apparatus Wagner-Jauregg, Julius 3/7/1857 to 9/27/1940 Austrian Discovery of Malaria inoculation to treat dementia paralytica Adrian, Edgar Douglas 11/30/1889 to 8/4/1977 British Function of neurons in sending messages Sherrington, Charles Scott, Sir 11/27/1857 to 3/4/1952 British Function of neurons in the brain and spinal cord Dale, Henry Hallett, Sir 6/9/1875 to 7/23/1968 British Chemical transmission of nerve impulses Loewi, Otto 6/3/1875 to 12/25/1961 German, American Citizen Chemical transmission of nerve impulses Erlanger, Joseph 1/5/1874 to 12/15/1965 American Differentiated functions of single nerve fibers Gasser, Herbert Spencer

18. ISIHighlyCited.com - Author Record [v.1] gilman, alfred G. Home Biography URL http//swnt240.swmed.edu/gradschool/webrib/gilman.htm.Personal Information, 1994, nobel Prize in Physiology or Medicine, http://isihighlycited.com/author.cgi?id=180

19. News Current News News Releases By Date News Releases By Topic alfred G. gilman, UT Southwestern Medical Center at Dallas, nobel Prizein Physiology or Medicine, 1994. The nobel Prize was awarded http://www.utsystem.edu/News/Nobels.htm

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20. QB3: California Institute For Quantitative Biomedical Research alfred gilman shared the nobel Prized in Physiology or Medicine in 1994 for hisdiscovery of Gproteins and their role in signal transduction in cells. http://www.qb3.org/aeacomm.htm

Your browser does not support script External Advisory Committee Stephen P.A. Fodor, Ph.D. Stephen P.A. Fodor founded Affymetrix in 1993, served as the President and CEO from 1995-1999 and is currently the Chairman and CEO. Dr. Fodor previously held various positions at the Affymax Research Institute from 1989 to 1992, where he led the development of the GeneChip® DNA microarray technology. In 2001, Dr. Fodor founded Perlegen, Inc., a new venture that uses DNA chip technology to uncover the basic patterns of human diversity. The adoption of the technology by both commercial and research institutions for these and other applications continues to grow rapidly. Development of high-density DNA microarrays using photolithographic fabrication, and the promotion of the technology by commercialization of the GeneChip® array. Dr. Fodor serves on the Board of Directors for EOS Biotechnology and Sunesis Pharmaceuticals, Inc., in addition to being the Chairman of the Board for Perlegen, Inc. He also serves on the Board of Trustees of the Carnegie Institute of Washington.

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