61. Bioquimica.Online.pt Translate this page em Estocolmo, decidiu no passado dia 8 de Outubro atribuir o Prémio nobel em Fisiologiaou Medicina de 2001 em conjunto a leland H. hartwell, R. Timothy Hunt http://www.bioquimica.online.pt/artigos/nobel2001.htm

Voltar à Página Principal Interactividade Fórum Entre em contacto com outros bioquímicos, discuta, pergunte! Livro de Visitas Diga-nos o que achou deste site. Mailing List Para saber das últimas actualizações do site e novidades da bioquímica portuguesa, basta introduzir o seu e-mail: Subscrever Remover Contacte-nos Não se iniba! Critique, dê ideias e sugestões, pergunte! Secções Agenda Bolsa de Emprego Arquivo de páginas do mês Arquivo de entrevistas ... Reportagens Informações Quem somos Bookmark este site Torne este portal a sua Homepage (Internet Explorer) Recomende este site a um amigo Press Release: Prémio Nobel em Fisiologia ou Medicina 2001 Tradução e adaptação por Gonçalo Castelo-Branco, Licenciado em Bioquímica, aluno de Doutoramento no Instituto Karolinska - Estocolmo, Suécia e colaborador Bioquimica.Online.pt (versão original em inglês disponível em www.nobel.se O Comité Nobel, sediado no Instituto Karolinska em Estocolmo, decidiu no passado dia 8 de Outubro atribuir o Prémio Nobel em Fisiologia ou Medicina de 2001 em conjunto a Leland H. Hartwell, R. Timothy Hunt e Paul M. Nurse, pelas suas descobertas em reguladores chave do ciclo celular. O Bioquimica.Online.pt reproduz nesta secção o press release divulgado por este Comité. No início do mês de Dezembro contamos igualmente fazer uma reportagem sobre a conferência Nobel que os laureados irão dar em Estocolmo, no Instituto Karolinska.

62. Company Congratulates Sydney Brenner And H. Robert Horvitz Distinguished Achievement Award winners who have also received the nobel Prize in RobertE. Furchgott, Ph.D.; Paul Greengard, Ph.D.; leland H. hartwell, Ph.D http://www.bms.com/news/features/data/fg_features_3184.html

Newsroom Home Press Releases Other News Features ... Press Archives Company Congratulates Sydney Brenner and H. Robert Horvitz Two Former Bristol-Myers Squibb Distinguished Achievement Award Winners Selected To Receive Nobels In Medicine On December 10 in Stockholm, two previous recipients of Bristol-Myers Squibb Distinguished Achievement Awards Sydney Brenner, D.Phil., and H. Robert Horvitz, Ph.D., will receive this year’s Nobel Prize in Medicine. In a letter to the two Nobel laureates, Peter Dolan, chairman and CEO of Bristol-Myers Squibb, said, "Congratulations on being selected a recipient of the Nobel Prize in Medicine. On behalf of the scientists and employees of Bristol-Myers Squibb Company, I salute you and the landmark discoveries you made that led to this great honor." Dr. Brenner was the 1992 recipient of the Bristol-Myers Squibb Distinguished Achievement Award in Neuroscience Research, and Dr. Horvitz was the 2001 recipient of the same award. Dr. Brenner, currently of The Salk Institute in La Jolla, Calif., and Dr. Horvitz, of the Massachusetts Institute of Technology, will share the Nobel Prize in Medicine with John E. Sulston, Ph.D., of the Sanger Centre, Cambridge, England. According the Nobel committee, the three are being recognized "for their discoveries concerning genetic regulation of organ development and programmed cell death." Sydney Brenner, D.Phil.

63. American And British Scientists Win Nobel Prize For Cell Discoveries won the nobel Prize for medicine Monday for discoveries about cell division thatcould open the way to new cancer treatments. leland H. hartwell, 61, director http://www.lef.org/newsarchive/disease/2001/10/08/eng-canadianp_health/eng-canad

News Home News Archive American and British Scientists Win Nobel Prize for Cell Discoveries Canadian Press October 08, 2001 STOCKHOLM (AP) - An American scientist and two British researchers won the Nobel Prize for medicine Monday for discoveries about cell division that could open the way to new cancer treatments. Leland H. Hartwell, 61, director of the Fred Hutchinson Cancer Research Center in Seattle; R. Timothy Hunt, 58, of the Imperial Cancer Research Fund in Hertfordshire, England; and Paul M. Nurse, 52, of the Imperial Cancer Research Fund in London will share the prize, worth about $1.5 million Cdn. The scientists were honoured for their study of the cell cycle, the process by which a cell grows and divides. Along the way, the cell must duplicate its chromosomes and distribute them equally to the two new cells. Cell division happens several billion times every day in the adult human body, and most of the time it goes fine. But when something goes wrong, it can lead to cancer, which is characterized by runaway cell division. The Nobel winners all discovered genes and proteins that regulate the cell cycle.

64. Caltech Nobel Site AHMED H. ZEWAIL (b.1946) Ahmed H. Zewail won the 1999 nobel Prize in Chemistry lelandhartwell (b.1939) leland hartwell was awarded the 2001 nobel Prize in http://pr.caltech.edu/events/caltech_nobel/home2.html

Caltech Nobel Recipients [ List 1 List 2 DAVID BALTIMORE RENATO DULBECCO ... LELAND HARTWELL DAVID BALTIMORE (b. 1938) RENATO DULBECCO (b. 1914) Howard Temin shared the 1975 Nobel Prize in Physiology or Medicine with Renato Dulbecco and David Baltimore for their joint discovery of the enzyme reverse transcriptase. Identification of this enzyme helped explain how certain viruses transform the cells they infect into cancer cells. WILLIAM NUNN LIPSCOMB, JR. (b. 1919) ROBERT WOODROW WILSON (b. 1936) Roger Sperry was a corecipient (with David Hubel and Torsten Wiesel) of the 1981 Nobel Prize in Physiology or Medicine for their research on the workings of the brain. Sperry was particularly recognized for discovering that each brain hemisphere controls different kinds of functions. KENNETH GEDDES WILSON (b. 1936 Kenneth Wilson was awarded the 1982 Nobel Prize in Physics for his work to construct improved theories about the transformations of matter called continuous, or second-order, phase transitions. His research led to a very general and effective mathematical strategy for understanding how complex microscopic behavior underlies gross macroscopic effects. Willy Fowler shared (with S. Chandrasekhar) the 1983 Nobel Prize in Physics for his work on nucleosynthesis, the process whereby the nuclei of lighter chemical elements fuse to create heavier ones. In groundbreaking work in the late 1950s, he and his colleagues demonstrated that, starting only with the hydrogen and helium produced in the Big Bang, all the elements from carbon to uranium could be produced by the nuclear processes in stars.

65. Emerge - College Staff An American and two Britons won the 2001 nobel Prize in Physiology or The winners,who will share the $943,000 award, were leland H. hartwell, 61, director http://emerge.spunstudio.com/staff/article_fact1.cfm

66. GIẢI NOBEL Y HỌC 2001 Gi?i nobel y h?c và sinh lý h?c nam 2001 du?c trao cho ba nhà khoah?c, m?t ngu?i M? và hai leland H. hartwell (61 tu?i http://www.ykhoa.net/tapchiyhoc/B0112IN/24NOBEL2TR356_7.htm

Leland H. Hartwell R. Timothy Hunt Paul M. Nurse Leland Hartwell Paul Nurse Timothy Hunt

67. Red Escolar / Actividades Permanentes / Conciencia / Premio Nobel 2001 / Fisiolo Translate this page La Asamblea del nobel del Karolinska Institutet decidió premiar este año con elnobel por Medicina o Fisiología a leland H. hartwell, R. Timothy (Tim) Hunt http://redescolar.ilce.edu.mx/redescolar/act_permanentes/conciencia/nobel2001/me

68. Cáncer: Novedades Translate this page Press, Estocolmo).- El científico estadounidense leland H. hartwell, y los británicosR. Timothy Hunt y Paul M. Nurse, ganaron el Premio nobel de Medicina http://www.healthig.com/cancer/cancer57.html

Un norteamericano y dos británicos Nobel de Medicina 2001 a investigadores del cáncer (Fuente: Associated Press, Estocolmo).- El científico estadounidense Leland H. Hartwell, y los británicos R. Timothy Hunt y Paul M. Nurse, ganaron el Premio Nobel de Medicina del año 2001 por sus descubrimientos sobre "reguladores claves del ciclo celular", que podrían contribuir a la lucha contra el cáncer. Estos hallazgos están a punto de ser "aplicados al diagnóstico de tumores" y podrían, "a largo plazo, abrir nuevos caminos para la terapia oncológica", dijo el Instituto Karolinska, encargado de otorgar el galardón. Los ganadores compartirán el premio, dotado con 943.000 dólares. Los científicos fueron distinguidos por su descubrimiento de reguladores claves del ciclo celular, el proceso por el cual se dividen las células. Según éste, las células deben crecer, duplicar sus cromosomas y dividirlos luego de forma precisa en las nuevas células que surgen de la división. Los defectos en el control de ese proceso abren el camino al cáncer. Detalles Los organismos se componen de células que se multiplican por división celular. Un humano adulto tiene aproximadamente 100 000 billones de células, todas ellas originadas de una sola célula, el óvulo. En los adultos hay también un número enorme de células continuamente dividiendo, reemplazando las células muertas. Antes de que una célula se pueda dividir tiene que aumentar su tamaño, ha de duplicar sus cromosomas y separarlos para la distribución exacta entre las células hijas.

69. Themes Geography History History Prize Winners Nobel Themes Geography History History Prize Winners nobel Prize Medicine.Year, Winners. 2001, hartwell, leland H. Hunt, R. Timothy - Nurse, Paul M. -. http://www.cartage.org.lb/en/themes/GeogHist/histories/prizewinners/nobelprize/m

70. La Division Celular Translate this page El médico estadounidense leland H. hartwell y los británicos Timothy Hunt y PaulM. Nurse han sido galardonados con el Premio nobel de Medicina 2001 por sus http://ar.geocities.com/moni2201/division_celular_nobel.htm

CIENCIA Nobel.- Los doctores Leland Hartwell, Paul Nurse y Timothy Hunt, galardonados con el Nobel de Medicina 2001 “Nosotros descubrimos genes que controlan la división celular y los mismos genes fueron encontrados en las células humanas, es por lo tanto la unidad, la relación en la evolución de todo eso que está vivo, es esa la gran noticia que es alentadora", agregó el profesor Hartwell. "Cuando comencé, hace 30 años, me interesé en el , en la ", explicó el científico. Hartwell,es presidente y director del Fred Hutchinson Cancer Research Center,( http://www.fhcrc.org/award/news_release.html ) y profesor de genetica y medicina en la Universidad de Washington. Hartwell, conduce una investigacion que llevo al descubrimiento del mecanismo universal que controla la division celular en las celulas eucariotas,desde la levadura,las ranas y los humanos.Usando levaduras como modelo de organismo,controlo las herramientas geneticas para estudiar las funciones celulares y determinar los genes que promueven la division celular( http://www.arrakis.es/~lluengo/mitosis.html

71. Announcement Of The 2001 Nobel Prizes: Fine Library, Princeton University Medicine and Physiology jointly to leland H. hartwell (Fred of the cell cycle lelandhartwell (born 1939 hartwell also introduced the concept checkpoint , a http://www.princeton.edu/~finelib/nobel01.html

Announcement of the 2001 Nobel Prizes and the Sveriges Riksbank (Bank of Sweden) Prize in Economic Sciences in Memory of Alfred Nobel Announcements week of October 8-12 Medicine and Physiology : jointly to Leland H. Hartwell (Fred Hutchinson Cancer Research Center, Seattle, USA), R. Timothy (Tim) Hunt (Imperial Cancer Research Fund, London, UK)and Paul M. Nurse "key regulators of the cell cycle" Leland Hartwell (born 1939), Fred Hutchinson Cancer Research Center, Seattle, USA, is awarded for his discoveries of a specific class of genes that control the cell cycle. One of these genes called "start" was found to have a central role in controlling the first step of each cell cycle. Hartwell also introduced the concept "checkpoint", a valuable aid to understanding the cell cycle. Paul Nurse (born 1949), Imperial Cancer Research Fund, London, identified, cloned and characterized with genetic and molecular methods, one of the key regulators of the cell cycle, CDK (cyclin dependent kinase). He showed that the function of CDK was highly conserved during evolution. CDK drives the cell through the cell cycle by chemical modification (phosphorylation) of other proteins. Timothy Hunt (born 1943), Imperial Cancer Research Fund, London, is awarded for his discovery of cyclins, proteins that regulate the CDK function. He showed that cyclins are degraded periodically at each cell division, a mechanism proved to be of general importance for cell cycle control.

72. La Repubblica/cultura_scienze Nobel Per La Medicina Alla Ricerca Translate this page La scelta del Karolinska Institutet, l'istituzione svedese che assegna i premi Nobelper la Medicina, quest'anno è caduta leland H. hartwell, del Fred http://www.repubblica.it/online/cultura_scienze/nobel2001/medicina/medicina.html

73. CNRS-SDV/Dossier : Prix Nobel 2001 Translate this page En résumé, le comité nobel reconnaît, cette année, que la découverte du MarcelDorée Références 1. hartwell, leland H. et al., 1974, Science, 183, 46 http://www.cnrs.fr/SDV/nobel2001.html

Département des sciences de la vie Espace Sciences Prix Nobel 2001 de physiologie et médecine : le cycle cellulaire couronné checkpoint ) qui empêchent la cellule d'avancer au stade suivant du cycle si un défaut est constaté : ces mécanismes de checkpoint introduisent ainsi des délais que la cellule utilise pour réparer les défauts avant que le cycle ne progresse à un stade où ils seraient irréversibles. Le prix Nobel 2001 de Physiologie et Médecine a été décerné à Leland Hartwell, Tim Hunt et Paul Nurse pour leurs découvertes séminales, réalisées dans les années 70 et 80, sur le mécanisme de contrôle du cycle cellulaire. Comme il est indiqué dans le communiqué du comité Nobel : "Leland Hartwell est récompensé pour la découverte d'une catégorie de gènes qui commandent le cycle cellulaire, et pour avoir introduit la notion de checkpoint , conduisant à une approche novatrice du cycle cellulaire. Tim Hunt est récompensé pour la découverte des cyclines et la mise en évidence de leur dégradation lors de la division des cellules, mécanisme qui s'est avéré essentiel pour la régulation du cycle cellulaire. Enfin, Paul Nurse est crédité pour avoir identifié par des méthodes de génétique et de biologie moléculaire les CDK, et montré que leur fonction dans le contrôle du cycle cellulaire est conservée tout au long de l'évolution."

74. PREMIOS NOBEL RELACIONADOS CON LA GENÉTICA Translate this page polimerasa. 1993, Michael Smith. nobel de Química Por de infección. 2001,leland H. hartwell R. Timothy Hunt Paul M. Nurse. Por sus http://www.ucm.es/info/genetica/AVG/nobel/nobel.htm

Alfred Nobel La mayoría de los Premios Nobel que figuran en la siguiente lista son de Fisiología y Medicina, salvo algunos de Química y de la Paz que se indican de forma expresa en la tabla. Albrecht Kossel Por sus trabajos sobre las sustancias albuminoides, incluyendo las nucleínas, que han contribuido al conocimiento de la química de las células. Karl Landsteiner Por sus descubrimientos de los grupos sanguíneos de la especie humana. Thomas H. Morgan Por su descubrimiento sobre la función de los cromosomas como portadores de la herencia. Hermann J. Muller Por su descubrimiento de la inducción de mutaciones mediante radiación con rayos X. Linus Carl Pauling Por sus investigaciones sobre la naturaleza de los enlaces químicos y su aplicación en la elucidación de la estructura de las sustancias complejas. También recibió el Premio Nobel de la Paz en 1962 por su lucha contra el desarrollo de las armas nucleares. George W. Beadle Edward L. Tatum Por su descubrimiento de que los genes actúan regulando sucesos químicos definidos.

75. Theses Of MIT Alumni Nobel Prize Winners: Document Services: MIT Libraries Year of nobel Prize 2001, leland H. hartwell, shared Medicine/Physiology Prize MITPhD 1964, Studies on the induction of histidase in Bacillus subtilis. http://libraries.mit.edu/docs/nobeltheses.html

Document Services Home Digital Thesis Library MIT-related Nobel Prize Winners Nobel e-Museum ... MIT home page Theses of MIT Alumni Nobel Prize Winners Fifty-five current or former members of the MIT community have won the Nobel Prize. They include 21 professors, 22 alumni, 13 researchers and one staff physician. Below are direct links to the online theses of MIT alumni who have won Nobel Prizes. A complete list of MIT-related Nobel Prize Winners has been compiled by the MIT News Office. These online page images are freely available to everyone. For PDF and paper copies, see pricing information for MIT Users and non-MIT users Year of Nobel Prize Kofi Annan , shared Peace Prize MIT SM 1972, International joint venture with a government partner case study: copper mining in Zambia. George A. Akerlof , shared Economics Prize MIT PhD 1966

76. Premio Nobel En Medicina 2001: La Maquinaria Del Ciclo Celular Translate this page El Comité nobel del Instituto Karolinska, de Estocolmo, adjudicó el Premio nobelde Medicina o Fisiología de este leland H. hartwell, Director del http://cancerteam.tripod.com/poli052.html

Premio Nobel en Medicina 2001: La maquinaria del ciclo celular ciclinas . Estos reguladores (llamados quinasas dependientes de ciclinas Dr. Pedro M. Politi Buenos Aires, octubre de 2001 Material: Three share Nobel for their molecular studies. www.newyorktimes.org , octubre 9, 2001. Equipo Interdisciplinario de Oncologia wins Nobel Prize. www.cnn.com , octubre 8, 2001. Pub Med, base de datos de la Biblioteca Nacional de Medicina, EEUU. www.nlm.nih.gov/entrez/query.fcgi

77. HUM-MOLGEN: Leland H. Hartwell, R. Timothy Hunt And Paul M. Nurse Receive The No leland H. hartwell, R. Timothy Hunt and Paul M. Nurse receive the NobelPrize in Medicine, October, 8 2001 1356, Press release http http://www.hum-molgen.de/NewsGen/10-2001/msg13.html

home genetic news bioinformatics biotechnology ... register for news alert Leland H. Hartwell, R. Timothy Hunt and Paul M. Nurse receive the Nobel Prize in Medicine October, 8 2001 13:56 Press release: http://www.nobel.se/medicine/laureates/2001/press.html Summary All organisms consist of cells that multiply through cell division. An adult human being has approximately 100 000 billion cells, all originating from a single cell, the fertilized egg cell. In adults there is also an enormous number of continuously dividing cells replacing those dying. Before a cell can divide it has to grow in size, duplicate its chromosomes and separate the chromosomes for exact distribution between the two daughter cells. These different processes are coordinated in the cell cycle. This year's Nobel Laureates in Physiology or Medicine have made seminal discoveries concerning the control of the cell cycle. They have identified key molecules that regulate the cell cycle in all eukaryotic organisms, including yeasts, plants, animals and human. These fundamental discoveries have a great impact on all aspects of cell growth. Defects in cell cycle control may lead to the type of chromosome alterations seen in cancer cells. This may in the long term open new possibilities for cancer treatment. Leland Hartwell (born 1939), Fred Hutchinson Cancer Research Center, Seattle, USA, is awarded for his discoveries of a specific class of genes that control the cell cycle. One of these genes called "start" was found to have a central role in controlling the first step of each cell cycle. Hartwell also introduced the concept "checkpoint", a valuable aid to understanding the cell cycle.

78. Nobel Prize: Lee Hartwell & Don Thomas Visitor Center nobel Prizes , Lee hartwell, Ph.D. -, E. Donnall Thomas, MD. Leehartwell, Ph.D. Lee hartwell photo. E. Donnall Thomas, MD. E. Donnall Thomas photo. http://www.fhcrc.org/award/

HOME Visitor Center Nobel Prizes Visitor Center Nobel Prizes Lee Hartwell, Ph.D. E. Donnall Thomas, M.D. Prepared By: Internet Services Last Modified: Jun 18, 2002

79. La Red De Icarito-Premio Nobel 2001: Medicina Translate this page británicos Timothy Hunt y Paul M. Nurse y el estadounidense leland H. Hartwellfueron los tres científicos que ganaron el Premio nobel de Medicina 2001 http://icarito.tercera.cl/especiales/nobel_2001/medicina.htm

Los galardonados Paul M. Nurse Timothy Hunt Leland H. Hartwell L Timothy Hunt y Paul M. Nurse y el estadounidense Leland H. Hartwell fueron Las investigaciones ciclos celulares fases del ciclo celular ciclina utilizando erizos de mar. Tomothy Hunt estudió un tipo especial de moléculas que trabaja como una máquina durante la división de las células. Además investigó ciertas proteínas que actúan como "la caja de cambios de un auto" para controlar la velocidad del desarrollo. http://www.icarito.cl e-mail: icarito@copesa.cl

80. Nobel Tip ödülü Sahiplerini Buldu 8 Ekim — nobel Tip Ödülü, bu yil, Amerikali bilim adami leland H. Hartwellile Ingiliz bilim adamlari R. Timothy Hunt ve Paul M. Nurse’e verildi. http://www.ntvmsnbc.com/news/111438.asp

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