1. Phillip A. Sharp Winner Of The 1993 Nobel Prize In Medicine phillip A. sharp, a nobel Prize Laureate in Physiology and Medicine, at the nobelPrize Internet Archive. phillip A. sharp. 1993 nobel Laureate in Medicine http://almaz.com/nobel/medicine/1993b.html

P HILLIP A S HARP 1993 Nobel Laureate in Medicine for discovery of split genes. Background Born: 1944 Residence: U.S.A. Affiliation: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA Featured Internet Links Prize co-recipient Richard J. Roberts Search WWW Search The Nobel Prize Internet Archive Nobel News Links Let Nobelists Inspire, Menino Says Two from Mass. Win Nobel for Medicine Latest Nobel Affirms MIT Leadership in Biology Sharp Jolts MIT, Rejects Top Post (1990) Links added by Nobel Internet Archive visitors Home town reaction Biogen Winner of The Gairdner Foundation Int'l Award Back to The Nobel Prize Internet Archive ... Medicine We always welcome your feedback and comments

2. Index Of Nobel Laureates In Medicine ALPHABETICAL LISTING OF nobel PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE.Name, Year Awarded. Schally, Andrew V. 1977. sharp, phillip A. 1993. http://almaz.com/nobel/medicine/alpha.html

ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Medicine We always welcome your feedback and comments

3. Phillip A. Sharp - Nobel Lecture phillip A. sharp – nobel Lecture. Split genes and RNA splicing. phillip A.sharp Autobiography nobel Lecture Interview Other Resources. 1992, 1994. http://www.nobel.se/medicine/laureates/1993/sharp-lecture.html

Split genes and RNA splicing Nobel Lecture December 8, 1993 From Nobel Lectures The Lecture in pdf-format Download Adobe Acrobat Reader is free software that lets you view and print Adobe Portable Document Format (PDF) files. The Nobel Prize in Physiology or Medicine 1993 Press Release Presentation Speech Illustrated Presentation ... Other Resources The 1993 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Last modified September 7, 2001 The Official Web Site of The Nobel Foundation

4. Phillip A. Sharp - Autobiography phillip A. sharp – Autobiography. Dr. sharp has a distinguished record of publicservice, which partially includes having served as a From Les Prix nobel 1993 http://www.nobel.se/medicine/laureates/1993/sharp-autobio.html

A sense of place was and remains an important part of my life. I was born in a rural community in the northern hill country of Kentucky. My earliest memories are those of a child playing around the house on our family farm, located in a bend of the Licking River near McKinneysburg. My mother, Kathrin Colvin Sharp, had grown up in that same house and her family had been part of this community for many generations. My father, Joseph Walter Sharp, grew up nearby within walking distance of the nearest town and county-seat, Falmouth. Both parents came from large families and I was surrounded by grandparents, aunts, uncles, siblings and cousins. My formal education was entirely in the public schools of Pendleton County: McKinneysburg Elementary, Butler Elementary and High School and Pendleton County High School. Even though my studies never interfered with sports or fun, I managed to gain an appreciation of math and science. The 1966 volume of the Cold Spring Harbor Symposium on The Genetic Code stimulated my interest in molecular biology and genetics. A subsequent letter to Norman Davidson at the

5. Sharp, Phillip A. in full phillip ALLEN sharp (b. June 6, 1944, Falmouth, Ky., US), American molecularbiologist, awarded the 1993 nobel Prize for Physiology or Medicine, along http://www.britannica.com/nobel/micro/541_28.html

Sharp, Phillip A., Phillip A. Sharp, 1993 in full PHILLIP ALLEN SHARP (b. June 6, 1944, Falmouth, Ky., U.S.), American molecular biologist, awarded the 1993 Nobel Prize for Physiology or Medicine , along with Richard J. Roberts , for his independent discovery that individual genes are often interrupted by long sections of DNA that do not encode protein structure. Sharp received a doctorate in chemistry from the University of Illinois at Urbana-Champaign in 1969. In that year he began working at the California Institute of Technology, moving to the Cold Spring Harbor Laboratory in New York in 1971. In 1974 he went to the Massachusetts Institute of Technology, where he did his prize-winning research. In 1977 Sharp helped found Biogen Ltd., a biotechnology company. In 1977 Sharp and his team discovered that the messenger RNA (mRNA) of an adenovirus corresponded to four separate, discontinuous segments of DNA. They found that the segments of DNA that coded for proteins, now called exons, were separated by long stretches of DNA, now called introns, that did not contain genetic information. At the same time, a team working independently under Roberts came up with the same finding. Previously biologists had believed that genes were continuous stretches of DNA that served as direct templates for mRNA in the assembly of proteins; this model was based on studies of prokaryotic organisms such as bacteria. Following the discovery of Sharp and Roberts, it was demonstrated that the discontinuous gene structure is the most common one found in eukaryotes, among which are all higher organisms, including human beings.

6. Nobel Prize Winners For 1991-Present genetic structure, physiology/medicine, sharp, phillip A. US, discoveryof split, or interrupted, genetic structure, 1994, chemistry, http://www.britannica.com/nobel/1991_pres.html

7. Sharp Garners Share Of Nobel Prize FIFTH IN FIELD AT MIT sharp Shares 1993 nobel Prize By Elizabeth A. Thomson NewsOffice Professor phillip A. sharp, researcher, teacher and head of the http://web.mit.edu/newsoffice/tt/1993/oct20/32033.html

Published by the MIT News Office at the Massachusetts Institute of Technology, Cambridge, Mass. October 20 Tech Talk Search MIT News ... MIT Sharp Garners Share of Nobel Prize FIFTH IN FIELD AT MIT Sharp Shares 1993 Nobel Prize By Elizabeth A. Thomson News Office Professor Phillip A. Sharp October 20 Tech Talk Search ... MIT

8. Nobel Prize Winner Phillip Sharp Will Speak At UF Monday nobel Prize Winner phillip sharp Will Speak At UF Monday. phillip A.sharp, a 1993 nobel Prize winner, will speak at 330 pm Monday http://www.napa.ufl.edu/digest/old/1998-99/nobelsharp.htm

Nobel Prize Winner Phillip Sharp Will Speak At UF Monday Phillip A. Sharp, a 1993 Nobel Prize winner, will speak at 3:30 p.m. Monday in Room C1-15 of the Health Science Center Communicore Building. The presentation, "Biology of RNA Splicing," is part of the University of Florida 1999 Presidential Lecture Series. Sharp is the Salvador E. Luria professor and head of the department of biology at the Massachusetts Institute of Technology's Center for Cancer Research. His research interests have centered on the molecular biology of tumor viruses and the mechanisms of RNA splicing. Sharp's landmark achievement was the discovery of RNA splicing in 1977. His work provided one of the first indications of the startling phenomenon of "split genes" in the cells of mammals. The discovery that genes contain nonsense segments that are edited out by cells in the course of utilizing genetic information is important in understanding the genetic causes of cancer. For this work, Sharp shared the 1993 Nobel Prize in Physiology or Medicine. The lecture will be broadcast into rooms C1-17 and C1-3 to accommodate zaudience members who cannot find a seat in the main room.

9. Sharp Awarded Nobel Prize Professor phillip A. sharp was awarded the 1993 nobel Prize in Medicine and PhysiologyMonday for his 1977 discovery of split genes. The award will be shared http://www-tech.mit.edu/V113/N49/sharp.49n.html

Sharp Awarded Nobel Prize Kevin S. Subramanya Staff Reporter Professor Phillip A. Sharp was awarded the 1993 Nobel Prize in Medicine and Physiology Monday for his 1977 discovery of "split genes." The award will be shared with Dr. Richard J. Roberts of the New England Biolabs, who made the same discovery independently. The $825,000 award was announced by the Swedish Academy of Sciences in Stockholm, Sweden. Sharp, 49, who is also head of the biology department, is the twenty-fifth Nobel laureate affiliated with MIT. "The discovery of split genes has been of fundamental importance for today's basic research in biology, as well as for more medically oriented research concerning the development of cancer and other diseases," the Nobel Committee said in its formal announcement. "The discovery has changed our view on how genes in higher organisms develop during evolution. The discovery also led to the prediction of new genetic processes" known as gene splicing, the committee said. "When I got the telephone call from the Swedish Academy Monday morning I could hardly believe the news. I was surprisingly thrilled," Sharp said.

10. Phillip Sharp Next President as second only to the nobel Prize in he is a great administrator, said phillip W.Robbins biology department, placed focus on sharp's administrative abilities http://www-tech.mit.edu/V110/N4/pres.04n.html

Phillip Sharp next president @ByName: [co Top of file; Name of event in caps.] DEFAULT By Reuven M. Lerner, and The full Corporation will meet on March 2 to consider the nomination. Approval is expected. Sharp, if his nomination is approved, will take over from President Paul E. Gray '54 on July 1. Gray announced last March that he would resign as president and succeed David S. Saxon '41 as chairman of the MIT Corporation. The nomination was made public yesterday in a letter Faculty Chair Henry D. Jacoby mailed to members of the faculty. Sharp made his own announcement at the Center for Cancer Research at 11:45 am, according to several of his colleagues. When contacted, he refused to comment on his nomination. The Corporation and the faculty search committees decided last Friday to recommend Sharp. They have been working together to find a new president since April 1989. [el Early announcement [el Institute Professor Robert M. Solow, the chair of the faculty search committee, believed the early decision left too much time before the March Corporation meeting to delay an announcement. "It is just a peculiarity of institutional timing," he said. "It is very hard to keep a thing like that quiet for three weeks." As late as Tuesday, faculty and administrators aware of the rumors refused to confirm the Sharp selection.

11. Phillip A Sharp sharp, PA Split genes and RNA splicing (nobel Lecture). Cell 77, 805815 (1994).sharp, PA Split Genes and RNA Splicing nobel Lecture, pp. 162-193. http://www.uchsc.edu/sm/mstp/aspen2000/speakers/sharp_pubs.html

List of Recent Publications Aird, W. C., Parvin, J. D., Sharp, P. A., and Rosenberg, R. D. The interaction of GATA-binding proteins and basal transcription factors with GATA box-containing core promoters: a model of tissue specific gene expression. J. Biol. Chem. Query, C. C., Moore, M. J. and Sharp, P. A. Branch nucleophile selection in pre-mRNA splicing: Evidence for the bulged duplex model. Genes Dev. Parvin, J. D., Shykind, B. M., Meyers, R. E., Kim, J. and Sharp, P. A. Multiple sets of basal factors initiate transcription by RNA polymerase II. J. Biol. Chem Sharp, P. A. Split genes and RNA splicing (Nobel Lecture). Cell Sharp, P. A. Split Genes and RNA Splicing Nobel Lecture, pp. 162-193. 1993 Les Prix Nobel. Published by the Nobel Foundation (1994). Crispino, J., Blencowe, B. J. and Sharp, P. A. Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science Pomerantz, J. L. and Sharp, P. A. Homeodomain determinants of major groove recognition. Biochemistry J. Cell Biol.

12. Phillip A Sharp phillip sharp, Ph.D. RNA interference and splicing. Bowdoin College, Brunswick, MEHonorary Doctor of Science Degree, University of Kentucky The nobel Prize in http://www.uchsc.edu/sm/mstp/aspen2000/speakers/sharp.html

Phillip Sharp, Ph.D. RNA interference and splicing. Description of Research: Shortened Curriculum Vitae: EDUCATION Ph.D., Chemistry, University of Illinois, Urbana POSITIONS 2000-date 1999-date: Director, The McGovern Institute for Brain Research Institute Professor, MIT Salvador E. Luria Professor of Biology, MIT Head, Department of Biology, MIT Director, Center for Cancer Research, MIT Associate Director, Center for Cancer Research, MIT Professor, Center for Cancer Research and Department of Biology, MIT Associate Professor, Center for Cancer Research and Department of Biology, MIT Senior Research Investigator, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York Postdoctoral Fellow, Cold Spring Harbor Laboratory Postdoctoral Fellow, California Institute of Technology Research Assistant, Department of Chemistry, University of Illinois HONORS AND AWARDS Doctor Honoris Causa, University of Buenos Aires, Argentina Honorary Doctor of Medicine, Uppsala University, Sweden Institute Professor, MIT

13. Board Of Directors Chief Executive Officer; phillip A. sharp, Ph.D. Director of the McGovern Institutefor Brain Research, Massachusetts Institute of Technology; nobel Laureate; http://www.biogen.com/site/content/about/board_of_directors.asp?bio=sharp

14. Our Corporate History Two of Biogen’s founders phillip sharp of the Massachusetts Institute of Technologyand Walter Gilbert of Harvard University - received the nobel Prize for http://www.biogen.com/site/content/about/our_corporate_history.asp

Our Corporate History Select Milestones On May 5, Biogen N.V. is incorporated in Luxembourg Biogen N.V. is incorporated in the Netherlands Antilles Biogen scientists are the first to announce the synthesis in bacteria (expression) of hepatitis B virus protein antigens Biogen enters into an exclusive worldwide license agreement with Schering-Plough Corporation for alpha interferon Biogen scientists are the first to announce the expression of a biologically active human leukocyte alpha interferon Biogen scientists are the first to announce the expression of a biologically active human fibroblast beta interferon Biogen enters into an exclusive worldwide license agreement with Schering-Plough Corporation for beta interferon Biogen opens its manufacturing facility in Cambridge, MA Biogen offers 2.5 million shares of stock priced at $5.75 (reflects subsequent stock splits) per share through its Initial Public Offering Biogen transfers legal seat of incorporation from the Netherlands Antilles to Massachusetts, becoming Biogen, Incorporated Biogen licenses its hepatitis B technology to SmithKline Beecham for use in hepatitis vaccines Biogen licenses its hepatitis B technology to Abbott for use in hepatitis diagnostics Biogen reacquires from Schering-Plough its worldwide rights to recombinant beta interferon Phillip Sharp, Ph.D., of MIT and a founder of Biogen, receives the Nobel Prize in Medicine for his discovery of split genes

15. Ganapit Biology For Kids Roberts, Richard (born 1943) Molecular biologist and cowinner (with phillip sharp)of the 1993 nobel prize in medicine or physiology, born in Derby, England. http://www.ganapitkids.com/biology.html

Welcome to Ganapit Kids' biology page. Here you will find biographies, clipart, costume ideas and links all to help you finish a paper or project. We also have a link to our "paper help" page so your paper can be the best. Explore and have fun. BIOGRAPHIES Nuesslein-Volhard, Christiane (1942 Developmental biologist. Christiane Nuesslein-Volhard won the Nobel prize in medicine in 1995 for work done in the study of how embryos develope into adults. Christiane Nuesslein-Volhard was born on Oct. 20, 1942, in Frankfurt, Germany. Malpighi, Marcello (1628-94). The Italian physician and biologist Marcello Malpighi founded the sciences of microscopic anatomy and histology. Malpighi died in Rome on Nov. 30, 1694. Roberts, Richard (born 1943) Molecular biologist and cowinner (with Phillip Sharp) of the 1993 Nobel prize in medicine or physiology, born in Derby, England. Sharp, Phillip (born 1944) Molecular biologist and cowinner (with Richard Roberts) of the 1993 Nobel prize in medicine or physiology. Phillip Sharp and Richard Roberts won the Nobel prize for their seperate discoveries that genes are often split and and not continuious. They also both discovered that long sections of genes called introns, are not used for anything. This discovery gave scientists a new understanding of how genetic material evolves. Richard Roberts was born in Falmouth. Ky. COSTUMES To dress like a biologist you need a lab coat. All you need is an old, white, long sleeved shirt. Cut off the cuffs to make the sleeves straight, hem with fabric glue or hem tape. Cut the bottom of the shirt so it is straight (cut off the shirt tails) and hem the bottom as you did the sleeves. Add a test tube you can make from a piece of 1 inch clear tubing (found at hardware stores). For more costume help go to our costume pages.

16. Untitled Document of the “split gene” in 1977 by Dr. phillip A. sharp sharp, now the Salvador E.Luria Professor of Biology Island, New York, received the 1993 nobel Prize in http://depts.washington.edu/~uweek/archives/1999.03.MAR_11/_article20.html

Wilson named to chair Immunology Sir Michael Berridge to speak on discoveries in calcium signaling Perfusionists to present John Gibbon Award to cardiothoracic chief Poll Scholar to present public lecture on new approaches to a cure for diabetes ... Memorial service for Dodge Phillip A. Sharp Scientists work around the clock trying to understand precisely how RNA segments are spliced in the subregions of our cells. All our hereditary data, including genetic disease, is passed on at this level. What chemical reactions take place? Can the process be regulated? How is the RNA itself formed? In light of recent cloning and gene therapy advances, it may be surprising to hear investigators say that little is known about this process. The fact is that what knowledge there is has come rapidly and dramatically. In the early 1970s, biotechnology companies did not exist. Genetic research was conducted primarily in academic labs. The first biotech company, Genentech Inc., was founded in 1976. Today, there are hundreds of biotech companies around the world. Working independently, Sharp and Roberts were attempting to identify the location of genes on the DNA molecule in the adenovirus nucleus. Using electron microscopy, they found that single RNA segments corresponded to separate segments of DNA in the larger molecule. In other words, they found that genes exist as discontinuous segments on a DNA molecule.

17. Union College News Release 10-01-00: Nobel Prize Winning Alumnus Returns To Camp Union College News. nobel Prize- Winning-Alumnus Returns to Campus to Dedicate AcademicCenter. Dr. phillip and Ann sharp, both graduates from the class of http://www.unionky.edu/News/00/100100_SharpDed.asp

News Home News Archives Sports Information Sports Releases ... Staff Union College News Nobel- Prize- Winning-Alumnus Returns to Campus to Dedicate Academic Center A pair of distinguished alumni are returning to Union to dedicate the building that bears their name. Dr. Phillip and Ann Sharp, both graduates from the class of 1966, will help cut the ribbon at the Sharp Academic Center on Saturday, October 14. The ceremony, to which the public is invited, begins at 10 a.m. The dedication falls on Homecoming Saturday, and will be followed by a parade down College and Manchester Streets. Conversations with Phillip Sharp begins at 11 a.m. in the Sharp Academic Center, with Dr. Sharp discussing science and research with alumni, college and high school students, and community members. The discussion will take place in rooms 3125 and 3127. "We are pleased to name this new facility in honor of Dr. and Mrs. Sharp," said Union's President David Joyce. "It is not simply recognition of their generous financial support, it is recognition of the deep personal commitment both of them share for higher education." Dr. Sharp's path to a leadership role in the global medical community began when he graduated from Union with a bachelor's degree in chemistry and mathematics. That path has since led him to the Massachusetts Institute of Technology (MIT), where in March he was named director of MIT's new McGovern Institute for Brain Research. Sharp joined MIT in 1974 as associate professor in the Center for Cancer Research and the department of biology. In 1979, he was named professor; in 1982, he was appointed associate director of the Center for Cancer Research, and became its director in 1985. He has served as head of MIT's department of biology since 1991.

18. 2002 Biotechnology Heritage Award phillip A. sharp received the 1993 nobel Prize in physiology or medicine, alongwith Richard J. Roberts, for the discovery of “split genes.” sharp and http://www.chemheritage.org/ExternalRelations/New/BiotechAward/bioaward2002.htm

2002 Biotechnology Heritage Award Walter Gilbert and Phillip Sharp Walter Gilbert, a molecular biologist, shared the Nobel Prize in chemistry in 1980 for his development of a method for determining the sequence of nucleotide links in the chainlike molecules of nucleic acids (DNA and RNA). Gilbert developed a widely used technique of using gel electrophoresis to read the nucleotide sequences of DNA segments. In 1979, while retaining his affiliation with Harvard, he joined a group of other scientists and businessmen to form Biogen, a commercial genetic-engineering research corporation. Gilbert resigned from Biogen in 1984 and, while continuing to teach at Harvard, became a chief proponent of the Human Genome Project, a government-funded effort to compile a complete map of the gene sequences in human DNA. Phillip A. Sharp received the 1993 Nobel Prize in physiology or medicine, along with Richard J. Roberts, for the discovery of “split genes.” Sharp and Roberts independently discovered that individual genes are often interrupted by long sections of DNA that do not encode protein structure. In 1977 Sharp and his team found that the messenger RNA (mRNA) of an adenovirus corresponds to four separate, discontinuous segments of DNA, and that the segments of DNA that code for proteins (exons) are separated by long stretches of DNA (introns) that do not contain genetic information. Sharp did his prize-winning research at the Massachusetts Institute of Technology. In addition, he was one of the cofounders of Biogen.

19. Premios Nobel De Medicina Premios nobel de Medicina. Año, Tema, Ganador. 1993, por el descubrimientode los genes ¨split¨, Roberts, Richard J.; sharp, phillip A. http://fai.unne.edu.ar/biologia/nobeles/nobelmed.htm

Premios Nobel de Medicina Tema Ganador Behring, Emil Adolf Von Ross, Sir Ronald Finsen, Niels Ryberg Pavlov, Ivan Petrovich Koch, Robert Cajal, Santiago Ramon Y.; Golgi, Camillo Laveran, Charles Louis Alphonse Ehrlich, Paul; Metchnikoff, Ilya Ilyich Kocher, Emil Theodor Kossel, Albrecht Gullstrand, Allvar Carrel, Alexis Richet, Charles Robert Barany, Robert Bordet, Jules Krogh, Schack August Steenberger Hill, Sir Archibald Vivian; Meyerhof, Otto Fritz; Banting, Sir Frederick Grant; Macleod, John James Richard; Einthoven, Willem; Fibiger, Johannes Andreas Grib Wagner-Jauregg, Julius Nicolle, Charles Jules Henri Eijkman, Christiaan; Hopkins, Sir Frederick Gowland Landsteiner, Karl Warburg, Otto Heinrich Adrian, Lord Edgar Douglas; Sherrington, Sir Charles Scott Morgan, Thomas Hunt Minot, George Richards; Murphy, William Parry; Whipple, George Hoyt Spemann, Hans Dale, Sir Henry Hallett; Loewi, Otto Nagyrapolt, Albert Szent-Gyorgyi Von Heymans, Corneille Jean Francois Domagk, Gerhard Dam, Henrik Carl Peter; Doisy, Edward Adelbert Erlanger, Joseph; Gasser, Herbert Spencer

20. ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE FRONTIERS IN BIOSCIENCE; ALPHABETICAL LISTING OF nobel PRIZE LAUREATESIN PHYSIOLOGY AND MEDICINE, Name, Year Awarded. sharp, phillip A. 1993. http://www.bioscience.org/urllists/nobelm.htm

FRONTIERS IN BIOSCIENCE; ALPHABETICAL LISTING OF NOBEL PRIZE LAUREATES IN PHYSIOLOGY AND MEDICINE Name Year Awarded Adrian, Lord Edgar Douglas Arber, Werner Axelrod, Julius Baltimore, David ... Zinkernagel, Rolf M.

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