1. K. Barry Sharpless - Nobel Diploma K. barry sharpless – nobel Diploma. Artist Nils G. Stenqvist CalligrapherAnnika Rücker. Last modified December 11, 2001 Copyright http://www.nobel.se/chemistry/laureates/2001/sharpless-diploma.html

Artist: Nils G. Stenqvist Last modified December 11, 2001 The Official Web Site of The Nobel Foundation

2. K. Barry Sharpless - Nobel Lecture K. barry sharpless – nobel Lecture. K. barry sharpless Autobiography nobel LectureInterview nobel Diploma Prize Award Photo Other Resources. 2000, 2002. http://www.nobel.se/chemistry/laureates/2001/sharpless-lecture.html

"The Search for New Chemical Reactivity," December 8, 2001, at Aula Magna, Stockholm University. Video Presentation (1,30 min.) Nobel Lecture (41 min.) (In order to see the videos you need Real Player Webcasting: Kamera Communications Internet Infrastructure Partner: Cisco Systems The Lecture in pdf-format From Les Prix Nobel (In order to download the text you need Adobe Acrobat Reader The Nobel Prize in Chemistry 2001 Press Release Advanced Information ... Other Resources The 2001 Prize in: Physics Chemistry Physiology or Medicine Literature ... Economic Sciences Find a Laureate: Last modified October 3, 2002 The Official Web Site of The Nobel Foundation

3. K. Barry Sharpless Winner Of The 2001 Nobel Prize In Chemistry K. barry sharpless – nobel Lecture (submitted by Chinnappan Baskar). Back to The nobel Prize Internet Archive Literature http://almaz.com/nobel/chemistry/2001c.html

K B ARRY S HARPLESS Nobel Laureate in Chemistry for his work on chirally catalysed oxidation reactions. Background Born: 1941 Place of Birth: Philadelphia, PA, U.S.A. Residence: CA Affiliation: Scripps Research Institute , La Jolla, USA Address: 10550 North Torrey Pines Blvd. La Jolla, CA 92037 Education: Dartmouth College , B. A. 1963 Stanford University , Ph. D. 1968 Book Store Asymmetric Catalysis in Organic Synthesis (The George Fisher Baker Non-Resident Lectureship in Chemistry at Cornell) by Ryoji Noyori (1994) Comprehensive Asymmetric Catalysis (Comprehensive Overviews in Chemistry) by Eric N. Jacobsen (Editor), Andreas Pfaltz (Editor), Hisashi Yamamoto (Editor) (1999) Stereochemistry of Organic Compounds by Ernest L. Eliel, Samuel H. Wilen (Editor), Lewis N. Mander (Editor) (1994) Classics in Total Synthesis : Targets, Strategies, Methods by K. C. Nicolaou, E. J. Sorensen (1995) Asymmetric Synthesis : Chiral Catalysis by James D. Morrison (Editor) (1985) Books about chiral catalysis Featured Internet Links Prize co-recipient: William S. Knowles

4. NIH News Release--NIGMS Grantee K. Barry Sharpless Wins Nobel Prize For Advances NIGMS Grantee K. barry sharpless Wins nobel Prize for Advances in MirrorImage ChemistryDr. K. barry sharpless, a long-time grantee of the National Institute http://www.nih.gov/news/pr/oct2001/nigms-10.htm

NATIONAL INSTITUTES OF HEALTH National Institute of General Medical Sciences FOR IMMEDIATE RELEASE Wednesday, October 10, 2001 Contact: Alison Davis , NIGMS NIGMS Grantee K. Barry Sharpless Wins Nobel Prize for Advances in Mirror-Image Chemistry "Dr. Sharpless' creativity has helped the entire field of chemistry produce extremely useful molecules, including many different therapeutics, that continue to improve the health and enhance the lives of all Americans," said Dr. Ruth L. Kirschstein, acting director of NIH. "This year's Nobel Prizes in Chemistry and Physiology or Medicine both beautifully underscore the value of basic biological research in yielding vital medical advances." The Royal Swedish Academy of Sciences in Stockholm announced the chemistry prize winners this morning. Dr. Sharpless, W.M. Keck Professor of Chemistry at The Scripps Research Institute in La Jolla, California, received half of this year's chemistry award for his work on "chirally catalyzed oxidation reactions." Sharing the other half of the prize for their work on "chirally catalyzed hydrogenation reactions," are Dr. William S. Knowles of St. Louis, Missouri (formerly of the Monsanto Company) and Dr. Ryoji Noyori of Nagoya University, Chikusa, Nagoya, Japan. After more than a decade of trying, in 1980 Dr. Sharpless figured out how to force a chemical reaction to go one-handed. The winning combination turned out to be a mixture of two inexpensive commercial chemicals: a relatively simple titanium compound and either the right or left hand of a chemical called "tartrate."

5. NIH Record--10/30/2001--NIH Grantees Win Nobel Prizes And winning the nobel Prize for Chemistry was Dr. K. barry sharpless, a grantee ofthe National Institute of General Medical Sciences, who was honored for his http://www.nih.gov/news/NIH-Record/10_30_2001/story03.htm

Front Page Previous Story Next Story NIH Grantees Win Nobel Prizes Hartwell, president and director of the Fred Hutchinson Cancer Research Center in Seattle and professor of genetics at the University of Washington, also in Seattle, received the award jointly with Dr. Paul M. Nurse and Dr. R. Timothy Hunt, both of the Imperial Cancer Research Fund in London. Dr. Leland Hartwell Saccharomyces cerevisiae In 1990, NIGMS gave Hartwell a MERIT award, which provides investigators who have demonstrated superior competence and outstanding productivity with long-term, stable support to foster their continued research contributions. Hartwell has also received funding from the National Cancer Institute and the National Center for Research Resources. Of the 79 American Nobel laureates in physiology or medicine since 1945, 60 either worked at or were funded by NIH before winning the prize. During the same period, 123 scientists worldwide have won that prize, 70 with support from or work experience at NIH prior to receiving the honor. Sharpless, who is the W.M. Keck professor of chemistry at the Scripps Research Institute in La Jolla, received half of this year's chemistry award for his work on "chirally catalyzed oxidation reactions." Sharing the other half of the prize for their work on "chirally catalyzed hydrogenation reactions," are Dr. William S. Knowles of St. Louis (formerly of Monsanto Co.), and Dr. Ryoji Noyori of Nagoya University, Chikusa, Nagoya, Japan.

6. CollegeNews.org - Nobel Laureate Chemist K. Barry Sharpless To Lecture At Pomona K. barry sharpless, winner of the 2001 nobel Prize in Chemistry, will give fourlectures on his current research as part of the 41st Fred J. Robbins http://www.collegenews.org/x2133.xml

ABOUT THIS SITE ABOUT LIBERAL ARTS COLLEGES THE ANNAPOLIS GROUP MEMBER COLLEGES ON CAMPUS EXPERTS DATABASE TOP NEWS ON CAMPUS ADDITIONAL RESOURCES Nobel Laureate Chemist K. Barry Sharpless to Lecture at Pomona College K. Barry Sharpless, winner of the 2001 Nobel Prize in Chemistry, will give four lectures on his current research as part of the 41 st The lectures are: "How to Discover Something New," January 28, Tuesday, 8 p.m.; "New Chemistry and How to Discover It," January 29, Wednesday, 4:30 p.m.; "Click Chemistry - The Concept," January 30, Thursday, 4:30 p.m.; and "Click Chemistry Applications," January 31, Friday, 4:30 p.m. Sharpless is the W. M. Keck Professor of Chemistry at The Scripps Research Institute (TSRI) in La Jolla, Calif. Along with his co-workers, he has discovered and developed many widely used catalytic oxidation processes. According to Dan O'Leary, associate professor of chemistry at Pomona College, "These processes have been used to produce new pharmaceuticals that couldn't have been imagined 20 years ago. And, academic chemists have widely incorporated his methodology in their own teaching and research." In addition to the Nobel Prize, Sharpless has received the 2001 Wolf Prize, the 1995 King Faisal Prize for Science, the 1993 Tetrahedron Prize, the 1997 Roger Adams Award in Organic Chemistry, the 1992 Arthur C. Cope Award and the 1983 Award for Creative Work in Organic Synthesis.

7. Sharpless, Former MIT Professor, Wins Nobel In Chemistry K. barry sharpless, an MIT chemistry professor for 17 years until he joined ScrippsResearch Institute in 1990, was chosen October 10 to share the 2001 nobel http://web.mit.edu/newsoffice/nr/2001/sharpless.html

News Releases MIT News Office Search Comments ... MIT Sharpless, former MIT professor, wins Nobel in chemistry October 10, 2001 Contact Information Nobel Foundation announcements: The Nobel Prize in Chemistry 2001 The Bank of Sweden Prize in Economic Sciences 2001 Eight from MIT win 2001 Nobels in 5 fields MIT News Office, October 12, 2 MIT-related Nobel Prize winners - MIT News Office CAMBRIDGE, Mass. K. Barry Sharpless, an MIT chemistry professor for 17 years until he joined Scripps Research Institute in 1990, was chosen October 10 to share the 2001 Nobel Prize in chemistry with two other researchers. Sharpless, 60, received a Ph.D. degree in 1968 from Stanford University. Since 1990, he has been W. M. Keck Professor of Chemistry at the Scripps Research Institute. After starting his career at MIT as an assistant professor, Sharpless moved back to Stanford in 1977. Although he had started his quest for a practical catalyst for asymmetric epoxidation while at MIT, after 10 years of effort, the key breakthrough took place in January 1980 at Stanford. Sharpless decided that he wanted to return to MIT to pursue this important discovery. He and his lab moved back to MIT that summer. It was at MIT that he fully developed the process now known as the Sharpless Asymmetic Epoxidation and it was also here that he and his coworkers discovered the Sharpless Asymmetric Dihydroxylation. Sharpless left MIT in 1990 to join the Scripps Research Institute.

8. Eight From MIT Win Nobels In 5 Fields; Kofi Annan's Peace Prize Caps Week K. barry sharpless, an MIT chemistry professor for 17 years until he joined ScrippsResearch Institute in 1990, on Tuesday shared the 2001 nobel Prize in http://web.mit.edu/newsoffice/nr/2001/nobels-eight.html

News Releases MIT News Office Search Comments ... MIT Leland H. Hartwell Wolfgang Ketterle Eric A. Cornell Carl E. Wieman K. Barry Sharpless George A. Akerlof Joseph E. Stiglitz Kofi Annan Eight from MIT win Nobels in 5 fields; OCTOBER 12, 2001 Contact Information Eight Nobel Prize recipients with MIT connections won Nobel Prizes in five fields this weekmedicine, physics, chemistry, economics and peace. The Peace Prize award Friday to the United Nations and Kofi Annan (MIT S.M. 1972) capped a week in which a current professor, a former professor and six alumni shared the prestigious prizes. MIT President Charles M. Vest commented, "It is thrilling and absolutely extraordinary that eight people who have taught or studied at MIT are among the 13 Nobel Prize winners in physics, chemistry, biology, economics, and peace. This is testimony to the excellence of students and faculty who are attracted to MIT, and to our dedication to intense work in fields of fundamental importance. Among the winners I know personally, the quality and creativity of students at MIT is frequently cited as a great strength of MIT. "Looking at the history of the Nobel Prizes in recent years, it is noteworthy that in many fields, the basic research done early in an individual’s career, shortly after attaining a Ph.D., is the work that is rewarded years later with the Nobel Prize," Vest said.

9. The Scripps Research Institute - News And Publications K. barry sharpless is Awarded the 2001 nobel Prize in Chemistry.La Jolla, CA, October 10, 2001 K. barry sharpless, Ph.D., WM http://www.scripps.edu/news/press/101001.html

K. Barry Sharpless is Awarded the 2001 Nobel Prize in Chemistry La Jolla, CA, October 10, 2001 K. Barry Sharpless, Ph.D., W.M. Keck Professor of Chemistry at The Scripps Research Institute (TSRI), and member of The Skaggs Institute for Chemical Biology, has been awarded the 2001 Nobel Prize in Chemistry. Awarded annually by the Royal Swedish Academy of Sciences for achievements in physics, chemistry, medicine, literature, economics, and peace, the prize recognizes individuals who, as stipulated in Alfred Nobel's will, "have conferred the greatest benefit on mankind." The prize carries a cash award of about a million dollars. Sharpless was awarded this year's prize in chemistry along with William S. Knowles, formerly of Monsanto, and Ryoji Noyori of Nagoya University in Japan for "the development of catalytic asymmetric synthesis." "We are obviously delighted that Dr. Sharpless has received this recognition," says TSRI President Richard Lerner. "In my mind, it was inevitable that he would be awarded the Nobel Prize—the extent and significance of his work are so far reaching. [Dr. Sharpless] has been recognized for his prodigious work by the scientific community for many years and has been acknowledged by the philanthropic community, most notably Mr. Sam Skaggs, whose contributions have enabled Dr. Sharpless to achieve many research breakthroughs."

10. The Scripps Research Institute - News And Views TSRI Professor K. barry sharpless Receives nobel Prize from Sweden's King On Monday,December 10, TSRI Professor K. barry sharpless officially received the http://www.scripps.edu/newsandviews/nobel/

TSRI News Nobel Talk: TSRI and the 2001 Nobel Prize in Chemistry Individuals across campus react with excitement to the news that TSRI investigator K. Barry Sharpless is a winner of the 2001 Nobel Prize in Chemistry. Money Well Spent: Foundations Support Cutting-Edge Science The research of Nobel laureate K. Barry Sharpless and other innovative scientists at TSRI would not be possible without support from foundations, donors, and agencies. Press Reports on the 2001 Nobel Prize in Chemistry For those interested in what the press had to say on TSRI investigator K. Barry Sharpless and the 2001 Nobel Prize in Chemistry, here are some links: The Washington Post CNN San Diego Union-Tribune TSRI Professor K. Barry Sharpless Receives Nobel Prize from Sweden's King On Monday, December 10, TSRI Professor K. Barry Sharpless officially received the Nobel Prize in Chemistry from the King of Sweden Carl XVI Gustaf in a ceremony with much pageantry. Video coverage of the award ceremony and other information about the proceedings are available on The

11. NIGMS -- News & Events: Archived News Releases & Announcements November 5, 2001; NIGMS Grantee K. barry sharpless Wins nobel Prize forAdvances in MirrorImage Chemistry October 10, 2001; NIH Grantee http://www.nigms.nih.gov/news/releases/archnews.html

skip navigation NIGMS Home What's New Site Map ... Search NIGMS for: Text size: A A A Research Funding ... Pharmacogenetics Research Network Chooses Journal to Publish PharmGKB Data November 9, 2001 NIH Funds Synchrotron Beamlines to Advance Studies of Molecular Structures November 5, 2001 NIGMS Grantee K. Barry Sharpless Wins Nobel Prize for Advances in Mirror-Image Chemistry October 10, 2001 NIH Grantee Leland Hartwell Wins Nobel Prize for Breakthroughs in Understanding the Cell Cycle October 8, 2001 NIGMS Awards "Glue Grant" to Study Cell Talk October 5, 2001 NIGMS Protein Structure Initiative Establishes Advisory Committee October 3, 2001 NIGMS Awards "Glue Grant" to Probe Body's Response to Burn and Trauma Injury October 2, 2001 NIGMS Protein Structure Initiative Announces New Members September 28, 2001 NIGMS Awards "Glue Grant" to Study How Cells Move September 26, 2001 September 20, 2001 NIH Pharmacogenetics Research Network Announces New Members September 4, 2001 Pharmacogenetics Research Network Seeks Journal Partnership June 1, 2001 NIGMS Creates Center for Bioinformatics and Computational Biology May 14, 2001

12. K. Barry Sharpless / Chemistry When K. barry sharpless describes his research synthesizing molecules, for whichhe was awarded a share of this year's nobel Prize in chemistry, he sounds like http://www.latimes.com/features/printedition/magazine/la-120201sharpless.story

Home Register Home Delivery Site Map ... Help Join now! Careers Cars Homes Rentals ... Editorials, Op-Ed Weekly Health Food Highway 1 Sunday Books Calendar Magazine Opinion ... Editorials, Op-Ed Sections Books Chess Columns Education ... For the Record Editions Print Edition National (PDF) Wireless NewsDirect Extras College Connection Sweepstakes Crossword Horoscope ... Multimedia Archives Enter Keyword(s): Detailed Search SITE MAP Subscription Services Home Delivery Subscriptions NewsDirect Gift Subscriptions College Discount ... Recycler.com LA Times Initiatives Times in Education Reading by 9 LA Times Books LA Times Family Fund ... Inside the Times Partners December 2, 2001 E-mail story Print Winner's Circle K. Barry Sharpless / Chemistry Photos K. Barry Sharpless (MICHAEL KELLEY) Winner's Circle K. Barry Sharpless Paul Berg Kary B. Mullis F. Sherwood Rowland ... 100 More Winners Story Gallery Nobel Prize 100th Anniversary Issue Times Headlines More on the Border Vigilantes How Fair Is It to Label Wallace Stegner a Plagiarist? Suitwear for the Morning After Fashionable Liaisons ... Classics, With a Twist By TERENCE MONMANEY, Times Staff Writer When K. Barry Sharpless describes his research synthesizing molecules, for which he was awarded a share of this year's Nobel Prize in chemistry, he sounds like an ad for a soap opera, with his talk of passion, obsession, suffering, excitement, love and monomania. In experiments dating back more than two decades, the 60-year-old Sharpless, a professor at the Scripps Research Institute in La Jolla since 1991, created ways to synthesize valuable chemicalsincluding insecticides, fragrances, flavors and a variety of drugs, from taxol, a cancer chemotherapy, to erythromycin, an antibiotic. His work has dazzled chemists, saved drug and chemical companies vats of cash and helped bring to market lots of stuff that people need.

13. Nobel Prize 100th Anniversary Issue By TERENCE MONMANEY When K. barry sharpless describes his research synthesizingmolecules, for which he was awarded a share of this year's nobel Prize in http://www.latimes.com/la-magazine-nobel,0,173207.storygallery

Home Register Home Delivery Site Map ... Help Join now! Careers Cars Homes Rentals ... Editorials, Op-Ed Sections Books Chess Columns Education ... For the Record Editions Print Edition National (PDF) Wireless NewsDirect Extras College Connection Sweepstakes Crossword Horoscope ... Multimedia Archives Enter Keyword(s): Detailed Search SITE MAP Subscription Services Home Delivery Subscriptions NewsDirect Gift Subscriptions College Discount ... Recycler.com LA Times Initiatives Times in Education Reading by 9 LA Times Books LA Times Family Fund ... Inside the Times Partners Nobel Prize 100th Anniversary Issue The Los Angeles Times Magazine examines the secular sainthood. Plus, profiles of Californian winners and more. Los Angeles Times Magazine High Priests of the Unknown By ROBERT LEE HOTZ The Nobel Prize can influence research priorities and confer a remarkablesometimes undeservedmoral authority on its winners. Now some wonder if there's a risk in creating a secular sainthood. December 2, 2001 Los Angeles Times Magazine The Cult of Richard Feynman By J. MICHAEL KENNEDY His peculiar immortality springs from more than his scientific achievements.

14. Sharpless, K. Barry sharpless, K. barry. Since some family background and professional activities (andlots more about fishing) are in the nobel lecture that follows, and http://www.cartage.org.lb/en/themes/Biographies/MainBiographies/S/sharpless/shar

Sharpless, K. Barry From 6th through 12th grades I attended a Quaker school on the Philadelphia city line. Twice a week the entire school attended Quaker Meeting, silent gatherings except when someone received a personal call to speak. I never got a call, but nonetheless my head was full: I thought about fishing and boats. Or else I thought about when next I could get from Philadelphia to our cottage on the New Jersey Shore in order to go out fishing in a boat. Beneath my picture in one high school yearbook it says, "I'm going to the Shore". While I had an overwhelming passion for fishing, school I merely enjoyed and I never planned to be a scientist. In fact, passion, not planning, is the engine driving all my thought and action. The almost unimaginably good fortune of my youth was that other people made such very, very good plans and choices for me. Generally speaking, colleges have the best undergraduate teaching, and universities, whose labs are filled by graduate and post-graduate students, have the best research. When I arrived at Dartmouth College in 1959, the chemistry department had a graduate program, which meant great teachers who were just as good at research. However, the program was small, and only a master's degree was awarded, so consequently professors were perpetually hungry for more manpower for their labs, more "hands". Undergraduates who performed well in lab courses were actively recruited to do "real" graduate- level research.

15. Morningstar - PR Newswire: Nobel Laureate Professor K. Barry Sharpless And Profe boards. nobel Laureate Professor K. barry sharpless and Professor JamesP. Collman Join Chiral Quest's Scientific Advisory Board, 02 http://news.morningstar.com/news/PR/M02/D26/1046264480664.html

Home Premium Portfolio Stocks ... Discuss To see what Morningstar analysts are saying about the latest news, click here If you have questions or comments about this topic, check out our message boards Nobel Laureate Professor K. Barry Sharpless and Professor James P. Collman Join Chiral Quest's Scientific Advisory Board 02-26-03 08:07 AM EST /PRNewswire-FirstCall/ Chiral Quest, Inc. (OTC Bulletin Board: CQST) today announced that Professor K. Barry Sharpless of The Scripps Research Institute and Professor James P. Collman of Stanford University will join the Company's Scientific Advisory Board. Professor Sharpless will also become Chairman of the Scientific Advisory Board. Professor Collman is the Daubert Professor of Chemistry at Stanford University where he has been on the faculty for 35 years. Collman is a member of The National Academy of Sciences and has received numerous awards for his research from the American Chemical Society and other international organizations. More than 40 of his graduate and postdoctoral students occupy teaching positions at universities around the world; twelve of Collman's former students have founded companies. "Professors Sharpless and Collman are two of the great pioneers in the chiral chemistry and catalysis field. We are delighted to have leading scientists of their expertise and caliber on our scientific advisory board," commented Alan D. Roth, Ph.D., President and Chief Executive Officer of Chiral Quest.

16. Tech - Kémiai Nobel-díj A Királis Molekulák Szintéziséért Kémiai nobel-díj a királis molekulák szintéziséért.Category World Magyar Tudomány Természettudományok Kémia...... évi kémiai nobeldíj díj felét megosztva kapja az amerikai William S. Knowlesés a japán A díj másik felét az amerikai K. barry sharpless kapja, a http://www.index.hu/tech/tudomany/kemnobel2001/

a magyar weben az Indexen a fórumokban a tár.hu-n okos keresõ segítség Hotelek Piactér ... Jetfly h i r d e t é s Rövid hírek Net Szoftver Hardver ... Papírvékony képernyõt gyártott a Pioneer Kémiai Nobel-díj a királis molekulák szintéziséért Új tudományágat teremtettek a katalizáló eljárások vomit 2001. október 10., szerda 14:56 A svéd királyi tudományos akadémia úgy határozott, hogy a 2001. évi kémiai Nobel-díjjal három kutató a katalitikus aszimmetrikus molekuláris szintézis terén kifejtett munkáját ismeri el. A díj felét megosztva kapja az amerikai William S. Knowles és a japán Nojori Rjodzsi, a másik fele az amerikai K. Barry Sharplessé lesz. Nyomtatható változat a támogatásával A 2001. évi kémiai Nobel-díj díj felét megosztva kapja az amerikai William S. Knowles és a japán Nojori Rjodzsi, a királis katalizáló hidrogénezési reakciók terén végzett kutatásáért. A díj másik felét az amerikai K. Barry Sharpless kapja, a királis katalizáló oxidációs folyamatok vizsgálatáért. Molekuláris tükörszimmetrikus katalízis Sok molekula létezik két formában, melyek tükörszimmetrikusak, ahogy az ember kezei egymásnak pontos tükörképei. Az ilyen molekulákat királisnak nevezik. A természetben beigazolódott, hogy a két molekulaváltozat közül gyakran dominánssá válik az egyik. Például a sejtekben a molekula egyik változata illeszkedik, szemben a másikkal, mely egyenesen káros hatású is lehet.

17. Index - Kémiai Nobel-díj A Királis Molekulák Szintéziséért - Nyomtatható A hülyeség nobeldíjasai, http//index.hu/tech/fightclub/nobelbodoky/. • NojoriRjodzsi, http//www-noyori.os.chem.nagoya-u.ac.jp. • K. barry sharpless, http http://www.index.hu/tech/tudomany/kemnobel2001/?print

18. SunSITE India : 2001 Nobel Chemistry Prize The Royal Swedish Academy of Sciences has decided to award the nobel Prize in Chemistryfor 2001 for the development of K. barry sharpless the Scripps http://sunsite.iisc.ernet.in/nobel2001/che2001_rel.html

2001 Nobel Prize 2001 Nobel Prize in Chemistry Press Release The 2001 Nobel Prize in Chemistry 10 October 2001 The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2001 for the development of catalytic asymmetric synthesis, with one half jointly to William S. Knowles St Louis, Missouri, USA, and Ryoji Noyori Nagoya University, Chikusa, Nagoya, Japan, "for their work on chirally catalysed hydrogenation reactions" and the other half to K. Barry Sharpless the Scripps Research Institute, La Jolla, California, USA, "for his work on chirally catalysed oxidation reactions". Mirror Image Catalysis Many molecules appear in two forms that mirror each other - just as our hands mirror each other. Such molecules are called chiral. In nature one of these forms is often dominant, so in our cells one of these mirror images of a molecule fits "like a glove", in contrast to the other one which may even be harmful. Pharmaceutical products often consist of chiral molecules, and the difference between the two forms can be a matter of life and death - as was the case, for example, in the thalidomide disaster in the 1960s. That is why it is vital to be able to produce the two chiral forms separately. This year's Nobel Laureates in Chemistry have developed molecules that can catalyse important reactions so that only one of the two mirror image forms is produced. The catalyst molecule, which itself is chiral, speeds up the reaction without being consumed. Just one of these molecules can produce millions of molecules of the desired mirror image form.

19. INFORMEX® - SOCMA - News - Press Room nobel Laureate Professor K. barry sharpless and Professor James P.Collman join Chiral Quest's Scientific Advisory Board. Professor http://www.informex.org/news/pressroom/ChiralQuestBoard_22603.htm

Press Room Press Room FOR IMMEDIATE RELEASE February 26, 2003 Nobel Laureate Professor K. Barry Sharpless and Professor James P. Collman join Chiral Quest's Scientific Advisory Board Professor K. Barry Sharpless will become Chairman of the Scientific Advisory Board State College, PA - February 26, 2003 Chiral Quest, Inc. (OTC Bulletin Board: CQST) today announced that Professor K. Barry Sharpless of The Scripps Research Institute and Professor James P. Collman of Stanford University will join the Company's Scientific Advisory Board. Professor Sharpless will also become Chairman of the Scientific Advisory Board. Professor Sharpless is the W.M. Keck Professor of Chemistry at The Scripps Research Institute and a member of the Skaggs Institute for Chemical Biology. Sharpless is the world authority in chiral chemistry and is best known for discovering three "name" reactions - the general methods for catalytic asymmetric epoxidation, dihydroxlylation, and aminohydroxylation. His 2001 Nobel Prize in Chemistry citation says, "many scientists have identified Sharpless's epoxidation [discovered in 1980 with Tsutomu Katsuki] as the most important discovery in the field of synthesis during the past few decades." In 2000, Chemical and Engineering News selected him as one of the top 75 most influential chemists in the 20th century. In 2001, Sharpless received not only the Nobel Prize in Chemistry, but also Israel's Wolf Prize, the Benjamin Franklin Medal and the John Scott Medal Award. After receiving his Stanford Ph.D. from Professor E. E. vanTamelen, he did postdoctoral work with Professor James Collman at Stanford University and Nobel Laureate Konrad Bloch at Harvard University. Sharpless began his academic career as an assistant professor at the Massachusetts Institute of Technology. Except for several years in the 1970s when he was a member of Stanford's chemistry faculty, Sharpless remained at MIT until moving to the Scripps Research Institute (TSRI) in 1990.

20. ScienceDaily News Release: Scientists Share Nobel Prize In Chemistry For Their D Royal Swedish Academy of Sciences has decided to award the nobel Prize in catalysedhydrogenation reactions and the other half to K. barry sharpless of the http://www.sciencedaily.com/releases/2001/10/011010073855.htm

Search Our Archives Keywords: Order by: date relevance More options Get ad-free access with email updates sign up or log in Text size: A A A Welcome Home page About this site Awards, reviews News Summaries Headlines Topics Shop Our stuff Browse books Magazines Software Contribute Register free Post release Edit profile Review hits Advertise Media kit Traffic stats Contact us Previous Story ... Related Stories Next Story Source: The Nobel Foundation Date: Scientists Share Nobel Prize In Chemistry For Their Development Of Catalytic Asymmetric Synthesis The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2001 for the development of catalytic asymmetric synthesis, with one half jointly to William S. Knowles of St Louis, Missouri, and Ryoji Noyori of Nagoya University in Japan, "for their work on chirally catalysed hydrogenation reactions" and the other half to K. Barry Sharpless of the the Scripps Research Institute in La Jolla, California, "for his work on chirally catalysed oxidation reactions." Mirror Image Catalysis Many molecules appear in two forms that mirror each other – just as our hands mirror each other. Such molecules are called chiral. In nature one of these forms is often dominant, so in our cells one of these mirror images of a molecule fits "like a glove", in contrast to the other one which may even be harmful. Pharmaceutical products often consist of chiral molecules, and the difference between the two forms can be a matter of life and death – as was the case, for example, in the thalidomide disaster in the 1960s. That is why it is vital to be able to produce the two chiral forms separately.

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