81. The Scientist - John Scott Award Goes To Recent Nobelist To say that K. barry sharpless has had an eventful year might be as understated assaying that he likes chemistry. In addition to receiving the nobel Prize for http://www.the-scientist.com/yr2001/dec/maher_p12_011210.html

The Scientist 15[24]:12, Dec. 10, 2001 NEWS John Scott Award Goes to Recent Nobelist Philadelphia chemist returns home for one more honor E-mail article By Brendan A. Maher Courtesy of Scripps Research Institute K. Barry Sharpless To say that K. Barry Sharpless has had an eventful year might be as understated as saying that he likes chemistry. In addition to receiving the Nobel Prize for chemistry on Dec. 10, Sharpless, W.M. Keck Professor of chemistry at The Scripps Research Institute in La Jolla, Calif., returned to his hometown of Philadelphia earlier in April to receive the Benjamin Franklin Medal, and then again this autumn to receive the John Scott Award. The latter award was bestowed by the Philadelphia Board of City Trusts Nov. 16 at the College of Physicians of Philadelphia. "Being a local boy," exclaims Sharpless, "it feels like Philadelphia has really come through for me this year." Sharpless pegs the beginnings of his inquisitive nature that spirited his prize-winning research on the long summer days spent at the New Jersey shore fishing or seining for crabs. Be it snapping turtle, eel, or even coelacanth, Sharpless always hoped for a new and outlandish catch, and today he continues to look for new reactivity and conduct chemistry the way he used to fish. His research on chirally-catalyzed oxidation reactions is no fish story, however.

82. NIGMS -- News & Events: NIGMS Grantee K. Barry Sharpless Wins Nobel Prize For Ad A news release on NIGMS grantee K. barry sharpless winning the NobelPrize in Chemistry for advances in mirrorimage chemistry. http://www.nigms.nih.gov/news/releases/nobel_sharpless.html

skip navigation NIGMS Home What's New Site Map ... Search NIGMS for: Text size: A A A Research Funding ... E-mail this link NIGMS Grantee K. Barry Sharpless Wins Nobel Prize for Advances in Mirror-Image Chemistry by Alison Davis October 10, 2001 "Dr. Sharpless' creativity has helped the entire field of chemistry produce extremely useful molecules, including many different therapeutics, that continue to improve the health and enhance the lives of all Americans," said Dr. Ruth L. Kirschstein, acting director of NIH. "This year's Nobel Prizes in Chemistry and Physiology or Medicine both beautifully underscore the value of basic biological research in yielding vital medical advances." The Royal Swedish Academy of Sciences in Stockholm announced the chemistry prize winners this morning. Dr. Sharpless, W.M. Keck Professor of Chemistry at The Scripps Research Institute in La Jolla, California, received half of this year's chemistry award for his work on "chirally catalyzed oxidation reactions." Sharing the other half of the prize for their work on "chirally catalyzed hydrogenation reactions," are Dr. William S. Knowles of St. Louis, Missouri (formerly of the Monsanto Company) and Dr. Ryoji Noyori of Nagoya University, Chikusa, Nagoya, Japan. Nearly all small moleculeseither natural or syntheticcome in two, "mirror-image" forms, much like a pair of gloves. When chemical reactions occur in living systems, only the "correct" form is made. In contrast, laboratory reactions nearly always produce a potful of both left and right "hands" of a molecule. The active part of most medicines consists of a single hand of a molecule. A mixture that includes the "wrong" hand of a molecule can be ineffective or even harmful to the body.

83. Página/12 Translate this page K. barry sharpless, por otro lado, fue galardonado con otra mitad del Premio Nobelpor el desarrollo de catalizadores quirales para otro tipo de reacción http://www.pagina12.com.ar/2001/01-10/01-10-11/pag27.htm

NOBEL DE QUIMICA A DOS NORTEAMERICANOS Y UN JAPONES Los tres científicos premiados investigaron la quiralidad de las moléculas, es decir su orientación espacial. Sus hallazgos se utilizan hoy en un gran número de productos farmacológicos. El norteamericano Barry Sharpless, uno de los premiados con el Nobel de Química. Por Leonardo Moledo OPINION Por Ernesto Calvo * Abrieron un nuevo campo PRINCIPAL

84. SunSITE India : 2001 Nobel Chemistry Prize 2001 nobel Prize 2001 nobel Prize in Chemistry William S.Knowles Ryoji Noyori K.BarrySharpless Biography. William S. Knowles, 84 years, born 1917 (US citizen). http://sunsite.iisc.ernet.in/nobel2001/che2001_bio.html

2001 Nobel Prize 2001 Nobel Prize in Chemistry William S.Knowles Ryoji Noyori K.Barry Sharpless Biography William S. Knowles , 84 years, born 1917 (US citizen). PhD 1942 at Columbia University. Previously at Monsanto Company, St Louis, USA. Retired since 1986. Ryoji Noyori , 63 years, born 1938 Kobe, Japan (Japanese citizen). PhD 1967 at Kyoto University. Since 1972 Professor of Chemistry at Nagoya University and since 2000 Director of the Research Center for Materials Science, Nagoya University, Nagoya, Japan. http://www-noyori.os.chem.nagoya-u.ac.jp K. Barry Sharpless , 60 years, born 1941 Philadelphia, Pennsylvania, USA (US citizen). PhD 1968 at Stanford University. Since 1990 W.M. Keck Professor of Chemistry at the Scripps Research Institute, La Jolla, USA. http://www.scripps.edu/chem/sharpless/kbs.html Comments/Suggestions to Webmaster, SunSITE

85. Expressnews - Nobel Prize Winner Puts Trust In Nature | University Of Alberta May 6, 2002 – One of the 2001 winners of the nobel Prize in chemistry, Dr. K. BarrySharpless, walks across the north end of the University of Alberta campus http://www.expressnews.ualberta.ca/expressnews/articles/news.cfm?p_ID=2483&s=a

86. International: Italiano: Scienze: Chimica: Chimici_e_Ricercatori: Sharpless,_K._ Translate this page In tutta la Directory. http://open-site.org/International/Italiano/Scienze/Chimica/Chimici_e_Ricercator

Open Site The Open Encyclopedia Project Pagina Principale Aggiungi Contenuti Diventa Editore In tutta la Directory Solo in Chimici_e_Ricercatori/Sharpless,_K._Barry Top International Italiano Scienze ... Chimici e Ricercatori : Sharpless, K. Barry Vedi anche: International: Italiano: Societ : Strutture Sociali: Persone: Biografie: Premio Nobel Questa Categoria ha bisogno di un Editore - Richiedila Open Site Code 0.4.1 modifica

87. Tricking Diseases Into Synthesizing Their Own Worst Enemies In the current issue of the journal Angewandte Chemie, 2001 nobel laureate K. BarrySharpless, WM Keck Professor of Chemistry at TSRI, and colleagues at TSRI http://www.eurekalert.org/pub_releases/2002-03/sri-tdi031402.php

Public release date: 15-Mar-2002 Contact: Robin B. Goldsmith rgoldsmi@scripps.edu Scripps Research Institute Tricking diseases into synthesizing their own worst enemies A revolutionary strategy for drug discovery at The Scripps Research Institute (TSRI) succeeds on an enzyme In a first attempt to test a new general strategy for drug discovery, chemists at The Scripps Research Institute (TSRI) and TSRI's Skaggs Institute for Chemical Biology created the most potent blocking agent known against an enzyme implicated in Alzheimer's disease. In the current issue of the journal Angewandte Chemie, 2001 Nobel laureate K. Barry Sharpless, W.M. Keck Professor of Chemistry at TSRI, and colleagues at TSRI and the University of California at San Diego, describe how click chemistry, a modular protocol for organic synthesis that Sharpless developed, was used to make a drug-like molecule that powerfully blocks the neurotransmitter destruction caused by the brain enzyme, acetylcholinesterase. Unlike existing methods, this new drug-discovery strategy—click chemistry—mobilizes the target itself, acetylcholinesterase in this case, to play a decisive role and select the final synthetic step. The acetylcholinesterase enzyme actually catalyzed the click reaction that created that enzyme's own inhibitor, and, remarkably, the result is by far the most potent inhibitor ever discovered for this important, widely studied brain enzyme. "Think of this as a Trojan Horse approach for battling disease, but this horse goes the Greeks one better," says Sharpless. "We create the pieces that can be clicked together to make the horse, then we leave them outside the gates of, for example, a bacterium. If the pieces look right, it goes to work, constructing its own worst enemy, and doing so within its own defensive walls."

88. Scripps Foundation - News Passionate About the Periodic Table The goal, says 2001 nobel laureate K. BarrySharpless, is finding something new, hopefully unimagined and, better still http://www.scrippsfoundation.org/newsletter2088/newsletter_list.htm?section=In t

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