61. PREMIOS NOBEL RELACIONADOS CON LA GENÉTICA Translate this page 1987, susumu tonegawa. Por su descubrimiento del fundamento genético de laformación de una rica variedad de anticuerpos. 1989, nobel de Química http://www.ucm.es/info/genetica/AVG/nobel/nobel.htm

Alfred Nobel La mayoría de los Premios Nobel que figuran en la siguiente lista son de Fisiología y Medicina, salvo algunos de Química y de la Paz que se indican de forma expresa en la tabla. Albrecht Kossel Por sus trabajos sobre las sustancias albuminoides, incluyendo las nucleínas, que han contribuido al conocimiento de la química de las células. Karl Landsteiner Por sus descubrimientos de los grupos sanguíneos de la especie humana. Thomas H. Morgan Por su descubrimiento sobre la función de los cromosomas como portadores de la herencia. Hermann J. Muller Por su descubrimiento de la inducción de mutaciones mediante radiación con rayos X. Linus Carl Pauling Por sus investigaciones sobre la naturaleza de los enlaces químicos y su aplicación en la elucidación de la estructura de las sustancias complejas. También recibió el Premio Nobel de la Paz en 1962 por su lucha contra el desarrollo de las armas nucleares. George W. Beadle Edward L. Tatum Por su descubrimiento de que los genes actúan regulando sucesos químicos definidos.

62. John Polanyi Official Website Nobel Statement, Signatories, Statement By Nobel L Signatores, Statement by nobel Laureates on the occasion of the onehundredth anniversaryof the nobel Prize. Physics, 1993); susumu tonegawa (Physiology/Medicine http://www.utoronto.ca/jpolanyi/nobelstatement/signatures.html

Signatores, Statement by Nobel Laureates on the occasion of the one-hundredth anniversary of the Nobel Prize Zhores I. Alferov (Physics, 2000) Sidney Altman (Chemistry, 1989) Philip W. Anderson (Physics, 1977) Oscar Arias Sanchez (Peace, 1987) J. Georg Bednorz (Physics, 1987) Bishop Carlos F. X. Belo (Peace, 1996) Baruj Benacerraf (Physiology/Medicine, 1980) Hans A. Bethe (Physics, 1967) Gerd K. Binnig (Physics, 1986) James W. Black (Physiology/Medicine, 1988) Guenter Blobel (Physiology/Medicine, 1999) Nicolaas Bloembergen (Physics, 1981) Norman E. Borlaug (Peace, 1970) Paul D. Boyer (Chemistry, 1997) Bertram N. Brockhouse (Physics, 1994) Herbert C. Brown (Chemistry, 1979) Georges Charpak (Physics, 1992) Claude Cohen-Tannoudji (Physics, 1997) John W. Cornforth (Chemistry, 1975) Francis H.C. Crick (Physiology/ Medicine, 1962) James W. Cronin (Physics, 1980) Paul J. Crutzen (Chemistry, 1995) Robert F. Curl (Chemistry, 1996) His Holiness The Dalai Lama (Peace, 1989) Johann Deisenhofer (Chemistry, 1988) Peter C. Doherty (Physiology/Medicine, 1996) Manfred Eigen (Chemistry, 1967)

63. John Polanyi Official Website Nobel Statement, Statement By Nobel Laureates Statement by nobel Laureates on the occasion of the onehundredth anniversary ofthe nobel Prize. (Physics, 1993); susumu tonegawa (Physiology/Medicine, 1987 http://www.utoronto.ca/jpolanyi/nobelstatement/statement.html

Statement by Nobel Laureates on the occasion of the one-hundredth anniversary of the Nobel Prize THE NEXT HUNDRED YEARS Zhores I. Alferov (Physics, 2000) Sidney Altman (Chemistry, 1989) Philip W. Anderson (Physics, 1977) Oscar Arias Sanchez (Peace, 1987) J. Georg Bednorz (Physics, 1987) Bishop Carlos F. X. Belo (Peace, 1996) Baruj Benacerraf (Physiology/Medicine, 1980) Hans A. Bethe (Physics, 1967) Gerd K. Binnig (Physics, 1986) James W. Black (Physiology/Medicine, 1988) Guenter Blobel (Physiology/Medicine, 1999) Nicolaas Bloembergen (Physics, 1981) Norman E. Borlaug (Peace, 1970) Paul D. Boyer (Chemistry, 1997) Bertram N. Brockhouse (Physics, 1994) Herbert C. Brown (Chemistry, 1979) Georges Charpak (Physics, 1992) Claude Cohen-Tannoudji (Physics, 1997) John W. Cornforth (Chemistry, 1975) Francis H.C. Crick (Physiology/ Medicine, 1962) James W. Cronin (Physics, 1980) Paul J. Crutzen (Chemistry, 1995) Robert F. Curl (Chemistry, 1996) His Holiness The Dalai Lama (Peace, 1989) Johann Deisenhofer (Chemistry, 1988) Peter C. Doherty (Physiology/Medicine, 1996) Manfred Eigen (Chemistry, 1967)

64. Nobel For Medicine All Laureates W. Black, Gertrude B. Elion, George H. Hitchings 1987 susumu tonegawa 1986 Stanley TheNobel Prize A History of Genius, Controversy and Prestige by Burton http://www.popular-science.net/nobel/med-list.html

65. Untitled Ph.D. Dr. susumu tonegawa, of the Massachusetts Institute of Technology is the FourthAnnual CNBC Lecturer. In 1987 Dr. tonegawa received the nobel Prize in http://www2.ipcku.kansai-u.ac.jp/~ttank/04tonegawa.htm

Back to the TABLE The Fourth Annual CNBC Lecture "From Genes to Synaptic Plasticity to Spatial Memory" Susumu Tonegawa, Ph.D. Center for Learning and Memory Massachusetts Institute of Technology Friday, April 11, 1997 3:30 - 6:00 pm Auditorium 2nd Floor, Mellon Institute Reception immediately following ABSTRACT We have developed a method to create mice in which the deletion (knockout) of virtually any gene of interest is restricted to a subregion or a specific cell type in the CNS such as the pyramidal cells of the hippocampal CA1 region. We applied this technique to the gene encoding the essential subunit of all known isoforms of NMDA receptors. These mice lack the NMDAR1 gene specifically and exclusively in the CA1 pyramidal cells and only after the third postnatal week. The latter temporal restriction of the gene knockout makes it highly unlikely that any impairments observed in these knockout mice are due to a developmental abnormality. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation specifically in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial memory. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories. To investigate further the role of NMDA receptor-dependent CA1 synaptic plasticity in spatial memory, we studied in collaboration with Matthew Wilson place-specific firing of the mutant hippocampal CA1 pyramidal cells using multiple electrode recording techniques applied to freely behaving mice. We have discovered that although the CA1 pyramidal cells in the NMDAR1 knockout mice retain place-related activity, there is a significant decrease in the spatial specificity of individual place fields. We have also found a striking deficit in the coordinated firing of pairs of neurons tuned to similar spatial locations. Pairs have uncorrelated firing even if their fields overlap. These results demonstrate that NMDA receptor-mediated synaptic plasticity is necessary for the proper representation of space in the CA1 region of the hippocampus. The results also suggest that the reason why NMDAR1 knockout mice are poor in acquiring spatial memory is because the lack of NMDA receptors in the CA1 region causes a failure in the formation of refined place fields in the CA1 and its downstream regions. SUSUMU TONEGAWA, Ph.D. Dr. Susumu Tonegawa, of the Massachusetts Institute of Technology is the Fourth Annual CNBC Lecturer. In 1987 Dr. Tonegawa received the Nobel Prize in Physiology or Medicine for his work on the genetics of antibody production. In recent years, he turned his attention to neurobiology and became rapidly established as a leader in the application of new genetic techniquies for the study of the nervous system. Dr. Tonegawa received his B.S. degree in chemistry from Kyoto University in Kyoto, Japan and his doctorate in biology from the University of California, San Diego. He completed postdoctoral work at the University of California, San Diego and the Salk Institute. He continued his research at the Basel Institute for Immunology in Switzerland. Dr. Tonegawa is a professor at the Center for Cancer Research at MIT and an investigator for the Howard Hughes Medical Institute. In April of 1994, he became the Director of MIT's newly created Center for Learning and Memory. THE CENTER FOR THE NEURAL BASIS OF COGNITION ANNUAL LECTURE The annual CNBC lecture provides an opportunity for the Cognitive and Neuroscience communities in Pittsburgh to gather together to consider an important aspect of cognitive neuroscience through the work of a recognized leader of the field. The series was inaugurated in 1994 by Dr. Mortimer Mishkin. The Fourth Annual CNBC Lecture, From Genes to Synaptic Plasticity to Spatial Memory, will be given by Dr. Tonegawa in the Mellon Institute Auditorium on the 2nd Floor of Mellon Institute. The proceedings will begin at 3:30 with a brief update on the state of the Center, which will be followed by Dr.Tonegawa's lecture. The lecture will be followed by a reception from 5:00 - 6:00 pm in the auditorium lobby. The reception will give participants an opportunity to meet Dr. Tonegawa and to talk with colleagues in the cognitive and neural sciences. Faculty and students from throughout the community are welcome to attend. CENTER FOR THE NEURAL BASIS OF COGNITION (CNBC) IS A JOINT PROJECT OF CARNEGIE MELLON UNIVERSITY and the UNIVERSITY OF PITTSBURGH Back to the TABLE

66. Laureatii Premiilor Nobel ale Americii. 1986, Stanley Cohen Rita Levi Montalcini, Statele Uniteale Americii Italia. 1987, susumu tonegawa, Japonia. 1988, Sir James http://www.rotravel.com/medicine/nobel/r_laur.htm

67. Nobel Prize For Physiology Or Medicine nobel Prize for Physiology or Medicine. for their contributions to the understandingof substances that influence cell growth 1987 susumu tonegawa (Japan), for http://www.factmonster.com/ipa/A0105787.html

Huge assortment of web cameras, spycams and live surveillance products - at great prices ! Bargain.com.. Movies , videos with your favorite celebrity ! Magazines, newsletters, stories and pics from around the world! All Infoplease All Almanacs General Entertainment Sports Biographies Dictionary Encyclopedia Infoplease Home Almanacs Atlas Dictionary ... Fact Monster Kids' reference Info:Daily Fun facts Homework Center Newsletter You've got info! Help Site Map Visit related sites from: Family Education Network Arts and Entertainment Awards Nobel Prizes Nobel Prize for Physiology or Medicine For years not listed, no award was made. Emil A. von Behring (Germany), for work on serum therapy against diphtheria Sir Ronald Ross (U.K.), for work on malaria Niels R. Finsen (Denmark), for his treatment of lupus vulgaris with concentrated light rays Ivan P. Pavlov (U.S.S.R.), for work on the physiology of digestion Robert Koch (Germany), for work on tuberculosis Camillo Golgi (Italy) and (Spain), for work on structure of the nervous system Charles L. A. Laveran

68. Nobel Prizes In Medicine THE nobel PRIZE IN PHYSIOLOGY OR MEDICINE 1987 tonegawa, susumu, Japan, MassachusettsInstitute of Technology (MIT), Cambridge, MA, USA, * 1939 för hans http://felix.unife.it/Root/d-Medicine/d-The-physician/t-Nobel-prizes-medicine

Nobel prizes in Medicine

69. 100 Nobel Laureates Warn Our Planet! Physics, 1993 susumu tonegawa Physiology/Medicine, 1997 Charles H. Townes Physics,1964 Daniel T. Tsui Physics, 1998 Archbishop Source http//www.nobel.se. http://www.lovearth.net/100NobelLaureatesWarnOurPlanet.htm

100 Nobel Laureates Warn Our Planet OSLO, Norway December 7, 2001 At the Nobel Peace Prize Centennial Symposium here yesterday celebrating the 100th anniversary of the Nobel prize, 100 Nobel laureates have issued a brief but dire warning of the "profound dangers" facing the world. Their statement predicts that our security depends on immediate environmental and social reform. The following is the text of their statement: THE STATEMENT The most profound danger to world peace in the coming years will stem not from the irrational acts of states or individuals but from the legitimate demands of the world's dispossessed. Of these poor and disenfranchised, the majority live a marginal existence in equatorial climates. Global warming, not of their making but originating with the wealthy few, will affect their fragile ecologies most. Their situation will be desperate and manifestly unjust. It cannot be expected, therefore, that in all cases they will be content to await the beneficence of the rich. If then we permit the devastating power of modern weaponry to spread through this combustible human landscape, we invite a conflagration that can engulf both rich and poor. The only hope for the future lies in co-operative international action, legitimized by

70. Winners Of The Nobel Prize In Medicine Or Physiology Taken from The nobel Prize Internet Archive. 2000. 1987. susumu tonegawa for hisdiscovery of the genetic principle for generation of antibody diversity. 1986. http://www.manbir-online.com/htm3/nobel-med-list.htm

71. 100 Nobel Laureates Call For Environmental And Social Reforms The nobel PrizeWinning Signatories Zhores I. Alferov Physics, 2000 Sidney Physics,1993 susumu tonegawa Physiology/Medicine, 1987 Charles H. Townes Physics http://www.policyalternatives.ca/publications/articles/article341.html

E-mail this page to a friend Return to the main CCPA web page 100 Nobel laureates call for environmental and social reforms The statement The Nobel Prize-Winning Signatories Zhores I. Alferov Physics, 2000 Sidney Altman Chemistry, 1989 Philip W. Anderson Physics, 1977 Oscar Arias Sanchez Peace, 1987 J. George Bednorz Physics, 1987 Bishop Carlos F.X. Belo Peace, 1996 Baruj Benacerraf Physiology/Medicine, 1980 Hans A. Bethe Physics, 1967 James W. Black Physiology/Medicine, 1988 Guenter Blobel Physiology/Medicine, 1999 Nicolaas Bloembergen Physics, 1981 Norman E. Borlaug Peace, 1970 Paul D. Boyer Chemistry, 1997 Bertram N. Brockhouse Physics, 1994 Herbert C. Brown Chemistry, 1979 Georges Charpak Physics, 1992 Claude Cohen-Tannoudji Physics, 1997 John W. Cornforth Chemistry, 1975 Francis H.C. Crick Physiology/Medicine, 1962 James W. Cronin Physics, 1980 Paul J. Crutzen Chemistry, 1995 Robert F. Curl Chemistry, 1996 The Dalai Lama Peace, 1989

72. Nobel Prizes HyperCounter. nobel prizes – Microbiologi, Virologi, Genetisti, Immunologi. Milstein.1987 susumu tonegawa. 1989 J. Michael Bishop, Harold E. Varmus. http://150.217.100.14/didonline/anno-ii/microbiologia/2001-2002/Lezioni/nobel_pr

UNIVERSITÀ DEGLI STUDI DI FIRENZE DIPARTIMENTO DI SANITÀ PUBBLICA (Direttore: Prof. Nicola Comodo) Sezione di Microbiologia "Renzo Davoli" Accesso n° Nobel prizes – Microbiologi, Virologi, Genetisti, Immunologi Cliccando sull’anno o sul nome si va al sito ufficiale, dove si trovano le foto, le biografie, le motivazioni, e altro. Emil Adolf von Behring Ronald Ross Robert Koch Charles Louis Alphonse Laveran ... Stanley B. Prusiner

73. Susumu Tonegawa HHMI INVESTIGATORS / susumu tonegawa. susumu tonegawa, Ph.D. Investigator,Massachusetts Institute of Technology Biography Summary http://www.hhmi.org/research/investigators/tonegawa.html

HHMI INVESTIGATORS / Susumu Tonegawa HHMI INVESTIGATORS INTERNATIONAL RESEARCH SCHOLARS HHMI-NIH RESEARCH SCHOLARS LAB SAFETY ... HHMI HOME ALSO OF INTEREST Search PubMed The Picower Center for Learning and Memory The Tonegawa Lab in the Biology Department at MIT The Tonegawa Lab in the Department of Brain and Cognitive Sciences ... Dr. Tonegawa's Nobel Autobiography Learning and Memory in Genetically Engineered Mice Susumu Tonegawa, Ph.D. Investigator, Massachusetts Institute of Technology Biography... Summary: Susumu Tonegawa uses genetically engineered mice to investigate neural development and the molecular, cellular, and neuronal ensemble mechanisms underlying learning and memory. Our primary research interests are the molecular, cellular, and neuronal circuitry mechanisms underlying acquisition, consolidation, and retrieval of hippocampus-dependent memory in rodents. We are also interested in deciphering mechanisms underlying neural activity-dependent development of sensory systems. To study these problems, we produce conditionally engineered (i.e., spatially targeted and/or temporally regulated) mice and analyze these mice by multifaceted methods, including molecular and cellular biology, in vitro and in vivo physiology, and behavioral studies. We attempt to identify deficits at each of the multiple levels of complexity in specific brain areas or cell types and to determine which deficits underlie specific learning or memory, or developmental impairments observed in the mutants.

74. Robert T. Wong, MD, Lecture Series Robert T. Wong, MD, Lecture Series. nobel Prize Winner susumu Tonegawato Speak in March. The Robert T. Wong, MD, Lecture Series features http://www.hawaii.edu/news/kulama/990305/wonglecture.html

Robert T. Wong, MD, Lecture Series Nobel Prize Winner Susumu Tonegawa to Speak in March The Robert T. Wong, MD, Lecture Series features Nobel Prize recipient Susumu Tonegawa in three lectures March 12 and 15. Tonegawa received the 1987 Nobel Prize in physiology or medicine for his discovery of the genetic principle of generation of antibody diversity. Tonegawa is the Amgen Professor of Biology and Neuroscience and director of the Center for Learning and Memory at MIT's Center for Cancer Research. He attended the University of Kyoto and received his PhD from the University of California, San Diego. He will speak on the following dates: Friday, March 12 4:30 p.m. John A. Burns School of Medicine, Biomed B-103 on the UHM campus The topic will be 40 years of experience in scientific research in Japan, Europe and the United States. Monday, March 15 8 a.m Queen's Medical Center Kamehameha Auditorium "Molecular and Cellular Mechanisms for Learning and Memory" 12:30 p.m. Kapi`olani Medical Center, second floor auditorium. "Mechanisms for Somatic Diversification of Antibody Diversity"

75. Susumu Tonegawa: Awards Won By Susumu Tonegawa Awards of susumu tonegawa. http://www.123awards.com/artist/7250.asp

hardwork is paid in form of awards Awards of Susumu Tonegawa OTHER-NOBEL MEDICINE Enter Artist/Album Partner Sites Stardose.com RealLyrics.com OnlyHitLyrics.com Biography Search Engine ... privacy

76. Mt Time At MIT talking with MIT Professor susumu tonegawa 1987Nobel Prize in Physiology and Medicine. http://web.media.mit.edu/~reilly/tonegawa.html

talking with MIT Professor Susumu Tonegawa 1987 Nobel Prize in Physiology and Medicine

77. Datastream Latinamerica Translate this page Datastream Systems, Inc. (NASDAQ DSTM) anunció que el ganador del Premio NobelDr. susumu tonegawa fue orador en el seminario que la empresa organizó para http://www.datastream.net/latinamerica/site/noticias/togenawa.asp

Latinamerica Argentina Brasil Noticias Regionales ... Foros Datastream noticias regionales Una vez recibido su Ph.D. en biología molecular de la Universidad de California, San Diego, continuo con una capacitación posdoctoral en el Salk Institute y una práctica en el Base Institute for Immunology. En 1981, Dr. Tonegawa fue designado profesor de biología en el Massachusetts Institute of Technology (MIT) y socio del Centro para Investigación del cáncer (Center for Cancer Research). En 1994, fundó el Centro Picower para Aprendizaje y memoria MIT. Recibió varios premios: Louisa Gross Horwitz, Premio Internacional de la Fundación Gairdner, Orden de Cultura "Bunkakunsho" del Emperador de Japón, Premio a la Investigación sobre Cáncer del Bristol Myers Squibb, el Premio Albert and Mary Lasker y el Premio Nobel en 1987 en Fisiología o Medicina. Acerca de Datastream www.datastream.net/latinamerica

78. ACS :: Nobel Prize Winners The most recent Societysupported grantee to be awarded the nobel Prize (2001) is 1987Susumu tonegawa, PhD Discovered how antibodies are made by cells of the http://www.cancer.org/docroot/RES/content/RES_7_6_Nobel_Prize_Winners.asp?sitear

79. Nobel Laureates At MIT 1/3 Samuel CC Ting, professor of physics, shared the 1976 nobel Prize in physics 1/3Susumu tonegawa, professor of biology, won the 1987 prize in physiology or http://www-tech.mit.edu/V110/N43/nobel4.43n.html

Nobel laureates at MIT Nobel laureates at MIT There are 10 current or emeritus MIT faculty members who have won Nobel Prizes: 1/3 Har Gobind Khorana, a professor of biology and chemistry, won the 1968 Nobel Prize in physiology or medicine for interpreting "the genetic code and its function in protein synthesis." His work was done at the University of Wisconsin. 1/3 Salvador Luria, professor of biology, emeritus, shared the 1969 prize in physiology or medicine for discoveries concerning "the replication mechanism and the genetic structure of viruses." 1/3 Paul A. Samuelson, Institute professor of economics, emeritus, won the 1970 Nobel Memorial Prize in Economic Science for working to raise the level of scientific analysis in economic theory. He was the first American to win the award. 1/3 Samuel C. C. Ting, professor of physics, shared the 1976 Nobel Prize in physics for discovering the J particle, a heavy elemental particle of subatomic matter. 1/3 Franco Modigliani, Institute professor of economics, emeritus, won the 1985 economics prize for his "pioneering analyses of saving and of financial markets," often referred to as "life-cycle savings." 1/3 Susumu Tonegawa, professor of biology, won the 1987 prize in physiology or medicine for discovering how gene fragments combine to produce countless variations in the immune response of humans.

80. SIMR - Centenary Survey Of Nobel Laureates through the study of intact organisms. Harold E. Varmus, nobel Prizewinner 1989. 1987Susumu tonegawa - describes the basic principles of antibody synthesis. http://www.simr.org.uk/pages/nobel/time_line_9.html

Home Biotechnology Celebrity support Benefits of animal research ... Links Nobel Prize Winners in Physiology and Medicine (1980 - 1989) Alfred Bernhard Nobel Nobel Survey Index Photo: Wellcome Institute Library The Timeline "Now, more than ever, research with laboratory animals is required to bring the benefits of advances in molecular genetics, neuroscience, and other highly productive fields to clinical application through the study of intact organisms." - Harold E. Varmus, Nobel Prizewinner 1989 Baruj BENACERRAF, Jean DAUSSETT and George D. SNELL - describe histocompatibility antigens and the regulation of immunological reactions. Roger W. SPERRY, David H. HUBEL and Torsten N. WIESEL - describe the processing of visual information by the brain. Sune K. BERGSTRÖM, Bengi I. SAMUELSON and Sir John R. VANE - discover the prostaglandin group of hormone-like compounds found in all animals. Barbara McCLINTOCK - studies maize and finds chromosomes can sometimes transfer segments from one to another.

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