41. Hannah's Heart Network A professional community website that aims to act as a single business portal for all who are actively Category Science Biology Animal Mammal Human gene therapy......Fall Update. October 2002. Join us at the Macaroni Grill on December5! New Women's Support Group starting January 9! New Couple's http://www.gtherapy.co.uk/

42. Department Of Surgery, University Of Liverpool Research focusing on treatment of pancreatic cancer and acute pancreatitis using gene therapy and surgical techniques, from the Department of Surgery. http://www.liv.ac.uk/surgery/resrch.html

Department of Surgery Department Home Page Staff Research EUROPAC ... University home page RESEARCH The Department of Surgery has an extremely active research profile. Please click on a topic to find out more: Feedback: greenhaf@liv.ac.uk Last reviewed 22/1/2001.

43. Vical,cancer,cancer Research,cancer Cells,melanoma,skin Cancer,hiv,aids,gene The Develops genebased pharmaceutical products for human gene therapy. (Nasdaq VICL). http://www.vical.com/

Company Information Financials Clinical Trials Product Pipeline Company Information Financials Clinical Trials Product Pipeline ... Contact Us

44. Gene Therapy Companies / Journal Of Gene Medicine http://www.wiley.co.uk/genetherapy/clinical/

45. Applied Tissue Technologies - Home Licenses advanced core technologies for wound healing and gene therapy. Based in Wellesley Hills, MA. http://www.appliedtissue.com/

home gene therapy patents licensing contact Applied Tissue Technologies LLC licenses advanced core technologies for gene delivery. Our technologies allow delivery of genetic material to skin, bone, and other tissues with or without viral vectors. Licensee partners can use these technologies for a wide variety of applications. Our technologies represent major opportunities for improvement in the delivery of therapeutic genes. Applied Tissue Technologies LLC 70 Walnut Street Wellesley Hills, MA 02481 Telephone 781.239.8232 FAX 781.239.8248 webmaster@appliedtissue.com Last modified: October 16, 2002

46. Department Of Molecular Microbiology And Immunology ::Welcome To MMI Ph.D. degree training focusing on hostpathogen interactions, include virology, viral pathology, biodefense, cancer gene therapy, and vaccine development.  Site includes information on curriculum and faculty research. http://medschool.slu.edu/mmi

Saturday,March 22, 2003 Home Services History Labs ... Students William S. M. Wold, Ph.D. Molecular Microbiology and Immunology Take a tour of our department Tour and Introduction Welcome to Molecular Microbiology and Immunology Research in the Department of Molecular Microbiology and Immunology reflects the strength and diversity of its faculty through a unifying focus of the study of host-pathogen interactions, especially in the area of virology. Areas of interest include viral pathogenesis, immunology, molecular and cellular biology, vaccine development (discovery and clinical trials), biodefense, and cancer gene therapy. The virology program is one of the strongest in the USA, and it encompasses research on adenoviruses, flaviviruses, hepatitis B and C viruses, herpesviruses (herpes simplex virus, Varicella Zoster virus), HIV, and poxviruses (including model studies for smallpox). Other research addresses parasites (T. cruzi), fungi, cell cycle regulation, programmed cell death (apoptosis), and the role of mitochondrial mutations in disease. MMI Key Features The Department has state-of-the-art laboratories located in a research and teaching complex together with other basic science departments in the School of Medicine.

47. Fact Sheet 7.18 Date reviewed 6/7/2000. Questions and Answers About gene therapy. Flaws in genescan result in disease. What is gene therapy and what are its objectives? http://cis.nci.nih.gov/fact/7_18.htm

Cancer Facts CIS Home Cancer.gov Dictionary Search Date reviewed: 6/7/2000 Questions and Answers About Gene Therapy What are genes Genes are the biological units of heredity. Genes determine obvious traits, such as hair and eye color, as well as more subtle characteristics, such as the ability of the blood to carry oxygen. Complex traits, such as physical strength, may be shaped by the interaction of a number of different genes along with environmental influences. A gene is part of a deoxyribonucleic acid DNA molecule . Humans have between 50,000 and 100,000 genes. Genes carry instructions that allow the cells to produce specific proteins such as enzymes . Only certain genes in a cell are active at any given moment. As cells mature, many genes become permanently inactive. The pattern of active and inactive genes in a cell and the resulting protein composition determine what kind of cell it is and what it can and cannot do. Flaws in genes can result in disease. What is gene therapy and what are its objectives? Advances in understanding and manipulating genes have set the stage for scientists to alter patients' genetic material to fight or prevent disease. Gene therapy is an experimental medical intervention that involves modifying the genetic material of living cells to fight disease.

48. Human Endothelial Cells For Biomedical Research Endothelial cells for biomedical research in cell adhesion, angiogenesis, gene therapy, and drug targeting. http://www.endothelial-cells.com

Endothelial Cells used in Dynamic Flow Assay Visit GlycoTech Website for Glycobiology Research Endothelial Cells Description and Pricing Human Endothelial Cells for Research Studies in Cell Adhesion Angiogenesis Gene Therapy Drug Targeting 14915 Broschart Road, Suite 200, Rockville, MD 20850 301-738-1080, FAX 301-738-1077 1-800-Glycotk ( 459-2685 ) Contact Us: Research Alliances Questions about Products

49. Terms And Definitions: A - E - Office Of Rare Diseases Technical terms and definitions developed from glossaries prepared by or found in US Congress' Office of Technology Assessment, NIH's Understanding gene therapy Online Glossary , and Genetics Education Center, University of Kansas Medical Center. http://rarediseases.info.nih.gov/glossary_a-e.html

Office of Rare Diseases Skip Navigation Links These terms and their definitions have been developed from glossaries prepared by (1) U.S. Congressional Office of Technology Assessment, (2) National Institutes of Health's Understanding Gene Therapy On-line Glossary, and (3) Genetics Education Center, University of Kansas Medical Center. To find a term in this glossary, select a letter (the first letter of the word you are seeking) or browse the complete glossary. Letters in lower case have no entries. Acronyms not appearing in the glossary, may be included in the List of Acronyms at the end of the glossary. A B C D ... H j K L M N ... P q R S T U ... Z A Acquired mutations Gene changes that arise within individual cells and accumulate throughout a person's lifetime; also called somatic mutations. (See hereditary mutation.) Adenine (A) A nitrogenous base, one member of the base pair A-T (adenine-thymine). Advanced maternal age Women over age 34 (age 35 at delivery) at increased risk for genetic changes in fetus. Alleles Variant forms of the same gene. Different alleles produce variations in inherited characteristics such as eye color or blood type.

50. Human Gene Therapy Human gene therapy. Some commentators on gene therapy have objected to any formof genetic manipulation, no matter how wellintentioned (VII, Rifkin 1983). http://www.georgetown.edu/research/nrcbl/scopenotes/sn24.html

SCOPE NOTE National Reference Center for Bioethics Literature The Joseph and Rose Kennedy Institute of Ethics Georgetown University Washington, DC 20057-1212 800-MED-ETHX; 202-687-3885; fax: 202-687-6770 e-mail: bioethics@georgetown.edu http://bioethics.georgetown.edu Human Gene Therapy Table of Contents I. Background II. Organizational Statements/Policies III. General IV. Philosophical Aspects ... VII. Additional Readings - 2001 Last Updated March, 2002 I. Background On September 14, 1990 researchers at the U.S. National Institutes of Health performed the first (approved) gene therapy procedure on four-year old Ashanti DeSilva. Born with a rare genetic disease called severe combined immune deficiency (SCID), she lacked a healthy immune system, and was vulnerable to every passing germ. Children with this illness usually develop overwhelming infections and rarely survive to adulthood; a common childhood illness like chickenpox is life-threatening. Ashanti led a cloistered existenceavoiding contact with people outside her family, remaining in the sterile environment of her home, and battling frequent illnesses with massive amounts of antibiotics. In Ashanti's gene therapy procedure, doctors removed white blood cells from the child's body, let the cells grow in the lab, inserted the missing gene into the cells, and then infused the genetically modified blood cells back into the patient's bloodstream. Laboratory tests have shown that the therapy strengthened Ashanti's immune system; she no longer has recurrent colds, she has been allowed to attend school, and she was immunized against whooping cough. This procedure was not a cure; the white blood cells treated genetically only work for a few months, and the process must be repeated every few months.

51. Ingenta Select Human gene therapy. Human gene therapy is available online via IngentaSelect. There are currently 77 issues available for viewing. http://www.catchword.com/titles/10430342.htm

Human Gene Therapy Human Gene Therapy is available online via Ingenta Select. There are currently 77 issues available for viewing. You can browse the contents pages of online issues free of charge. Please note that, in order to view the full text of online articles, you will need to follow the steps below. Accessing Full Text Documents If you, or your institution, have an online subscription to Human Gene Therapy then please browse the volumes and issues available To enable online subscriptions you need to quote your CatchWord Identification number ("CID") to your Subscription Agent or to the Publisher. If you do not have a CID, please register online The Current Issue is always free The Mar 1st 2003 issue is available free of charge. Table of Contents Alerting Service If you would like to receive an email notification of the Table of Contents for each new online issue of Human Gene Therapy please enter your email address below: E-mail address:

52. Index Of / Offers MIDGE and other innovative DNA expression vectors for molecular biology, gene therapy and genetic vaccination. Product properties are discussed. http://www.readyvector.com/

Index of / Name Last modified Size Description GeneratedItems/ 09-Dec-2002 14:25 1K MIDGERV/ 09-Dec-2002 14:23 1K abstracts/ 09-Dec-2002 14:24 1K adv/ 09-Dec-2002 14:24 1K bin/ 05-Dec-2002 10:45 1K cgi-bin/ 09-Dec-2002 14:24 1K contact.html 09-Dec-2002 14:24 3K downloads/ 09-Dec-2002 14:25 1K imgs/ 09-Dec-2002 14:20 1K index.htm 09-Dec-2002 14:23 8K index1.html 09-Dec-2002 14:22 8K index2.html 09-Dec-2002 14:22 3K index3.html 09-Dec-2002 14:22 2K index4.html 09-Dec-2002 14:22 2K index5.html 09-Dec-2002 14:22 2K mailinglist.html 09-Dec-2002 14:22 1K nav/ 09-Dec-2002 14:22 1K 09-Dec-2002 14:25 1K 09-Dec-2002 14:25 1K order/ 09-Dec-2002 14:26 1K pix.gif

53. Report And Recommendations Of The Panel To Assess The NIH Investment In Research REPORT AND RECOMMENDATIONS OF THE PANEL TO ASSESS THE NIH INVESTMENT IN RESEARCHON gene therapy. The rationale for gene therapy of human disease. http://www.nih.gov/news/panelrep.html

REPORT AND RECOMMENDATIONS OF THE PANEL TO ASSESS THE NIH INVESTMENT IN RESEARCH ON GENE THERAPY Stuart H. Orkin, M.D. Arno G. Motulsky, M.D. Co-chairs December 7, 1995 Executive Summary of Findings and Recommendations Dr. Harold Varmus, Director, National Institutes of Health (NIH), appointed an ad hoc committee to assess the current status and promise of gene therapy and provide recommendations regarding future NIH-sponsored research in this area. The Panel was asked specifically to comment on how funds and efforts should be distributed among various research areas and what funding mechanisms would be most effective in meeting research goals. The Panel finds that 1. Somatic gene therapy is a logical and natural progression in the application of fundamental biomedical science to medicine and offers extraordinary potential, in the long-term, for the management and correction of human disease, including inherited and acquired disorders, cancer, and AIDS. The concept that gene transfer might be used to treat disease is founded on the remarkable advances of the past two decades in recombinant DNA technology. The types of diseases under consideration for gene therapy are diverse; hence, many different treatment strategies are being investigated, each with its own set of scientific and clinical challenges. 2. While the expectations and the promise of gene therapy are great, clinical efficacy has not been definitively demonstrated at this time in any gene therapy protocol, despite anecdotal claims of successful therapy and the initiation of more than 100 Recombinant DNA Advisory Committee (RAC)-approved protocols.

54. Gene Therapy / Gene Transfer - Bioethics Resources On The Web - NIH Genetics. gene therapy / Gene Transfer. University of Pennsylvania Institutefor Human gene therapy conducts clinical research in gene therapy. http://www.nih.gov/sigs/bioethics/genengineering.html

Directory Genetics Gene Therapy / Gene Transfer NIH's Office of Biotechnology Activities (OBA) - monitors scientific progress in human genetics research in order to anticipate future developments, including ethical, legal, and social concerns, in basic and clinical research involving Recombinant DNA. It also manages the operation of, and provides analytical support to, the NIH Recombinant DNA Advisory Committee. Catalog of NIH Guidelines on Recombinant DNA and Gene Transfer - provided by the NIH's Office of Biotechnology Activities (see above) University of Pennsylvania Institute for Human Gene Therapy - conducts clinical research in gene therapy. Their website provides fact sheets on gene therapy, links to online resources, information of seminars, events, and training opportunities, and recent news. NIH Home Page NIH Scientific Resources NIH Health Information Last updated: 7/25/02 10:30 AM

55. Zentrum Für Innere Medizin, Medizinische Klinik I gene therapy research program in colon, lung and bladder cancer are being conducted by the laboratory of Dr. Andreas Block. http://www.uke.uni-hamburg.de/Clinics/InternalMed/Kernklinik/Pages/block/bl_intr

Direktor: Prof. Dr. Heiner Greten Tel.: (040) 428 03-3910 Fax (040) 48 30 65 greten@uke.uni-hamburg.de Prof. Dr. D. Ameis Prof. Dr. F.U. Beil Prof. Dr. G. Kreymann Prof. Dr. A. Pforte PD Dr. H.-J. Stellbrink PD Dr. A. de Weerth Die Medizinische Klinik I ist mit sieben Stationen Forschungsschwerpunkte Fachgebiete Medizinische Poliklinik mit Spezialambulanzen Neu: Elektronische Ressourcen Aktuell: Doktorarbeiten ZAD-Richtfest am 11.04.2002 Home Mail ... Suche

56. Pharmaceutical Company Devoted to the needs in oncology, hematology, and neurology this French producer is focused on biotechnology, gene therapy, and cell therapy. Site provides product information and introduces the visitor to the company background. http://www.otl-pharma.com

Otl-Pharma conforms to the HON Code of Conduct for Medical web Sites Otl-Pharma conforms to the HON Code of Conduct for Medical web Sites

57. Online NewsHour -- Genetic Research gene therapy trials come under fire for underreporting harmful side effects.(2/2/00) Susan Dentzer explores the growing controversy over gene therapy. http://www.pbs.org/newshour/bb/health/july-dec99/gene_therapy_splash.htm

Gene therapy trials come under fire for underreporting harmful side effects. (2/2/00) Susan Dentzer explores the growing controversy over gene therapy. (12/8/99) A timeline of important moments in the history of gene therapy. David Lunneborg describes his experience with gene therapy as a patient at the Mayo Clinic. Paul Gelsinger talks about his son's death while undergoing gene therapy for a rare metabolic disorder. Preeminent researcher Dr. W. French Anderson talks about the early stages and risks of gene therapy Abby Meyers, a patient advocate for people with rare diseases, talks about gene therapy trials. A conversation with Matt Ridley , author of Genome: The Autobiography Of A Species In 23 Chapters FORUM: Matt Ridley answers your questions NewsHour Extra What is the genome and what do we do with it? The Human Genome Sequence, by NCBI

58. Transgene Discovers and develops gene therapy technologies and products for the treatment of acquired or inherited diseases for which there is no cure or adequate therapy at present. (Nasdaq TRGNY). http://www.transgene.fr/

English version TRANSGENE S.A. 11, r ue de Molsheim 67082 STRASBOURG Cedex - FRANCE Tel : 33 (0)3 88 27 91 00 Fax : 33 (0)3 88 27 91 11 Version Française

59. Virus Vectors & Gene Therapy Virus Vectors and gene therapy A review by David Peel, University of Leicester. VirusVectors gene therapy Problems, Promises Prospects. David Peel. http://www-micro.msb.le.ac.uk/335/peel/peel1.html

Search David Peel MBChB Special Study Module Project Report University of Leicester. Introduction: Viruses as Vectors Retrovirus Vectors Adenovirus Vectors Adeno-Associated Virus ... Electronics Search for ... (keywords): Search for ... (keywords): Bestsellers Music DVDs Videos ... Electronics Introduction: Snyder et al, 1997 ), whereby the functional form of the gene would be added to the cell restoring it to a normal phenotype. However, research is underway to treat monogenic dominantly inherited diseases such as hypercholesteroleamia ( ). Regulation of cellular proliferation e.g. to prevent atherosclerosis following angioplasty ( Kim et al, 1997 ), or to promote of cellular repair following trauma to the CNS ( Federoff et al, 1992 ) are also currently being investigated. Viruses as Vectors: ^TOP^ Next Section University of Leicester

60. Gene Therapy Website The gene therapy Program is located in the Department of Medicine and affiliated with the Stanley S. Scott Cancer Center and the Center for Human and Molecular Genetics at Louisiana State University Health Sciences Center at New Orleans. The major aim of the LSUHSC gene therapy Program is to develop new therapies for a series of genetic and acquired diseases including Cystic Fibrosis, Hemophilia, Krabbes Disease and infectious diseases such as AIDS, TB, and pneumonia. http://www.medschool.lsumc.edu/GeneTherapy/Default.htm

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