Geometry.Net - Health_Conditions: Creutzfeldt Jakob Disease

UK Creutzfeldt-Jakob Disease Surveillance Unit
Summarizes the research in progress at the CJD unit and also provides background information about Category Health Conditions and Diseases creutzfeldt jakob diseaseThe UK CreutzfeldtJakob Disease Surveillance Unit. The incidence of Creutzfeldt availableon the Web. Creutzfeldt-Jakob Disease Surveillance.
http://www.cjd.ed.ac.uk/

Extractions: The UK Creutzfeldt-Jakob Disease Surveillance Unit The incidence of Creutzfeldt-Jakob disease (CJD) is monitored in the UK by the CJD surveillance unit based at the Western General Hospital in Edinburgh, Scotland. The unit brings together a team of clinical neurologists, neuropathologists and scientists specialising in the investigation of this disease. This document is intended to summarise the research in progress at the CJD unit and also provide some background information about CJD and other human spongiform encephalopathies. We have also provided some links to other resources and contrary points of view available on the Web. Figures for the number of confirmed cases of the new variant of CJD and referrals of suspected cases of CJD to the surveillance unit over the last twelve years. NCJDSU protocol for CJD surveillance across the UK. Text and figures of the latest annual report of the CJD unit (published 9th July 2002). Reporting CJD cases to public health departments - guidance document Potential treatments for Creutzfeldt-Jakob disease.
Bovine Spongiform Encephalopathy: Main Index, CDC
of Health investigate a likely case of variant creutzfeldt jakob disease in a U.K. citizen residing in the U.S. April
http://www.cdc.gov/ncidod/diseases/cjd/cjd.htm

Extractions: Since 1996, evidence has been increasing for a causal relationship between ongoing outbreaks in Europe of a disease in cattle, called bovine spongiform encephalopathy (BSE, or "mad cow disease"), and a disease in humans, called variant Creutzfeldt-Jakob disease (vCJD). Both disorders are invariably fatal brain diseases with unusually long incubation periods measured in years, and are caused by an unconventional transmissible agent. BSE has not been detected in the United States, despite active surveillance efforts since May 1990. It is extremely unlikely that BSE would be a foodborne hazard in this country. CDC monitors the trends and current incidence of CJD in the United States, while the U.S. Department of Agriculture has conducted active surveillance efforts for BSE since May 1990.
The Many Faces Of CJD
Factsheet, latest news and families'/CJD victims' personal stories and tributes.
http://www.fortunecity.com/healthclub/cpr/798/cjd.htm

Extractions: Creutzfeldt-Jakob Disease (CJD) is a horrendous infectious rapidly progressive fatal brain-deteriorating disease for which there is no treatment or cure. One strain, nvCJD, is linked to bovine spongiform encephalopathy (i.e. Mad Cow Disease) in Great Britain. CJD often escapes detection. A common misdiagnosis is Alzheimer's Disease. The personal stories on this website put a face on CJD. The stories are written by teenagers and adults. Most of the stories tell of people who have died of CJD or currently have CJD. These stories describe the symptoms and progression of the disease as well as the problems in getting it correctly diagnosed. Other stories tell what it is like to receive a notice that the blood products your child received as a baby have been recalled from the market due to the theoretical risk of Creutzfeldt-Jakob Disease. While the risk may be theoretical, the anxiety that results from receiving such a notice is very real and changes one's life forever.
NINDS Creutzfeldt-Jakob Disease Information Page
CJD information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke.
http://www.ninds.nih.gov/health_and_medical/disorders/cjd.htm

Extractions: Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder. Typically, onset of symptoms occurs at about age 60.. There are three major categories of CJD: sporadic CJD, hereditary CJD, and acquired CJD. There is currently no single diagnostic test for CJD. The first concern is to rule out treatable forms of dementia such as encephalitis or chronic meningitis. The only way to confirm a diagnosis of CJD is by brain biopsy or autopsy. In a brain biopsy, a neurosurgeon removes a small piece of tissue from the patient's brain so that is can be examined by a neurologist. Because a correct diagnosis of CJD does not help the patient, a brain biopsy is discouraged unless it is need to rule out a treatable disorder. While CJD can be transmitted to other people, the risk of this happening is extremely small.
EMERGENCY CONTRACEPTION
World Health Organization factsheet on CJD. Includes brief history, different forms of the disease, clinical features, diagnosis, epidemiology, CJD/BSE link and WHO involvement.
http://www.who.int/inf-fs/en/fact180.html

Extractions: Fact Sheet N° 180 VARIANT CREUTZFELDT-JAKOB DISEASE (vCJD) To find the new version of this fact sheet please see http://www.who.int/mediacentre/factsheets/fs180/en/ For further information, journalists can contact the Spokespersons Office, WHO, Geneva. Telephone (+41 22) 791 2599. Fax (+41 22) 791 4858. E-mail: inf@who.int All WHO Press Releases, Fact Sheets and Features can be obtained on Internet on the WHO home page: www.who.int Press Releases 2001 Press Releases 2002
Blood Recall/Withdrawal - Creutzfeldt-Jakob Disease (CJD)
Details of the BloodCJD international e-mail support group for blood product withdrawal notification recipients due to the theoretical risk of CJD.
http://members.aol.com/debbieoney/blood.htm

Extractions: Margaret Mead Welcome to the Blood Recall/Withdrawal - Creutzfeldt-Jakob Disease (CJD) website. This website was created to fill the needs of people who have received notices that the blood products that they, or their children, received, or that were used in the In Vitro Fertilization (IVF) cultures that produced their children, were recalled/withdrawn from the market because a member of the donor pool was diagnosed with Creutzfeldt-Jakob Disease (CJD) or was at risk for the disease. CJD is an infectious rapidly progressive fatal brain-deteriorating disease for which there is no treatment or cure. It is a member of the class of diseases called Transmissible Spongiform Encephalopathies (TSEs). Another TSE is Bovine Spongiform Encephalopathy (i.e. Mad Cow Disease) which is found in England . The jury is still not in on whether CJD is transmitted through blood. The risk is said to be theoretical. There have been no documented cases of such transmission in humans. However, the CJD infectious agent has been found in blood. People who have received blood recall/withdrawal notifications can still donate blood.
Please Help Fight Creutzfeldt-Jakob Disease
Personal stories of CJD and virtual memorials. Links to information and research related to CJD.
http://www.angelfire.com/nc/NATURAL1/PAGE2.html
Without A Title - F02.1 Dementia In Creutzfeldt Jakob Disease
Article on CJD. Clinical description and diagnostic guidelines; diagnostic criteria for research.
http://www.informatik.fh-luebeck.de/icd/icdchVF-F02.1.html

Extractions: Categories Chapter Index A-Z All pages ... Forum A progressive dementia with extensive neurological signs, due to specific neuropathological changes (subacute spongiform encephalopathy) that are presumed to be caused by a transmissible agent. Onset is usually in middle or later life, typically in the fifth decade, but may be at any adult age. The course is subacute, leading to death within 1-2 years. Diagnostic guidelines Creutzfeldt-Jakob disease should be suspected in all cases of a dementia that progresses fairly rapidly over months to 1 or 2 years and that is accompanied or followed by multiple neurological symptoms. In some cases, such as the so called amyotrophic form, the neurological signs may precede the onset of the dementia. There is usually a progressive spastic paralysis of the limbs, accompanied by extrapyramidal signs with tremor, rigidity, and choreoathetoid movements. Other variants may include ataxia, visual failure, or muscle fibrillation and atrophy of the upper motor neuron type. The triad consisting of rapidly progressing, devastating dementia
CREUTZFELDT JAKOB DISEASE FACT SHEET 1/1998
of CJD, who gets it, symptoms, CJD and the internet, plus a resource list.
http://www.kansas.net/~cbaslock/cjd1.html

Extractions: CREUTZFELDT-JAKOB DISEASE FACT SHEET 1/1998 BY DEBORAH ONEY, MASTER OF SOCIAL WORK CO-FOUNDER, BLOOD RECALL/WITHDRAWAL - CJD Creutzfeldt-Jakob Disease (CJD) is an infectious rapidly progressive fatal brain-deteriorating disease for which there is no treatment or cure. Most scientists believe CJD is caused by a prion, which is a protein. People in the United States and throughout the world get CJD. One strain nvCJD is thought to be related to bovine spongiform encephalopathy (i.e. Mad Cow Disease) in the United Kingdom. To date no nvCJD cases have been observed in the United States. Normal sterilization procedures do not inactivate the CJD infectious agent. The incubation period varies greatly with symptoms emerging in known cases in 15 months to 30 years after exposure. There is no preclinical test to determine if infection took place after a possible exposure. WHO GETS CJD AND HOW? CJD most frequently appears in people ages 50-75. However, there are victims in their 40s, 30s and even 20s. The officially stated mortality rate of about one person per million per year appears to be an under statement since CJD often escapes detection. In a Yale University study 13% of clinically-diagnosed Alzheimer patients were found on autopsy to have CJD. There are three forms of CJD: familial (about 5-10% of cases), sporadic (cause unknown, about 90-95%) and iatrogenic (caused by a medical procedure such as contaminated cadaver-derived growth hormones, dura mater implants, and cornea transplants, less than 1%). Athletes who use cadaver-derived growth hormones are at risk for CJD.
Creutzfeldt-Jakob Disease
Contacts, links and information about CJD from Family Village.
http://www.familyvillage.wisc.edu/lib_cjd.htm

Extractions: Website: http://members.aol.com/crjakob/index.html This foundation was created on April 7, 1993, by two families who had each lost a relative to CJD, and the neurologist who treated the CJD patients. It seeks to promote the research, education and awareness of CJD, as well as to reach out to people who have lost loved ones to this illness. Creutzfeldt-Jakob Disease: Answers to Common Questions
Tufts Neurology: Creutzfeldt-Jakob Disease And Other Prion Diseases
Image of brain biopsy specimen of patient with CJD, and links to relevant articles.
http://tuftsneurology.org/webres/prion.htm

Extractions: showing intracytoplasmic vacuoles containing fragments and loops of membranes (arrow). (Cresyl violet, x300) N Engl Med 1998 Dec 31;339(27):1994-2004 MEDLINE Medical Progress: Creutzfeldt-Jakob Disease and Related Transmissible Spongiform Encephalopathies .N Engl J Med 1998 Dec 31;339(27):1994-2004.Johnson RT, Gibbs CJJ Jr. Dr. Johnson at Meyer 6-181, Johns Hopkins Hospital, Baltimore, MD 21287. The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies . N Engl J Med 1996 Sep 26;335(13):924-30 Hsich G, Kenney K, Gibbs CJ, Lee KH, Harrington MG. Laboratory of Central Nervous System Studies, National Institutes of Health, Bethesda, MD 20892-4122, USA. Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene . Nature 1996 Apr 11;380(6574):528-31. Sakaguchi S, Katamine S, Nishida N, Moriuchi R, Shigematsu K, Sugimoto T, Nakatani A, Kataoka Y, Houtani T, Shirabe S, Okada H, Hasegawa S, Miyamoto T, Noda T. Department of Bacteriology, Nagasaki University School of Medicine, Nagasaki, Japan. Altered circadian activity rhythms and sleep in mice devoid of prion protein.
Infectious Disease News: Spiroplasma May Cause Creutzfeldt-Jakob Disease
Interview with Frank O. Bastian MD.
http://www.slackinc.com/general/idn/199606/cjd.htm

Extractions: [Search] Spiroplasma may cause Creutzfeldt-Jakob Disease Frank O. Bastian, MD, is professor of pathology and director of neuropathology at the University of South Alabama, Mobile. He has published numerous research articles relating to the etiology of Creutzfeldt-Jakob Disease. In 1991, Bastian edited a book entitled Creutzfeldt-Jakob Disease and Other Transmissible Spongiform Encephalopathies (Mosby-Year Book). In 1992, Bastian arranged an international symposium on bovine spongiform encephalopathy (BSE), popularly referred to as mad-cow disease. [What is Creutzfeldt-Jakob Disease (CJD?)] [How did you connect spiroplasmas with CJD?] ... [Your turn] June 1996 Electron microscopic study of brain biopsy from a patient with CJD showed coiled membranous structure in neuronal process. This structure closely resembles spiroplasma morphology. CJD is a transmissible disease characterized by spongy degeneration of the brain. It strikes about one in 1 million people annually. About 5% of CJD cases occur in families or among certain ethnic groups. The disease has been transmitted inadvertently during medical treatment and surgical procedures. CJD has been transmitted by administration of growth hormone derived from the pituitary glands of people who died from CJD. The disease also has been transmitted by transplantation of corneas and dura tissue obtained from people who died from CJD. CJD has been transmitted experimentally to monkeys by oral feeding of contaminated tissue and to lab animals by infusion of white cells.
CJDVoice.org Support - Education - News Updates - Chat
find help, support, understanding and information concerning creutzfeldt jakob disease, CJD.
http://members.aol.com/larmstr853/cjdvoice/cjdvoice.htm
CJD Foundation, Inc. On The World Wide Web
Information about CJD, interactive pages, profiles, polls and details of conferences.Category Health Conditions and Diseases creutzfeldt jakob diseaseCreutzfeldtJakob Disease Foundation, Inc. The Foundation has moved. Our newwebsite address is cjdfoundation.org. Please update your bookmarks!
http://members.aol.com/crjakob/
Document Link
Article and links about Japanese research findings.
http://aepo-xdv-www.epo.cdc.gov/wonder/PrevGuid/m0049829/m0049829.htm
CJD/BSE Guidance Documents
May 2001 Guidance on local reporting of creutzfeldt jakob disease (CJD) and localaction by Consultants in Communicable Disease Control (CsCDC) This document
http://www.doh.gov.uk/cjd/cjdguidance.htm
Australian CJD Support Group Network Inc - CJDSGNI - Creutzfeldt-Jakob Disease S
Australian CJD Support Group Network Inc CJDSGNI - Creutzfeldt-Jakobdisease support website. creutzfeldt jakob disease - an Overview.
http://www.cjdsupport.org.au/cjdoverv.htm

Extractions: Creutzfeldt Jakob Disease - an Overview text courtesy of Jennifer Cooke From the jungles of Papua New Guinea in the 1950s, through Australian fertility clinics, to the butcher shops of Britain in the 1990s, a creeping epidemic has claimed the lives of thousands of men, women and children. The Eastern Highlanders of PNG called it kuru - the shivering disease In the West, we know it as Creutzfeldt-Jakob disease (CJD). To the world's media, it is now notorious as mad cow disease. All three are among a group of rare human and animal diseases that induce neurological disaster - microscopic holes in the brain, sticky plaques of protein that prevent vital messages between nerve cells - and a plethora of symptoms including staggering, jerking, memory loss, personality change and dementia. Collectively, they are known as transmissible spongiform encephalopathies, or TSE. Their incidence in humans, sheep farmed mink, deer and elk and, more recently, in cows, cats and zoo animals, has created a global jigsaw for which the pieces are only gradually coming together. Several theories about the elusive cause of TSE remain just that - despite two Nobel prizes among the elite group of scientists and researchers battling to identify the diseases' source. The biggest TSE killer in humans is CJD, first identified in the 1920s by German neuropsychiatrists Hans Creutzfeldt and Alfons Jakob. Since then, painstaking detective work by scientists in the United States, Europe and Japan has followed the zigzag course of the disease.
Creutzfeldt-Jakob Disease/Prion Diseases
Public Health Links. creutzfeldt jakob disease. General Health Links. MiscellaneousLinks. Articles Written by Donna Alden. CreutzfeldtJakob Disease/Prion Diseases.
http://imanurse.tripod.com/bse.html
Document Link
Article and links about Japanese research findings.Category Health Conditions and Diseases creutzfeldt jakob diseaseThe document you requested, m0049829.htm, is now m0049829.asp.
http://wonder.cdc.gov/wonder/PrevGuid/m0049829/m0049829.htm
ScienceNet - Biology & Medical Science - What Is Creutzfeldt Jakob Disease And W
What is creutzfeldt jakob disease and what causes it. What are the symptoms? WhoCan Be Stricken By CreutzfeldtJakob Disease? Creutzfeldt
http://www.sciencenet.org.uk/database/Biology/0106/b00972d.html

Extractions: Creutzfeldt-Jakob Disease ("CJD") is a rare, fatal brain disorder which causes a rapid, progressive dementia and associated neuromuscular disturbances. The disease is often referred to as a subacute spongiform encephalopathy because it usually produces microscopic vacuoles in neurons that appear "sponge-like". Scientists recognise that a transmissible agent is responsible for causing Creutzfeldt-Jakob Disease, as shown by experiments involving the injection of CJD-affected brains into the normal brains of healthy animals. The identification of this transmissible agent has been the subject of much scientific inquiry and debate.

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