Geometry.Net - Health_Conditions: Familial Hypercholesterolemia


Home - Health_Conditions - Familial Hypercholesterolemia

e99.com Bookstore

Images

Newsgroups

61-80 of 90 Back | 1 | 2 | 3 | 4 | 5 | Next 20

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Familial Hypercholesterolemia: more detail

Screening of APOB gene mutations in subjects with clinical diagnosis of familial hypercholesterolemia.: An article from: Human Biology by Erardo Merino-Ibarra, Sergio Castillo, et all 2005-10-01

Familial hypercholesterolemia: genetic predisposition to atherosclerosis.(Advanced Practice): An article from: MedSurg Nursing by Mary B. Engler, 2004-08-01

Statin reverses atherogenesis in highest-risk children: familial hypercholesterolemia.: An article from: Pediatric News by Bruce Jancin, 2004-02-01

Familial Hypercholesterolemia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications, 2004-10-01

Ultrasound Measurement of Intima-media Thickness and Atherosclerotic Plaques in Carotid and Femoral Arteries (Methodological Studies & a Five-year Observational Study in Familial Hypercholesterolemia)

Statin reverses atherogenesis in highest-risk kids familial hypercholesterolemia.(Children's Health): An article from: Family Practice News by Bruce Jancin, 2004-02-01

Familial hypercholesterolemia and other disorders of lipoprotein metabolism (Medical Grand Rounds) by Joseph L Goldstein, 1979

A familial-racial analysis of serum cholesterol and triglyceride levels by Jess David Curb, 1973

Lowering plasma cholesterol by raising LDL receptors (Medical Grand Rounds) by Michael S Brown, 1981

lists with details

Health Library Find Information On Familial Hypercholesterolemia
Find information on familial hypercholesterolemia at MerckSource. Learnmore familial hypercholesterolemia. Definition A dominantly
http://www.mercksource.com/pp/us/cns/cns_hl_adam.jspzQzpgzEzzSzppdocszSzuszSzcns
EMedicine - Hypercholesterolemia, Familial : Article By Elena Citkowitz, MD, PhD
Hypercholesterolemia, Familial familial hypercholesterolemia (FH) is an autosomaldominant disorder that causes severe elevations in total cholesterol and low
http://www.emedicine.com/MED/topic1072.htm

Extractions: (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Endocrinology Last Updated: October 30, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: FH, heterozygous familial hypercholesterolemia, homozygous familial hypercholesterolemia, monozygous hypercholesterolemia AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Elena Citkowitz, MD, PhD, FACP , Director of Cholesterol Management Center, St Raphael Physicians, Inc, Associate Clinical Professor of Internal Medicine, Department of Internal Medicine, Hospital of St Raphael, Yale University School of Medicine Elena Citkowitz, MD, PhD, FACP, is a member of the following medical societies: American College of Physicians American Heart Association , and Sigma Xi Editor(s): Gregory William Rutecki, MD
Cholesterol
familial hypercholesterolemia. familial hypercholesterolemia is a monogenicdisorder caused by LDL receptor dysfunction. Inheritance
http://aci.mta.ca/Courses/Biochemistry/BC4511B-Lipid/Corey/chol7.htm

Extractions: Familial hypercholesterolemia is a monogenic disorder caused by LDL receptor dysfunction. Inheritance is an autosomal dominant trait with a gene dosage effect, this means that homozygotes are more severely affected than heterozygotes. Heterozygotes are found in one in every 500 people, while homozygotes are 1 per million. What happens is that LDL levels become increasingly high due to the disfunction or complete lack of the LDL receptor. Cholesterol then begins to deposit in abnormal sites, particularly arteries. In homozygotes, death usually occurs before the age of 15, caused by heart attacks. It is less severe in heterozygotes, men will have a 75% chance of experiencing a heart attack before age 60, as opposed to 15% in normal men. Female risk is 45%, as opposed to 10% in normal women. [back]
Health Ency.: Disease: Familial Hypercholesterolemia
familial hypercholesterolemia See images.
http://www.austin360.com/shared/health/adam/ency/article/000392trt.html

Extractions: Important notice Ency. home Disease F Familial hypercholesterolemia See images Overview Symptoms Treatment ... Prevention Alternative names: Type II hyperlipoproteinemia; Hypercholesterolemic xanthomatosis; Low density lipoprotein receptor mutation Treatment The goal of treatment is to reduce the risk of atherosclerotic heart disease and resulting myocardial infarction heart attack Diet modification is the initial phase of treatment and is tried for several months before drug therapy is added. Diet modifications include reducing total fat intake to less than 30% of the total calories consumed. Saturated fat intake is reduced by decreasing the amounts of beef, pork, and lamb; substituting low-fat dairy products; and eliminating coconut and palm oil. Cholesterol intake is reduced by eliminating egg yolks, organ meats and sources of animal-derived saturated fat. Further reductions in the percentage of fat in the diet may be recommended after the initial trial period. Dietary counseling is often recommended to assist people with these adjustments to their eating habits.
Health Ency.: Disease: Familial Hypercholesterolemia
familial hypercholesterolemia See images. Symptoms. a strong family historyof familial hypercholesterolemia or early myocardial infarction;
http://www.austin360.com/shared/health/adam/ency/article/000392sym.html

Extractions: Important notice Ency. home Disease F Familial hypercholesterolemia See images Overview Symptoms Treatment ... Prevention Alternative names: Type II hyperlipoproteinemia; Hypercholesterolemic xanthomatosis; Low density lipoprotein receptor mutation Symptoms Signs and Tests A physical examination may reveal xanthomas, xanthelasmas and cholesterol-laden deposits called a corneal arcus. Laboratory testing may show: elevated triglycerides protein electrophoresis may show abnormal results total plasma cholesterol that is greater than 300 mg/cc (adult) total plasma cholesterol that is greater than 250 mg/cc (children) serum LDL that is higher than 200 studies of heart function, such as a stress test, may be abnormal
Mathews/van Holde/Ahern 3rd Edition
familial hypercholesterolemia (FH) familial hypercholesterolemia (FH) isa hereditary disease. INTERNET LINK familial hypercholesterolemia.
http://www.awlonline.com/mathews/ch18/c18fh.htm

Extractions: Familial Hypercholesterolemia FH ) is a hereditary disease. Individuals with FH typically have mutations affecting their LDL Receptor (see below). The result of these mutations is a higher than normal level of serum cholesterol. Individuals who are homozygous for the disease have very high levels of cholesterol in the blood and usually die of heart disease before age 20. People heterozygous for the disease have higher than normal cholesterol and are at high risk for heart attacks in their thirties and forties. Cultured fibroblasts from FH individuals synthesize cholesterol at abnormally high levels in the presence of LDLs, compared to normal cells. This activity is linked to the enzyme HMG-CoA reductase, the major regulatory enzyme of cholesterol biosynthesis, which is allosterically inactivated by cholesterol. Cells from FH individuals have an impaired ability to take up cholesterol, via receptor mediated endocytosis, thus requiring endogenous synthesis. LDL levels in the bloodstream remain high, due to lack of uptake. High LDL levels favor oxidation of the components of the LDL and ultimately formation of atherosclerotic plaques. Phenotypes of the LDL receptor mutations in FH individuals are as follows: 1. Reductions in amount of LDL receptor made;
Hypercholesterolemia
genetics. familial hypercholesterolemia is the most common inherited disease.About way. *Quotes taken from familial hypercholesterolemia. For
http://www.usoe.k12.ut.us/curr/Science/core/bio/genetics/hypercholesterolemia.ht

Extractions: Hypercholesterolemia - Familial Inheritance autosomal dominant Occurrence of heterozygotes 1 in 500 Occurrence of homozygotes 1 per million Description excessive levels of cholesterol in the blood stream Cause Mutations in the LDL receptor (LDLR) gene on chromosome 19 Cholesterol the good, the bad and the ugly Introduction: Most of your students should have at least some knowledge about cholesterol. Most probably feel it has a negative connotation. The purpose of this discussion is to introduce students to HDL, LDL and hypercholesterolemia (respectively, the good, the bad, and the ugly). Activity: There are two ways to approach this activity: (1) Have students record their nutritional information for one entire meal. They should record what they ate, how much, and the nutrition information from the labels on the packages. It is important to remind them to include everything. For example, if they had a sandwich they would need to record bread, mayonnaise, mustard, lettuce, tomatoes, pickles, and turkey. Students like this option because they have autonomy, and it is individual; however, it will still be necessary to prepare for the second way in the event that students forget. Have the students calculate the number of calories, grams of fat, grams of carbohydrates, grams of protein, milligrams of sodium, and milligrams of cholesterol consumed for one of their meals. (2) Plan a regular meal. Have copies of the nutrition information for each food item. Have the students calculate the number of calories, grams of fat, grams of carbohydrates, grams of protein, milligrams of sodium, and milligrams of cholesterol consumed.
Searchalot Directory For Familial Hypercholesterolemia
Drkoop.com Medical Encyclopedia An in depth look at familial hypercholesterolemia. MedicineNet- A brief article about familial hypercholesterolemia.
http://www.searchalot.com/Top/Health/ConditionsandDiseases/GeneticDisorders/Fami

Extractions: Home Search News Email Greetings Weather ... Global All the Internet About AltaVista AOL Search Ask Jeeves BBC Search BBC News Business Dictionary Discovery Health Dogpile CheckDomain CNN Corbis eBay Education World Employment Encyclopedia Encarta Excite Fast Search FindLaw FirstGov Google Google Groups Infomine iWon Librarians Index Looksmart Lycos Metacrawler Microsoft Northern Light Open Directory SearchEdu SearchGov Shareware Teoma Thesaurus Thunderstone WayBackMachine Webshots WiseNut Yahoo! Yahoo! Auctions Yahoo! News Yahooligans Zeal Sponsored Links Top Health Conditions and Diseases Genetic Disorders : Familial Hypercholesterolemia Related Web Sites Drkoop.com: Medical Encyclopedia - An in depth look at familial hypercholesterolemia.
High Cholesterol Often Goes Undetected --- HealthandAge
it. familial hypercholesterolemia is an inherited disorder markedby lifelong elevated levels of blood cholesterol. Left untreated
http://www.healthandage.com/Home/gm=7!gid2=840

Extractions: October 22, 2000 (Reviewed: December 13, 2002) An article in a recent issue of the British Medical Journal warns physicians that those people at greatest risk for heart attack may have dangerously high blood levels of cholesterol and not even be aware of it. Familial hypercholesterolemia is an inherited disorder marked by lifelong elevated levels of blood cholesterol. Left untreated, up to one-half of men and one-third of women with this condition will suffer a heart attack. In an attempt to determine the scope of this problem, researchers in England examined the medical records of people thought to have a family history of high cholesterol. People were considered to be at high risk for familial hypercholesterolemia if they had a total cholesterol level greater than 7.5 mmol/l (equal to 276 mg/dl in American measurements) or an LDL cholesterol level greater than 4.9 mmol/l (equal to 180 mg/dl in American measurements). Researchers also checked the medical records for mention of tendon xanthomas, which are painful nodules or deposits commonly found in or near the joints of those with familial hypercholesterolemia.
Clinical Study: 85-H-0105, Cardiovascular Evaluation Of Patients With Familial H
Title Cardiovascular Evaluation of Patients with familial hypercholesterolemiaand Normal Individuals Number 85H-0105 Summary Homozygous familial
http://clinicalstudies.info.nih.gov/detail/A_1985-H-0105.html

Extractions: Protocol Number: 85-H-0105 Cardiovascular Evaluation of Patients with Familial Hypercholesterolemia and Normal Individuals 85-H-0105 Homozygous familial hypercholesterolemia is a rare inherited disease of metabolism. It occurs in less than 1 in 1 million people within the United States. Patients with the disease are typically children and young adults who develop heart disease early in life. Children less than age 5 years with this disease have suffered heart attacks and death. The normal process that removes cholesterol particles from the blood stream does not work in patients with this disease. It causes cholesterol to build-up in the arteries and leads to hardening of the arteries (atherosclerosis). The goal of this study is to detect and measure atherosclerosis in these patients before it becomes permanent and potentially life threatening. Patients with this disease can participate in this study. Researchers plan to evaluate patients with homozygous familial hypercholesterolemia using new and standard methods for detecting atherosclerosis. Researchers plan to use information gathered during this study to develop new, promising treatments such as liver transplantation and gene therapy.
Untitled Document
Effect of LDL Apheresis on Obstructive Changes in Aortocoronary Saphenousvein BypassGrafts in a Case of Heterozygous familial hypercholesterolemia with the
http://www.liposorber.com/physician/clinical/clin.htm

Extractions: References Some of the references may include discussions of off-label uses not listed in the approved Full Prescribing Information included in this site. Kaneka Pharma America Corp. has included these abstracts as educational and background information only. Stefanutti C, Di Giacomo S, Vivenzio A, Isacchi G.C, Masella R, Caprari P, et al. Acute and long-term effects of low-density lipoprotein (LDL)-apheresis on oxidative damage to LDL and reducing capacity of erythrocytes in patients with severe familial hypercholesterolaemia. Clinical Science Stefanutti C, Di Giacomo S, Vivenzio A, Colloridi V, Bosco G, Berni A, et al. Low-density lipoprotein apheresis in a patient aged 3.5 years. ACTA PAEDIATR Takahashi K, Kobayashi J, Bujo H, Takahashi M, Taira K, et al. Long-term (14 years) Effect of LDL Apheresis on Obstructive Changes in Aortocoronary Saphenous-vein Bypass Grafts in a Case of Heterozygous Familial Hypercholesterolemia with the LDL Receptor Proline664 to Leucine Mutation. Intern Med Lepage S, Nigon F, Bonnefont-Rousselot D, Assogba U, Goulinet S, Chancharme L, et al.
Simvastatin Safe And Effective For Children With Familial Hypercholesterolemia
Simvastatin Safe and Effective for Children with familial hypercholesterolemia.11/08/2002 Simvastatin at doses up to 40 mg is
http://www.geocities.com/rmcra3/simvachild.html

Extractions: 11/08/2002 Simvastatin at doses up to 40 mg is safe and effective therapy for children with familial hypercholesterolaemia. Saskia de Jongh, MD, and colleagues at the University of Amsterdam's Academic Medical Center, in Amsterdam, the Netherlands, conducted a multicentre, randomised, double-blind, placebo-controlled trial of simvastatin in a cohort of 173 children with familial hypercholesterolaemia. Their goal was to evaluate the effect on low-density lipoprotein (LDL) cholesterol, safety, and tolerability of simvastatin in children with this inherited disorder, including any effects of therapy on their growth and pubertal development. After a four-week diet and placebo run-in period, 98 boys and 75 girls with familial hypercholesterolaemia were randomised to receive either simvastatin or placebo in a ratio of 3:2. Simvastatin was started at 10 mg/d and titrated at 8-week intervals to 20 mg/d and then 40 mg/d. During a 24-week extension period, the patients continued to receive 40 mg of simvastatin or placebo according to their assignment.
Pp. 125-128 In Intractable Neurological Disorders, Human Genome
coronary artery disease, it is possible to analyze the responsible genes, or theirprotein products, in the case of familial hypercholesterolemia due to the
http://www.biol.tsukuba.ac.jp/~macer/IND/INDHH.html

Extractions: Professor, Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, JAPAN Presymptomatic diagnosis for common diseases in which preventive measures and therapy are available is considered to be useful for the prevention of the diseases. Good examples include premature coronary artery disease where genetic and environmental factors contribute to risk. There is ample possibility to prevent premature coronary artery disease by dietary therapy, no smoking and medication. Among the genetic factors of premature coronary artery disease, it is possible to analyze the responsible genes, or their protein products, in the case of familial hypercholesterolemia due to the mutant low density lipoprotein (LDL) receptor gene and in the case of high plasma lipoprotein(a) (Lp(a)) concentrations due to genetically determined small size apolipoprotein(a) (apo(a)) genes (Table 1). Table 1: Presymptomatic diagnosis for common diseases where intervention is possible Example: Coronary artery disease (1) Familial hypercholesterolemia due to the mutant LDL receptor gene
Hypo4
Primary Hypercholesterolemia familial hypercholesterolemia autosomaldominant trait; Serum cholesterol (heterozygous adults) 260
http://www.pharmacology2000.com/Cardio/hypo/hypo4.htm
Familial Hypercholesterolemia (FH)
familial hypercholesterolemia (FH). Brown and Goldstein studies. Mutation at asingle autosomal locus. ~ Absence of deficiency of functional. receptors for LDL.
http://opbs.okstate.edu/~Blair/Bioch4113/1999 Student Presentations/Twyman LSL R
WebGuest - Open Directory : Health : Conditions And Diseases : Genetic Disorders
Sites MedicineNet A brief article about familial hypercholesterolemia. When ShouldPatients With Heterozygous familial hypercholesterolemia Be Treated?
http://directory.webguest.com/index.cgi/Health/Conditions_and_Diseases/Genetic_D
Familial Hypercholesterolemia
familial hypercholesterolemia Alternative Names type IIa hyperlipoproteinemia Definitionfamilial hypercholesterolemia is an inherited disease that causes high
http://atoz.iqhealth.com/HealthAnswers/encyclopedia/HTMLfiles/27.html

Extractions: If an abnormal gene is inherited from one parent, the body makes only half of the usual number of docking sites. If the abnormal gene is inherited from both parents, the body makes no docking sites. In either case, the level of cholesterol gets too high in the blood. This can lead to heart attacks strokes , and other problems.
Alessandri Cesare [801]
Translate this page Stefanutti C. Long-term evaluation of high dosage administration ofsimvastatin in patients with familial hypercholesterolemia, 181, 91.
http://www.fatma.cnr.it/pub801.htm

Extractions: Primo autore Titolo Rivista vol. pag. anno Alessandri C. Effects of hydroxymethylglutaryl-coenzyme a reductase inhibitors on some blood coagulation parameters Curr. Ther. Res. Alessandri C. Relationship between lipoprotein(a) levels in serum and some indices of protein synthesis in liver cirrhosis Clin. Chim. Acta Alessandri C. Multifactorial therapeutic approach to secondary prevention in coronary heart disease: preliminary report after 3-year follow-up Curr. Ther. Res. Alessandri C. Lipoprotein (a) does not influence hyperfibrinolysis in patients with liver cirrhosis Fibrinolysis Primo autore Titolo Rivista vol. pag. anno Alessandri C. Comportamento della curva di polimerizzazione del fibrinogeno in soggetti ipercolesterolemici Clin. Ter. Alessandri C. Rapporti tra fibrinogemia e lipoproteine plasmatiche in pazienti ipercolesterolemici Minerva Med. Primo autore Titolo Rivista vol. pag. anno Stefanutti C. Il trattamento extracorporeo della ipercolesterolemia familiare omozigote mediante plasmaferesi selettiva delle lipoproteine aterogene (LDL-aferesi) Stefanutti C.
On-going Projects
Ongoing Projects. GENTHROFH - Genetics of Thrombosis in familial hypercholesterolemia.TF-FVII activation pathway polymorphisms and
http://www.cmns.mnegri.it/en/institute/other/Iacoviello/projects/genthrofh.html
Search Results For Familial Hypercholesterolemia
Search familial hypercholesterolemia (All words), Date 05/03/2002. When ShouldPatients With Heterozygous familial hypercholesterolemia Be Treated? JAMA.
http://www.uam.es/personal_pdi/ciencias/gpepe/g-humana/clases/Tema_09-metabolism

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

61-80 of 90 Back | 1 | 2 | 3 | 4 | 5 | Next 20