New Page 1 Designed to share research information as well as provide a location where others who are either suffering from this condition or attempting to treat it can share information and experiences. http://www.melorheostosis.com
New Page 1 Links to research, articles, personal histories of patients and a discussion board.Category Health Conditions and Diseases melorheostosis http://206.139.180.51/default.htm
Melorheostosis a CHORUS notecard document about melorheostosis melorheostosis. rare condition of cortical thickening of unknown etiology most commonly seen in the long bones http://chorus.rad.mcw.edu/doc/01061.html
Extractions: Click On Images for Enlarged View Clinical History: Patient presents with lower extremity pain and swelling. Findings: Images #1 and 2 are plain films of the tibia demonstrating peripherally located hyperostosis producing a wavy sclerotic bony contour along the tibial diaphysis. There are similar findings involving the first metatarsal as well as the navicular and first cuneiform bone. In addition, there are soft tissue calcifications adjacent to the navicular and cuneiform. Diagnosis: Melorheostosis. Discussion: Melorheostosis is a rare disorder of bone which generally presents in early childhood. There are no known hereditary factors. The initial clinical presentation includes diffuse joint pain as well as swelling with associated limitation of motion. Other potential complications include muscle contractures as well as soft tissue involvement including calcifications. More severe cases will demonstrate growth disturbance which may lead to scoliosis, contractures, and deformities which may be severe. Radiologic manifestations are most commonly limited to a single limb, although multiple limbs may on occasion be involved. Melorheostosis most commonly involves the lower extremity, and is rarely see in the skull, facial bones, and ribs. The findings most commonly consist of osseous excrescences extending along the length of a bone simulating the appearance of "candle wax" dripping down the side of a candle. In the carpal and tarsal bones, there may be more discrete rounded regions of bony sclerosis as well as adjacent soft tissue calcifications. Nucleide scintigraphy cases of melorheostosis demonstrate a region of increased nucleide uptake. MR imaging demonstrate regions of decreased signal intensity on all pulse sequences.
MELORHEOSTOSIS OF THE HAND: A COMPREHENSIVE REVIEW ABSTRACT. melorheostosis is an uncommon disorder characterized by soft tissue contractures and sclerosis of bone. http://www.worldscinet.com/hs/03/0301/S0218810498000167.html
Extractions: Department of Orthopaedic Surgery, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, MI ABSTRACT Melorheostosis is an uncommon disorder characterized by soft tissue contractures and sclerosis of bone. The sclerosis appears to flow along the long axis of the bone, akin to candle wax dripping down one side of a candle. Numerous reports of lower extremity involvement exist, but there are few detailed reports of melorheotosis involving the hand. This condition is benign but slowly progressive and can usually be managed conservatively. Loss of function of the hand from swelling, pain, or stiffness, however, may necessitate operative intervention. Two recent cases prompted a review of the literature relating to melorheostosis and the hand. Correspondence to: Dr Dean S. Louis, Section of Orthopaedic Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, USA 48109.
Melorheostosis This 26 y/o male came to the ER complaining of increasing arm pain. An xray was performed. A selected image shown above demonstrates findings of melorheostosis. http://home.earthlink.net/~radiologist/tf/120301.htm
Extractions: This 26 y/o male came to the ER complaining of increasing arm pain. An x-ray was performed. A selected image shown above demonstrates findings of melorheostosis. Rotate the image (or your monitor) to the left (or your head to the right) and you will see the "flowing wax" appearance better. Vanhoenacker FM, De Beuckeleer LH, Van Hul W, Balemans W, Tan GJ, Hill SC, De Schepper AM. Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol 2000;10(9):1423-33 PMID:10997431 Greenspan A, Azouz EM. Bone dysplasia series. Melorheostosis: review and update. Can Assoc Radiol J 1999 Oct;50(5):324-30 PMID:10555508 Rozencwaig R, Wilson MR, McFarland GB Jr. Melorheostosis. Am J Orthop 1997 Feb;26(2):83-9 PMID:9040882 Azuma H, Sakada T, Tanabe H, Handa M. Melorheostosis of the hand: a report of two cases. J Hand Surg [Am] 1992 Nov;17(6):1076-8 PMID:1430941 Williams JW, Monaghan D, Barrington NA. Cranio-facial melorheostosis: case report and review of the literature. Br J Radiol 1991 Jan;64(757):60-2 PMID:1998841 Perlman MD. Melorheostosis: a case report and literature review. J Foot Surg 1990 Jul-Aug;29(4):353-6 PMID:2229911
Electronic Journal Of Hand Surgery - Edition 2 A case study of a girl who had progressive and abnormal growth of the index finger of her left hand which was not enlarged at birth but grew steadily after birth. The suggested diagnosis is melorheostosis. http://www.leeds.ac.uk/handsurgery/EJHS/overgr.htm
Extractions: Case Report for discussion This girl had progressive and abnormal growth of the index finger of her left hand which was not enlarged at birth but grew steadily after birth. The hand did not resemble a typical macrodactyly in that there was peculiarities of cortical bone growth as seen in the scans and these abnormalities were particularly confined to the ulnar surface. Surgical exploration did not reveal any evidence of lipomatous infiltration at the digital nerves. Suggested explanations have included fibrous dysplasia and there are no endocrine or metabolic abnormalities. Does anybody have a suggestion for diagnosis or investigation here? Responses received on this case report:
PERSONAL INFORMATION AND EXPERIENCE Personal Histories. Shared by melorheostosis Patients. Alice, Adult, 2/23/2001,Left arm and shoulder (melorheostosis and osteopoikilosis), Lansing, Michigan. http://206.139.180.51/PIF master.htm
Extractions: Personal Histories Shared by Melorheostosis Patients The following information is shared by fellow m elorheostosis patients about their own personal experience in dealing with this rare condition. It is in no way intended as a recommendation of any particular treatment, surgery, therapy or course of action, nor as a substitute for the expertise and judgment of your physician or other health care professional. Name Child/Adult Date Submitted Area of Body Affected Location Michelle Adult Right foot; knees, back and pelvis Fareham, Hampshire, England Michele Adult Right ankle and foot Edgewater, New Jersey Jody (Jill, mother) Child Left arm and hand Portland, Oregon Pamula Adult Left tibia, fibula Madison Heights, VA Michael Adult Left leg and foot Stevens Point, WI Elaine Adult Foot, femur, hand Hamden, Connecticut Steve Adult Right hip to foot Stamford, CT Krystal Austin (Terry, mother) Adult Foot Brownsville, TN Jessica (Becky, mother) Child Hand, wrist, forearm and shoulder Fort Madison, Iowa Elizabeth Adult Left knee Reading, Berkshire, UK Maria Daniela Adult Right leg Santa Rosa, Argentina
Melorheostosis The etiology and incidence of melorheostosis is unknown. Bone dysplasia series. melorheostosisreview and update. Can Assoc Radiol J. 1999 Oct;50(5)32430. http://www.stevensorenson.com/residents6/melorheostosis.htm
Extractions: Home Up Cleidocranial dysostosis [ Melorheostosis ] Osteopathia striata Osteopetrosis Osteopoikilosis Proximal focal femoral deficiency ... Camurati-Engelmann disease The etiology and incidence of melorheostosis is unknown. It is often discovered as an incidental finding on radiographs acquired for other reasons. Other patients may have bone pain, limited range of motion, and joint fusion. The disease consists of cortical hyperostosis ("candle wax") in a dermatomal distribution. The location is usually diaphyseal. The process often crosses joints and may result in flexion contractures. The overlying skin may become thickened. REFERENCES Greenspan A, Azouz EM. Bone dysplasia series. Melorheostosis: review and update. Can Assoc Radiol J. 1999 Oct;50(5):324-30. Vanhoenacker FM, De Beuckeleer LH, Van Hul W, Balemans W, Tan GJ, Hill SC, De Schepper AM. Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol. 2000;10(9):1423-33 BACK
MELORHEOSTOSIS Features Listed For melorheostosis. McKusick 155950. Cortical hyperostosis/thickening;Dislocated patella; Joint stiffness/arthritis; Melorrheostosis; http://www.hgmp.mrc.ac.uk/dhmhd-bin/hum-look-up?1111
Melorheostosis only. melorheostosis,, Print this article, sequences. Other diseases withwhich melorheostosis has been associated are listed in Table 1. http://www.amershamhealth.com/medcyclopaedia/Volume III 1/MELORHEOSTOSIS.asp
Extractions: *For Medical Professionals only, registration required Melorheostosis, a rare bone disorder whose initial manifestations include swelling of joints, pain, and limitation of motion. Eventually profound muscle contractures, tendon and ligament shortening, and soft tissue involvement with severe growth disturbances may ensue. Scoliosis, joint contracture and foot deformities may be seen. Frequently the radiographic alterations are limited to a single limb, more often the lower extremity. Cortical hyperostosis having the appearance of bone excrescences extending along its length resembles candle wax flowing down the side of a lit candle ( Fig.1
Melorheostosis only. melorheostosis,, Print this article, nonhereditary ankylosis. GL TheEncyclopaedia of Medical Imaging Volume VII. melorheostosis, Fig. 1 http://www.amershamhealth.com/medcyclopaedia/Volume VII/MELORHEOSTOSIS.asp
Extractions: *For Medical Professionals only, registration required Melorheostosis, nonhereditary condition of unknown aetiology usually confined to one limb, most commonly the leg, and usually involving at least 2 bones in a dermatomal distribution. Clinically the limb is stiff and painful, there may be thickening of the overlying skin and soft tissue contractures and fibrosis. Radiographs show dense cortical hyperostosis along long bones with a "dripping candlewax" appearance which may appear to flow from one bone to the next ( Fig.1 ). In a child the hyperostosis appears predominantly endosteal as opposed to an adult in whom it is usually more dramatic and causes an increase in the width of the bone. Epiphyses, carpal or tarsal bones tend to show more discrete rounded sclerotic foci (similar to osteopoikolosis) and flat bones may show radiating sclerotic patches. Radiographs may also show soft tissue calcification or ossification and joint ankylosis.
Melorheostosis melorheostosis. rare condition of cortical thickening of unknown etiology most commonly seen in the long bones http://chorus.rad.mcw.edu/to-go/01061.html
TOUS: CAS MELORHEOSTOSIS Les dossiers classés en melorheostosis . ABNORMALITIES melorheostosis,HAND,ABNORMALITIES. BONES melorheostosis,BONES, SCLEROSIS,BONES, MRSTUDIES. http://www.med.univ-rennes1.fr/cerf/iconocerf/idx/tous/MELORHEOSTOSIS.html
OSTEO-ARTICULAIRE: CAS MELORHEOSTOSIS OSTEOARTICULAIRE Les dossiers classés en melorheostosis . SCLEROSIS melorheostosis,BONES, SCLEROSIS,BONES, MRSTUDIES. Total 2 cas cliniques http://www.med.univ-rennes1.fr/cerf/iconocerf/idx/O/MELORHEOSTOSIS.html
Osteopoikilosis - Melorheostosis - HUM-MOLGEN We are searching for families with autosomal dominant osteopoikilosis (with orwithout individuals with melorheostosis)in order to determine the genetic http://www.hum-molgen.de/bb/Forum2/HTML/000104.html
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