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Rocky Mountain Spotted Fever:     more books (65)

Rocky Mountain Spotted Fever: History of a Twentieth-Century Disease (The Henry E. Sigerist Series in the History of Medicine) by Victoria Harden, 1990-08-01 Rocky Mountain Spotted Fever (Deadly Diseases and Epidemics) by David H. Walker, 2007-11-30 Cases of Rocky Mountain spotted fever increase almost threefold.(Infectious Diseases): An article from: Family Practice News by Doug Brunk, 2007-12-15 Rocky Mountain spotted fever reported in Arizona: brown dog tick is new vector.(Clinical Rounds): An article from: Family Practice News by Nancy Walsh, 2004-05-15 Rocky Mountain spotted fever, Panama.(DISPATCHES)(Case study)(Clinical report): An article from: Emerging Infectious Diseases by Dora Estripeaut, Maria Gabriela Aramburu, et all 2007-11-01 Brown dog tick is behind Ariz. Rocky Mountain spotted fever outbreak.(News): An article from: Skin & Allergy News by Nancy Walsch, 2004-05-01 Circular / United States Department of Agriculture by F.C. Bishopp, 1938 21st Century Complete Medical Guide to Rocky Mountain Spotted Fever (RMSF) and Related Tick Bite Diseases, Authoritative Government Documents, Clinical ... for Patients and Physicians (CD-ROM) by PM Medical Health News, 2004-07 Gale Encyclopedia of Medicine: Rocky Mountain spotted fever by Rosalyn Carson-DeWitt MD, 2002-01-01 Rocky Mountain spotted fever, by Jerry Kazuo Aikawa, 1966 The Official Patient's Sourcebook on Rocky Mountain Spotted Fever by James N. Parker, Icon Health Publications, 2002-08-27 Death results from Rocky Mountain Spotted Fever.: An article from: Medical Law's Regan Report by A. David Tammelleo, 2005-08-01 Early Dx vital in Rocky Mountain spotted fever.(Infectious Diseases)(Disease/Disorder overview): An article from: Pediatric News by Doug Brunk, 2007-03-01 Rocky Mountain Spotted Fever: Anatomy of a Pestilence by Robert N. Philip, 2000-09

lists with details

1. Infectious Diseases - Rocky Mountain Spotted Fever
   The history, prevalence, symptoms, and treatment of this rickettsial infection.  
   http://www.mc.vanderbilt.edu/peds/pidl/infect/rmsf.htm
   
   Extractions: PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Infectious Diseases ROCKY MOUNTAIN SPOTTED FEVER Rocky Mountain Spotted Fever is the most prevalent rickettsial disease in the United States and is a growing infectious disease problem. First recognized in parts of Idaho and Montana it has since been reported throughout the United States. Nearly two thirds of RMSF patients are under 15 years of age. Though both chloramphenicol and the tetracyclines are highly effective, there is still a regular mortality rate of 5- 7%. A considerable number of deaths in children with RMSF are attributable to atypical initial symptoms and late onset of rash as well as failure to consider the diagnosis. Rickettsia rickettsii, the etiologic agent in RMSF, consists of small coccobacillary microorganisms. Usually they occur singly but may also appear in strands. EM reveals a two layered cell wall and a cytoplasmic membrane. The chemical composition of rickettsiae is similar to that of gram negative bacteria. The wood tick in the west, the dog tick in the east, and the Lone Star tick in the southwest are all natural carriers and vectors of the disease. RMSF rickettsiae do not kill their arthropod hosts but are passed through unending generations of ticks transovarially. Many small wild animals as well as dogs possess antibodies to RMSF, indicating that they may be involved in the life cycle. RMSF has a marked seasonal character with most cases occur during the period of greatest tick activity from April to September. In addition RMSF has a focal nature; for example, relatively small areas in a state may account for a high percentage of that state's recorded RMSF cases.

2. Rocky Mountain Spotted Fever, Introduction
   Viral and Rickettsial Zoonoses Branch Rocky Mountainspotted fever VRZB Home DVRD Home NCID Home,  
   http://www.cdc.gov/ncidod/dvrd/rmsf/
   
   Extractions: Introduction Rocky Mountain spotted fever is the most severe and most frequently reported rickettsial illness in the United States. The disease is caused by Rickettsia rickettsii , a species of bacteria that is spread to humans by ixodid (hard) ticks. Initial signs and symptoms of the disease include sudden onset of fever, headache, and muscle pain, followed by development of rash. The disease can be difficult to diagnose in the early stages, and without prompt and appropriate treatment it can be fatal. This web page presents a general overview of Rocky Mountain spotted fever; more detailed information can be found in the resources listed in Suggested Reading Figure 1. Characteristic spotted rash of late-stage Rocky Mountain spotted fever on legs of a patient, ca. 1946 (photo courtesy of Rocky Mountain Laboratories

3. This Page Has Moved: Rocky Mountain Spotted Fever
   CDC Home, Search, Health Topics AZ, This Page Has Moved. The Rocky Mountain spottedfever page has moved. Please update your bookmarks or links to the new address  
   http://www.cdc.gov/ncidod/diseases/rmsf/rmtnsfvr.htm
   
   Extractions: This Page Has Moved The Rocky Mountain spotted fever page has moved. Please update your bookmarks or links to the new address: http://www.cdc.gov/ncidod/dvrd/rmsf/index.htm Top of Page NCID Home Disease Information ... Health Topics A-Z This page last reviewed July 5, 2001 National Center for Infectious Diseases

4. Rocky Mountain Spotted Fever Facts
   rocky mountain spotted fever rocky mountain spotted fever is a serious, generalized illness that is usually spread by the bite of an infected tick.  
   http://www.astdhpphe.org/infect/rms.html
   
   Extractions: What is Rocky Mountain spotted fever? Rocky Mountain spotted fever is a serious, generalized infection that is usually spread to people by the bite of infected ticks. The disease gets its name from the Rocky Mountain area where it was first identified. What is the infectious agent that causes Rocky Mountain spotted fever? Rocky Mountain spotted fever is caused by Rickettsia rickettsii, a specialized bacteria. Ticks infected with the organism transmit the disease to humans. Where is Rocky Mountain spotted fever found?

5. THE MERCK MANUAL, Sec. 13, Ch. 159, Rickettsial Diseases
   rocky mountain spotted fever (RMSF) is limited to the Western Hemisphere.  
   http://www.merck.com/pubs/mmanual/section13/chapter159/159e.htm
   
   Extractions: (Spotted Fever; Tick Fever; Tick Typhus) An acute febrile disease caused by Rickettsia rickettsii and transmitted by ixodid ticks, producing high fever, cough, and rash. Epidemiology and Pathology Hard-shelled ticks (family Ixodidae) harbor R. rickettsii, and infected females transmit the agent to their progeny. These ticks and some mammalian hosts are the natural reservoirs; animals provide blood nourishment. Dermacentor andersoni (the wood tick) is the principal vector in the western USA; D. variabilis (dog tick) is the vector in the eastern and southern USA. The organism is also maintained in rabbits and other small mammals. RMSF is probably not transmitted directly from person to person even via infectious particles produced by the cough. Small blood vessels are the sites of the characteristic pathologic lesion. Rickettsiae propagate within damaged endothelial cells, and vessels may become blocked by thrombi, producing vasculitis in the skin, subcutaneous tissues, CNS, lungs, heart, kidneys, liver, and spleen. Disseminated intravascular coagulation often occurs in severely ill patients (see Disseminated Intravascular Coagulation under Acquired Coagulation Disorders in Ch. 131).

6. Rocky Mountain Spotted Fever Hub
   A brief introduction of rocky mountain spotted fever, followed by links to overviews, research articles, diagnosis and prevention methods.  
   http://www.projectlinks.org/rmsf
   
   Extractions: Rocky mountain spotted fever is an infectious disease caused by Rickettsia rickettsii, a species of bacteria that is spread to humans by ixodid ticks. Symptoms of the disease include sudden onset of fever, headache, and muscle pain, followed by development of rash. Symptoms usually appear within two weeks of the bite of an infected tick. People can protect themselves by avoiding tick bites and by keeping pets tick-free. Prompt removal of attached ticks, using tweezers, may prevent disease transmission. Rocky Mountain spotted fever, introduction - by CDC. Rocky Mountain Spotted Fever - from Lucile Packard Children's Hospital. Rocky Mountain Spotted Fever by MEDLINEplus Rocky Mountain Spotted Fever by Merck Manual Rocky Mountain Spotted Fever Occurring After Hospitalization for Unrelated Illnesses - case reports. Rocky Mountain Spotted Fever - by Calgary Health Region Education Services. Rocky Mountain Spotted Fever from the Vanderbilt University Medical Center Tick-borne Diseases,Rocky Mountain Spotted Fever - by Michael Wilson, MD, Consulting Staff, Department of Emergency Medicine, Rowan Regional Medical Center. Consequences of Delayed Diagnosis of Rocky Mountain Spotted Fever in Children West Virginia, Michigan, Tennessee, and Oklahoma, May–July 2000

7. Rocky Mountain Spotted Fever
   Los Angeles County West Vector Control District rocky mountain spotted fever How do people get rocky mountain spotted fever? The organism that causes rocky mountain spotted fever is transmitted by the bite of an infected tick. see right (Dermacentor andersoni) are the primary vectors of rocky mountain spotted fever bacteria in the United States.  
   http://www.lawestvector.org/rocky_mountain_spotted_fever.htm
   
   Extractions: Los Angeles County West Vector Control District Rocky Mountain Spotted Fever How do people get Rocky Mountain spotted fever? The organism that causes Rocky Mountain spotted fever is transmitted by the bite of an infected tick. The American dog tick see left Dermacentor variabilis ) and Rocky Mountain wood tick see right Dermacentor andersoni ) are the primary vectors of Rocky Mountain spotted fever bacteria in the United States. Less commonly, infections may occur following exposure to crushed tick tissues, fluids, or tick feces. What is Rocky Mountain spotted fever? Rocky Mountain spotted fever (RMSF) is the most severe tick-borne rickettsial illness in the United States. This disease is caused by infection with the bacterial organism Rickettsia rickettsii It was first recognized as a disease in the 1890's. This disease is so named because it was discovered in the Rocky Mountains and infected persons had a rash with red-purple-black spots. What are the symptoms of Rocky Mountain spotted fever? Patients infected with R. rickettsii

8. Rocky Mountain Spotted Fever
   rocky mountain spotted fever A 22year-old man presented with fever, malaise, headache, and rash of the palms of his hands and soles of his feet . Symptoms developed 10 days after tick exposure while the patient had been camping.  
   http://www.netmedicine.com/photo/pto0006.htm
   
   Extractions: Click here for more information Rocky Mountain spotted fever: A 22-year-old man presented with fever, malaise, headache, and rash of the palms of his hands and soles of his feet . Symptoms developed 10 days after tick exposure while the patient had been camping. The presentation of fever, headache, and rash of the palms and soles is characteristic of Rocky Mountain spotted fever. (L.S.) Return to Medical Photograph Index

9. Tick-Borne Illness Memorial Page
   A memorial page dedicated to those who have died of tickborne illness- Lyme disease, Tularemia (aka Rabbit Fever ), Babesiosis, Ehrlichiosis, Colorado Tick Fever, Relapsing Fever, Tick-Borne Encephalitis and rocky mountain spotted fever.  
   http://www.angelfire.com/punk/lymedisease/memorial.html
   
   Extractions: These pages are dedicated to those who have died of Tick-Borne Illness: Lyme disease, Bartonella, Q Fever, Tularemia, Babesiosis, Ehrlichiosis, Relapsing Fever, Colorado Tick Fever, Tick-Borne Encephalitis, Rickettsia Helvetica, Crimean Congo Hemorrhagic Fever and Rocky Mountain Spotted Fever. If you have a loved one who has died of a tick-borne illness and you would like to see them on this page, you are more than welcome. Please email AramSarah@cs.com, given again at the bottom of this page. Please provide as much information as possible and any page preferences. This site also links to Memorial Pages made by people's families or friends. Even, if reading a newspaper, you find an article or Obituary about someone who has died of a Tick-Borne Illness, please email the contact person so they may be included. Most, but not all of the people on this site have a Tick-Borne Illness on their death certificate as Cause of Death.

10. Publications - Factsheets - Rocky Mountain Spotted Fever
    org. Publications. Current Fact Sheets. rocky mountain spotted fever. RockyMountain What is rocky mountain spotted fever? Rocky Mountain spotted  
    http://www.astdhpphe.org/rms.asp
    
    Extractions: director@astdhpphe.org What is Rocky Mountain spotted fever? Rocky Mountain spotted fever is a serious, generalized infection that is usually spread to people by the bite of infected ticks. The disease gets its name from the Rocky Mountain area where it was first identified. What is the infectious agent that causes Rocky Mountain spotted fever? Rocky Mountain spotted fever is caused by Rickettsia rickettsii

11. EMedicine - Tick-Borne Diseases, Rocky Mountain Spotted Fever : Article By Richa
    TickBorne Diseases, rocky mountain spotted fever - rocky mountain spotted fever(RMSF), characterized by fever, myalgias, headache, and a petechial rash, is  
    http://www.emedicine.com/EMERG/topic510.htm
    
    Extractions: (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Emergency Medicine Infectious Diseases Last Updated: July 26, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: RMSF, Rickettsia rickettsii, American dog tick, Dermacentor variabilis, Rocky Mountain wood tick, Dermacentor andersoni AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Richard Medlin, Jr, MD , Consulting Staff, Department of Emergency Medicine, Morehead Memorial Hospital Coauthor(s): Michael Wilson, MD , Consulting Staff, Department of Emergency Medicine, Rowan Regional Medical Center; Richard Sinert, DO , Associate Professor of Emergency Medicine, Clinical Assistant Professor of Medicine, State University of New York College of Medicine; Consulting Staff, Department of Emergency Medicine, Kings County Hospital Center Richard Medlin, Jr, MD, is a member of the following medical societies: American College of Emergency Physicians , and American Medical Association Editor(s): Peter MC DeBlieux, MD

12. EMedicine - Rocky Mountain Spotted Fever : Article By Richard H Snyder, MD
    rocky mountain spotted fever rocky mountain spotted fever (RMSF) is a lethalbut curable tick-borne disease caused by the organism Rickettsia rickettsii.  
    http://www.emedicine.com/MED/topic2043.htm
    
    Extractions: (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Infectious Diseases Last Updated: January 3, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: RMSF, tick fever, spotted fever, tick typhus, New World spotted fever, Sao Paulo fever, fiebre manchada, fiebre petechial, fiebre maculosa brasiliensis AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Richard H Snyder, MD , Vice-Chair, Program Director, Department of Medicine, Norfolk General Hospital; Clinical Associate Professor, Department of Internal Medicine, East Virginia Medical School Coauthor(s): Marie Spevak, BS , Philadelphia College of Osteopathic Medicine Richard H Snyder, MD, is a member of the following medical societies: American College of Physicians Editor(s): Gary L Gorby, MD

13. ROCKY MOUNTAIN SPOTTED FEVER
    rocky mountain spotted fever. What is rocky mountain spotted fever?Rocky Mountain active. Who gets rocky mountain spotted fever? Both  
    http://www.idph.state.il.us/public/hb/hbrmsf.htm
    
    Extractions: ROCKY MOUNTAIN SPOTTED FEVER What is Rocky Mountain spotted fever? Rocky Mountain spotted fever is an acute infectious disease transmitted to humans by the bite of an infected tick. The disease occurs throughout the United States during months when ground temperatures reach 40 degrees Fahrenheit or more and ticks are active. Who gets Rocky Mountain spotted fever? Both children and adults can be affected by Rocky Mountain spotted fever. Disease incidence is directly related to exposure to tick-infested habitats or to infested pets. In spite of the disease's name, few cases have been reported from the Rocky Mountain region of the United States. How is Rocky Mountain spotted fever spread? Rocky Mountain spotted fever is spread by the bite of an infected tick (the American dog tick or the lone-star tick) or by contamination of the skin with tick blood or feces. Person-to- person transmission does not occur. What are the symptoms of Rocky Mountain spotted fever? Rocky Mountain spotted fever is characterized by a sudden onset of moderate to high fever (which can last for two or three weeks), severe headache, fatigue, deep muscle pain, chills and rash. The rash begins on the legs or arms, may include the soles of the feet or palms of the hands and may spread rapidly to the trunk or the rest of the body. Not every case of Rocky Mountain spotted fever will have the rash. How soon do symptoms appear?

14. MEDLINEplus Medical Encyclopedia: Rocky Mountain Spotted Fever
    rocky mountain spotted fever. The complications of untreated Rocky Mountainspotted fever can be life threatening. Prevention Return to top.  
    http://www.nlm.nih.gov/medlineplus/ency/article/000654.htm
    
    Extractions: Skip navigation Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Contents of this page: Rocky mountain spotted fever, lesions on arm Deer ticks Ticks Rocky mountain spotted fever on the arm ... Antibodies Alternative names Return to top Spotted fever Definition Return to top An infectious disease caused by Rickettsia rickettsii transmitted to humans by the bite of ticks Causes, incidence, and risk factors Return to top In the western U.S., the causative agent R rickettsii is transmitted by the wood tick , and in the eastern U.S., by the dog tick. Other ticks transmit the infection in the southern U.S. and in Central and South America. Contrary to the name "Rocky Mountain" most recent cases have been reported in the eastern United States: North and South Carolina, Virginia, Maryland, Georgia, Tennessee, and Oklahoma. Most cases occur in the spring and summer with about 1,000 cases reported per year. Most of the reported cases have been in children.

15. Rocky Mountain Spotted Fever
    rocky mountain spotted fever rocky mountain spotted fever. 2.Discuss factors whichinfluence the prognosis for ehrlichiosis and rocky mountain spotted fever.  
    http://www.cah.com/library/rsms.html
    
    Extractions: Objectives 1.Describe the clinicopathologic abnormalities associated with Rickettsia rickettsii infection in dogs. 2.Discuss factors which influence the prognosis for ehrlichiosis and Rocky Mountain spotted fever. 3.Describe how you would confirm a diagnosis of Rocky Mountain spotted fever. 4.Describe the zoonotic considerations associated with the diagnosis of Rocky Mountain spotted fever in a dog. Rocky Mountain spotted fever (RMSF) is an infectious rickettsial disease of dogs, that is characterized by severe vascular damage. Canine susceptibility to Rickettsia rickettsii was demonstrated in 1933. Recent reports emphasize that, contrary to previous literature, untreated naturally-occurring RMSF can result in death. Clinical reports suggest that RMSF is a much more common cause of disease in dogs than was previously recognized. Geographic Distribution Despite its name and original description as a disease of humans in the western United States, the majority of human cases of RMSF occur in the southeastern United States. Human cases of RMSF have been reported from nearly every state in the United States, western Canada, Mexico, and South America. Distribution of the disease is related to the distribution of the vector ticks Dermacentor variabilis, the American dog tick found in the eastern United States, and Dermacentor andersoni, the wood tick, which is the principal vector in the western United States. Canine RMSF has been recognized in most southeastern states, New York, Massachusetts, and Ohio.

16. Medicine-Worldwide: Rocky Mountain Spotted Fever
    http://www.m-ww.de/krankheiten/infektionskrankheiten/rocky_mountain.html
    
    Extractions: Sie befinden sich hier: startseite krankheiten infektionskrankheiten Infektionskrankheiten ... Über uns Zusammenfassung Definition/Allgemeines Erreger Inkubationszeit ... Prophylaxe Rocky Mountains Bakterien der Gattung Rickettsia verursacht werden und durch Arthropoden, z.B. Zecken Typhus . Andere, zu den Rickettsiosen gehörende Erkrankungen sind das Q-Fieber, das Tsutsugamushi-Fieber, das Wolhynische Fieber und das "Fievre boutonneuse". Die Inkubationszeit des Rocky Mountain spotted fever ist kurz und dauert ca. drei Tage bis eine Woche. Symptome Die Behandlung der Betroffenen sollte im Krankenhaus erfolgen und besteht in der Gabe von Antibiotika . Verwendet werden Tetrazykline und Chloramphenicol. Um einer Infektion mit dem Erreger des Rocky Mountain spotted fever vorzubeugen, muss ein Kontakt mit

17. Page Moved - Rocky Mountain Spotted Fever
    rocky mountain spotted fever, Version en español (tickborne typhusfever). What is rocky mountain spotted fever? Rocky Mountain  
    http://www.health.state.ny.us/nysdoh/consumer/rocky.htm

18. Infectious Diseases - Rocky Mountain Spotted Fever - Methodist Health Care Syste
    rocky mountain spotted fever What are the symptoms of Rocky Mountain SpottedFever? The following are the most common symptoms of RMSF.  
    http://www.methodisthealth.com/infectious/rmsf.htm
    
    Extractions: Rocky Mountain Spotted Fever Rocky Mountain Spotted Fever (RMSF) is an infection caused by the bite of an infected tick. It affects about 250 to 1200 people a year in the US and usually occurs from April until October, but it can occur anytime during the year where weather is warm. The mid-Atlantic and southeastern states are most affected. The disease is spread to humans from contact with the tick; it is not spread from one person to another. What are the symptoms of Rocky Mountain Spotted Fever?

19. Rocky Mountain Spotted Fever --- HealthandAge
    rocky mountain spotted fever. rocky mountain spotted fever. December 4, 2001. Question.As an 8year-old I was diagnosed with rocky mountain spotted fever (RMSF).  
    http://www.healthandage.com/Home/gid7=54
    
    Extractions: Rocky Mountain Spotted Fever December 4, 2001 Question As an 8-year-old I was diagnosed with Rocky Mountain Spotted Fever (RMSF). I'm now 33, and I'm wondering if RSMF can cause similar late complications as Lyme disease does. I suffer from joint pain, muscle pain, trouble sleeping, memory loss, and lack of concentration. This has been going off and on since I was 15. Answer Rocky Mountain Spotted Fever (RSMF) is the most prevalent rickettsial disease in the United States and is a growing infectious disease problem. First recognized in parts of Idaho and Montana it has since been reported throughout the United States. Nearly two thirds of RMSF patients are under 15 years of age, and, though antibiotics are highly effective, about 5%-7% of patients die. The wood tick in the west, the dog tick in the east, and the Lone Star tick in the southwest USA are all natural carriers of the disease. Fever, headache, rash, toxicity, mental confusion, and myalgia constitute the major clinical features of RMSF. Onset of disease usually occurs 2- 8 days after an infected tick bite. Fever rises rapidly and may be high. The rash appears by the second or third day in most patients - small red spots which occasionally bleed - first on the wrists and palm, ankles and soles, spreading to the trunk. Neurologic symptoms include seizures, blindness, deafness, and some paralysis.

20. Rocky Mountain Spotted Fever --- HealthandAge
    rocky mountain spotted fever. Home rocky mountain spotted fever. rocky mountain spotted fever. December 4, 2001. Question. As an  
    http://www.healthandage.com/Home/gm=20!gid7=54
    
    Extractions: Home ROCKY MOUNTAIN SPOTTED FEVER Rocky Mountain Spotted Fever December 4, 2001 Question As an 8-year-old I was diagnosed with Rocky Mountain Spotted Fever (RMSF). I'm now 33, and I'm wondering if RSMF can cause similar late complications as Lyme disease does. I suffer from joint pain, muscle pain, trouble sleeping, memory loss, and lack of concentration. This has been going off and on since I was 15. Answer Rocky Mountain Spotted Fever (RSMF) is the most prevalent rickettsial disease in the United States and is a growing infectious disease problem. First recognized in parts of Idaho and Montana it has since been reported throughout the United States. Nearly two thirds of RMSF patients are under 15 years of age, and, though antibiotics are highly effective, about 5%-7% of patients die. The wood tick in the west, the dog tick in the east, and the Lone Star tick in the southwest USA are all natural carriers of the disease. Fever, headache, rash, toxicity, mental confusion, and myalgia constitute the major clinical features of RMSF. Onset of disease usually occurs 2- 8 days after an infected tick bite. Fever rises rapidly and may be high. The rash appears by the second or third day in most patients - small red spots which occasionally bleed - first on the wrists and palm, ankles and soles, spreading to the trunk. Neurologic symptoms include seizures, blindness, deafness, and some paralysis.

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