Geometry.Net - Health_Conditions: Von Willebrand

Von Willebrand's Disease
What is von willebrand's disease? The much rarer types II and III vWD causesevere bleeding disorders. How is von willebrand's disease inherited?
http://www.upei.ca/~cidd/Diseases/clinical pathology/von Willebrand's disease.ht

Extractions: What is von Willebrand's disease? Von Willebrand's disease (vWD) is a common, usually mild, inherited bleeding disorder in people and in dogs. It is caused by a lack of von Willebrand factor (vWF), which plays an essential role in the blood clotting process. Normally the body responds to an injury causing bleeding through a complex defence system. This consists of local changes in the damaged blood vessels, activation of blood cells called platelets, and the coagulation process. A reduction in von Willebrand factor leads to abnormal platelet function and prolonged bleeding times. Affected dogs are prone to bleeding episodes such as nose bleeds, and generally experience increased bleeding with trauma or a surgical procedure. Three forms of the disease are distinguished based on vWF concentration and function. Dogs with Type I vWD (by far the most common) have mild to moderate bleeding abnormalities, depending on the level of vWF. The much rarer types II and III vWD cause severe bleeding disorders. How is von Willebrand's disease inherited?
How Von Willebrand Is Inherited
How von willebrand Disease.. is Inherited.. Unlike haemophilia, vonWillebrand disease is not genderrelated. So the effect is
http://www.haemophilia.org.za/Vonherit.htm

Extractions: Unlike haemophilia, von Willebrand disease is not gender-related. So the effect is the same regardless of whether the defective von Willebrand factor (vWF) is passed down from the mother or father. It also makes no difference whether the child is a boy or girl; the disease shows up in the same way. If one parent has a defective gene:
Laboratory Tests For Von Willebrand
Laboratory Tests for von willebrand Disease. This finding is related to both thenumber and function of platelets and the amount of von willebrand factor.
http://www.haemophilia.org.za/Vonlab.htm

Extractions: Bleeding time How long does it take to stop bleeding? This finding is related to both the number and function of platelets and the amount of von Willebrand factor. Factor VIII clotting activity This measurement, which is low or nonexistent in people with haemophilia A, is usually normal or only slightly lowered in people with von Willebrand disease. The measurement takes into account not just the level of Factor VIII, but also its ability to function. vWF antigen Ristocetin cofactor activity A measurement of how well the von Willebrand factor is working. vWF multimers Evaluates the structure of the von Willebrand factor molecule. Helps in correctly classifying the type of von Willebrand disease. Platelet function tests Measure how well platelets work. Helps identify the type of von Willebrand disease or other disorder. Mission Statement National News Regional News
HONselect - Von Willebrand Disease
English von willebrand Disease, Angiohemophilia - Hemophilia, Vascular - von willebrand'sDisease - Angiohemophilias - Disease, von willebrand - Disease, von
http://www.hon.ch/HONselect/RareDiseases/C15.378.100.141.900.html
Von Willebrand's Disease - The "Other" Bleeding Disorder
von willebrand'S DISEASE The Other Bleeding Disorder. von willebrand Panel(PT, APTT, Factor VIII, vWFAg, vWFRCo, Platelet Aggregations x 3)
http://www.hemex.com/vonwillebrands.htm

Extractions: The "Other" Bleeding Disorder von Willebrand's Disease (vWD) is the most common inherited bleeding disorder in humans occurring in approximately 1% of the population . Unlike hemophilia which is a sex-linked trait, vWD may be discovered at any age and in either sex. While hemophilia is usually associated with bleeding into joints and muscles, vWD is more commonly associated with easy bruising, recurrent nosebleeds, prolonged postoperative or posttraumatic bleeding, excessive bleeding from the gums or mouth and menorrhagia . vWD is a complex hemostatic defect with multiple variations. Diagnosis may require correlation of clinical observations with laboratory testing and family studies especially in mild forms of the disease. The disease process is mediated by a qualitative or quantitative deficiency of a large glycoprotein called von Willebrand Factor (vWF). vWF is synthesized in the endothelial cells where it is stored in the Weibel-Palade bodies and in megakaryocytes where it is stored in the -granules of platelets . The mature vWF subunit is assembled into multimers which are required for biological function. vWF functions in hemostasis by permitting adhesion of platelets to exposed endothelium and by forming a non-covalent complex with Factor VIII, thus stabilizing and protecting it from rapid removal from the circulation
AHVH - Vereniging Van Hemofilie En Von Willebrand-patiënten
http://www.ahvh.be/
One Percent Of Americans Have Von Willebrand Disease: What Is It?
von willebrand Disease (VWD) is a hereditary bleeding disorder that involves a proteinin the blood called von willebrand factor, or VWF, which helps our blood
http://healthlink.mcw.edu/article/1030552013.html

Extractions: Subscribe now >> Most of us have become accustomed to life's bumps and bruises...and scrapes, cuts, sprains and strains. We've all had those clumsy times where life seems like nothing but a series of minor mishaps. We're able to ignore many of these injuries, while others are easily put right with a bandage or a few days' rest. But for children and young adults with abnormal reactions to life's accidents - including heavy bleeding, bleeding that doesn't stop, or very frequent bruising - testing for von Willebrand disease could be in order. Von Willebrand disease (VWD) is a hereditary bleeding disorder, in fact, one of the most common bleeding disorders known: it affects about 1% of all Americans. The illness involves a protein in the blood called von Willebrand factor, or VWF, which helps our blood to clot. People with von Willebrand disease don't have enough of the factor available in their blood, or the VWF that is present doesn't perform effectively. Simple injuries can bring on heavier and longer bleeding episodes than usual or cause frequent bruises to form under the skin. Men and women can both have VWD, but women are usually more symptomatic, with heavy menstrual bleeding (menorrhagia) being a common symptom.
Jack Russell Terrier Medical - Canine Von Willebrand's Disease
Canine von willebrand's Disease We have seen so many breeders advertising theirbreeding stock as von willebrand's tested and vWD negative, we decided to do
http://www.jackrussell.net/faq/medical/vonwill.htm

Extractions: We have seen so many breeders advertising their breeding stock as von Willebrand's tested and vWD negative, we decided to do some research into this INHERITED disorder. We personally know of one Jack Russell Terrier that was diagnosed as having vWD after whelping her first litter of puppies. She didn't clean up normally, the bleeding never stopped, and after 6 weeks, the little bitch almost bleed to death. There were no earlier signs of this disease before the whelping. By the way, we are fortunate to have a veterinary teaching hospital and library 10 miles from our door. We make use of both facilities frequently. Diagnosis can be performed by measurement of plasma concentrations of vWF. TESTING SHOULD BE DONE AT AN EARLY AGE SINCE THE DISORDER OFTEN DIMINISHES WITH AGE, CAUSING FALSE-NEGATIVE TEST RESULTS IN OLDER ANIMALS. Additional screening tests such as bleeding times or platelet agglutination assays can also be performed. Precautions should be taken before surgery, so it is important to let your veterinarian know of bleeding problems in the past. Different breeds exhibit different variations of the disease, and some individual animals appear to "acquire" vWD. While the bulk of the information available is based upon purebred dogs, the disease is not unknown in mixed breeds. The total number of breeds affected by vWF exceeds 50. The disease also appears in cats, pigs, horses, and humans.
MEDLINEplus Medical Encyclopedia: Von Willebrands Disease
von willebrands disease. Definition Return to top von willebrand's disease is ahereditary bleeding disorder caused by a deficiency of von willebrand factor.
http://www.nlm.nih.gov/medlineplus/ency/article/000544.htm

Extractions: Skip navigation Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Contents of this page: Blood clot formation Blood clots Definition Return to top Von Willebrand's disease is a hereditary bleeding disorder caused by a deficiency of von Willebrand factor. Von Willebrand factor helps platelets to stick to the blood vessel wall and to each other, which is necessary for normal blood clotting. Causes, incidence, and risk factors Return to top Von Willebrand's disease is the most common hereditary bleeding disorder. It affects both sexes approximately equally. Most cases are mild, and bleeding may occur after a surgical procedure or tooth extraction. The condition is worsened by the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Bleeding may decrease during pregnancy
The Genetics Of Von Willebrand Disease By Michael Alimario
The Genetics of von willebrand Disease by Michael Alimario It was in 1931 that aman by the name of von willebrand first described a peculiar bleeding disorder
http://www-personal.umd.umich.edu/~jcthomas/JCTHOMAS/1997 Case Studies/M. Alimar

Extractions: It was in 1931 that a man by the name of von Willebrand first described a peculiar bleeding disorder amongst the Aaland Islanders in the Gulf of Bothnia. Today von Willebrand disease is recognized as the most common hereditary bleeding disorder that may occur in up to 1% of the population. Although the condition is known to be inherited as an autosomal dominant (affecting both males and females) individuals may also acquire the disease through a production of antibody that decreases the plasma concentration of von Willebrand factor. Von Willebrand factor is the plasma protein which is deficient and/ or defective in the disease. This factor is what causes platelets to bind damaged blood vessel walls which aids in the termination of bleeding (hemostaisis). Therefore sufferers who have the disease either yield a protein that does not function properly or exhibit diminished production of the vW factor- hence resulting in platelets that do not adhere properly when blood vessels are injured and longer overall bleeding times. Numerous studies conducted on the von Willebrand factor gene have yielded partial cDNA clones through such processes as sequential cleavage and re-ligation of restriction fragments derived from overlapping cDNA clones. The resulting identity reveals a cDNA clone of approximately 8794 bp with all of the DNA bases represented in the mature protein product of the vWF gene. The gene itself spans some 178kb and comprises 51 introns (between 97 bp and 19.9 kb in length) and 52 exons (between 40 and 1379 bp in length).
Hemophilia Of Georgia - Von Willebrand Disease
Learn about von willebrand Disease. What is von willebrand Disease? Oneof the most common bleeding disorders is von willebrand Disease.
http://www.hog.org/vwd.htm

Extractions: One of the most common bleeding disorders is von Willebrand Disease. It is named for the doctor from Finland who first described it. Von Willebrand Disease is often written and said "vWD." Like hemophilia, vWD is passed on through the genes from parent to child. But unlike hemophilia, men and women have an equal chance of getting vWD. People who have von Willebrand Disease don't have enough of a certain protein in their blood. This protein is called "von Willebrand factor". This factor is needed for platelets in the blood to work right. When a blood vessel is damaged, platelets move to the spot to plug the hole. Von Willebrand factor is what allows the platelets to stick to the blood vessel wall and to each other. In a person with vWD, the platelets can't stick together enough to make a good platelet plug. The bleeding will last longer. Unlike hemophilia, vWD is more likely to cause bleeding under the skin, easy bruising and nosebleeds. People with vWD rarely bleed into their joints. It is possible, though, for a person to have both von Willebrand Disease and hemophilia.
Von Willebrand Erkrankung (VWD)
Translate this page Nachweis der von willebrand Erkrankung (VWD) beim Scotch Terrier mittelsDNA-Test Was ist die von willebrand-Erkrankung? Die von
http://www.laboklin.de/l_forsch/for0205.htm

Extractions: Nachweis der von Willebrand Erkrankung (VWD) beim Scotch Terrier mittels DNA-Test Was ist die von Willebrand-Erkrankung? Die von Willebrand Erkrankung (vWD) ist eine Blutgerinnungsstörung von unterschiedlichem Schweregrad, die aus einem defekten oder gar fehlenden von Willebrand Faktor (vWF) im Blut resultiert. Der vWF ist ein wichtiger Faktor der Blutgerinnung. Der vWF hat die Funktion, den Faktor VIII im Blut zu stabilisieren und die Adhäsion der Thrombozyten an das Subendothel zu unterstützen. Ein fehlender oder defekter vWF hat zur Folge, daß betroffene Tiere bei Verletzungen sehr lange nachbluten und u.U. verbluten können. Welche Formen der von Willebrand-Erkrankung gibt es? Man unterscheidet drei verschiedene Formen dieser Erkrankung. Typ 3 vWD ist die schwerste Form dieser Erkrankung. Diese Form wird autosomal-rezessiv d.h. verdeckt vererbt. Reinerbig betroffene Tiere (d.h. von beiden Elternteilen wurde ein betroffenes Gen geerbt) haben keinen nachweisbaren vWF im Blut. Schwere Blutungen machen Transfusionen nötig, um den fehlenden vWF zu ersetzen. Mischerbige Anlageträger (d.h. von einem Elternteil wurde eine Erbanlage geerbt) weisen mäßig reduzierte vWF-Spiegel auf, scheinen aber generell eine normale Blutgerinnung zu haben. Unter welcher Form der von Willebrand-Erkrankung leidet der Scotch Terrier und wie häufig kommt diese Erkrankung vor?
Antihemophilic Factor/von Willebrand Factor Complex (Human), Centeon Pharma G.m.
Antihemophilic Factor/von willebrand FactorComplex (Human), Centeon Pharma GmbH.
http://www.fda.gov/cber/products/anticen040199.htm

Extractions: Indication for Use: For use in adult patients for treatment and prevention of bleeding in hemophilia A (classic hemophilia) and in adult and pediatric patients for treatment of spontaneous and trauma-induced bleeding episodes in severe von Willebrand disease and in mild and moderate von Willebrand disease where use of desmopressin is known or suspected to be inadequate
CBER, Approval Letter, Antihemophilic Factor/von Willebrand Factor Complex (Huma
CBER, Approval letter, Antihemophilic Factor/von willebrand Factor Complex (Human)HumateP® in adult patients for treatment and prevention of bleeding in
http://www.fda.gov/cber/approvltr/anticen040199L.htm

Extractions: GERMANY Dear Dr. Krahl: You are requested to submit samples of each future lot of this product together with protocols showing results of all applicable tests. No lots of product shall be distributed until notification of release is received from the Director, Center for Biologics Evaluation and Research (CBER). All adverse experience reports should be submitted according to 21 CFR 600.80 to the Center for Biologics Evaluation and Research, HFM 210, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852-1448. It is also requested that distribution reports be submitted according to 21 CFR 600.81. Please acknowledge receipt of the enclosed license to the Director, Division of Blood Applications, HFM-370, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, Maryland 20852-1448. Establishment License No. 1202 and the Product License for Antihemophilic Factor (Human), dated August 22, 1996, should be forwarded to the Director, Division of Manufacturing and Product Quality, HFM-670. These licenses should be returned in order that notation of revocation may be made thereon, after which they will be returned to you for your files.
Danmarks Bløderforening : Von Willebrand
Her er du Danmarks Bløderforening Sygdomsfakta Sygdomsbeskrivelser von willebrand. von willebrands sygdom. von willebrands
http://www.bloderforeningen.dk/neobuilder.20020321144750900000001272692228.html

Extractions: Her er du : Danmarks Bløderforening Sygdomsfakta Sygdomsbeskrivelser Von Willebrand Von Willebrands sygdom er den mest almindelige blødersygdom i verden og rammer omkring 1% af befolkningen. Både kvinder og mænd kan have von Willebrands sygdom. Men kun få er klar over at de har sygdommen, og kun få kender mulighederne for behandling. Nogle får ofte næseblod men har lært at leve med det. Andre døjer med kraftige menstruationer uden nogensinde at blive behandlet, for "det ligger bare til familien". Men det påvirker ens hverdag, og der skal ikke så meget til for at undgå problemer. Von Willebrands sygdom skyldes, at man enten har for lidt - eller slet intet - af den størkningsfaktor, som hedder von Willebrand-faktor. Det kan også være, at man har faktor nok, men at den er forkert opbygget. Når der er noget galt med von Willebrand-faktoren, tager det længere tid for en blødning at standse. Der findes 3 forskellige hovedtyper af von Willebrands sygdom, hvor type 1 er den mildeste og den mest udbredte. Type 3 er den sværeste, men også den mest sjældne.
Danmarks Bløderforening : Von Willebrand Kampagne
Her er du Danmarks Bløderforening Om foreningen Projekter og kampagner von willebrand Kampagne. von willebrand oplysningskampagne.
http://www.bloderforeningen.dk/neobuilder.20020408164410000000002089940483.html

Extractions: Her er du : Danmarks Bløderforening Om foreningen Projekter og kampagner Von Willebrand Kampagne I Juni 2001 fik Bløderforeningen tilsagn om støtte til at gennemføre en oplysningskampagne om von Willebrands sygdom fra Apotekerfonden af 1991. Kampagnen foregår i samarbejde med de danske hæmofililæger og repræsentanter fra Dansk selskab for almen medicin (DSAM) og Dansk Selskab for Obstetrik og Gynækologi (DSOG).
Von Willebrand Disease: A New Attempt At Classification Of A Complex Disorder
4. von willebrand Disease A new attempt at classification of a complexdisorder. Samuel A. Santoro, MD, Ph.D. References. von willebrand EA.
http://medicine.wustl.edu/~labmed/1996vol4no4.html

Extractions: April 1996, Volume 4 No. 4 V on Willebrand disease (VWD) was first described in 1926 by Erik von Willebrand who reported on a young Finnish girl from the Aland Islands with a bleeding disorder distinguishable from classical hemophilia by its autosomal pattern of inheritance, mucocutaneous hemorrhage rather than joint and soft tissue bleeding, and a prolonged bleeding time. We now know that the disorder arises from the deficiency or abnormal function of von Willebrand factor (VWF) a large, structurally complex platelet adhesive glycoprotein present in plasma, in platelets and in vascular endothelial cells. In fact, VWD is the most common of the hereditary coagulopathies. VWF serves two principal hemostatic functions. It supports adhesion of platelets to damaged vascular walls, and it serves as a carrier for the Factor VIII molecule. Bleeding arises from the loss of one or both of these functions. Laboratory diagnosis is currently established by measurement of the VWF antigen, determination of the ristocetin cofactor activity (a functional measure of the interaction of VWF with its principal platelet receptor), and determination of the level of Factor VIII procoagulant activity. Multimer analysis may be required to establish the presence or absence of the high molecular weight forms of VWF. For more detail on the diagnosis of VWD, the interested reader is referred to a recent review.
Florida State University College Of Medicine Digital Library
von willebrand Disease Patient/Family Resources. Miscellaneous. Miscellaneous VonWillebrand Disease Patient/Family Resources Healthfinder (US DHHS) Homepage
http://fsumed-dl.slis.ua.edu/patientinfo/hematology/bleedingdisorders/coagulatio

Extractions: Patient/Family Resources by Topic: Hematology Von Willebrand Disease Patient/Family Resources Pediatrics Spanish Miscellaneous See also: Summary Chart of Factor Deficiencies: Access document MEDLINE plus Medical Encyclopedia: Table of contents Merck Manual Home Edition Table of contents Pediatrics Spanish Miscellaneous Von Willebrand Disease Patient/Family Resources National Library of Medicine MEDLINE plus Health Topics: Index YAHOO - Health:Diseases and Conditions:Blood Disorders
Florida State University College Of Medicine Digital Library
von willebrand Disease Clinical Resources. CliniWeb Homepage (includes links totargeted PubMed MEDLINE searches) von willebrand Disease List of documents.
http://fsumed-dl.slis.ua.edu/clinical/hematology/bleedingdisorders/coagulation-d

Extractions: Clinical Resources by Topic: Hematology Von Willebrand Disease Clinical Resources Emergency Pediatrics Radiology Pathology ... Miscellaneous Resources See also: Chapter 116: Disorders of the Platelet and Vessel Wall: Table of contents Acquired vWD: Access document Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult): Table of contents Medical Library subscription INFO Chapter 106 - Laboratory Evaluation of Hemostatic Disorders: Access document Chapter 113 - Structure, Biology, and Genetics of von Willebrand Factor:
Von Willebrand Disease
HOME (Von) Willebrand Disease. von willebrand Disease A new attemptat classification of a complex disorder; vWF Database; von willebrand
http://www.bdid.com/vwd.htm

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