Book Description
This book has been created for parents who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells parents where and how to look for information covering virtually all topics related to fragile x syndrome (also FRAXA; Marker X Syndrome; Martin-Bell Syndrome; X-linked mental retardation; X-linked Mental Retardation and Macroorchidism), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on fragile x syndrome. Given parents' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms. ... Read more

Book Description
A work that encompasses both biological and psychological perspectives, Behavior and Development in Fragile X Syndrome provides a comprehensive and lucid analysis of fragile X syndrome, the disorder that has been linked to childhood autism and estimated to cause 10 percent of all mental retardation. The authors examine the prevalence and historical roots of the syndrome, discuss the wide range of behaviors symptomatic to fragile X, and recommend intervention and treatment techniques."Altogether, I feel this book provides a very useful reference book on the subject and would recommend its inclusion in any library for psychiatrists working in the field of learning disability. . . . Includes a comprehensive list of references."--British Journal of Psychiatry"It provides an excellent introduction and overview on FXS for practitioners and clinical trainees. . . . The book provides an excellent mixture of research-based information and opinion. . . . Of particular interest is the final chapter on intervention and treatment."--Clinical Psychology Forum"The book by Elisabeth M. Dykens and colleagues is an excellent, thorough review of research on the cognition, behavior, and psychopathology of the fragile X syndrome. . . . This book is highly recommended for various professionals, investigators, and clinicians who work with persons with this syndrome. Also, many parents will surely find it helpful."--W. Roy Breg, M.D., Professor Emeritus,Departments of Genetics and Pediatrics, Yale University ... Read more

Book Description
This new book is an up-to-date review of the clinical, epidemiological, and cytogenetic aspects of the fragile X (Martin-Bell) syndrome--the most common genetic cause of mental retardation after Down syndrome. The book includes the latest research findings concerning diagnosis on the basis of
the appearance of a fragile site in cultured lymphocytes. It assumes little prior knowledge of the subject, and provides a clearly written, easy-to-understand discussion previously unavailable in a single reference source.The book will be of special interest to molecular biologists,
cytogeneticists, medical geneticists, and clinicians and other professionals working with the mentally handicapped. ... Read more

Book Description
This digital document is a journal article from Neuropsychologia, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Fragile X syndrome (FXS) is due to the silencing of a single X-linked gene and it is associated with striking attentional difficulties. As FXS is well characterised at the cellular level, the condition provides a unique opportunity to investigate how a genetic dysfunction can impact on the development of neurocomputational properties relevant to attention. Thirteen young boys with FXS and 13 mental-age-matched typically developing controls performed a touch-screen-based search task that manipulated the similarity between targets and distractors and their heterogeneity in size. Search speed, path and errors were recorded as multiple measures of performance. Children did not differ in overall search speed or path when searching amongst distractors, but striking error patterns distinguished children with FXS from controls. Firstly, although clear markers of previously found targets remained on screen, children with FXS perseverated on touching previous hits more than typically developing controls, consistent with the well-documented inhibitory deficits in adults with the disorder. Secondly, they could accurately discriminate single target-distractor pairs, but, when searching a complex display, they touched distractors more often than control children when distractors were similar to targets and especially so when these were infrequent, highlighting difficulties in judging relative size and allocate attentional weight independently of stimulus frequency. Thirdly, their performance was also characterised by inaccuracies in pointing, suggesting additional motor control deficits. Taken together, the findings suggest that fragile X syndrome affects the early development of multiple processes contributing to efficient attentional selection, as would be predicted from an understanding of the neurocomputational changes associated with the disorder. ... Read more

Book Description

Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come byuntil now. The Gale Encyclopedia of Genetic Disorders addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the Gale Encyclopedia of Genetic Disorders for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.

Book Description
This digital document is a journal article from Brain and Cognition, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Fragile X and Turner syndromes are two X-chromosome-related disorders associated with executive function and visual spatial deficits. In the present study, we used ocular motor paradigms to examine evidence that disruption to different neurological pathways underlies these deficits. We tested 17 females with fragile X, 19 females with Turner syndrome, and 40 females with neither disorder who comprised the comparison group. Group differences emerged for both the fragile X and Turner syndrome groups, each relative to the comparison group: Females with fragile X had deficits in generating memory-guided saccades, predictive saccades, and saccades made in the overlap condition of a gap/overlap task. Females with Turner syndrome showed deficits in generating memory-guided saccades, but not during either the predictive saccade or gap/overlap task. Females with Turner syndrome, but not females with fragile X, showed deficits in visually guided saccades and anti-saccades. These findings indicate that different brain regions are affected in the two disorders, and suggest that different pathways lead to the similar cognitive phenotypes described for fragile X and Turner syndromes. ... Read more

Book Description
This digital document is an article from Internal Medicine News, published by International Medical News Group on April 15, 2004. The length of the article is 479 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Fragile X-associated syndrome: should carriers know of new risks?(Clinical Rounds)
Author: Debra Wood
Publication: Internal Medicine News (Magazine/Journal)
Date: April 15, 2004
Publisher: International Medical News Group
Volume: 37Issue: 8Page: 45(1)

Distributed by Thomson Gale ... Read more

Book Description
This digital document is an article from Family Practice News, published by International Medical News Group on August 1, 2004. The length of the article is 506 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Fragile X-linked syndrome: tell carriers of new risks.(Clinical Rounds)
Author: Debra Wood
Publication: Family Practice News (Magazine/Journal)
Date: August 1, 2004
Publisher: International Medical News Group
Volume: 34Issue: 15Page: 55(1)

Distributed by Thomson Gale ... Read more