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In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing. Since only the smallest fraction of information dealing with Friedreich ataxia is indexed in search engines, such as www.google.com or others, a non-systematic approach to Internet research can be not only time consuming, but also incomplete. This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. ... Read more

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This book has been created for parents who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells parents where and how to look for information covering virtually all topics related to friedreich's ataxia (also familial ataxia; Friedreich's Disease; Friedreich's Tabes; hereditary ataxia of Friedreich; Hereditary Ataxia, Friedrich's Type; hereditary spinal ataxia), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on friedreich's ataxia. Given parents' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms. ... Read more

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Targeted to patients, their families and allied health students, The “Gale Encyclopedia of Neurological Disorders” provides in-depth coverage of neurological diseases and disorders, including stroke, multiple sclerosis, Parkinson disease, Tourette Syndrome, Alzheimer's disease, cerebral palsy, vertigo, amnesia and epilepsy. Related topics include communication aids, electric personal assistive mobility devices, medications for treating neurological diseases and conditions, understanding the needs of Alzheimer patient caregivers and more. This two-volume set provides an alternative to resources that either fail to explore neurological disease in any depth and or do so at a level not appropriate for students and general readers.

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This digital document is an article from Journal of Medical Speech - Language Pathology, published by Delmar Learning on December 1, 2008. The length of the article is 3705 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Temporal and spatial variability in speakers with Parkinson's disease and Friedreich's ataxia.
Author: Andrew Anderson
Publication: Journal of Medical Speech - Language Pathology (Magazine/Journal)
Date: December 1, 2008
Publisher: Delmar Learning
Volume: 16Issue: 4Page: 173(8)

Distributed by Gale, a part of Cengage Learning ... Read more

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The article is excerpted fromGale Encyclopedia of Medicine.

Consultthe second edition of this authoritative, comprehensive, in-depthmedical guide for information on more than 1,700 medical topics inlanguage accessible to adult laypersons. Presented in a singlealphabetical sequence, articles range in length from one or twoparagraphs for minor topics, to several pages or more for major topics.Disease/disorder articles typically cover definition; description;causes and symptoms; diagnosis; treatments; prevention; and more.Test/treatment articles typically cover definition; purposes;precautions; preparation; risks; normal and abnormal results; and muchmore. This second edition includes more than 200 new entries, 300updated entries, approximately 650 color images and illustrations, anda comprehensive subject index. New features include biographical andhistorical sidebars throughout the text.

Disease/disorder articles contain some or all of the following sections:

• Definitions -- brief dictionary-style definition of the disorder
• Descriptions -- overview of the disorder; who gets it and why
• Causes & symptoms -- process, substance or organism thatproduces the condition; any risk factors that increase susceptibilityto the condition; signs and symptoms of the disease
• Diagnosis -- overview of procedures and tests used todiagnose the condition; how the test is done; who should be tested andwhen; time required; cost; whether it's typically covered by insurance
• Treatments -- overview of conventional methods of care ormanagement of the condition, such as drugs, surgeries, physicaltherapy, etc.
• Alternative treatments -- overview of alternative/complementary therapies that may be used to treat the condition
• Prognosis -- probable outcome of the disease
• Preventions -- what actions can be taken to prevent the condition from occurring

Test/treatment articles contain some or all of the following sections:

• Definitions -- brief dictionary-style definition of the test/treatment
• Purposes -- why and when this test/treatment is prescribed
• Precautions -- when this test/treatment should not be prescribed
• Descriptions -- overview of the test/treatment including cost,length of time required, procedures followed, whether typically coveredby insurance
• Preparation -- pre-test treatment procedures, if any
• Aftercare -- post-test treatment procedures, if any
• Risks -- any complications/side effects commonly associated with the test/treatment
• Normal results -- for tests, describes the normal values; for treatments, describes the anticipated outcomes
• Abnormal results -- defines abnormal test values

Published/Released: December 2001

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Friedreich's ataxia (FA) is a severeneurodegenerative condition with an incidence of1:50,000 in the European population. The defectiveprotein encoded by the FRDA gene is known asfrataxin. While the precise role of human frataxinremains to be determined, it appears to be involvedin regulating mitochondrial Fe. We examined frataxin in Femetabolism by implementing amodel of erythroid differentiation. Since decreasedfrataxin expression leads to mitochondrial Fe- loading in FA,our data suggest that reduced frataxin expressionresults in mitochondrial Fe sequestration for hemebiosynthesis. These findings suggest that the use ofspecific Fe chelators may have potential in thetreatment of this disease.In order to develop effective (Fe) chelators forFA, we synthesized and characterised three classesof aroylhydrazone analogues basedon: (1) 2-pyridylcarboxaldehyde isonicotinoylhydrazone (PCIH), (2) 2-quinoline carboxaldehydeisonicotinoyl hydrazone (QCIH), and (3) di-2- pyridylketone isonicotinoyl hydrazone (PKIH). Thisstudy identified not onlystructural features useful in the logical design ofchelators for the treatment of FA. ... Read more

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This digital document is an article from Original Internist, published by Thomson Gale on September 1, 2005. The length of the article is 439 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Co[Q.sub.10] and vitamin E slow progression of some aspects of Friedreich's ataxia while reversing others.(ABSTRACTS OF INTEREST)
Author: Steve Austin
Publication: Original Internist (Magazine/Journal)
Date: September 1, 2005
Publisher: Thomson Gale
Volume: 12Issue: 3Page: 138(1)

Distributed by Thomson Gale ... Read more

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Great informational magazine! Full color as well as b/w illustrations, diagrams and photos. ... Read more

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This digital document is an article from Gale Encyclopedia of Medicine, 3rd ed., brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 822 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.The third edition of this authoritative, comprehensive, in-depth medical guide features information on medical topics in language accessible to adult laypersons. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes; precautions; preparation; risks; normal and abnormal results; and much more. ... Read more

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Avoiding hard-to-understand medical jargon, the four-volume “Gale Encyclopedia of Children’s Health” uses language that parents can understand, while still providing enough depth to benefit today's health science students. The set provides in-depth coverage of pediatric diseases and disorders, along with issues related to physical and cognitive/behavioral development.

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Here, an overview is given on previous research and trial endeavours to treat Friedreich's ataxia (FRDA), the most common autosomal recessive neurodegenerative disease for which there are currently no effective treatments available. This book describes the search for possible drug targets at the DNA level with an emphasis on epigenetic mechanisms. During detailed investigation of the first part of the Frataxin (FXN) gene, the presence of an RNA pol II transcriptional pausing site was evident. This may represent a crucial site for new drug development approaches and might explain the relatively poor outcomes of current drug approaches to up-regulate this gene. This book should be a valuable source of information for anyone who is interested in FRDA and its molecular mechanisms. ... Read more

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Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come by—until now. The “Gale Encyclopedia of Genetic Disorders” addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the “Gale Encyclopedia of Genetic Disorders” for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.