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Helicobacter pylori is a globally significant pathogen that infects half of the population of the world. Its recognition enabled the development of new therapeutic and preventative strategies for serious health conditions such as gastric cancer, of which it is the major causative agent. Providing a broad overview of the current understanding of this pathogen and emphasising its world health impacts, this book explores a range of topics including virulence factors, vaccine development and obstacles, epidemiology, antibiotic resistance and the role of Nod receptors, with a foreword by Barry Marshall, the Nobel Laureate and co-discoverer of H. pylori. It is an essential resource for researchers, students and medics in infectious and Helicobacter-associated diseases. ... Read more

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Helicobacter pylori Protocols offers an outstanding collection of state-of-the-art protocols for the identification and molecular manipulation of H. pylori. The authoritative contributors supply detailed and readily reproducible protocols for the culturing of H. pylori, for the isolation and restriction endonuclease digestion of H. pylori chromosomal DNA, and for the transformation and insertional mutagenesis of H. pylori.They also provide molecular epidemiological techniques, including ribotyping, PCR-RFLP, and RAPD-PCR. These procedures have been developed by leading practitioners to solve the difficult technical problems created by the application of the powerful bacterial genetic and molecular cloning techniques to H. pylori. ... Read more

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H. pylori infection, both in man and in the laboratory animal, has become a standard model to investigate fundamental problems in biology, such as microbial-host interactions, intracellular signalling, modulation of inflammation, mucosal atrophic metaplasia, and microbial resistance, to name just a few. The issues addressed in this book are grouped according to their leading theme. Topics include: the new Helicobacters, strain differences of H. pylori and their consequence on microbial-host interactions and the effects of H. pylori infection on the gastric mucosa. The role of H. pylori is explained in relation to: gastric carcinogenesis; gastroesophageal reflux disease; dyspepsia and long-term acid suppression. Eradication therapies are reviewed with respect to their global consequences and problems. The last two sections are devoted to a global update on therapeutic indications and finally on priorities for further research.
These proceedings accurately reflect the state-of-the-art presentations delivered by world experts. This latest volume will further enrich this top-class series on H. pylori infection. ... Read more

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Helicobacter pylori is increasingly recognised as a cause of gastritis and peptic ulceration and, in order to successfully treat this common problem, gastroenterologists must be aware of the latest epidemiological, chemical and research developments. This volume is a thorough review of the epidemiological, microbiological, molecular biological and immunological background of H.pylori with strong emphasis on chemical diagnosis and management and treatment with drugs. Professor Marshall who discovered this organism and who has pioneered new treatments heads an impressive team of authors to provide a practical, positive, clinically oriented approach to diagnosis and therapy. ... Read more

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The explosion of new information on Helicobacterpylori-related disease, both in the basic sciences and in clinicalmedicine, has continued to progress at an unprecedented pace. In manyinstances H. pylori infection, both in man and in thelaboratory animal, has become a model to investigate fundamentalbiological issues such as micro-organism host interactions,intracellular signaling, development of mucosal atrophy, mechanism ofmicrobial resistance, disease modifying factors etc. In view of this bewildering flood of new information, another meetingon H. pylori in the successful series `Basic mechanisms toclinical cure' was organized in January 1998 in San Diego, California,to define the `state-of-affairs' in H. pylori research at thistime. The main objective was to integrate this new information in aseries of top-quality presentations and discussions betweeninvestigators and clinicians addressing all aspects of H. pyloriresearch and to review the current position and future researchdirections. The format included state-of-the-art presentations byworld experts heavily involved in H. pylori research followed byin-depth discussion on intriguing or controversial issues. Thepresentations were grouped according to the leading theme:characteristics of the organism, mode of transmission, mechanisms ofH. pylori-induced inflammation, causation of disturbances ofgastric secretory and motor function, aspects of clinical presentationand management, problems related to H. pylori-associated gastricadenocarcinoma and MALT-lymphoma, novel aspects of antimicrobialtherapy and vaccination. The meeting concluded with a synoptic agendaof suggested future studies for the microbiologist, thehistopathologist and the clinician. The chapters published in these proceedings accurately reflect thecontent of the superb presentations. The reader will readilyappreciate the excellent level of the `cutting-edge' research whichwas described and discussed. These proceedings are another testimonyto the enormous impact on basic science and clinical medicine of theH. pylori discovery. Although much was achieved, it is alsoreadily apparent that many questions remain to be answered and manyproblems remain to be solved. ... Read more

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Today there is overwhelming evidence that Helicobacterpylori is the major cause of chronic active gastritis and that itmay further predispose to peptic ulcers, of which there are severalthousand cases in the US each year. The most severe clinical outcomesof H. pylori infection are mucosa-associated lymphoid tissuelymphoma and gastric cancer. Because of these findings, theimplications for cancer etiology are intriguing. This book, a volumein the Infectious Agents and Pathogenesis series, presentschapters by major researchers in the field, including Dr. BarryMarshall whose research was responsible for establishing the linkingof gastric ulcers with the H. pylori bacterium. ... Read more

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Helicobacter pylori has been established as a major factor in gastroduodenal disease. As such it has become the centre of attention for an ever increasing number of researchers, drawn from many disciplines, eager to facilitate better diagnosis, improved therapies and ultimately the eradication of this most prevalent and fascinating of gastrointestinal pathogenic bacteria. This volume brings together the experience of those gastroenterologists, microbiologists, immunologists and others who have developed the many and varied techniques established as playing a vital role in the diagnosis, management and research into H. pylori and its many disease manifestations. The manual contains detailed instructions of each technique including: brief background putting the technique into clinical context; instructions "recipe" style; illustrated critical steps; guidance on interpretation of results; "Tips and traps" highlighting potential pitfalls and how to avoid them; a list of reagents used. ... Read more

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Helicobacter pylori: Biology and Clinical Practice is the first book to fully describe H. pylori and the pathogenesis of H. pylori infections. It delineates the genome of H. pylori, discusses the molecular biology of the unique urease enzyme, and examines the clinical application of these discoveries. The book describes the epidemiology of H. pylori and its relevance to gastric cancer, and it offers clear guidance to clinicians for the diagnosis and treatment of peptic ulcer and non-ulcer dyspepsia in adults and children. Vaccine principles and possibilities are presented for the first time. Edited by the leader of the microbiology team that achieved the first culture of H. pylori, and named the Helicobacter genus, this book is essential for bacteriologists, gastroenterologists, microbiologists, infectious disease specialists, and other researchers interested in H. pylori. ... Read more

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In the rapidly evolving field of Helicobacter infection newdata on pathogenetic and pathophysiological mechanism haveappeared. New methodswhich will be more sensitive andspecific in the diagnosis of the infection are beingdeveloped and in this proceedings the first attempt usingPCR technology is published. From the clinical point ofview, a challenging aspect that needs clarification, is theobservation which suggests an appearance of a correlationbetween the presence of the bacteria andabdominal pain andother symptoms in children whereas in old age no suchcorrelation is evident. The relationship of H. pylori andgastriccancer is studied with histopathological data andepidemiological approaches. On the treatment side schemesusing short courses and new antibiotic combinations arebeing investigated and preliminary data are reported. ... Read more

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The impact of Helicobacter pylori on basic science andthe clinical management of patients with the complications of thisinfection is bewildering. The explosion of new information both in thelaboratory and at the bedside has progressed at an unprecedented rate.Our main objective in furthering this progress has been to integratethis new information and organize a series of top qualitypresentations and discussions between investigators and clinicians onall aspects of H. pylori research and to review the currentposition and future research directions. To that end, the secondmeeting Helicobacter pylori: Basic Mechanisms to Clinical Cure wasorganized in June 1996 in Ottawa, Canada, following the successfulformat of the first such meeting held in Amelia Island, Florida, in1993. The meeting again focused on all timely aspects of H. pyloriresearch. Internationally renowned basic and clinical scientists, allexperts in their respective fields, explored in depth the spectrum ofH. pylori infection and the related complications of gastritis,peptic ulcer, gastric cancer and lymphoma. The presentations covered:the genetic heterogeneity of the organism, including the expression ofvirulence factors determined by the genetic pathogenicity island; theintricate cascade of chemokines and cytokines leading to mucosalinflammation; the complexities of the mucosal immune response,favoring a slight Th1 over Th2 lymphocyte imbalance; the fundamentalissue of the apparent paradox of the induction of both apoptosis andepithelial hyperproliferation; the pathophysiological consequences ofgastric mucosal inflammation with respect to the elevation of gastrinand the acid secretory response; the mechanisms leading to pepticulcer disease, gastric carcinoma and gastric mucosa-associatedlymphoid tissue (MALT) lymphoma; the established and novel therapeuticapproaches to eradication and finally the prospects for successfultherapeutic and preventative vaccination. The comprehensive manuscripts in this book of the proceedings of themeeting reflect the most up-to-date information and state of the artapproaches to research and management of H. pylori infection andwill provide an invaluable reference source. ... Read more

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(Horizon Scientific Press) Max-Planck Institut fur Infektionsbiologie, Berlin, Germany. Covers the history, taxonomy, and epidemiology of H. pylori infection, and continues with chapters on host responses including immunity, apoptosis, and animal models. Also summarizes genome analyses, molecular typing, and population genetics. All chapters are independent. ... Read more

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Since the appearance of the first edition of this work (Campylobacter Pylori and Gastroduodenal Disease, 1989) the pathogen in operation has changed its name and taken its place in the Sydney System of Classification of Gastritis. This new edition has been significantly revised and up-dated, chapter by chapter, and represents a concise clinical consolidation of the rapid progress of the pathology of ulcers and their treatment. There are new chapters on epidemiology, colonisation and alteration in gastric physiology and the biochemical and pharmacological basis for treatment. The significance of helicobacter pylori is debated in a controversial final chapter ... Read more

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This manual, written for general practitioners, contains definitions of terms, illustrated descriptions of pathophysiological mechanisms, step-by-step guidelines on procedures and tabular information on epidemiology, comparisons of treatment and other aspects of helicobacter pylon. ... Read more

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St. James's Univ. Hospital, Leeds, UK. Concise clinical manual on Helicobacter pylori infection and its clinical implications, particularly in ulcer disease. For gastroenterologists and researchers. Includes updated sections on diagnosis and treatment. Trim size: 8.5 x 5.5 inches. Softcover. ... Read more

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In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. ... Read more

Customer Reviews (1)

Helicobacter Pylori Infection in Childhood
Don't order this unless you are a medical doctor. This was written by a doctor who was trying to get a PHD and this was his dissertation. Not much in it for the layperson. ... Read more

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Central Middlesex Hospital NHS Trust, London, U.K. Practical text covering the recent scientific and clinical developments in the understanding and treatment of helicobacter pylori, for general practitioners, gastroenterologists, and surgeons. Softcover. ... Read more

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This book provides the current up-dated knowledge on essential aspects in the rapidly evolving area of helico- bacter pylori research. Both basic science and clinical research with actual practical consequences are taken into account. The chapters target the topics microbiology, pathogenic mechanisms on gastroduodenal mucosa, interactions with the immune system, pathomorphology, the role of helicobacter pylori in peptic ulcer disease and therapeutic consequences. Qualified international experts from different scientific disciplines have contributed to give detailed insight into the current understanding concerning the role of this bacterium. ... Read more