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A Brilliant, Complex Physician/Scientist

Charlotte Jacobs has meticulously documented the life of Henry Kaplan, MD.After the death of his father when Henry was 16, he decided he would dedicate his life to curing cancer. After medical school, he focused his energy on curing Hodgkin's Lymphoma.

Among the sources Dr. Jacobs tapped in writing this book were his talented wife Leah and their children, his sole sibling Richard, many colleagues, a few close friends, and a handful of carefully chosen patients.

Patient commentaries are presented chronologically and reflect the early use of radiation and its refinements, including dosing intensity, frequency and location.Next we learn about the advent of chemotherapy, new agents and the use of cocktails.Some patients survive and some do not. The diagnoses, treatments, and outcomes are presented along with the reactions of the patients and their families.

Henry Kaplan and his team began using staging laparoscopies and lymphangiograms to aid in the diagnosis and treatment of Hodgkins Lymphoma.He attempted to link cancer to viral causes.Before he died of lung cancer he conducted initial experiments to make monoclonal antibodies targeting cancers.

We learn about Dr Kaplan's significant influence on the evolution of Stanford University as a great clinical and scientific institution, which eventually rivals those established in the eastern US. He helped create the vision, and he was instrumental in recruiting Arthur Kornberg and others to Stanford.

Not all facets of this complex physician scientist were perfect.When Charlotte asked Henry's wife about writing this biography, Leah make it clear that she did not want hagiography, but a true picture of a complex man with many gifts and some flaws.

Because of his strained relationships with others at Stanford (physicians and administrators), he was not successful in establishing a cancer center there.The team assigned to make this happen sensed that Henry was the sole driver, and feared what would happen if he got "his" center.He was kind to his patients, and they loved him.He could be brutal in his feedback to some of his peers, subordinates, and deans, many of whom strived to avoid him.He became so engaged in curing cancer that he sometimes overlooked his relationships with his family.

The author, Charlotte Jacobs, MD, is a renowned oncologist who knew Dr. Kaplan at Stanford.Her part-time researching and writing this fascinating biography spanned 13 years.

This is a remarkable, well researched book about a multifaceted, driven physician/scientist.I highly recommend it for anyone interested in learning about scientific discoveries, incremental clinical advances, the treatment of difficult cancers, the history of a great university, and the life of a driven, accomplished man.

I await the opportunity to read her biography of Jonas Salk, the discoverer of the vaccine that helped eradicate polio.

Capturing A Life
"Dr. Charlotte Jacobs did a wonderful job of capturing Dr. Kaplan's life and impact on his patients like my brother.I was 10 when my brother, Joey, became ill.Stanford was our lifeline of hope.Dr. Kaplan and all the staff and nurses at Stanford were God sent.
Dr. Kaplan and Dr Rosenberg cared so much for each patient and took on so much responsibility for the outcome.Without their determination my brother would have died within months.
What mattered to us is that my brother was able to live and he did that very well!Even when his treatments left him weak and his immune system down we went camping with our friends and cousins.He wanted to just be a teenager and Dr. Kaplan and Dr. Rosenberg gave that to him.
We all learned so much about life from Joey and hope Dr. Jacobs' book will give others the courage to live.
Dr. Jacobs did a wonderful job of letting us know who Dr. Kaplan was and just how wonderful and dedicated of a man he was.The same can be said of Dr. Rosenberg.Thank you both again. "

A great biography
This book by Dr. Jacobs is the best science biography I have read since Lawrence and Oppenheimer (Davis, 1968). It should be read by every oncologist but beyond that by every academic physician who seeks greatness. It tells the story of a brilliant man, the smartest person I have every met or worked with. It shows how such a person can create great things but fails to achieve some goals because the rest of the world does not wish to participate in his vision. The book also documents Kaplan's empathy and passion in service to his patients. It is also a great book for the non physician reader who wants to understand how medical science makes progress in spite of the personalities involved. Charlotte Jacobs is a very skilled and insightful writer and this book is hard to put down. ... Read more

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In recent years a dramatic increase in knowledge of the biology of the lymphomas has been accompanied by the emergence of new treatments offering improvements in efficacy and reduction in toxicity. In this volume an internationally recognized group of experts review relevant aspects of the biology, diagnosis and management, with particular emphasis on the emerging data available for this disease.

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Customer Reviews (1)

Excellent
I am very happy with this book, although probably the only people who would want to read it are medical students or really autodidactic victims of Hodgkin's.It is very thorough, has good charts and illustrations, and is packed with statistical data.The book itself seems to be good quality; I expect it should hold up well.A family member was recently diagnosed and this book is giving me information and answers that I do not expect to get anywhere else.The discussion of long term life expectancy was very frank and complete.I would not recommend this book for the average lay person; it requires a pretty good foundation of medical knowledge.

I did not pay full price, but bought from one of the third party sellers, although I see today more are available at even less.The amount of information contained here is certainly worth well over $200, so if you get it for the bargain prices, you are getting a very good deal. ... Read more

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Totally worth the time to read this book.
Take the time to read this book.It is worth the read and it is a truly a touching account of a caring, loving husband and how he and his wife together battled through the years she battled with Hodgkin's.If this book does not move your heart to care about people, nothing will.Totally worth the time to read this book.It is not hard to pick up, but hard to put down. ... Read more

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This book has been created for parents who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells parents where and how to look for information covering virtually all topics related to childhood hodgkin's disease (also Cancer Hodgkin's lymphoma; child Lymphoma Hodgkin's; child Malignant lymphoma; Hodgkin Disease; Hodgkin's disease; Hodgkin's Lymphoma), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on childhood hodgkin's disease. Given parents' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms. ... Read more

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The lymphatic system plays a key role in fighting out the bacteria infested in the human body. More importantly, it aids in the fight against disease. Inside the lymphatic system, lymph vessels widen to produce lymph nodes. These lymph nodes usually appear under the arm or neck of those who are sick or infected. If cells continue to swell or multiply, they can often be considered as cancerous. Lymphoma is the actual type of cancerous cell that spreads throughout the lymphatic system. One main group of cells that spread within lymphatic system is Hodgkin's Disease, which is recognised by its growth of Reed-Sternberg cells. This book presents cutting edge research from around the world. ... Read more

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This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to hodgkin's disease during pregnancy (also Cancer Hodgkin's lymphoma; Hodgkin Disease; Hodgkin's disease; Hodgkin's Lymphoma; Lymphoma Hodgkin's; Malignant lymphoma), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on hodgkin's disease during pregnancy. Given patients' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms. ... Read more

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The book deals with the evaluation of high-dose chemotherapyfollowed byautologous bone marrow or blood stem cell trans-plantation as treatment forHodgkin's disease, non-Hodgkin'slymphoma and multiple myeloma. Alternative salvages strate-gies in this rapidly developing field are reviewed and riskfactors associated with clinical outcome of newlydiagnosedlymphomas and lymphomas in relapse are evaluated. Severalfundamental issues like detection of minimal residualdisease inbone marrow and blood, the need for bone marrowpurging and preferences ofblood stem cells to bone marroware discussed. The use of hematopoietic growth factors suchas GCSF and GMCSF after bone marrow transplantation aredescribed. ... Read more

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This is an OCR edition without illustrations or index. It may have numerous typos or missing text. However, purchasers can download a free scanned copy of the original rare book from the publisher's website (GeneralBooksClub.com). You can also preview excerpts of the book there. Purchasers are also entitled to a free trial membership in the General Books Club where they can select from more than a million books without charge. Original Published by: Columbia university in 1918 in 170 pages; Subjects: Pathogenic bacteria; Medical / Microbiology; Science / Life Sciences / Bacteriology; Science / Life Sciences / Biology / Microbiology; ... Read more

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This volume presents a wide-ranging selection of informativereviews on aspects of the malignant lymphomas, including Hodgkin'sdisease. Ten topical essays on issues relevant to the management of patientswith malignant lymphomas are presented. Treatment of common lymphomas,such as diffuse large cell lymphoma or Hodgkin's disease, isconsidered, as are approaches to unusual problems like CNS lymphoma orimmunosuppressive therapy-related lymphoproliferation.Results are presented both from long-term multicenter, Phase IIItrials and from single-institutions, Phase I studies. The data arediscussed by experienced and knowledgeable clinical scientists.Malignant Lymphomas, including Hodgkin's Disease: Diagnosis,Management, and Special Problems provides an illuminating updatefor anyone who treats these fascinating diseases. ... Read more