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First described in 1968, IgA nephropathy is now recognized as the commonest form of glomerulonephritis worldwide. This volume reports on the 5th meeting of "The IgA Club", a group of eminent nephrologists, immunologists, pathologists and other scientists with a special interest in IgA nephropathy. The contributions presented provide a comprehensive review of all major aspects of the disorder, including the latest research results and therapeutic developments. For the first time, a session of the meeting was devoted to the mesangium, and the involvement of mucosal immunity in IgA nephropathy was thoroughly discussed. ... Read more

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In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. ... Read more

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It is clear that IgA nephropathy is one of the most common types of chronic glomerulonephritis in the world. It is also recognized that this disease is the most frequent cause of end-stage renal disease. Since the pathogenesis of IgA nephropathy is still obscure, specific treatment is not yet available. However, efforts by many investigators around the world have gradually clarified various aspects of the pathogenesis and treatment of this disease. In this book, the author presents several findings in the fields of pathology, immunology, molecular biology and experimental pathology which shed light on the mechanism of development and progression of this disease. It reviews research on the treatment of IgA nephropathy and sets out to provide the most up-to-date findings on the subject. Topics include: diagnostic criteria; light-microscopic classifications of IgA nephropathy; disease activity; experimental animal models for IgA nephropathy; and blood coagualtion and fibrinolysis. ... Read more

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help me find out
i have this disease and iam tring to find out more about it can you help me ... Read more

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A further step towards unraveling this mysterious disease Primary IgA nephropathy has first been described as a new disease entity almost 40 years ago. This disorder, considered to be an immune-complex-mediated glomerulonephritis, is characterized by granular deposition of IgA (mainly IgA1) and C3 in the glomerular mesangial areas and is defined as nephropathy showing proliferative changes in the glomerular mesangial cells and increases in the mesangial matrices. Apart from being one of the most common types of chronic glomerulonephritis, it is also the most frequent case of end-stage renal disease. But even though continuing efforts have gradually clarified various aspects of the pathogenesis of the disease, specific treatment is not yet available. In this publication, international nephrologists and basic scientists report the most recent data on IgA nephropathy. Starting with clinical reviews on topics such as the clinico-pathological classification, new treatment approaches, and the role of renal biopsies, the focus then shifts towards basic reviews on, for example, candidate genes, the pathogenic role of IgA receptors or immune complex formation. Updates on clinical and basic advances, discussing among other things the influence of obesity or various therapeutic approaches, make up the second part of the book. Presenting up-to-date information on this still mysterious disease, the publication at hand constitutes a valuable source of information for nephrologists, general practitioners, residents and interns. ... Read more

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IgA Nephropathy (IgAN) is one of the most common glomerular diseases world-wide. Its natural history is consistent with a clinical onset in the first decades of life. Clinical indicators of poor prognosis are proteinuria and hypertension. Angiotensin-converting enzyme-inhibitors (ACE-I) are a promising treatment, since Angiotensin II plays a key role in glomerular hypertension and permselectivity and modulates mesangial and tubular cell functions.This Concerned Action was designed to evaluate the effect of ACE-I (benazepril 0.2 mg/Kg) versus placebo in young IgAN patients (1g/day50 ml/min/1.73m2). Activity and chronicity indexes are evaluated on renal biopsies together with the spatial distribution of IgA and C3 deposits by confocal microscopy. Ambulatory blood pressure measurements allow the identification of medium-high pressure levels. Enrolled patients are investigated for factors modulating the disease progression, including genetic predictors (gene polymorphism of HLA, IgA switch region, ACE, AT1 receptor, adducin, complement factors) and immunologic parameters (aberrantly glycosylated and macromolecular IgA in serum and cytokine urinary excretion)." ... Read more

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This comprehensive survey updates the genetic research, pathology and treatment of an enigmatic disorder. It contains new data on the role of leukocyte IgA receptors, cytokines in the mediation of IgA nephropathy and the recurrence of IgA deposits/disease in grafts. ... Read more

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The IgA Nephropathy Medical Guide is a publication which has been designed to better help readers understand IgA Nephropathy. This Qontro Medical Guide has been designed with the reader in mind, and is a useful information source for readers at all levels looking to learn more about IgA Nephropathy. The IgA Nephropathy Medical Guide is highly recommended for those interested in understanding and learning more about IgA Nephropathy. ... Read more

Customer Reviews (1)

lacking information
After being diagnosed with this, I read all the reviews on guides for more info.This has lots of info about what the diagnosis is.It has nothing about treatments. ... Read more

Product Description
This digital document is an article from Internal Medicine News, published by International Medical News Group on December 1, 2008. The length of the article is 682 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Steroid helps boost survival in IgA nephropathy.(Nephrology)(Immunoglobulin A)
Author: Nancy Walsh
Publication: Internal Medicine News (Magazine/Journal)
Date: December 1, 2008
Publisher: International Medical News Group
Volume: 41Issue: 23Page: 16(2)

Distributed by Gale, a part of Cengage Learning ... Read more

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This digital document is an article from Southern Medical Journal, published by Thomson Gale on June 1, 2007. The length of the article is 1424 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Pulmonary capillaritis in IgA nephropathy.
Author: Devanand Anantham
Publication: Southern Medical Journal (Magazine/Journal)
Date: June 1, 2007
Publisher: Thomson Gale
Volume: 100Issue: 6Page: 605(3)

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This digital document is an article from Nephrology Nursing Journal, published by Jannetti Publications, Inc. on April 1, 2001. The length of the article is 2946 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Primary IgA Nephropathy: Pathophysiology, Diagnosis, and Clinical Management.
Author: Betsy Jane Staples
Publication: Nephrology Nursing Journal (Refereed)
Date: April 1, 2001
Publisher: Jannetti Publications, Inc.
Volume: 28Issue: 2Page: 151

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IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney. This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.

Contents: IgA Nephropathy: Discovery of a Distinct Glomerular Disorder (K TWoo et al.); Epidemiology and Ancestral Difference (F P Schena & F Pesce);Genetic Contribution of IgA Nephropathy (P H Maxwell & Y-M Wang);Histopathology, Immunofluorescence and Ultrastructural Examination (F M Lai);Tubulointerstitial Injury in IgA Nephropathy (J J Roelofs & S Florquin);Podocyte Pathology (K N Lai & J C K Leung); Clinicopathologic Findings (B AJulian & R J Wyatt); Clinical Course of Primary IgA Nephropathy (F C Berthoux& H Mohey); Special Clinical Syndromes (J Nagy & T Kovács); IgA Nephropathy inChildren (R J Hogg); Recurrent IgA Nephropathy in Transplant (B Y Choy & K NLai); IgA Molecule (J-W Eijgenraam et al.); IgA Immune-Complex (J Novak & JMestecky); B and T Lymphocytes (A Rifai & A Chen); IgA Receptors and MesangialIgA Deposition (I C Moura & R C Monteiro); Antigen-Dependent Mechanism of IgANephropathy (Y Tomino & Y Shimizu); Complement Activation (S C W Tang & K NLai); Cytokines and Growth Factors (J Floege & T Ostendorf); Leukocytes,Macrophages and Monocytes (Y Ikezumi & D J Nikolic-Paterson);Renin-Angiotensin System (K N Lai & J C K Leung); Corticosteroids (C Pozzi & LDel Vecchio); Treatment for IgA Nephropathy: Renin-Angiotensin Blockade (RCoppo & L Peruzzi); Other Immunomodulatory Agents (S C W Tang & K N Lai);Other Non-Immunomodulatory Agents (J Barratt & J Feehally); Treatment of IgANephropathy: Tonsillectomy (O Hotta); Experimental Model of IgA Nephropathy (YSuzuki & Y Tomino); Future Prospect for IgA Nephropathy (R J Glassock). ... Read more