Product Description
This digital document is an article from Family Practice News, published by International Medical News Group on July 1, 2003. The length of the article is 512 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Insulin resistance syndrome tied to birth weight. (Gestational Diabetes, Maternal Obesity).
Author: Doug Brunk
Publication: Family Practice News (Magazine/Journal)
Date: July 1, 2003
Publisher: International Medical News Group
Volume: 33Issue: 13Page: 51(1)

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Product Description
This digital document is an article from Internal Medicine News, published by International Medical News Group on April 15, 2005. The length of the article is 505 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Insulin resistance raises teens' future HT risk.(Endocrinology)
Author: Patrice Wendling
Publication: Internal Medicine News (Magazine/Journal)
Date: April 15, 2005
Publisher: International Medical News Group
Volume: 38Issue: 8Page: 26(1)

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Product Description
Hepatic insulin resistance and altered insulin metabolism, as characterised by the desensitisation of hepatic parenchymal cells to insulin, play a role in the pathogenesis of liver disease, particularly resulting in steatosis and steatohepatitis. By the same token, type II diabetic patients are at higher risk for developing liver diseases, including steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma. On the other hand, established liver disease from any cause leads to glucose intolerance and peripheral insulin resistance systemically. The link between insulin resistance and liver pathology reviewed in this book suggests that insulin resistance is closely related with a variety of liver diseases. Recent evidence indicates that the AMP activating protein kinase (AMPK) in conjunction with p70 ribosomal S6 kinase 1 (S6K1) serves as a key signalling pathway regulating insulin-dependent physiological functions; thus, this pathway serves as a target for the therapy of diseases associated with insulin resistance.In this chapter, the regulatory role of the AMPK-S6K1 pathway is discussed in terms of enhancing insulin receptor signalling with insulin receptor substrate-1/2 and phosphatidylinositol phosphate kinase activity, which may contribute to preventing and/or treating insulin resistance in the liver. ... Read more

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Type II diabetes is a disease that has developed into a worldwide epidemic. At the time of the discovery of insulin in the 1920's there was approximately one Type II patient for every Type I patient. Today, 80 years later, there are close to twenty Type II patients for every Type I patient. Preceding the onset of overt diabetes in most Type II patients is a prolonged period of insulin resistance that entails a host of detrimental derangements including impaired glucose tolerance, dyslipidemia, hypertension and beta cell failure, comprising a disease entity which is best referred to as the 'Insulin Resistance Syndrome', or 'Metabolic Syndrome'. This book deals with the cellular and whole body pathogenic mechanisms and phenotypic expressions in various models of insulin resistance which will be instrumental in improving understanding and development of means for the prevention of the transition from insulin resistance into overt diabetes.

Presenting state-of-the-art knowledge in the field of insulin resistance, this book will be of great interest to all students, researchers, pharmaceutical scientists and clinicians interested in endocrinology, biochemistry and metabolism in diabetes. ... Read more

Product Description
Insulin resistance (IR) and elevated blood pressure are two key features of the metabolic syndrome, which play an important role in the development of secondary cardiovascular complications. In this book, the effects of insulin resistance on the various vasoactive pathways are explored, which affect the equilibrium between vascular relaxation and constriction. Furthermore, the interaction between oestrogen, testosterone and insulin signalling-dependent changes in vascular reactivity and blood pressure are discussed. Also addressed in this book are the mechanisms underlying reciprocal relationships between insulin secretion, insulin resistance and inflammation in the pathological state and in its subsequent improvement. Moreover, the current concepts in understanding the underlying risk factors contributing to insulin resistance are examined, focusing on the role of magnesium deficiency that emerges as potential pathogenic key related with decreasing insulin sensitivity. In addition, it is widely accepted that metabolic syndrome is related to cardiovascular disease and that insulin resistance is one of the causes of metabolic syndrome.The authors discuss thiazolidinediones (TZDs), a class of antidiabetes agents, as a means to improve endothelial dysfunction, prevent atherosclerosis, and significantly reduce the risk of cardiovascular disease. ... Read more

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Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.
... Read more

Customer Reviews (2)

Review copy request
Can we review this book and then either purchase or return the book?Iwill write the review within 3 days of getting the book.Please send us areview copy as soon as possible.

Thank you,

Ralph La Forge, M.Sc. DukeUniversity Lipid Clinic 8 North Poston Court Durham, NC 27705 (919)490-3794 ralphlaforge@msn.com

IR; The hidden resistance in a diversity of diseases
It was in 1986 at the end of his Banting Memorial lecture that Reaven said: "At first blush it appears outlandish to suggest an association between hypertension, hypertriglyceridemia and hyperinsulinemia.." Hiswords have rung in my ears ever since! Yes hyperinsulinemia is now widelyunderstood to be the measurable outcome of insulin resistance, now known bythe international acronym "IR". Insulin resistance is the"hidden resistance" that leads to an incredible diversity ofclinical disorders which "at first blush" appear even moreunlikely; these disorders in fact range from diabetes to polycystic ovarydisease; and from hypertension to unwanted facial hair in women to namejust four conditions! It is highly appropriate that Reaven has now giventhe world the benefit of his understanding of this ubiquitous MetabolicSyndrome. This syndrome has baffled science for decades and has lead to anincredidible explosion of research papers on this theme; it is almostimpossible to even read and understand all the abstracts for "insulinresistance" on Medline let alone read the published papers! Reaven'sbook is a welcome addition to our resources. ... Read more

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Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. Providing a state-of-the-art analysis of the connection between insulin resistance and PCOS, this book comprehensively covers a range of topics. It provides an up-to-date and balanced overview of PCOS, with specific attention to the role of insulin resistance in its pathogenesis. It also examines diet and lifestyle factors in the aetiology and management of PCOS.

Product Description
The past two decades have seen explosive gains in our understanding of the physiology and basic mechanisms of insulin action and the critical importance of insulin resistance in the pathogenesis of clinical disorders such as non-insulin dependent diabetes mellitus, essential hypertension and atherosclerotic cardiovascular disease.
Insulin Resistance offers the first comprehensive review of the field, with integrated chapters providing up to date coverage of the essential components of basic and clinical research that have contributed to current understanding of the topic. There are chapters on basic mechanisms of insulin action, in depth discussions of insulin resistance syndromes from epidemiological, clinical and biochemical viewpoints and a discussion of therapeutic approaches to insulin resistance.
Insulin Resistance will be an invaluable resource for clinicians and scientists with an interest in the mechanisms of insulin action, the clinical sequelae of hyperinsulinemia and future therapies of insulin resistance. ... Read more

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Celebrating more than twenty years as the single best source in the field, this Fifth Edition has now expanded into two cornerstone volumes with 53 fully inclusive chapters and 73 renowned contributors that comprehensively address every topic and trend relevant to the identification, diagnosis, and management of endocrine and endocrine-related disorders in children. Substantially revised, the Fifth Edition covers the most up-to-date appraisal of obesity in the pediatric population, as well as examines the latest breakthroughs in the care of diabetes, hypoglycemia, insulin resistance, and hypoglycemic syndromes. This Fifth Edition also devotes chapters to the diseases of the endocrine glands, including disorders of growth, the adrenal cortex and medulla, as well as sexual differentiation, thyroid, and parathyroid conditions and fluid balance diseases. ... Read more

Customer Reviews (1)

Peditatric Endocrinology Set ( Volume I & Volume II)
Althought this title is found when searching "pediatric endocrinology", the search fails to provide the information regarding Volume II and the Set information.
ISBN:142004270X is Pediatric Endocrinology Volume II
ISBN:1420042718 is Pediatric Endocrinology Set ( Volume I & Volume II) ... Read more

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Customer Reviews (8)

Great Book
Gave this to my neighbor and she has followed it with great results.

Finally - an answer to my ill health
Miryam Williamson's book is well researched, well written and couldn't have come at a better time in my life.I've been suffering for years with unexplained body pain, headaches, blood sugar crashes, IBS ... the list goes on ad infinitum.Not until I read Blood Sugar Blues (in late February 2004) did I finally find answers to the mysteries of my health issuesand can discuss this information with my health care professionals.Her comprehensive book details symptoms of insulin resistance (which I had never heard of) and clearly differentiates between Fibromyalgia and Chronic Fatigue Syndrome.I'm now adhering to a well-balanced, low carb diet and am feeling so much better.Shortly after changing my diet and living a far less driven life, I lost 14 pounds, am sleeping far better and the fatigue and body pain are barely noticeable.I'm convinced that I'm on the right track and will continue to improve.

one of the best low carb books available
This book is for both low carb newcomers and veterans alike. It covers the basics for the new folks while keeping us veterans engaged with lots of new little "nuggets," peices to the puzzle of why this way of eating improves health in so many ways. For me, reading books like this keep me motivated and on track. I probably have 30 low carb books, and this is one of my very favorites.

I'm 44 and I've been low carbing for 21 months.I have lost 80 lbs. through diet and exercise, and have reversed all of the following conditions: acne, leathery skin, overgrowth of moles, high blood pressure, painful legs and feet, anxiety, brain fog, PCOS, IBS, asthma, allergy to pollens and nuts, and heart palpitations. I feel like twenty years have been erased.

Miryam E. Williamson is a very intelligent and caring author as you will discover if you read her book. She is commited to this way of eating because it saved her as it as saved so many of us. Add this book to your library and enjoy.

Right On the Money If Your Problem Is Insulin Resistance
Miryam Williamson's "Blood Sugar Blues" is an excellent book for people who find themselves suffering from a multitude of health problems that are often difficult for mainstream doctors to diagnose.

Although insulin resistance is often the culprit, it is frequently overlooked by traditionally trained internists who, when all common blood and other testing comes back normal, don't understand the condition enough to explore it as the possible answer to their patients' complaints.

Williamson does an excellent job spelling out symptoms caused by insulin resistance-- which makes it easy for the reader to discern if this, in fact, is his or her problem.Her writing shows she has researched this condition thoroughly and understands how it can lead to severe illnesses including heart disease, diabetes, multiple sclerosis, and cancer-- and she writes in such a way that her research is easy for the lay person to understand.While the book does provide a good bit of scientific information about disease processes, she has written a book that is highly accessible to most anyone who reads it.

She also clearly presents strategies for altering one's diet and lifestyle to reduce damage caused by systemic dysfunction that leads to the body losing its ability to produce, process, and use insulin the way it is supposed to.She offers concise advice for helping restore the body to its healthier state and offers a comparison of 5 different popular diets in a way that helps the reader choose which one may be best for him/her.

Williamson obviously believes that, with proper information and guidance, many of us can make changes in our lives that will help us feel better and ward off serious disease, and she does an excellent job passing along that hopefulness to her readers.

Finally, she provides lists of 'safe' foods for people suffering from insulin resistance and a number of simple and tasty recipes that incorporate foods in combinations that help relieve symptoms of the disorder."Blood Sugar Blues" is a well-written and easily understood primer for anyone dealing with insulin resistance and the ills it can cause.

Read This Book First!
I feel very fortunate that I read Miryam Williamson's Blood Sugar Blues first on my search for insulin resistance. She was able to put together pieces of the health puzzle that even my doctor did not see. She is able to clearly convey a lot of complex metabolic issues so that everything starts to make sense. One of the best chapters is the one on choosing a low carbohydrate eating plan, in which she reviews five different plans, pros and cons. This saved me a lot of time and experimentation and was therefore successful from the start. ... Read more

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Customer Reviews (11)

Close but not quite
I love the premise of this book, that controlling insulin is the answer to being disease free, but much of the science and support for the argument in this book is elusive and/or wrong.Fat will NOT elicit an insulin secretion. ONLY carbohydrates will do that.On page 30 "When we eat a meal that's rich in calories - calories from fat or from carbohydrates - glucose levels rise rapidly in the blood." WRONG and WRONG!!! Fat will have no effect on glucose levels and calories in and of themselves have nothing to do with glucose levels.It's the makeup of those calories that matter.Shame on these authors. The title led me to believe someone would actually counter the erroneous mantra of "eat less move more" with the truth "don't eat carbohydrates and you will be able to move more, eat high fat and you will be energized"."Oh, and if you do so, your insulin issues will vanish." Darn. I was hoping for more.

Insulin Is Indeed The Problem, But This Is NOT The Solution!
It's becoming more and more commonplace, but Peter Morgan Cash and Jay Lombard want to make sure people know about it loud and clear-INSULIN is at the heart of most of the preventable diseases in modern society. Until we get this hormone under control inside of our bodies, no progress will be made on such health issues as cancer, heart disease, Alzheimer's disease, obesity, depression, hypertension, metabolic syndrome, and more. We are people who are walking around with insulin in excess which leads to inflammation and disease occurring in epidemic proportions. To attain "freedom from disease," the authors draw from current research on this subject and interview some of the biggest names is health today-to the detriment of the message, I believe. What starts off as a good premise for a book with a spot-on message quickly turns into more of the same we've always heard. Eat less fat. Eat more "good" whole grain-based carbs. Yadda yadda yadda. If the authors truly wanted to share information that would help to bring insulin under control for good, then they would have included much of the breadth of research that has been done on carbohydrate-restriction over the past decade in this book. But if you look up "low-carb" in the index at the back of the book, you'll come up empty. That's too bad because I think they have correctly identified the problem...they just missed the ultimate solution by a long shot!

Great advice for all!
At first I thought that this book was not going to tell me anything new, but it is actually very eye-opening.My mother had Alzheimers for 10 years and the fact that this book addresses possible causes for this disease and others, is quite interesting.I am trying to live a healthier lifestyle and this book is helping me do it!

Very good Science to back of Theory
This book will scare you into leading a better lifestyle.I appreciated the science but it may be a little too much science for the average lay person.The recipe and 3 week diet fell a little short.The book advocates Mediteranian and Japanese diet but this is mostly Asian with lots of items most people won't be familar with like agar flakes and umeboshi vinegar.Books says avoid dry fruit but many of the breakfast ideas include raisins.Maybe berries would have been a better pick.Basically the menus don't always jive with the recomendations. I would follow Dr. Weils anti-inflamation diet as it is easier to follow. Also theory gives no explanation for the 40% of people that get cancer and disease and are not overweight.Are these people still insulin resistant but don't gain weight?I was glad I read the book.Finally the medical community is giving us some information that makes sense.

very inspiring
the evidnece presented in this book should encourage and motivate everyone to eat a healthier diet
very informative
C.W. RN and Certified Diabetes Educator ... Read more

Product Description
Remarkable advances have been made in the field of insulin action with the aid of gene analysis techniques, which enable the clarification of the mechanism of the insulin receptor diseases and the structure - function relationship in glucose transporters. The book summarizes these recent advances in the field of insulin action. The volume also discusses insulin binding and action of insulin analogues, insulin receptor diseases, the substrates of insulin receptor kinase, abnormal insulin action in NIDDM and the mechanism of glucose transport, thus integrating the recent knowledge of insulin action from insulin to glucose transport. This proceedings volume is therefore an excellent review on recent advances in the research in insulin action and its disorders. ... Read more

Product Description
This digital document is an article from Internal Medicine News, published by Thomson Gale on March 1, 2006. The length of the article is 1344 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Should PCOS be treated with insulin sensitizers or oral contraceptives?(POINT/COUNTERPOINT)
Author: John Nestler
Publication: Internal Medicine News (Magazine/Journal)
Date: March 1, 2006
Publisher: Thomson Gale
Volume: 39Issue: 5Page: 10(1)

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Product Description
Providing information relating to the area of insulin resistance and disease, this book covers topics including: cellular insulin action and insulin resistance; hepatic glucose metabolism and insulin resistance in NIDDM and obesity; and genetics of insulin action. ... Read more

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Persons with type 2 diabetes develop diffuse atherosclerosis and consequent organ damage. In patients with atherosclerotic disease as well as in patients with type 2 diabetes there is an increased production and increased blood levels of the cytokine TNF-?. In the surroundings of atherosclerotic plaques there is accumulation of TNF-?, especially around culprit lesions. Atherosclerotic plaques are attached to the endothelium, which is the innermost layer of the vessels. Among other functions the endothelium helps to maintain a relaxed vascular tone by producing nitric oxide (NO). It has been shown that TNF-? impairs the intracellular signal that is initiated when insulin binds to its receptors, what results in insulin resistance. Since one of the endpoints of the insulin signal in endothelial cells is the activation of eNOS, that catalyzes NO production, it is reasonable to believe that TNF-? has a substantial role in the development of atherosclerosis in insulin-resistant states. The purpose of the studies described in this book is to contribute to the clarification of this role. ... Read more

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Insulin therapy. Insulin pump, Inhalable insulin, Islet cell transplantation, Artificial pancreas, Diabetes mellitus type 1, Diabetes mellitus type 2, Insulin resistance, Insulin analog, Insulin pen, Pulsatile insulin, High performance liquid chromatography ... Read more