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Provides a comprehensive guide to laboratory techniques for research and diagnosis in rabies, and the production of vaccine and immunoglobulin. Now in its fourth edition, this standard reference work has been substantially revised and expanded following more than two decades of widespread use of the previous edition. The book has six parts. The first provides a general overview of current techniques, including safety precautions, and summarizes the characteristics and molecular biology of the rabies virus. The second and third parts evaluate diagnostic and research techniques, including those involving the use of enzyme-linked immunosorbent assays (ELISAs), cell cultures, monoclonal antibodies and the polymerase chain reaction.

The production of rabies vaccines for human and veterinary use is considered in the fourth part, which includes 23 new chapters dealing with vaccines prepared in cell cultures (including continuous cell lines) and recombinant vaccines. Techniques for evaluating the safety and potency of rabies vaccines are then described, including in vitro tests for in-process control. The final part covers the production of human and equine antirabies serum and immunoglobulin. Further practical advice is given in the appendices, which describe techniques for the collection and shipment of brain specimens for rabies diagnosis, preparation of rabies conjugates, and calculation of virus titres and antirabies serum, immunoglobulin and vaccine potency.
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Harold Pinter was one of the world's leading and most controversial writers, and his impact and influence continues to grow. This Companion examines the wide range of Pinter's work - his writing for theatre, radio, television and screen, and also his highly successful work as a director and actor. Substantially updated and revised, this second edition covers the many developments in Pinter's career since the publication of the first edition, including his Nobel Prize for Literature win in 2005, his appearance in Samuel Beckett's play Krapp's Last Tape and recent productions of his plays. Containing essays written by both academics and leading practitioners, the volume places Pinter's writing within the critical and theatrical context of his time and considers its reception worldwide. Including three new essays, new production photographs, five updated and revised chapters and an extended chronology, the Companion provides fresh perspectives on Pinter's work. ... Read more

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In 1858, Alfred Russel Wallace, aged thirty-five, weak with malaria, isolated in the Spice Islands, wrote to Charles Darwin: he had, he said excitedly, worked out a theory of natural selection. Darwin was aghast--his work of decades was about to be scooped. Within two weeks, his outline and Wallace's paper were presented jointly in London. A year later, with Wallace still on the opposite side of the globe, Darwin published On the Origin of Species.

This new biography of Wallace traces the development of one of the most remarkable scientific travelers, naturalists, and thinkers of the nineteenth century. With vigor and sensitivity, Peter Raby reveals his subject as a courageous, unconventional explorer and a man of exceptional humanity. He draws more extensively on Wallace's correspondence than has any previous biographer and offers a revealing yet balanced account of the relationship between Wallace and Darwin.

Wallace lacked Darwin's advantages. A largely self-educated native of Wales, he spent four years in the Amazon in his mid-twenties collecting specimens for museums and wealthy patrons, only to lose his finds in a shipboard fire in the mid-Atlantic. He vowed never to travel again. Yet two years later he was off to the East Indies on a vast eight-year trek; here he discovered countless species and identified the point of divide between Asian and Australian fauna, 'Wallace's Line.'

After his return, he plunged into numerous controversies and published regularly until his death at the age of ninety, in 1913. He penned a classic volume on his travels, founded the discipline of biogeography, promoted natural selection, and produced a distinctive account of mind and consciousness in man. Sensitive and self-effacing, he was an ardent socialist--and spiritualist. Wallace is one of the neglected giants of the history of science and ideas. This stirring biography--the first for many years--puts him back at center stage, where he belongs. ... Read more

Customer Reviews (9)

A good pairing with a darwin biography
If you want to enrich your picture of where the theory of evolution came from,how men saw it emerge "on the ground," rather than in specimen jars and private laboratories, this is a great complement to any life of Darwin.Wallace was a much wider and woollier adventurer than Darwin.As a professional collector he had to be, and he lived in strange parts of the world rather than just drop by on cruise as Darwin had the luxury to do.I was especially moved by the story about Wallace's experience adopting and trying to sustain the life of an infant orangutan in Borneo or thereabouts.Wallace must have been a much more restless man than Darwin, more of the brew of industrial revolution and 19th century culture in turmoil.Take Me With You When You Go

Wallace may have seen something further than Darwin
As the great scientist Newton said " I see further for I stand on the shoulders of giants".Wallace may have seen further than Darwin when he suggested that we have souls that make us human.Ofcourse these kinds of things are hard to emperically observe by scientists that is the reason why they are skeptical but not everything has to be observed.It is true that "observation is the key to knowledge" but Einstein said that "imagination is much more important than knowledge".Probably Wallace knew that not everything could be explained by science because not everything could be observed.So even though Darwin was right about his observations of the process of evolution, Wallace saw further when he imagined that most probably we have souls that make us not only the highest form of animal but the only animals that has a soul, a human.Science cannot observe everything....there are things meant to be imagined along with our observations, that is how we could see further.

curiosity made the man
an elegant and fascinating account of a true pioneer of natural history and evolution. One must really be curious and patient to get into this book, as there are innumerable details given on not just this man's life but his actual work. The book proves to be an illuminating academic biography that deserves its place among other excellent biographies in your collection.

An informative overview
Victorian Britain was a time of exploration, industrial advance, social and political experiments and scientific speculation.Although many key figures appeared, few covered so many elements of this dynamic as did Alfred Russell Wallace.From almost desparately poor beginnings, Wallace became a dedicated explorer and specimen collector.Raby's sympathetic portrayal of this complex character is a good introduction.Wallace travelled and collected far more widely than did his contemporary Charles Darwin.That both developed the same concept, evolution of species by natural selection, was the result of keen powers of observation.Wallace's wide-spread interests took his attention into areas Darwin either ignored or avoided.Unlike the retiring Darwin, Wallace was at the forefront of many issues, speaking and writing on many issues.Some of these, as Raby carefully recounts, led him into difficulties, both financial and intellectual.

Raby traces the development of a man who almost beggars analysis.Wallace's life was dogged by near penury due to family commitments and lack of regular employment.His decision to explore the upper Amazon basin was almost an act of desparation, but it led to a lifelong interest in nature and "primitive" people.Overcoming the loss of four years of exploration and study, he recovered deftly with a long-term examination of the East Indies archipelago.Early flirtations with socialist ideals gave him a more sympathetic view of indigenous people than the average Victorian Briton.He adopted a strong sense of independence from authoritarian measures, leading him to oppose land enclosures and vaccination, which he saw as doing more harm than good.The great issue in his later years was spiritualism.This last proved a stumbling block to his scientific ambitions.Although many authors disparage this interest as demeaning, in Raby's view it is simply another aspect of Wallace's probing intellect.

The primary concern with Wallace remains his co-authorship of evolution by natural selection.Darwin's insight occupied his thinking for two decades while he considered evidence.Wallace had been considering the issue for several years, finally synthesising his ideas during confinement from a malarial attack.Wallace never disputed Darwin's priority nor his superiority as a scientific genius, although recent historians have taken up his "cause" in an attempt to erode Darwin's reputation.Raby examines these claims in some detail, either refuting them or questioning the validity of the evidence.Wallace diverged from Darwin's version of natural selection in some details, most notably over human evolution.In line with his spiritualism, Wallace insisted the human mind could not be an adaptation and must be the result of influence by a "higher power".He wasn't alone in that view either then or now.

Raby's examination of the life of another "tormented evolutionist" is an engaging read and fluent introduction to this charismatic figure.With his long life encompassing an era of many new ideas, Wallace doesn't stand out in the history of science nearly as much as is his due.This book goes far in restoring his image.Raby's prose style is clear and expressive without descending into unnecessary adulation of his subject.The greatest lack is in his failure to place Wallace more fully in the context of his times.Since that would cover the whole of the Victorian era and beyond, we may forgive this curtailment.There are, after all, numerous works providing that overview.A valuable summary for the reader interested in exploration, natural science and Victorian personalities. [stephen a. haines - Ottawa, Canada]

worth reading
Bronowski's Ascent of Man acquainted me with the main facts of Wallace's life. Frankly, that sufficed... Raby did not delve deeply enough into aspects of Wallace's character or contributions. The value of Raby's detailed biography lies not in learning more about Wallace's travels or seances, but in hiscareful, evenhanded examination of the relation between Darwin and Wallace.

Anybody pondering accusations of conspiracy would be well advised to read this book. The ending is particularly well done. ... Read more

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This is an EXACT reproduction of a book published before 1923. This IS NOT an OCR'd book with strange characters, introduced typographical errors, and jumbled words.This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ... Read more

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Rabies is still one of the most feared diseases in the world and its control remains a key objective in large parts of Europe. This major meeting brought together veterinarians, scientists, clinicians and public health officials to share their experience in rabies control, to examine the threat posed by the common rabies virus and emerging strains, and to develop strategies for the prevention, control and eradication of rabies in Europe. "Rabies in Europe" reveals the true epidemiological situation of an often overlooked menace and presents the latest research by over 40 prominent scientists in rabies prevention and control. It proposes practical solutions and includes the official WHO/OIE recommendations issuing from the meeting. The book provides researchers, healthcare professionals and public health officials with an up-to-date, in-depth look at the threat still posed by rabies and shows how medical and scientific advances have been employed to stem the growing number of infections spreading from Eastern to Western Europe since the end of World War II. ... Read more

Product Description
This is a reproduction of a book published before 1923.This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process.We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide.We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ... Read more

Product Description
This is an EXACT reproduction of a book published before 1923. This IS NOT an OCR'd book with strange characters, introduced typographical errors, and jumbled words.This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ... Read more

Product Description
This is an EXACT reproduction of a book published before 1923. This IS NOT an OCR'd book with strange characters, introduced typographical errors, and jumbled words.This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ... Read more

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Originally published in 1883.This volume from the Cornell University Library's print collections was scanned on an APT BookScan and converted to JPG 2000 format by Kirtas Technologies.All titles scanned cover to cover and pages may include marks notations and other marginalia present in the original volume. ... Read more

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This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to rabies (also Hydrophobia; Lyssa), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on rabies. Given patients' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms. ... Read more

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An illustrated look at the timely subject of rabies offers information about the types and manifestations of this deadly disease, explains how it is transmitted, discusses ways to protect yourself, and tells what to do if you are exposed. ... Read more

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This scarce antiquarian book is a selection from Kessinger Publishings Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the worlds literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone! ... Read more

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This book is part of the Our Name in History series, a collection of fascinating facts and statistics, alongside short historical commentary, created to tell the story of previous generations who have shared this name.The information in this book is a compendium of research and data pulled from census records, military records, ships' logs, immigrant and port records, as well as other reputable sources. Topics include:

• Name Meaning and Origin
• Immigration Patterns and Census Detail
• Family Lifestyles
• Military Service History
• Comprehensive Source Guide, for future research