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A moving account of patients and families dealing with the effects of sickle cell disease, a genetic disorder that mainly effects people of African descent. ... Read more

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High Quality Content by WIKIPEDIA articles! Sickle-cell disease, or sickle-cell anaemia (or drepanocytosis), is a genetic life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various complications. The sickling occurs because of a mutation in the hemoglobin gene. Life expectancy is shortened, with studies reporting an average life expectancy of 42 and 48 years for males and females, respectively. ... Read more

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This digital document is an article from Pediatric Nursing, published by Jannetti Publications, Inc. on November 1, 2004. The length of the article is 5163 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: The current ability to predict very young children with sickle cell disease who are likely to have severe complications later in life permits accurate tailoring of therapy to match disease-related risks. A valid and reliable instrument is essential to accurately assess these children prior to referring them to therapies that are not without risk. This study was designed to develop a Sickle Cell Disease Assessment Instrument with two domains--high-risk identification and disease severity classification--and to evaluate instrument validity and reliability. Instrument development involved identification and definition of critical attributes, assignment of numerical values to critical attributes, and development of a scoring system. Content validity was measured using a panel of five experts in the field of sickle cell disease. Registered nurses using the equivalence approach determined interrater reliability and using test-retest design determined stability. Nurses are often the first persons to identify sickle cell patients that need additional intervention. This instrument will allow them to accurately and objectively assess their patients for high-risk indicators and disease severity classification.

Citation Details
Title: Development and evaluation of a sickle cell disease assessment instrument.(Continuing Education Series)
Author: Sara W. Day
Publication: Pediatric Nursing (Refereed)
Date: November 1, 2004
Publisher: Jannetti Publications, Inc.
Volume: 30Issue: 6Page: 451(8)

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This digital document is an article from The Hastings Center Report, published by Hastings Center on July 1, 2002. The length of the article is 1528 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Medicine, culture, and sickle cell disease.(Dying in the City of the Blues: Sickle Cell Anemia and the Politics of Race and Health)
Author: Troy Duster
Publication: The Hastings Center Report (Refereed)
Date: July 1, 2002
Publisher: Hastings Center
Volume: 32Issue: 4Page: 46(3)

Article Type: Book Review

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This digital document is an article from Pediatric Nursing, published by Thomson Gale on November 1, 2006. The length of the article is 2454 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: Sickle cell disease anemia is an inherited blood disorder that affects many people of color in the U.S. Patients with sickle cell disease make abnormal blood cells that tend to clog and occlude blood vessels. Many sickle cell patients suffer from vaso-occlusive crisis and other complications leading to end-organ damage and failure. Hydroxyurea has been used to treat cancer patients for many years. Moreover, clinicians and researchers have determined that this medication increases fetal hemoglobin levels. Fetal hemoglobin does not interfere with sickle hemoglobin polymerization, yet prevents red blood cells from sickling. Hydroxyurea therapy significantly reduces the number of deaths from sickle cell complications. Additionally, hydroxyurea significantly reduces the number of hospitalizations, vaso-occlusive crisis, and acute chest problems; thereby reducing severity of the disease. Pediatric studies also have shown that hydroxyurea can be safely used in children.

Citation Details
Title: Hydroxyurea therapy: improving the lives of patients with sickle cell disease.
Author: Nina Anderson
Publication: Pediatric Nursing (Magazine/Journal)
Date: November 1, 2006
Publisher: Thomson Gale
Volume: 32Issue: 6Page: 541(3)

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The article is excerpted fromGale Encyclopedia of Medicine.

Consultthe second edition of this authoritative, comprehensive, in-depthmedical guide for information on more than 1,700 medical topics inlanguage accessible to adult laypersons. Presented in a singlealphabetical sequence, articles range in length from one or twoparagraphs for minor topics, to several pages or more for major topics.Disease/disorder articles typically cover definition; description;causes and symptoms; diagnosis; treatments; prevention; and more.Test/treatment articles typically cover definition; purposes;precautions; preparation; risks; normal and abnormal results; and muchmore. This second edition includes more than 200 new entries, 300updated entries, approximately 650 color images and illustrations, anda comprehensive subject index. New features include biographical andhistorical sidebars throughout the text.

Disease/disorder articles contain some or all of the following sections:

• Definitions -- brief dictionary-style definition of the disorder
• Descriptions -- overview of the disorder; who gets it and why
• Causes & symptoms -- process, substance or organism thatproduces the condition; any risk factors that increase susceptibilityto the condition; signs and symptoms of the disease
• Diagnosis -- overview of procedures and tests used todiagnose the condition; how the test is done; who should be tested andwhen; time required; cost; whether it's typically covered by insurance
• Treatments -- overview of conventional methods of care ormanagement of the condition, such as drugs, surgeries, physicaltherapy, etc.
• Alternative treatments -- overview of alternative/complementary therapies that may be used to treat the condition
• Prognosis -- probable outcome of the disease
• Preventions -- what actions can be taken to prevent the condition from occurring

Test/treatment articles contain some or all of the following sections:

• Definitions -- brief dictionary-style definition of the test/treatment
• Purposes -- why and when this test/treatment is prescribed
• Precautions -- when this test/treatment should not be prescribed
• Descriptions -- overview of the test/treatment including cost,length of time required, procedures followed, whether typically coveredby insurance
• Preparation -- pre-test treatment procedures, if any
• Aftercare -- post-test treatment procedures, if any
• Risks -- any complications/side effects commonly associated with the test/treatment
• Normal results -- for tests, describes the normal values; for treatments, describes the anticipated outcomes
• Abnormal results -- defines abnormal test values

Published/Released: December 2001

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This digital document is an article from BIOTECH Patent News, published by Biotech Patent News on July 1, 2001. The length of the article is 1231 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Cytrx announces reissue of key Flocor patent for treatment of sickle cell disease.(Brief Article)
Publication: BIOTECH Patent News (Newsletter)
Date: July 1, 2001
Publisher: Biotech Patent News
Volume: 15Issue: 7Page: NA

Article Type: Brief Article

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Chapters: Anemia, Sickle-cell disease, Diamond-Blackfan anemia, Anemia of prematurity, Aplastic anemia, Anemia of chronic disease, Macrocytic anemia, Myelophthisic anemia, Congenital dyserythropoietic anemia, Hypochromic anemia, Congenital hemolytic anemia, Refractory anemia, Acute posthemorrhagic anemia, Blackfan-Diamond anemia, Inherited erythroblastopenia,. Source: Wikipedia. Pages: 88. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Sickle-cell disease (SCD), or sickle-cell anaemia (or anemia; SCA) or drepanocytosis, is an autosomal recessive genetic blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various complications. The sickling occurs because of a mutation in the Hemoglobin gene. Life expectancy is shortened, with studies reporting an average life expectancy of 42 in males and 48 in females. Sickle-cell disease, usually presenting in childhood, occurs more commonly in people (or their descendants) from parts of tropical and sub-tropical regions where malaria is or was common. One-third of all indigenous inhabitants of Sub-Saharan Africa carry the gene, because in areas where malaria is common, there is a survival value in carrying only a single sickle-cell gene (sickle cell trait). Those with only one of the two alleles of the sickle-cell disease are more resistant to malaria, since the infestation of the malaria plasmodium is halted by the sickling of the cells which it infests. The prevalence of the disease in the United States is approximately 1 in 5,000, mostly affecting Americans of Sub-Saharan African descent, according to the National Institutes of Health. In the United States, about 1 in 500 black births have sickle-cell anaemia. Sickle-cell anaemia is the name of a...http://booksllc.net/?id=21010263 ... Read more

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Chapters: Hemoglobinopathy, Sickle-Cell Disease, Glucose-6-Phosphate Dehydrogenase Deficiency, Hereditary Elliptocytosis, Thalassemia, Hemolytic-Uremic Syndrome, Paroxysmal Nocturnal Hemoglobinuria, Hemolytic Anemia, Beta-Thalassemia, Sickle Cell Trait, Hereditary Spherocytosis, Warm Autoimmune Hemolytic Anemia, Alpha-Thalassemia, Hereditary Stomatocytosis, Triosephosphate Isomerase Deficiency, Pyruvate Kinase Deficiency, Paroxysmal Cold Hemoglobinuria, Acquired Hemolytic Anemia, Drug-Induced Nonautoimmune Hemolytic Anemia, Microangiopathic Hemolytic Anemia, Hereditary Persistence of Fetal Hemoglobin, Ovalocytosis, Drug-Induced Autoimmune Hemolytic Anemia, Hexokinase Deficiency, Minkowski-Chauffard Syndrome. Source: Wikipedia. Pages: 132. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Sickle-cell disease, or sickle-cell anemia (SCD or SCA) or drepanocytosis, is a genetic life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various complications. The sickling occurs because of a mutation in the haemoglobin gene. Life expectancy is shortened, with studies reporting an average life expectancy of 42 in males and 48 in females. Sickle-cell disease, usually presenting in childhood, occurs more commonly in people (or their descendants) from parts of tropical and sub-tropical regions where malaria is or was common. One-third of all indigenous inhabitants of Sub-Saharan Africa carry the gene, because in areas where malaria is common, there is a survival value in carrying only a single sickle-cell gene (sickle cell trait). Those with only one of the two alleles of the sickle-cell disease are more resistant to malaria, since the infestation of the malaria plasmodium is halted by th...More: http://booksllc.net/?id=21010263 ... Read more

Product Description
This digital document is an article from Family Practice News, published by International Medical News Group on February 1, 2005. The length of the article is 353 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Study suggests PH in sickle cell disease underdiagnosed.(Clinical Rounds)(Pulmonary hypertension)
Publication: Family Practice News (Magazine/Journal)
Date: February 1, 2005
Publisher: International Medical News Group
Volume: 35Issue: 3Page: 86(1)

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