Product Description
This up-to-date electronic book on CD-ROM provides the best collection available anywhere of official Federal government information and documents on the subject of tuberous sclerosis (TSC). This CD-ROM uses next-generation search technology that allows complete indexing and makes all files on the disc fully searchable. For patients, practical information is provided in clearly written patient education documents. For medical professionals, doctor reference tools and texts have detailed technical information and clinical background material.

This thoroughly researched collection presents vital information from many authoritative sources: National Institutes of Health (NIH), Food and Drug Administration (FDA), the Combined Health Information Database (CHID), the Centers for Disease Control (CDC), and the National Institute of Neurological Disorders and Stroke (NINDS). Contents include clinical and medical information, with information on signs, symptoms, testing, diagnosis, treatment, and more.

In addition, as a bonus we have included an encyclopedic collection of general medical and health documents – thousands of pages with extensive material from the CDC and NIH on hundreds of diseases and health topics from A to Z, along with FDA drug and medical publications, government consumer healthcare tips, disease prevention programs, dietary guidelines, and travelers’ health information. Since navigating the Internet to find additional non-governmental medical information can be confusing, we've also provided our exclusive "Guide to Leading Medical Websites" with updated links to 73 of the best sites for medical information! By using weblinks on the CD-ROM, you can quickly check for the latest clinical updates directly from the government.

This CD-ROM has over 28,000 pages reproduced using Adobe Acrobat PDF software and Reader software is included. Advanced search and indexing features are built into our reproduction, providing a complete full-text index. This enables the user to search all the files on the disk at one time for words or phrases using just one search command! The Acrobat cataloging technology adds enormous value and uncommon functionality to this impressive collection of government documents and material. There is no other reference that is as fast, convenient, comprehensive, and portable!

Our CD-ROMs are privately-compiled collections of official public domain U.S. government files and documents - they are not produced by the federal government. They are designed to provide a convenient user-friendly reference work, utilizing the benefits of the Acrobat format to uniformly present thousands of pages that can be rapidly reviewed or printed without untold hours of tedious searching and downloading. This book-on-a-disc makes a superb reference work and educational tool for patients and their families, physicians, and other medical professionals. (Information on this CD-ROM is NOT a substitute for professional medical advice; of course, readers are urged to consult with a professional health care provider for any suspected illness.) ... Read more

Product Description
This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to tuberous sclerosis (also Adenoma sebaceum; Bourneville disease; Bourneville Pringle Syndrome; Epiloia; Phakomatosis TS; Tuberose Sclerosis), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on tuberous sclerosis. Given patients' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms. ... Read more

Product Description
Tuberous Sclerosis is a genetic disease characterized by lesions of the skin and central nervous system, seizures, and sometimes severe mental retardation. This new edition of a classic work includes a biological analysis of underlying genetic causes. ... Read more

Customer Reviews (1)

Excellent resource.
This is an excellent resource for adult and pediatric neurologists.It isconcise and up to date.Those outside the medical profession will find itunderstandable.I recommend it. ... Read more

Product Description
Correlating new genetic data and basic science regarding tuberous sclerosis, this collection covers clinical presentation; reviews history and current diagnostic criteria; and notes recent advances in neuropathology, molecular genetics and neurobiology. Tuberous sclerosis incorporates malformations characterized by disturbances in cellular differentiation and growth. It appears with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. ... Read more

Customer Reviews (1)

TSC Best Book of Information yet
Tuberous Sclerosis is so complex and so involved. There are many symptoms and they vary in every person affected by this terrible disease. This book is a great reference put together with the newest available resources. There are many pix and explanations. A must-have for the medical professionals that come across TSC. Also for parents to use for a guide to make sure all bases are covered and all areas of care are checked. ... Read more

Product Description
Chapters: Tuberous Sclerosis. Source: Wikipedia. Pages: 187. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Tuberous sclerosis or tuberous sclerosis complex (TSC) is a rare, multi-system genetic disease that causes benign tumours to grow in the brain and on other vital organs such as the kidneys, heart, eyes, lungs, and skin. A combination of symptoms may include seizures, developmental delay, behavioral problems, skin abnormalities, lung and kidney disease. TSC is caused by mutations on either of two genes, TSC1 and TSC2, which encode for the proteins hamartin and tuberin respectively. These proteins act as tumour growth suppressors, agents that regulate cell proliferation and differentiation. The name, composed of the Latin tuber (swelling) and the Greek skleros (hard), refers to the pathological finding of thick, firm and pale gyri, called "tubers," in the brains of patients postmortem. These tubers were first described by Désiré-Magloire Bourneville in 1880; the cortical manifestations may sometimes still be known by the eponym Bourneville's disease. The physical manifestations of tuberous sclerosis are due to the formation of hamartia (malformed tissue such as the cortical tubers), hamartomas (benign growths such as facial angiofibroma and subependymal nodules) and, very rarely, cancerous hamartoblastomas. The effect of these on the brain leads to neurological symptoms such as seizures, developmental delay and behavioral problems. Tuberous sclerosis in MRI.About 50% of people with TSC have learning difficulties ranging from mild to significant , and studies have reported that between 25% and 61% of affected individuals meet the diagnostic criteria for autism, with an even higher proportion showing features of a broader pervasive developmental disorder. A 2008 study reported self-inju...More: http://booksllc.net/?id=602466 ... Read more

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This digital document is an article from Dermatology Nursing, published by Thomson Gale on October 1, 2005. The length of the article is 588 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: The "Clinical Snapshot" series provides a concise examination of a clinical presentation including history, treatment, patient education, and nursing measures. Using the format here, you are invited to submit your "Clinical Snapshot" to Dermatology Nursing.

Citation Details
Title: Tuberous sclerosis complex.(Clinical Snapshot)
Author: Laura Musse
Publication: Dermatology Nursing (Magazine/Journal)
Date: October 1, 2005
Publisher: Thomson Gale
Volume: 17Issue: 5Page: 376(2)

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Chapters: Turner Syndrome, Joubert Syndrome, Neurofibromatosis, Von Hippel-lindau Disease, Tuberous Sclerosis, Freeman-Sheldon Syndrome, Progeria, Ataxia Telangiectasia, Johanson-blizzard Syndrome, Ectrodactyly-ectodermal Dysplasia-cleft Syndrome, Klinefelter's Syndrome, Leopard Syndrome, X-Linked Ichthyosis, Dyskeratosis Congenita, Noonan Syndrome, Epidermolysis Bullosa, Epidermolytic Hyperkeratosis, Crouzon Syndrome, Keratolytic Winter Erythema, Proteus Syndrome, Adams-oliver Syndrome, Keratosis Pilaris, Bloom Syndrome, Lamellar Ichthyosis, Harlequin Type Ichthyosis, Costello Syndrome, Xeroderma Pigmentosum, Klippel-feil Syndrome, Ichthyosis Bullosa of Siemens, Apert Syndrome, Refsum's Disease, Silver-russell Syndrome, Treacher Collins Syndrome, Werner Syndrome, Poems Syndrome, Oculodentodigital Dysplasia, Albright's Hereditary Osteodystrophy, Hypohidrotic Ectodermal Dysplasia, Ichthyosis Vulgaris, Xxyy Syndrome, Cockayne Syndrome, Schindler Disease, Kabuki Syndrome, Multiple Sulfatase Deficiency, Cronkhite-Canada Syndrome, Epidermolysis Bullosa Dystrophica, Acrodermatitis Enteropathica, Netherton Syndrome, Rombo Syndrome, Darier's Disease, Cartilage-hair Hypoplasia, Wolf-hirschhorn Syndrome, Hay-wells Syndrome, Popliteal Pterygium Syndrome, Ichthyosis Hystrix, Conradi-hünermann Syndrome, Cardiofaciocutaneous Syndrome, Pachyonychia Congenita, Zunich-kaye Syndrome, Kindler Syndrome, Hailey-hailey Disease, Papillon-lefèvre Syndrome, Congenital Ichthyosiform Erythroderma, Zimmermann-laband Syndrome, Acrocephalosyndactylia, Cutis Verticis Gyrata, Townes-brocks Syndrome, Rothmund-thomson Syndrome, Marinesco-sjögren Syndrome, Disseminated Superficial Actinic Porokeratosis, Sjögren-larsson Syndrome, Van Der Woude Syndrome, Dermatopathia Pigmentosa Reticularis, Meleda Disease, Confluent and Reticulated Papillomatosis of Gougerot and Carteaud, Ibids Syndrome, Pfeiffer Syndrome, Lelis Syndrome, Child Syndrome, Ifap Syndrome, Naegeli-...More: http://booksllc.net/?id=49364 ... Read more

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In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing. Since only the smallest fraction of information dealing with tuberous sclerosis is indexed in search engines, such as www.google.com or others, a non-systematic approach to Internet research can be not only time consuming, but also incomplete. This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. ... Read more

Product Description
This digital document is an article from Pediatric News, published by International Medical News Group on June 1, 2002. The length of the article is 509 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Neurologic symptoms affect most tuberous sclerosis patients. (Seizure Disorder Very Common).
Author: Helen Lippman
Publication: Pediatric News (Magazine/Journal)
Date: June 1, 2002
Publisher: International Medical News Group
Volume: 36Issue: 6Page: 26(1)

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Product Description
This digital document is an article from Skin & Allergy News, published by International Medical News Group on January 1, 2003. The length of the article is 1016 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Ash leaf--shaped patch only sign of tuberous sclerosis. (Two Cases).
Author: Nancy Walsh
Publication: Skin & Allergy News (Magazine/Journal)
Date: January 1, 2003
Publisher: International Medical News Group
Volume: 34Issue: 1Page: 26(1)

Distributed by Thomson Gale ... Read more

Product Description
This digital document is a journal article from Mutation Research-Reviews in Mutation Research, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome that affects ~1 in 6000 individuals. It is characterized by the development of tumors, named hamartomas, in the kidneys, heart, skin and brain. The latter often cause seizures, mental retardation, and a variety of developmental disorders, including autism. This disease is caused by mutations within the tumor suppressor gene TSC1 on chromosome 9q34 encoding hamartin or within TSC2 on chromosome 16p13.3 encoding tuberin. TSC patients carry a mutant TSC1 or TSC2 gene in each of their somatic cells, and loss of heterozygosity has been documented in a wide variety of TSC tumors. Recent data suggest that functional inactivation of TSC proteins might also be involved in the development of other diseases not associated with TSC, such as sporadic bladder cancer, breast cancer, ovarian carcinoma, gall bladder carcinoma, non-small-cell carcinoma of the lung, and Alzheimer's disease. Tuberin and hamartin form a heterodimer, suggesting they might affect the same processes. Tuberin is assumed to be the functional component of the complex and has been implicated in the regulation of different cellular functions. The TSC proteins regulate cell size control due to their involvement in the insulin signalling pathway. Furthermore, they are potent positive regulators of the cyclin-dependent kinase inhibitor p27, a major regulator of the mammalian cell cycle. Here we review the current knowledge on how mutations within the TSC genes could trigger deregulation of stability and localization of the tumor suppressor p27. ... Read more

Product Description
This digital document is an article from Skin & Allergy News, published by International Medical News Group on November 1, 2009. The length of the article is 1151 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: See ash leaf macules, think tuberous sclerosis.(PEDIATRIC DERMATOLOGY)
Author: Doug Brunk
Publication: Skin & Allergy News (Magazine/Journal)
Date: November 1, 2009
Publisher: International Medical News Group
Volume: 40Issue: 11Page: 33(1)

Distributed by Gale, a part of Cengage Learning ... Read more

Product Description
This up-to-date and comprehensive set of two CD-ROM discs provides a superb collection of authoritative documents on the subject of tuberous sclerosis. Tuberous sclerosis is a rare genetic disease that causes noncancerous tumors to grow in the brain and other organs. Symptoms vary depending on the location of the tumors.For patients, practical information is provided in clearly written patient education documents. For medical professionals, doctor reference tools and texts have detailed technical information and clinical background material. There is no other reference that is as fast, convenient, and portable - everything you need to know, from the federal sources you trust. This thoroughly researched collection presents vital information from many authoritative sources: Food and Drug Administration (FDA), Centers for Disease Control (CDC), National Institutes of Health (NIH) and the relevant institute for this disease, and others.In addition to the comprehensive disease-specific coverage, this disc set also includes our Medical Encyclopedia, a $19.95 value! The Encyclopedia presents a collection of official documents about a wide range of medical topics, diseases, illnesses, health and wellness. There is vital information from the National Institutes of Health (NIH), the Centers for Disease Control (CDC), National Cancer Institute, and more. Topics covered include: major diseases, including cancer, heart and vascular disease, stroke, blood diseases and disorders, lung diseases, and neurological disorders such as dementia and epilepsy * CDC Health Topics A to Z, Foodborne Illnesses, Infants and Children, Injuries, Occupational Health, Older Adults, Women * CDC Travelers' Health - Destinations, Vaccinations, Diseases, Mosquito, Tick, Food, Water, Clinics, Yellow Book, Children, Airplanes, Cruise Ships, Special Needs, Relief Workers * Dietary Guidelines * NIH A to Z from abnormalities to X-rays.Since navigating the Internet to find additional non-governmental medical information can be confusing, we've also provided our exclusive "Guide to Leading Medical Websites" with updated links to 67 of the best sites for medical information! Built-in weblinks let you quickly check for the latest clinical updates directly from the government and the best commercial portals, news sites, reference/textbook/non-commercial portals, and health organizations. ... Read more