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Donald J. Cram is recipient of the 1987 Nobel Prize in Chemistry for his work on Host-Guest Complexes. A pioneer in physical organic chemistry, Dr. Cram developed early concepts for asymmetric synthesis ("Cram's rule"). His book is an interesting and lively account of this scientific research. ... Read more

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This volume covers the evolution of host-guest complexation chemistry in the minds of Nobel Prize-winner Donald Cram and his co-workers at UCLA, over the period from 1970-1994. It deals with the fundamental principles and objectives that govern this rapidly developing subject and illustrates the emergence of a new field of biomimetic chemistry. The book demonstrates how a number of techniques, such as molecular modelling, synthesis, crystal structure, NMR solution structure and mass spectral structure determinations can be combined to develop a new branch of organic chemistry. It discusses the chemistry of completely new families of complexes - the carceplexes, hemicarceplexes and velcraplexes - and reviews the uses of the interiors of hemicarceplexes as a new phase for carrying out chemical reactions and for protecting unstable species. The volume illustrates how complexation and decomplexation rates are measured to provide free energies of binding, discusses new phenomena such as constrictive binding, and shows how solvophobic forces drive complexation in a variety of organic solvents.It also covers catalysis through complexation and chiral recognition in catalysis, both secondary themes of this volume. ... Read more

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Die Organische Chemie nimmt in der Ausbildung eines jeden Chemikers einen wichtigen Platz ein. Von entsprechender Bedeutung ist ein Lehrbuch, das moderne Konzepte und Methoden sowohl theoretischer als auch praktischer Natur vorstellt und den Studenten an die schwierige Aufgabe, selbständig und gezielt Synthesen zu entwickeln, heranführt. Das Rüstzeug dazu vermitteln die Autoren dieses modernen Lehrbuches der Organischen Chemie in vorbildlicher Weise. Der Leser wird mit theoretischen Grundlagen, Konzepten und Modellvorstellungen vertraut gemacht. Konkrete Beispiele, die ausführliche Einführung in die verschiedenen spektroskopischen Methoden zur Strukturaufklärung sowie mehrere Kapitel über speziellere Themen - hierbei werden biochemische Probleme nicht ausgespart - stellen den Bezug zur Praxis her und führen den Leser an die aktuelle Forschung heran. Ein umfangreiches Register mit über 7000 Stichworten ergänzt dieses Buch. ... Read more

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This digital document, covering the life and work of Donald J(ames) Cram, is an entry from Contemporary Authors, a reference volume published by Thompson Gale. The length of the entry is 2259 words. The page length listed above is based on a typical 300-word page. Although the exact content of each entry from this volume can vary, typical entries include the following information:

• Place and date of birth and death (if deceased)
• Family members
• Education
• Professional associations and honors
• Employment
• Writings, including books and periodicals
• A description of the author's work
• References to further readings about the author

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Donald James Cram (April 22, 1919 – June 17, 2001) was an American chemist who shared the 1987 Nobel Prize in Chemistry with Jean-Marie Lehn and Charles J. Pedersen "for their development and use of molecules with structure-specific interactions of high selectivity." They were the founders of the field of host-guest chemistry. ... Read more