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Chapters: Friedrich Loeffler, Richard Kuhn, Erwin Neher, Bernhard Rensch, Rudolph Schoenheimer, Bert Sakmann, Feodor Felix Konrad Lynen, Charlotte Auerbach, Carl Von Voit, Hartmut Michel, Robert Remak, Carl Neuberg, Johann Baptist Von Spix, Oskar Minkowski, Regine Hildebrandt, Hans Ernst August Buchner, Heinrich Simroth, Karl Bogislaus Reichert, Christian Haass, Franz-Ulrich Hartl, Carl Flügge, Leonor Michaelis, Ernst Leopold Salkowski, Emil Adolf Rossmässler, Hans Vogel, Georg Theodor August Gaffky, Julius Richard Petri, Patrick Cramer, J. Heinrich Matthaei, Hugo Kronecker, Carl Franz Robinow, Rodolfo Armando Philippi, Thomas Carell, Emmy Klieneberger-Nobel, Hans Buchner, Johann Samuel Eduard D'alton, Adalbert Ricken, Julius Von Flotow, Peter Gruss, Carl Chun, Martin Rathke, David Nachmansohn, Moritz Schiff, Otto Renner, Karl Spiro, Franz Ziehl, Gerhard Braunitzer, Ernst Ehrenbaum, Max Fürbringer, Peter Hirsch. Source: Wikipedia. Pages: 118. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Friedrich August Johannes Loeffler (24 June 1852 9 April 1915) was a German bacteriologist at the University of Greifswald. He obtained his MD degree from the University of Berlin in 1974. He worked with Robert Koch from 1879-1884. Among his discoveries was the organism causing diphtheria (Corynebacterium diphtheriae) and the cause of foot and mouth disease (Aphthovirus). He also created a coagulated blood serum used for the detection of the bacteria. The Friedrich Loeffler Institute on the Isle of Riems near Greifswald is named in his honor. ...More: http://booksllc.net/?id=1175331 ... Read more

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From reviews of the First Edition: 'A landmark in the field of membrane biophysics.'--Science 'A first-class laboratoryguide...an indispensable reference.'--NeuroscienceEdited by the 1991 winners of the Nobel Prize in Physiology orMedicine, this Second Edition includes new chapters covering suchapplications as capacitance measurements; single-cell PCRmeasurements; whole-cell recording from brain slices in combinationwith imaging techniques; atomic force microscopy of cells andmembranes attached to glass pipettes; and patch clamping. ... Read more

Customer Reviews (4)

The most "complete" book on the subject yet
Simple, precise, easy to read and understand, methodical, plenty of explanation - the INDISPENSABLE HANDBOOK for patch clamp/single channel recording. It's one of the books that's a "must have" for all grads, post docs and scientists working on electrophysiology and am sure that everyone will have something to gain from it.

Only complaint - since single channel analysis so heavily relies on building on models, there needs to be more description on it. There are only a couple of chapters with very elementary model building stuff which isn't going to be of much help to people, except to the ones who are just starting out. (But that's just a personal opinion)

Fantastic book on electrophysiology!
The information on Single-Channel Recording is excellent and this book should be a reference book for all electrophysiology students likewise the mentor.A must have in every lab.

A truly gripping read
A frequent complaint about neuroscience books is that they are a bit dry, but I am pleased to report that "Single Channel Recording" is as taut and suspenseful a tale as has ever hit the mystery shelf. Jumping immediately into the action with Chapter one, "A Practical Guide to Patch Clamping", the book provides a sinister foreshadowing of hidden dangers yet to come. Will recording noise preclude detection of the crucial signals? Will junction potentials throw the investigation off completely? And what of poor Calcium?

I don't want to give away the explosive finale (although I will give a hint: dielectric membrane breakdown), but suffice it to say that by the time the book is over, you will be exposed to a bigger bag of tricks than was ever dreamed up by "Q branch" from the James Bond series (The analogy was obviously on the authors' minds, with direct references to the "Q matrix").

Not only is the plot crisp, but the writing is also highly satisfying and complex, sometimes with a whimsical air that vaguely recalls Vonnegut's "Breakfast of Champions" but other times with a cold analytical nature that more closely resembles Truman Capote's "In Cold Blood". The book is truly a masterpiece, and Neher and Sakmann work as well together as their Sesame Street namesakes. Dust off the shelves for another Nobel, boys, this time in literature!

The Patcher's Bible
Single Channel Recording is the possibly the single most useful text for the patch-clamp novice, and the text continues to be a fundamental resource for veterans.Sakmann and Neher, inventors of the technique, have compileda book to give both theoretical background and practical advice regardingboth experimental setup and data analysis.Whole-cell, single channels,and perforated patch are discussed.The practicalities of suitable patchglass, noise abatement, and capacitance cancelation are also covered.Thisbook is a must have for all electrophysiologists. ... Read more

Product Description
The Fidia Research Foundation annually honours distinguished investigators in the neurosciences and invites them to contribute to a special volume of timely review articles on significant developments in their particular areas of research. Because of the eminent stature of the award-winning authors, and their coverage of advances that are opening up new vistas for future research, the books are uniquely suited for use as teaching aids in most neuroscience courses. This volume contains review articles by Michael J. Berridge, Bert Sakmann, John A. Connor, and Eric A. Barnard, the recipients of the 1990-1991 awards. Dr. Berridge's article focuses on inositol lipids and calcium signalling. Dr. Sakmann describes a new model for studying synaptic plasticity. Dr. Connor presents studies using fluorescence imaging and electrophysiology to examine calcium responses of mammalian central nervous system neurons to excitatory amino acids. Dr. Barnard discusses the significance of cloned receptor genes in contemporary pharmacology and neuroscience. ... Read more