Product Description
The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens.

After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electro­phoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results.

• A clearly written, practical, integrated approach to the basics of analytical toxicology.
• Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications.
• Assumes only a basic knowledge of analytical chemistry.
• An accompanying website provides additional material and links to related sites.

Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. 

Praise from the reviews:

“This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.”   Review from Randall Baselt

"This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists

“Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard.  Understanding of the text is enhanced by the use of many illustrations.  Specifications, guidelines, and methods are highlighted in grey background “Boxes”.  The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information.  Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.”  GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German)

“Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology

“The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.” International Journal of Environmental Analytical Chemistry ... Read more

Product Description
This new edition of a successful textbook has been completely revised and enlarged. In particular the chapters on measurement uncertainty, calibration and validation are practically all new. The authors provide an in-depth but easy to understand coverage of quality assurance for chemical measurements. This includes both internal as well as external quality assurance, necessary statistics as well as total quality management. All this is presented with more than 800 commented slides, which are also provided as downloadable Extra Material. The book will serve as an advanced textbook for analytical chemistry students and professionals in industry and service labs and as a reference text and source of course materials for lecturers. ... Read more

Product Description
The enormous success of the CRC Handbook of Chemistry and Physics results from many factors, including the attention, expertise, and commitment to excellence that Dr. Lide contributes as the Handbook's Editor-in-Chief. When updating and creating each new edition, Dr. Lide balances new and revised material with the content of existing tables to ensure that the "Four Cs" are met:Amazon.com Review
No physics or chemistry laboratory is complete without thisbook, which since 1922 has been the authoritative series on chemicaland physical data. If you're still using an old edition, now's thetime to update. And if you're taking a physics or chemistry class,it's a great investment in your education. ... Read more

Customer Reviews (21)

Things You Need
I knew that I was going to go in to some form of Chemistry in High School, and in College, I decided to go into Chemical Education. I am now a High School teacher who teaches Chemistry. It is with this background that I recommend that parents or students who plan to persue chemistry as a life-long ambition attain a copy (doesn't have to be the latest, get a cheap one) of the CRC or Lange's. This is because at some point in your life, you will need to look up the enthalpy of Al(OH)3 which can NOT be found on the net and not in most textbooks. Also, if you are going in to organic chemistry, get a Merck Index.

An incredible resource
If I were allowed only two reference books, they would be the OED and this.

This book doesn't have everything, it just seems that way. Listing the content would take pages, and much of it is chemical or physical arcana - if you need the data, you already know what to look for. At a more accessible level, it lists the frequencies of notes in several musical scales, information about common wire sizes, astronomical information, the chemical makeup of the human body, and ways to create carefully controlled humidity. That last one can be helpful to woodworkers; this book really does have something for almost everyone.

Although it comes out every few years, most people won't need to update very often. The definition of a volt, for example, changes rarely and only in small ways. This is a pricey book, but it holds its value pretty well.

This is the scientific reference book to have. If you know a student interested in any of the sciences, it's also a great book to give, and it's something that will be valued for years to come.

//wiredweird

A FORMIDABLE SUPERLATIVE GEM
Very useful and very relevant, nearly all the chapters of this edition of "CRC Handbook of Chemistry and Physics" have been revised. The book is up-to-date, and provides extensive coverage on all the significant physico-chemical phenomena. Chemists, physicists, biochemists, engineers, pharmacists, and other scientists and professionals would value this textbook. Its CD-ROM version would be of great benefit to mobile users.
I was impressed by the way it analyzed molecular interactions in each of the three states of matter: solid, liquid, and gas. Electron transfer, and transformations of pure substances were the focus here. Its biochemical section simplified many of the physiological reactions that are often considered complex.
In the same vein, I am certain that most readers would appreciate the classical exposure which optics, thermodynamics, geophysics, nuclear chemistry, and atomic physics sections received. All the recent advances in rotational and vibrational spectroscopy were included. David Lide did a commendable job in moulding this 2700-paged single-volume gem.
Each chapter indulged in practical analysis; with suggestions on how to improve day-to-day applications. Safety measures, as well as guidelines on how to cope with industrial and laboratory hazards were provided. Also, further information sources were made avalaible in one of its numerous appendices.
This is surely an outstanding text: no major weaknesses! It is a formidable reference tool that would please scientists and allied professionals. I recommend it with all pleasure!

a critical reference for chemists
While this doesn't contain *everything* for a single topic, it certainly contains all that a chemist usually needs for easy reference about chemistry and physics.

If you (or your current copy of the CRC) are a bit older, you'll probably find some sections in the new edition missing - e.g., no more trigonometry tables with the proliferation of cheap calculators - and new things added. This is the sort of book which has SO much stuff, you will never use it all - but it will (almost) always be able to help you.

This is the one reference book I was willing to pay for out of pocket, whether or not my employer paid for it.

I found a 1927 copy of this at a used book store a few years ago ... - I still have it, and believe it or not, I do use it. It's got really neat stuff the modern editions don't. Which is why you shouldn't hesitate to drop [money] for one today. It will still be useful 60 years from now.

This is not the sort of thing I would replace annually!

What's to say?
This is THE reference book used by all chemists and physicists. If you need it, buy it. Beats fighting over old beat up copies at school or library. ... Read more

Product Description
This new edition of a successful, bestselling book continues to provide you with practical information on the use of statistical methods for solving real-world problems in complex industrial environments. Complete with examples from the chemical and pharmaceutical laboratory and manufacturing areas, this thoroughly updated book clearly demonstrates how to obtain reliable results by choosing the most appropriate experimental design and data evaluation methods.
Unlike other books on the subject, Statistical Methods in Analytical Chemistry, Second Edition presents and solves problems in the context of a comprehensive decision-making process under GMP rules: Would you recommend the destruction of a $100,000 batch of product if one of four repeat determinations barely fails the specification limit? How would you prevent this from happening in the first place? Are you sure the calculator you are using is telling the truth? To help you control these situations, the new edition:
* Covers univariate, bivariate, and multivariate data
* Features case studies from the pharmaceutical and chemical industries demonstrating typical problems analysts encounter and the techniques used to solve them
* Offers information on ancillary techniques, including a short introduction to optimization, exploratory data analysis, smoothing and computer simulation, and recapitulation of error propagation
* Boasts numerous Excel files and compiled Visual Basic programs-no statistical table lookups required!
* Uses Monte Carlo simulation to illustrate the variability inherent in statistically indistinguishable data sets
Statistical Methods in Analytical Chemistry, Second Edition is an excellent, one-of-a-kind resource for laboratory scientists and engineers and project managers who need to assess data reliability; QC staff, regulators, and customers who want to frame realistic requirements and specifications; as well as educators looking for real-life experiments and advanced students in chemistry and pharmaceutical science.
From the reviews of Statistical Methods in Analytical Chemistry, First Edition:
"This book is extremely valuable. The authors supply many very useful programs along with their source code. Thus, the user can check the authenticity of the result and gain a greater understanding of the algorithm from the code. It should be on the bookshelf of every analytical chemist."-Applied Spectroscopy
"The authors have compiled an interesting collection of data to illustrate the application of statistical methods . . . including calibrating, setting detection limits, analyzing ANOVA data, analyzing stability data, and determining the influence of error propagation."-Clinical Chemistry
"The examples are taken from a chemical/pharmaceutical environment, but serve as convenient vehicles for the discussion of when to use which test, and how to make sense out of the results. While practical use of statistics is the major concern, it is put into perspective, and the reader is urged to use plausibility checks."-Journal of Chemical Education
"The discussion of univariate statistical tests is one of the more thorough I have seen in this type of book . . . The treatment of linear regression is also thorough, and a complete set of equations for uncertainty in the results is presented . . . The bibliography is extensive and will serve as a valuable resource for those seeking more information on virtually any topic covered in the book."-Journal of American Chemical Society
"This book treats the application of statistics to analytical chemistry in a very practical manner. [It] integrates PC computing power, testing programs, and analytical know-how in the context of good manufacturing practice/good laboratory practice (GMP/GLP) . . .The book is of value in many fields of analytical chemistry and should be available in all relevant libraries."-Chemometrics and Intelligent Laboratory Systems ... Read more

Product Description
This is a concise and critical treatise on the most important analytical methods in wood chemistry related to pulping and papermaking. The emphasis is on principles and important applications, needed not only in academic research, but especially for industrial applications. It starts with basic information on the chemical composition with analytical techniques of wood and wood components of the main groups (carbohydrates, lignin, and extractives), proceeds to the methods used for the characterization of the chemical properties of wood and pulp fibers (with special emphasis on the fiber surfaces), and concludes with the methods applied to the analysis of pulping and bleach liquors, papermaking waters and effluents, and those used for the analysis of inorganic components in wood and pulps. ... Read more

Product Description

The application of statistics is central to the assessment of data quality and an understanding of statistics is essential for the interpretation of analytical results. This book is a completely revised and updated version of the very successful first edition and is a statistical manual designed to help analytical scientists identify the correct statistical parameters and tests to apply to their data. The fully revised and updated 2nd edition describes the most common statistical parameters used in an analytical laboratory and contains new sections on method validation, measurement uncertainty, effective experimental design and proficiency testing.

Product Description
Written by some of the most talented young chemists in Europe, this text covers most of the groundbreaking issues in materials science. It provides an account of the latest research results in European materials chemistry based on a selection of leading young scientists participating in the 2008 European Young Chemists Award competition. The contributions range from nanotechnology to catalysis. In addition, the authors provide a current overview of their field of research and a preview of future directions.
For materials scientists, as well as organic and analytical chemists.
... Read more

Product Description
This fully updated and revised Second Edition assists the novice and seasoned professional alike in systematically approaching problems with currently available tools and methods in the modern analytical chemistry domain.Covers all fields from basic theory and principles of analytical chemistry to instrumentation classification, design, and purchasing!Maintaining the expansive scope that distinguished the first edition, Analytical Instrumentation Handbook, Second Edition now includes new and pertinent information on X-ray methods and analysis capillary electrophoresis infrared and Raman technique comparisonsand much more! ... Read more

Product Description
This clear and thorough introduction to modern analytical chemistry is essential for readers from all disciplines--including chemistry, forensic science, and the biosciences--where a familiarity with analytical techniques is required. Providing extensive coverage, it ranges from basic principles to the latest emerging techniques in the field. Numerous diagrams, worked examples, and self-assessment questions help readers test their understanding. ... Read more

Product Description
Analytical chemical results touch everyones livescan we eat the food? do I have a disease? did the defendant leave his DNA at the crime scene? should I invest in that gold mine? When a chemist measures something how do we know that the result is appropriate? What is fit for purpose in the context of analytical chemistry?Many manufacturing and service companies have embraced traditional statistical approaches to quality assurance, and these have been adopted byanalytical chemistry laboratories. However the right chemical answer is never known, so there is not a direct parallel with the manufacture of ball bearings which can be measured and assessed.The customer of the analytical services relies on the quality assurance and quality control procedures adopted by the laboratory.It is the totality of the QA effort, perhaps first brought together in this text, that gives the customer confidence in the result. QA in the Analytical Chemistry Laboratory takes the reader through all aspects of QA, from the statistical basics and quality control tools to becoming accredited to international standards. The latest understanding of concepts such as measurement uncertainty and metrological traceability are explained for a working chemist or her client. How to design experiments to optimize an analytical process is included, together with the necessary statistics to analyze the results.All numerical manipulation and examples are given as Microsoft Excel spreadsheets that can be implemented on any personal computer. Different kinds of interlaboratory studies are explained, and how a laboratory is judged in proficiency testing schemes is described. Accreditation to ISO 17025 or OECD GLP is nearly obligatory for laboratories of any pretension to quality. Here the reader will find an introduction to the requirements and philosophy of accreditation. Whether completing a degree course in chemistry or working in a busy analytical laboratory, this book is a single source for an introduction into quality assurance. ... Read more

Customer Reviews (1)

Quality Assurance in the Analytical Chemistry Laboratory
Very good book in the field of application.It is very importance in my country(Chile, Sud America)for the use in the Accreditation of the Laboratories in Analytical Chemistry ... Read more

Product Description
Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in the laboratory. It will serve as an educational tool as well as a first reference book for the practicing instrumental analyst. The text covers five major sections:
1. Overview, Sampling, Evaluation of Physical Properties, and Thermal Analysis
2. Spectroscopic Methods
3. Chromatographic Methods
4. Electrophoretic and Electrochemical Methods
5. Combination Methods, Unique Detectors, and Problem Solving

Each section has a group of chapters covering important aspects of the titled subject, and each chapter includes applications that illustrate the use of the methods. The chapters also include an appropriate set of review questions.

* Covers the fundamentals of instrumentation as well as key applications
* Each chapter includes review questions that reinforce concepts
* Serves as a quick reference and comprehensive guidebook for practitioners and students alike ... Read more

Product Description
Laser Remote Chemical Analysis, Raymond M. Measures
Laser Remote Chemical Analysis, after beginning with the fundamentals of how lasers can be used for remote sensing-particularly in chemistry-proceeds with a comprehensive set of reviews covering the different facets of the subject, written by seven of today's top authorities on laser remote sensing. Includes a detailed study of atmospheric transmission, an overview on environmental sensing based on infrared absorption of laser radiation, a discussion of how lasers can be used to map specific atmospheric pollutants, a review of how lasers can measure trace constituents in the atmosphere, and more. This is a definitive source of information for any scientist, researcher, or student interested in the use of a laser as a remote sensing tool. ... Read more

Product Description
In recent years, interest in proteins has surged. This resurgence has been driven by the expansion of the post-genomic era when structural genomics and proteomics require new techniques in protein chemistry and new applications of older techniques. Protein chemistry methods are used by nearly every discipline of biomedical research. Many techniques have been used in less traditional ways with exciting results. Modern Protein Chemistry: Practical Aspects describes the practical side of advanced techniques in protein chemistry. The book gives researchers an excellent "cost-benefit" analysis of these techniques. The contributors have been selected for their prominence in their specific fields and because they run laboratories that actively collaborate with other scientists. Researchers and practitioners, both beginners and experienced, who are looking for new ideas and who are interested in applying these more advanced methods will be assisted in their work by these commentaries.This guide provides hands-on information to complement theoretical understanding. The theory behind these methods can be found in existing books and in the original literature. However, no other guide will help you make a practical evaluation of these methods and their value to your work. ... Read more

Product Description
In the recent past quantitative chemical analysis textbook writers included selected experiments to complete and complement the text and thus give instructors a choice to select the experiments to be performed by students in quantitative analysis course. On the other hand, this is not so for courses in instrumental analysis which is a sequential course to quantitative analysis. This is, perhaps, due to the numerous instrumental techniques that have been developed over the years for chemical analysis. In its stead, textbooks on experiments in instrumental analysis are common, and these are as diversified as the topics covered in lecture courses.Most of the experimental topics covered, especially, in quantitative analysis, lean heavily on determination of materials or compounds of inorganic chemistry origin. This seems to be the tradition with only a few exceptions.However, recently, textbooks on quantitative analysis have emerged and continue to emerge, without any experimental section. This is not quite surprising though, since many instructors nowadays, tend to design their own experiments to suit and complement their lecture materials. On the other hand, the trend in the production of books on instrumental analysis experiments has remained the same.The objective of this book is therefore two fold. One is to design a reasonably comprehensive laboratory text that embodies both areas of analytical chemistry. The other is to shy away from the tradition of making quantitative analysis experiments lean too heavily on inorganic materials. To this end, several topics ranging from inorganic to organic materials are included in this laboratory text book. A new element is also introduced in this book. That is, students are exposed throughout the book to the analysis of compounds of pharmaceutical relevance. ... Read more

Customer Reviews (1)

Nice draft.
I really like the idea of this book.I got it with plans to use (at least some of) the experiments in my instrumental analysis class, and I'm definitely taking some of it for that purpose.

Concerning the experiments - I would have liked to see more background information.I try to give a little more context & background on why the analyte and sample material are interesting or significant, and this is largely missing from most of the experiments.As an instructor, additional background is also needed:Potential interferents, expected range for the analyte in the sample, etc.Instructors should probably test each method on their own equipment to get this information, which makes the book less useful as an "automatic" source of lab handouts.Only three "separation" experiments are included, one of which is really a liquid-liquid extraction to measure the distribution coefficient.

Production values - book is effectively self-published and it really needs some professional help.Some of the figures are well drawn, while others are reproduced from computer images so that they're nearly illegible.Some of the equations are correctly typeset, while others (again) are copy & pasted into the text as (low resolution) images.(In some chapters they alternate, which is particularly jarring.)One table in the appendix appears to end prematurely.

Hopefully the author will be encouraged by the success of this edition to pursue a professionally published followup; there's definitely a need for well-researched and easy-to-follow lab procedures for advanced labs. ... Read more

Product Description
For what is thought of as an essentially mechanical process, paper manufacture involves a large amount of chemistry. The Chemistry of Paper provides an overview of the process of making paper from a chemical perspective. It deals with both the chemistry of paper as a material and the chemistry of its production, setting out the main principles involved at every stage of the process.

Early chapters provide a chemical definition of paper in the light of the many uses to which it is put. Subsequent chapters deal with the chemical processes involved in the production of paper: the delignification of the wood fibres performed at elevated temperature and pressure, the bleaching of the cellulose-rich pulp using environmentally-friendly systems, the formation of the pulp into sheets of fibres strengthened by extensive inter-fibre hydrogen bonding, and finally the coating of the sheets in a manner appropriate to their end use.

Chemistry is involved at every stage of the process, including carbohydrate chemistry, the chemistry of inorganic pigments and organic resins, colloid and surface chemistry, as well as elements of environmental and analytical chemistry. The Chemistry of Paper provides an informative and entertaining overview of the chemical principles involved. It will be especially suitable for students and others who require an introduction to the chemistry of paper manufacture. ... Read more

Product Description
This book is designed to be a central text for young graduate students interested in mass spectrometry as it relates to study of protein structure and function as well as proteomics.
It is a definite must have work for:
- libraries at academic institutions with Master and Graduate programs in Biochemistry, Molecular Biology, Structural Biology and Proteomics;
- individual laboratories with interests covering these areas; and
- libraries and individual laboratories in the pharmaceutical and biotechnology industries.

. serves as an essential reference to those working in the field
. incorporates the contributions of prominent experts
. features comprehensive coverage and a logical structure ... Read more

Customer Reviews (1)

Best massspectrometry book I have ever read
Its a must have for a person who want to get into proteomics field or who want to understand different mass spectrometry techniques.

The editor/authors have done a great job of simplifying the complex concepts and different chapters are presented in a way, so easy to understand and slowly build the reader to understand the advanced mass spectrometry techniques, current challenges and different way to solve those challenges.

I thoroughly enjoyed reading it and understood the complex concepts lingered with me. Trust me I have gone through other mass spectrometry books, this is the best book I have came across. Its an valuable addition to my personal library.

I would definitely recommend it to anyone. Go and get this book!!!! ... Read more

Product Description
This is an EXACT reproduction of a book published before 1923. This IS NOT an OCR'd book with strange characters, introduced typographical errors, and jumbled words.This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ... Read more

Product Description
Archaeologists, historians, chemists, and physicists have employed a variety of chemical and physical approaches to study artifacts and historical objects since at least the late 18th century. During the past 50 years, the chemistry of archaeological materials has increasingly been used to address a broad spectrum of anthropological topics, including preservation, dating, nativity, exchange, provenance, and manufacturing technology. This book brings together 28 papers that address how various analytical techniques can be used to address specific archaeological questions. Chemists, archaeologists, geologists, graduate students, and others in related disciplines who are investigating the use of archaeometric techniques will find this book of interest. ... Read more

Customer Reviews (1)

cost prohibitive
I would love to review this book, but at $195.00, neither I nor my university library can afford a copy. The point of publishing research is to share it with your peers and the public. I think that the point of publishing research has been "colonized" by greed. Very disappointed. ... Read more

Product Description
This supplement contains many spreadsheet exercises correlating directly with sections in the text. The exercises teach students how to use Microsoft? Excel? using applications from statistics, data analysis equilibrium calculations, curve fitting, and more. Operations include everything from basic arithmetic and cell formatting to Solver, Goal Seek, and the Data Analysis Toolpak. The authors show students how to use a spreadsheet to construct log diagrams and to plot the results. Statistical data treatment includes descriptive statistics, linear regression, hypothesis testing, and analysis of variance. Tutorial exercises include nonlinear regression such as fitting the Van Deemter equation, fitting kinetics data, determining error coefficients in spectrophotometry, and calculating titration curves. Additional features include solving complex systems of equilibrium equations and advanced graphical methods: error bars, charts with insets, matrices and determinants, and much more. ... Read more

Customer Reviews (1)

Super-Helpful supplemental text
Awesome. This book is VERY helpful for analytical chem. It's written as a supplement to Skoog's Fundamentals of Analytical Chemistry, so it refers to that text, but really, I've learned alot about Excel just from this book. Want to make a groovy looking titration curve? Consult this easy to read, "cookbook" for using Excel to compile the data. Yup, it has been a lifesaver. That and the solution manual. Don't skrimp, this book is worth it. ... Read more

Product Description
An Alphabetical Reference Catalogue, Arranged Under Authors And Subjects, And Including Analytical References To The Contents Or Important Works. ... Read more