Product Description
Angina pectoris with normal coronary arteriograms is a commonentity which has puzzled cardiologists almost since the advent ofcoronary arteriography. Despite major advances in the understanding ofthe pathophysiology of angina in recent years and a multitude ofstudies on the subject, the cause and mechanisms underlying thesyndrome of angina with normal coronary arteries remain unknown.Indeed, results of investigations are controversial and speculationstill prevails regarding the nature of the so called `Syndrome X'.Almost every important aspect of Syndrome X has been tackled in thebook and the reader is exposed not only to the cardiologists' opinion,but also to the authoritative views of the gastroenterologists,gynaecologists and psychiatrists, extremely well represented in thismonograph. The book deals with `cardiologists' Syndrome X' and not themetabolic entity termed `Syndrome X'. The possible connection betweenthe two, however, is discussed. Angina with Normal Coronary Arteries: Syndrome X contributes tothe understanding of Syndrome X and helps clinicians manage theirSyndrome X-patients better and investigators to open new avenues forresearch. ... Read more

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Fragile sites--points where chromosomes are apt to break--came to prominence in the late 1970s and are now the subject of much clinical concern and laboratory investigation. They are known or suspected agents in the genesis of mental retardation, birth defects, and cancer. This book, the first to deal with fragile sites on human chromosomes, takes a broad interdisciplinary approach to the subject, incorporating findings from cytogenetics, medical and clinical genetics, population genetics, mental retardation, dysmorphology, and oncology.The book has three interrelated sections.The first, focusing on the laboratory, presents what is known about fragile sites, their cytogenetics, and the conditions of cell culture needed to demonstrate them.A clinical section follows, covering X-linked forms of mental retardation, the clinical features associated with the fragile X, and genetic counseling with fragile sites.The final section considers fragile sites as they relate to genetics, including the possible relationship of fragile sites to cancer and to constitutional chromosome abnormalities.This book contains much previously unpublished material and will be an important resource for geneticists and cytogeneticists, molecular and cancer biologists, oncologists, pediatricians, and other health professionals. ... Read more

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Customer Reviews (10)

Not recommended to parents with newly diagnosed children with Fragile X
I downloaded this book to my iPhone Kindle app months after my son's Fragile X diagnosis.The emotional theme of this book is extremely depressing with very little hope, I wish I had never read it as it threw me into a deep depression that took a long time rebound from.I feel that the author is depressed and it shown clearly through her subjective lens of raising her son with Fragile X.DO NOT READ if you have just had a diagnosis!Depression for parents after their children's FX diagnosis is very normal and for me and my wife it was devastating, this book was like being hit in the head with a hammer after I had already been knocked out.

My wife and I are doing better and are working diligently to raise our son with positive feelings, happiness, focusing on the good things, being thankful for what we have, and enjoying the simple things in life.This book does nothing to help you in any of these positive ways.

A Classic Love Story
While informing us about Fragile X Syndrome, Clare Dunsford reminds us in a distinctive voice that much more than genes binds us.Her well-told tale captures the complexity of competing realities running through most of our lives -- identity, vocation, family, faith, parenthood (and the profound difference between motherhood and fatherhood), friendship, support, loneliness and love.So we laugh, cry and rejoice with her as she recounts the frustrations and surprises of her childhood, romances, career and parenting experiences. Her references to classic literature make manifest the mystery encountered in human differences no matter the time or culture, a mystery best understood in the binding of body and spirit despite the fragility of either."Spelling Love With an X" is a classic love story.Dunsford's X is her and her family's cross (a cross that marks others' lives in other ways) and is only made bearable in anyone's life by Love which is more Divine than human.Her story offers hope to all of us who want to live and love well.

A Mother's Story Told with Great Courage
As a parent of a son with Fragile X who is a couple of years younger than Ms. Dunsford's son, J.P., we've experienced the despair as well as the joy she writes of. Her story is beautifully written and shines with the love we have and hope we need for the future for our adult children. She is able to describe the charming, witty character of her son in a way that rings true for parents ofchildren with Fragile X. It's her own story as well. Life as a carrier of Fragile X has its own challenges - ones you might believe are your own character faults - until you find out, at whatever age, that you are a carrier and that the personal battles you've fought for so long are the result of a genetic defect you were born with. The science is helpful. The research is hopeful. Parents, family, carriers, friends should read this book to get a good look at life with Fragile X.

Every Parent and Child
This book is still with me. Those are the best kinds of books, I think, the ones that you remember well after reading them. I think it's because "Spelling Love With An X" resonates beyond its specific circumstances. It's not just about Clare Dunsford and her son, but in some way every parent and child. Or, really, every relationship. As Dunsford wonders aloud at one point in the book, since her family carries the gene, is it possible this or that relatives slight eccentricity is really just an extremely mild manifestation of Fragile X. In other words, most brain disorders are merely exaggerations of characteristics we all understand to some degree. We are all on a spectrum of varying consciousness and need. As a result, Dunsford's exploration of the extreme challenges she faces with her son are more than just a faceless "case study." They do what literature should do at its best. They make her and her son's situation universal.

Touching and Intelligent
Clare Dunsford's book is an unusual blend of personal memoir and scientifically researched information drawn from a mother's poignant journey raising a child with Fragile X.Dunsford's book blends poetic elegance with important up to date information about her son's genetic condition,a useful read for anyone living or working with children or adults with any developmental disorder. As a special educator who is also an avid reader I was fascinated. Further, I learned of the relationship that this disorder may have to autism which has touched my extended family and of the hope that the future of medical research holds for all those affected by developmental conditions. Ms Dunsford tells her story with strong emotion and wonderfully crafted writing but does not stray from her goal of sharing the knowledge base she has been accumulating over the 21 years of her charming and interesting son's life. ... Read more

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This digital document is an article from Clinical Psychiatry News, published by International Medical News Group on March 1, 2004. The length of the article is 670 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: New fragile X often misdiagnosed as Parkinson's.(Across Specialties)
Author: Timothy F. Kirn
Publication: Clinical Psychiatry News (Magazine/Journal)
Date: March 1, 2004
Publisher: International Medical News Group
Volume: 32Issue: 3Page: 84(1)

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This digital document is a journal article from Neurobiology of Learning and Memory, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Fragile X mental retardation protein (FMRP), which is absent in fragile X syndrome, is synthesized in vitro in response to neurotransmitter activation. Humans and mice lacking FMRP exhibit abnormal dendritic spine development, suggesting that this protein plays an important role in synaptic plasticity. Previously, our laboratory demonstrated increased FMRP immunoreactivity in visual cortex of rats exposed to complex environments (EC) and in motor cortex of rats trained on motor-skill tasks compared with animals reared individually in standard laboratory housing (IC). Here, we use immunohistochemistry to extend those findings by investigating FMRP levels in visual cortex and hippocampal dentate gyrus of animals exposed to EC or IC. Rats exposed to EC for 20 days exhibited increased FMRP immunoreactivity in visual cortex compared with animals housed in standard laboratory caging. In the dentate gyrus, animals exposed to EC for 20 days had higher FMRP levels than animals exposed to EC for 5 or 10 days. In light of possible antibody crossreactivity with closely related proteins FXR1P and FXR2P, FMRP immunoreactivity in the posterior-dorsal one-third of cerebral cortex was also examined by Western blotting following 20 days of EC exposure. FMRP levels were greater in EC animals, whereas levels of FXR1P and FXR2P were unaffected by experience. These results provide further evidence for behaviorally induced alteration of FMRP expression in contrast to its homologues, extend previous findings suggesting regulation of its expression by synaptic activity, and support the theories associating FMRP expression with alteration of synaptic structure both in development and later in the life-cycle. ... Read more

Product Description
This digital document is an article from Science News, published by Thomson Gale on December 22, 2007. The length of the article is 515 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Limiting damage: fragile X symptoms modulated in mice.(This Week)
Author: P. Barry
Publication: Science News (Magazine/Journal)
Date: December 22, 2007
Publisher: Thomson Gale
Volume: 172Issue: 25-26Page: 387(2)

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This digital document is an article from Family Practice News, published by International Medical News Group on March 1, 2004. The length of the article is 684 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: New fragile X condition affects males over age 50: develops a pseudo-Parkinson's disease.(Clinical Rounds)
Author: Timothy F. Kirn
Publication: Family Practice News (Magazine/Journal)
Date: March 1, 2004
Publisher: International Medical News Group
Volume: 34Issue: 5Page: 50(1)

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This digital document is an article from Science News, published by Thomson Gale on November 17, 2007. The length of the article is 512 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Flawed stem cells yield fragile X clues: researchers study genetic disorder via discarded embryos.(SCIENCE NEWS This Week)
Author: B. Vastag
Publication: Science News (Magazine/Journal)
Date: November 17, 2007
Publisher: Thomson Gale
Volume: 172Issue: 20Page: 310(1)

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Product Description
This digital document is an article from Human Biology, published by Thomson Gale on February 1, 2005. The length of the article is 6862 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

From the author: KEY WORDS: FRAGILE X DYNAMIC MUTATION, CGG REPEAT, FMR1 GENE, INTERMEDIATE-LENGTH ALLELES, DXS548, FRAXAC1, ATL1, FMRb, HAPLOTYPE ASSOCIATIONS.

Citation Details
Title: Haplotype study of intermediate-length alleles at the fragile X (FMR1) gene: ATL1, FMRb, and microsatellite haplotypes differ from those found in common-size FMR1 alleles.
Author: Yvette Curlis
Publication: Human Biology (Magazine/Journal)
Date: February 1, 2005
Publisher: Thomson Gale
Volume: 77Issue: 1Page: 137(15)

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Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come by—until now. The “Gale Encyclopedia of Genetic Disorders” addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the “Gale Encyclopedia of Genetic Disorders” for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.

Product Description

Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come by—until now. The “Gale Encyclopedia of Genetic Disorders” addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the “Gale Encyclopedia of Genetic Disorders” for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.

Product Description

Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come by—until now. The “Gale Encyclopedia of Genetic Disorders” addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the “Gale Encyclopedia of Genetic Disorders” for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.

Product Description

Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come by—until now. The “Gale Encyclopedia of Genetic Disorders” addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the “Gale Encyclopedia of Genetic Disorders” for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.

Product Description

Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come by—until now. The “Gale Encyclopedia of Genetic Disorders” addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the “Gale Encyclopedia of Genetic Disorders” for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.

Product Description
This digital document is an article from Internal Medicine News, published by Thomson Gale on August 15, 2007. The length of the article is 637 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: FMR1 premutation linked with ovarian failure.(Women's Health)
Author: Mary Ellen Schneider
Publication: Internal Medicine News (Magazine/Journal)
Date: August 15, 2007
Publisher: Thomson Gale
Volume: 40Issue: 16Page: 13(1)

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Product Description
This digital document is an article from Internal Medicine News, published by International Medical News Group on October 1, 2009. The length of the article is 777 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Premature ovarian failure.(GENETICS IN YOUR PRACTICE)(Clinical report)
Author: Howard P. Levy
Publication: Internal Medicine News (Magazine/Journal)
Date: October 1, 2009
Publisher: International Medical News Group
Volume: 42Issue: 17Page: 47(1)

Article Type: Clinical report

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Customer Reviews (1)

Has anyone READ this book????
????I am on a low-carb diet -I am looking for good info/recipies/etc. and don't know if I should bother with reading this or not??? ... Read more

Product Description
This digital document is an article from Family Practice News, published by International Medical News Group on March 1, 2004. The length of the article is 362 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Options given for ADHD treatment: diagnosable causes.(Children's Health)(Attention Deficit Hyperactivity Disorder)
Author: Ben Van Houten
Publication: Family Practice News (Magazine/Journal)
Date: March 1, 2004
Publisher: International Medical News Group
Volume: 34Issue: 5Page: 111(1)

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