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Through the integration of bioinformatic, genetic, transcriptomic, proteomic, metabolomic, phenomic and other massive datasets, genomics is revealing exciting new insights into fungal cell biology. The central theme of this volume is the strong impact that genomics is having upon our understanding of fungal biology, across a wide range of species, including model yeasts (such as Saccharomyces cerevisiae and Schizosaccharomyces pombe), filamentous fungi (such as Neurospora crassa and Aspergillus nidulans) and pathogenic fungi (such as Magnaporthe grisae, Candida albicans, Cryptococcus neoformans and Histoplasma capsulatum). World-renowned scientists address the following topics in these fungi: systems biology and evolution, circadian rhythms, apoptosis and stress responses, secretion, and environmental signalling networks. Particular emphasis is placed on fungal pathogenicity. Various genomic technologies are discussed, including genome-wide sequence comparisons, transcript profiling, proteomics, metabolomics and bioinformatics. ... Read more

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Ten articles provide an overview of the recently flowering research into the genetics and molecular biology of fungus species that are economically significant in industry. The contributors, from a variety of disciplines, report on work in such areas as industrial enzymes, antibiotics, toxins, heter ... Read more

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The identification and characterization of genes from filamentous fungi has become easier because of the rapid advances that have taken place in molecular biology, including the generation of whole genome sequences. The new challenge facing researchers is to determine the functions of genes and how they contribute to the biology of fungi. To do this it is clear that a wide variety of different experimental techniques will be necessary, ranging from classical genetic analysis and mutant production, right through to cell biology, biochemistry and immunological methods. This book brings together detailed practical guidance from experienced researchers using the full range of these genetic, genomic, cellular and biochemical methods. The authors describe laboratory procedures that have been proven effective for the investigation of a variety of fungal species. They give essential background information, technical tips and detailed experimental protocols, which will prove invaluable to researchers and students studying filamentous fungi. ... Read more

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In all eukaryotic cells, each fundamental process cycle progression and its control, protein secretion and targeting, transcription and its regulation, mRNA processing, and DNA replication accomplished by essentially identical cellular machinery composed of essentially identicalprotein components. This conservation of function has catapulted the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe from parochial backwaters to the forefront of experimental molecular biology: What is true for a yeast is true for an elephant, and in experiments you can get the answer a lot faster from a yeast. This burgeoning appreciationof yeasts as model systems for the study of fundamental cellular processeshas highlighted the need for an update of the seminal 1981 monograph The Molecular Biology of the Yeast Saccharomyces. This need is now met by the publication of a three-volume series to serve as the authoritative sequel.The first volume focuses on the genome organization of the yeast Saccharomyces as well as protein translation and its regulation and energymetabolism. Subsequent volumes emphasize such topics as the cell cycle, secretion, and transcription. Together, these volumes provide a comprehensive survey of the molecular and cellular biology of Saccharomyces and Schizosaccharomyces, serving not only as a current summary of every significant area of investigation, but also as a thoroughreference source. These volumes are required reading for everyone in the field and anyone curious about the state of the art of molecular and cellular biology. ... Read more

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This comprehensive reference work presents an in-depth analysis on the juvenile justice systems of 19 different countries, both in EU-member states (old and new) and in the United States and Canada. The book is the result of research conducted by a group of outstanding scholars working in the field of juvenile justice. The book reflects a collective concern about trends in juvenile justice over the past two decades; trends that have begun to blur the difference between criminal and juvenile justice. The last chapter highlights similarities and differences between the various systems, identifying three clusters of countries with a similar approach to juvenile justice. In particular, differences are found between the Anglo-Saxon countries, and continental Europe. The former have a more formal "justice" approach, with a strong emphasis on the accountability of juveniles, "just desert" principles, and retribution, while the latter still operate on a "welfare" philosophy. Two special systems, the Scottish Hearing system and the Scandinavian model, are presented as well.

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Molecular mycology has been playing a pivotal role in 21st century. It is emerging with full impact. It is multi-disciplinary and includes molecular markers, recombinant DNA techniques, cloning, phylogeny and bioinformatics. Varying in application of concepts, practice, scale, style and substance, molecular mycology is amongst the latest globalising frontiers of the corporate world. This branch is being regarded as a core subject in many colleges and universities. In the book, various topics on molecular mycology are uniquely combined to provide a complete overview of the subject. The book addresses the role of molecular and bioinformatics tools in solving the problems of identification of fungi and discusses current trends in Molecular Mycology. ... Read more

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The yeast two-hybrid system is among the most powerful methods for screening genes that are functional in various physiological processes and systems, and for determining gene interactions.This volume provides a summary of the methods and range of applications of gene screening possible with the system. ... Read more

Customer Reviews (1)

Somewhat useful
This book has an overview of several types of Y2H screens and the critical points on getting success. As a first book for someone who was a yeast novice, I found it useful up to a point, but did not bother to read the whole thing, as much of it was irrelevent. Perhaps it's not intended to be read through in this way. Certainly this is a difficult subject to cover fully, as there are now many new variations on the screen which all have their own peculiarity.
A novice might want to read the most relevent chapters, someone with a problem with a specific screen might get something out of their specific chapter, but overall there is an almost equal amount (or greater) of information in the protocol booklets that come for free (or are freely downloadable) with commercial kits for Y2H. Personally I would read some of those first, and they may well make the purchase of this book unnecessary. ... Read more

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Univ. of Edinburgh, UK. Comprehensive review of Saccharomyces cerevisiae and Schizosaccharomyces pombe, making comparisons wherever possible. Also discusses whether parallel mechanisms might operate in other eukaryotic cells. For students and researchers. Hardcover, softcover also available. ... Read more

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The original work, published in 1985, appeared at the first interface between classical fungal genetics and modern genetic engineering, reflecting the excitement of a young and promising discipline. Since then, molecular mycology has come of age. The entirely new More Gene Manipulations in Fungi reviews state-of-the-art research with an intent to inform the researcher about what can be achieved by studying fungal systems with the tools of molecular biology. This book is a current reference providing overviews as well as practical information.

Updates Bennett and Lasure's classic Gene Manipulations in Fungi published in 1985**Describes fungi for the study of fundamental problems in biology and biochemistry**Explains both classical and molecular genetics for the study of fungi**Contains special appendixes on genetic analysis, growth media, and coding conventions**Demonstrates the progress of molecular mycology since the seminal paper published by Beadle and Tatum in 1941 ... Read more

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Drawing on the great advances made over the past 10 years, this volume provides illuminating insights into the molecular details of cell-type specification, mating-type switching, pheromone perception and signaling, and cellular and nuclear fusion. ... Read more

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Fungal cellular and molecular biology has entered an unprecedented phase of rapid growth and change. The availability of complete genome sequences coupled with the advent of new genetic and molecular tools has made possible analyses that were deemed unthinkable just 5 years ago. In the current environment, it is advantageous to have access to books that synthesize and rationalize the new information gleaned from genomics with the accumulated literature from years of research in the field, such as this text. ... Read more

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Johnson and Johnson Pharmaceutical Research and Development, L.L.C., San Diego, CA. Offers specialists an analysis of the new genomic technologies and their productive application to drug discovery, vaccine development, and diagnostics. Covers the genomics of infectious viruses, bacteria, fungi, and protozoa. DNLM: Microbiologic Phenomena--genetics. ... Read more

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Viruses of Fungi and Simple Eukaryotes focuses on the developments in and experimental approaches to the study of fungi and simple eukaryotic viruses. Emphasizing molecular biology and genetics, the book provides the first comprehensive description of lower eukaryotic viruses.

Featuring the work of more than 45 international authorities, the book includes more than 1,000 citations, numerous illustrations, tables, and micrographs. It discusses both retrovirus and reovirus systems in simple eukaryotes and examines how simple eukaryotes can serve as important models for research in eukaryotic molecular and cell biology. The book also covers a diverse group of RNA and DNA viruses, describes possible applications of fungi and simple eukaryotes to biotechnological, agricultural, and medicinal products, and explains the significance of lower eukaryotic viruses to biological control. Key topics covered include protein secretion and processing, nucleic acid enzymology, yeast biology, plant pathology, and human pathogenic yeast killer systems. ... Read more

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Saccharomyces cerevisiae is an important research tool and industrial reagent. This organism is the basis for much of our understanding of the molecular and cellular biology of eukaryotes. The second edition of this authoritative reference updates certain chapters and includes new chapters on aging and the cell wall. With a wealth of new research data collected since the first edition, The Metabolism and Molecular Physiology of Saccharomyces cervisiae remains a leading reference for bioscientists across many disciplines. ... Read more