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In recent years much enthusiasm and energy has been directedtoward the development of human gene therapies, especially forinherited conditions and cancers. However, current gene transfertechnology is limited in its transduction efficiency and ability topermanently and safely correct genomic defects. Thus the promise ofgene therapy for these conditions is as yet unrealized. Theprogression of gene transfer technology will eventually surmount theselimitations.

Gene Therapy for Acute and Acquired Diseases includes selectedexamples of ongoing studies in molecular genetics that have thepotential to evolve into human therapies for acute illnesses. Thesechapters are intended to highlight lesser known applications of genetherapy for acquired disorders. It is expected that human gene therapytrials for these conditions will be forthcoming in the near future,leading to previously unimaginable therapies. Thus, this first-everbook about gene therapy for acute and acquired diseases is intended toserve as a glimpse into the future. ... Read more

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This econometric study covers the world outlook for gene therapy across more than 200 countries. For each year reported, estimates are given for the latent demand, or potential industry earnings (P.I.E.), for the country in question (in millions of U.S. dollars), the percent share the country is of the region and of the globe. These comparative benchmarks allow the reader to quickly gauge a country vis-a-vis others. Using econometric models which project fundamental economic dynamics within each country and across countries, latent demand estimates are created. This report does not discuss the specific players in the market serving the latent demand, nor specific details at the product level. The study also does not consider short-term cyclicalities that might affect realized sales. The study, therefore, is strategic in nature, taking an aggregate and long-run view, irrespective of the players or products involved.

This study does not report actual sales data (which are simply unavailable, in a comparable or consistent manner in virtually all of the 230 countries of the world). This study gives, however, my estimates for the worldwide latent demand, or the P.I.E. for gene therapy. It also shows how the P.I.E. is divided across the world's regional and national markets. For each country, I also show my estimates of how the P.I.E. grows over time (positive or negative growth). In order to make these estimates, a multi-stage methodology was employed that is often taught in courses on international strategic planning at graduate schools of business. ... Read more

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Cornell University, New York City.Research on the use of adeno-associated virus as a new viral vector for gene therapy, for investigators. Covers protocols for preparing recombinant AAV vectors and their delivery. 26 U.S. contributors. ... Read more

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This remarkable book focuses on the field of cytokines and tumor immunogenicity, in which there has been a recent resurgence of interest, especially with the advent of gene therapy. With major sections devoted to concepts, experimental models, and clinical perspectives, this volume includes chapters from nearly every research group actively contributing to this area. The excitement that pervades the field is captured, and the prospects for the future discussed. The information presented here will provide essential reading for a wide spectrum of basic as well as clinical investigators interested in cytokines and the prospects for successful cancer therapy. ... Read more

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The idea of human gene therapy was accepted by the medical community and society at large long before believable clinical benefits began to emerge. In this book, some of the fields most distinguished contributors chronicle the evolution of this momentous direction for medicine, illustrating how imaginative concepts shaped the development of technologies and brought the daring new idea to its current position of imminent practical success. This is a book designed to endure as clinical advances accumulate, a clear-eyed work of reference that will anchor the further development of this revolution in therapy. It is an essential addition to libraries of clinical medicine, biotechnology, and public policy, and a resource that no laboratory investigator with an interest in the biology of gene transfer should be without. ... Read more

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This volume is produced from digital images created through the University of Michigan University Library's large-scale digitization efforts. The Library seeks to preserve the intellectual content of items in a manner that facilitates and promotes a variety of uses. The digital reformatting process results in an electronic version of the original text that can be both accessed online and used to create new print copies. The Library also understands and values the usefulness of print and makes reprints available to the public whenever possible. This book and hundreds of thousands of others can be found in the HathiTrust, an archive of the digitized collections of many great research libraries. For access to the University of Michigan Library's digital collections, please see http://www.lib.umich.edu and for information about the HathiTrust, please visit http://www.hathitrust.org ... Read more

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Antibodies have long been used in the biomedical sciences as in vitro tools for the identification, purification and functional manipulation of target antigens. They are also being exploited in vivo for diagnostic and therapeutic applications and play an important role in cancer and AIDS research. This book summarizes preclinical studies from laboratories worldwide that have used intrabodies intracellular antibodies - for gene therapy and research applications. ... Read more

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This book deals with the various aspects of gene therapy from the point of view of leading experts in their respective fields. It provides not only an overview to the various topics of gene therapy, but also discusses current problems and potential solutions. The various gene delivery vehicles and specific problems encountered in the individual target diseases (genetic and nongenetic diseases, as well as AIDS and cancer) are discussed in depth. This book should be useful reading for students, scientists and physicians interested in molecular medicine. ... Read more

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Gene Therapy describes the delivery systems now available to target a given tissue with specific gene or oligonucleotide sequences, and explores the utility of animal modules as test systems. In the context of selected disease states, it summarises in vitro and in vivo studies and clinical trials performed to date. ... Read more

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This digital document is an article from Indiana Business Magazine, published by Curtis Magazine Group, Inc. on October 1, 2003. The length of the article is 774 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: ICVBM launches coronary gene therapy trial.(Neighborhood Heart Watch)
Author: Keith L. March
Publication: Indiana Business Magazine (Magazine/Journal)
Date: October 1, 2003
Publisher: Curtis Magazine Group, Inc.
Volume: 47Issue: 10Page: S6(1)

Distributed by Thomson Gale ... Read more

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This econometric study covers the outlook for gene therapy in The Americas & the Caribbean. For each year reported, estimates are given for the latent demand, or potential industry earnings (P.I.E.), for the country in question (in millions of U.S. dollars), the percent share the country is of the region and of the globe. These comparative benchmarks allow the reader to quickly gauge a country vis-a-vis others. Using econometric models which project fundamental economic dynamics within each country and across countries, latent demand estimates are created. This report does not discuss the specific players in the market serving the latent demand, nor specific details at the product level. The study also does not consider short-term cyclicalities that might affect realized sales. The study, therefore, is strategic in nature, taking an aggregate and long-run view, irrespective of the players or products involved.

This study does not report actual sales data (which are simply unavailable, in a comparable or consistent manner in virtually all of the countries in The Americas & the Caribbean). This study gives, however, my estimates for the latent demand, or the P.I.E. for gene therapy in The Americas & the Caribbean. It also shows how the P.I.E. is divided across the national markets of The Americas & the Caribbean. For each country, I also show my estimates of how the P.I.E. grows over time (positive or negative growth). In order to make these estimates, a multi-stage methodology was employed that is often taught in courses on international strategic planning at graduate schools of business. ... Read more

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Univ. of Pittsburgh, PA. Describes current techniques in gene therapy and tissue engineering and their potential applications in the management of orthopedic trauma and sports-related injuries. For clinicians and researchers. ... Read more

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Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This book presents the latest research in the field from around the world. ... Read more

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This econometric study covers the latent demand outlook for gene therapy across the states, union territories and cities of India. Latent demand (in millions of U.S. dollars), or potential industry earnings (P.I.E.) estimates are given across over 3,300 cities in India. For each city in question, the percent share the city is of it's state or union territory and of India as a whole is reported. These comparative benchmarks allow the reader to quickly gauge a city vis-a-vis others. This statistical approach can prove very useful to distribution and/or sales force strategies. Using econometric models which project fundamental economic dynamics within each state or union territory and city, latent demand estimates are created for gene therapy. This report does not discuss the specific players in the market serving the latent demand, nor specific details at the product level. The study also does not consider short-term cyclicalities that might affect realized sales. The study, therefore, is strategic in nature, taking an aggregate and long-run view, irrespective of the players or products involved.

This study does not report actual sales data (which are simply unavailable, in a comparable or consistent manner in virtually all of the cities in India). This study gives, however, my estimates for the latent demand, or the P.I.E., for gene therapy in India. It also shows how the P.I.E. is divided and concentrated across the cities and regional markets of India. For each state or union territory, I also show my estimates of how the P.I.E. grows over time. In order to make these estimates, a multi-stage methodology was employed that is often taught in courses on strategic planning at graduate schools of business. ... Read more

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Gene therapy for inflammatory diseases is a new, burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic.It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren's syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by the le aders in the field, this volume will appeal to both medical and graduate students, medical reseachers, members of the biotechnology community, physicians and all those interested in this latest frontier of molecular medicine. ... Read more

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This book is about retrovectors, the gene transfer systems used in 80% of ongoing clinical trials of gene therapy. Retroviruses and cellular retroelements are natural gene transfer materials that have been involved in the dispersal and regulation of genes throughout eons of evolutionary history. The retroelements (so-called because of their unique property of reverse transcribing RNA sequences into DNA and integrating them into a host chromosome) naturally comprise more than a quarter of the DNA in the human genome. They are now being adapted for an important role in gene therapy. Conventional retroviruses and vector helper systems are discussed, as well as more recently developed retrotransposon and synthetic retrovectors. ... Read more

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Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field. ... Read more

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This volume examines the current state and future prospects of cell therapy. The coverage is broad, including the scientific principles of hematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy (including treatment of AIDS), and the principles and practice of cellular immunotherapy. ... Read more