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An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals

Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition.

Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include:

• New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics
• Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters
• Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity

Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects. ... Read more

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This book covers all aspects of toxicology, including toxic diseases of large animals, small animals, and exotic pets. It provides key information on how poisons affect the body, how the body responds to a foreign substance, how poisonings are diagnosed, and how poisonings are treated.

Coverage includes every organ system of every species of animal with details on each body system's susceptibility to poison. Poisons affect animals differently depending on species, breed, age, gender, health status, and reproductive status. This resource addresses these differences, allowing the veterinarian to determine the class of toxicant, the mechanism of action, and the proper course of treatment. If confronted with an unknown poison, the information in this book will assist the veterinarian in formulating a list of potential poisons based on the clinical signs that the animal is exhibiting, and in choosing the appropriate tests to narrow the list to one or a few possible poisons.

* Most comprehensive toxicology book available
* Written in a user-friendly style that makes it easy to master the content
* Covers poisonings in both large and small domestic animals
* The Principles of Toxicology section provides comprehensive coverage of concepts & terminology, toxicokinetics, treatments, and regulatory information
* The Manifestations of Toxicoses section is devoted to differentiating between poisons based on lesions and clinical signs
* The Classes of Toxicants section offers detailed information on each poison, including sources, risk factors, pathophysiology, clinical signs and lesions, diagnostic testing, and treatment
* The author is board-certified in toxicology, and the contributors are all toxicologists and educators, ensuring authoritative, up-to-date clinical information ... Read more

Customer Reviews (1)

Best Veterinary Clinical Toxicology Book Available.
Reasons this is the bestv vet clin tox reference book:
1. Concise information- no unnecessary wording
2. Up to date information with current standard of care treatment
3. Edited by THE expert in clinical veterinary toxicology ... Read more

Product Description
In Two Volumes. Other ISBNs In This Set Include: 1430485353. This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature. ... Read more

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In Two Volumes. Other ISBNs in this set include: 1432513168. This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature. ... Read more

Product Description
This scarce antiquarian book is a selection from Kessinger Publishings Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the worlds literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone! ... Read more

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Parke-Davis Pharmaceutical Research, Ann Arbor, MI. Examines recent results of thirty years of research on calcium-activated-neutral protease (CANP or calpain). Addresses the pathophysiological role of calpain in various human disorders such as cerebral ischemia, traumatic brain and spinal cord injury, and more. For researchers. ... Read more

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The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater sense of urgency within the field of chemical defense since this event, research related to chemical warfare agents (CWAs) continues to expand at a remarkable pace.

Chemical Warfare Agents: Pharmacology, Toxicology, and Therapeutics, Second Edition explores the latest methods and products for preventing, diagnosing, and treating the acute and chronic effects of toxic CWA exposure. This edition citesthe key developments in chemical defense research since 2001, including new epidemiological or clinical studies of exposed or potentially exposed populations; new treatment concepts and products; improved organization of the national response apparatus in the U.S. addressing the potential for CWA terrorism; and improved diagnostic tests that enable rapid diagnosis and treatment.

Leading researchers explain how these breakthroughs help researchers determine physiologically relevant detection thresholds and develop more effective countermeasures and national response procedures. Chemical Warfare Agents provides first responders and emergency medical teams with the most up-to-date information they need to prepare for and handle natural disasters, chemical spills, terrorism, and warfare situations—quickly and effectively. ... Read more

Customer Reviews (1)

amazing research
I did not read the whole book, which was quite technical.
There was a section describing the nerve agent soman, and the separation of its four stereoisomers by capillary gas chromatography. There was also research described in which the four stereoisomers were separated and had their individual toxicities determined in animals. This section was fascinating and its contemplation gave me the shivers to think of the danger involved handling this dreadful poison.
One thing I would criticize( as a neophyte in this area of research) is the constant use of acronyms. A glossary would be very helpful.
I noticed one error : the authors characterized dieldrin and aldrin as organophosphates, which they are not. ... Read more

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This unique resource introduces the fundamental principles and current concepts of toxicology and risk assessment offering comprehensive discussions on clinical testing, risk assessment of chemicals and hazardous materials, the application of animal data to human health risk assessment, mathematical models, statistical approaches, environmental laws, information resources, and risk management. ... Read more

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Everyday, we come into contact with many relatively harmless substances that could, at certain concentrations, be toxic. This applies not only to obvious candidates such as asbestos, lead, and gasdline, but also to compounds such as caffeine and headache tablets. While the field of toxicology has numerous texts devoted to aspects of biology, chemistry, and mechanism of action, the need remains for a book that places toxicology within the framework of our daily lives.A Small Dose of Toxicology presents the principles of toxicology by exploring the effects of common chemical agents such as caffeine, nicotine, and alcohol. It reviews the fundamentals of dose-response and factors of individual sensitivity in regard to these drugs, and then applies this knowledge to environmental contaminates such as lead, arsenic, pesticides, mercury, and radiation. Chapters discuss neurotoxicology, risk assessment, carcinogenicity, and with a variety of specific toxic agents, with each chapter designed as a self-contained module to allow for flexibility in the selection of personal or academic material. Exploring current toxicology concerns within a human context, this text discusses how toxicology affects our everyday lives while providing insight into the broader issues of public health and disease prevention. Environmental and public health professionals, as well as novices and students requiring a basic foundation in toxicology will find this resource incredibly useful. ... Read more

Customer Reviews (1)

Small Dose- but large information
Steven Gilbert, Ph.D., DABT has compiled a user-friendly book of toxicology that has utility in beginner and advanced courses of the toxicology field. It is layman friendly and selectively includes toxic product hazards of everyday life. The common chemicals include alcohol, caffeine, nicotine, pesticides, lead, mercury, arsenic, heavy metals, solvents and radiation for starters; all products of human ingestion, inhalation or dermal absorption in everyday life. In simple terms and understandable paragraphs that are digestible, one learns of the dangers to human exposure. The additional reference lists at the end of each subject enhances the ability of one to research issues further. Government agencies that can assist the reader are also presented. Toxicology is literally "the science of poisons" and is often one of the "heaviest" curriculum/ biological subjects. "A Small Dose" allows the reader to enjoy the subject matter and still learn the issues at hand in the new millennium. Dr. Gilbert makes it palatable...Thank you! He was awarded a commendation in 2004 from the British Medical Association Library book competition- a most prestigious award. ... Read more

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The book has no illustrations or index. Purchasers are entitled to a free trial membership in the General Books Club where they can select from more than a million books without charge. Subjects: Reference / General; Medical / General; ... Read more

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REAL-LIFE CASES, TUTORIAL QUESTIONS, NARRATIVE HISTORYIntriguing anecdotal pedagogy, like the alleged arsenical poisonings of Napoleon and President Taylor and the probable mercury overdose of Isaac Newton, is one of the things that set Toxicology: A Case-Oriented Approach apart from other toxicology texts. Based on an undergraduate-graduate combined toxicology course at West Chester University, this innovative text captures readers' interest by combining modern case studies, historical cases, and hundreds of illustrations and tables. Each chapter presents several case scenarios that involve the reader with questions about diagnosis, testing methods, treatment, and other pertinent information. TOXICOLOGY FOR THE LABORATORY AND THE EMERGENCY ROOMIn an easy-to-read style, this book covers the major organ systems and reviews the effects of toxins in each system. Most contemporary books are almost entirely clinical or entirely analytical. Toxicology: A Case-Oriented Approach treats each area extensively to benefit students and professionals who need to know aspects of both. It describes diagnosis and treatment of each specific poisonous exposure and discusses chemical basis and the laboratory testing of toxins. This dual perspective, coupled with the book's interesting narrative approach, lets readers quickly absorb the information they need to understand toxicology in the laboratory and in the Emergency Department. ... Read more

Customer Reviews (2)

forensic toxicology
i am very pleased with my copy of this text. i did choose to buy it new because i wanted to make my own markings and my not have to worry about anyone else's work. i am surprised that the book did come as quickly as it did. i opted for the free shipping and i received the book in 3 days instead of the indicated 5-9. thanks amazon!

A good start
This text book is a great starting book in the field of toxicology.I am a new student to this field. The author's combination of clinical and technical knowledge makes this book all the more interesting. ... Read more

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This book stems from the belief that scientists and policy makers should be guided by the most reliable predictive models available, among which the hormetic dose response model has considerable evidence to support it, is very generalizable, has a strong mechanistic foundation and can be applied in the assessment of single agents and complex mixtures. For these reasons, the hormetic model should become the default in risk assessment.

This book summarizes and analyzes the various positives of hormesis in an attempt to revel hormesis as a fundamental principle of toxicology, biology, and biomedical sciences as a whole. A focused discussion of how acceptance of the hormedis based model of toxicology would affect environmental standards and clean up values is mounted. A panel of scientists has been recruited to critically evaluate the hormetic dose response model and its comparison with current default models in their individual fields, including cellular biology, evolutionary biology, gerontology, and pharmacology. In-depth investigations are provided into how biological systems respond to increasing doses of environmental toxins while attempting to understand how cells respond to stress in the contexts of aging and neurological disorders.

Product Description
This textbook is based on Volume 1 of "Clarke's Analysis of Drugs and Poisons" by Moffatt, Osselton and Widdop (ISBN 9780853694731). The text is aimed at students undertaking Forensic Science degrees (B.Sc or M.Sc). Existing chapters from Clarke's have been edited for a student audience.Forensic science courses in the UK have been developed since 1990. To date, there are over 50 degree programmes (now also including M.Sc) and over 350 possible course combinations with a Forensic element to them. A brief survey of student intake for these courses over the past three years revealed an exponential rise in numbers which is set to continue. This situation is mirrored in the US, Europe and the rest of the world.Analytical Toxicology is an important subject within Forensic Science and this textbook has been developed based on Volume 1 of "Clarke's Analysis of Drugs and Poisons" (ISBN 9780853697114). The existing chapters from Clarke's have been edited for a student audience, rendering the material suitable for a recommended course textbook.The editors, Sue Jickells and Adam Negrusz are actively engaged in teaching analytical toxicology at respected universities (King's College, London and University of Illinois at Chicago).This title will be of interest to academics teaching Forensic Science, Analytical Chemistry, Biomedical Science and to students of Forensic Science (MSc and BSc). ... Read more

Customer Reviews (2)

Exxcellent text
Very thorough text.Fundamental and with appplications. Although not immediately applicable in my lab, I appreciate having had for the first time a clear explanation of what Raman rays are and how their analysis is helped by Fourier transformation.

Still use it...
I had to buy this book for my Drug Chemistry and Toxicology class, however, I still reference it now.

This book provides a lot of necessary information in a very concise way. ... Read more

Product Description
Introduction to Biochemical Toxicology
Third Edition
Over the past several decades, biochemical toxicology has contributed greatly to the advancement of scientific disciplines ranging from medicine and pharmacology to environmental science and industrial hygiene. In its never-ending quest to define the biochemical, cellular, and molecular events occurring when toxicants interact with organisms, biochemical toxicology provides the rational basis for, among other things, our understanding of acute and chronic toxic processes, the development of new therapies, the determination of toxic hazards, and the development of medical and agricultural biocides.
Recent applications of new molecular and cellular techniques have greatly expanded our knowledge of how toxicants produce their adverse effects. As a consequence, the time has come for a substantial revision of Professor Ernest Hodgson's classic reference in the field. This Third Edition now contains updated overview chapters on immunochemical and molecular techniques. It also features entirely new chapters covering such crucial topics as immunotoxicology, cutaneous toxicology, reproductive and developmental toxicology, and molecular epidemiology. ... Read more

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The first book in two decades to address this multi-faceted field, The Toxicology and Biochemistry of Insecticides provides the most up-to-date information on insecticide classification, formulation, mode of action, resistance, metabolism, environmental fate, and regulatory legislation. The book draws on the author’s groundbreaking research in insect detoxification. It discusses mechanisms at the molecular level such as specific enzymes that contribute to insecticide resistance, the modification of which can change insecticide susceptibility and influence host plant selections in phytophagous insects.
Beginning with a general introduction, eleven chapters integrate classical toxicology with physiology, biochemistry, and molecular biology to present a comprehensive look at the field. The book discusses the demand and formulation of pesticides and describes each type from dusts and powders to baits and aerosols. It classifies insecticides by target, chemical compound, and mechanism; evaluates toxicity testing procedures; explains pesticide uptake, mode of action, and metabolism; and explores species differences, resistance, and interactions. It also considers pesticides in the environment and federal and state regulatory legislation and enforcement.
A long-awaited, state-of-the-science review on insect toxicology, this indispensable book brings you up-to-date on the many aspects and implications of pesticide use and provides the necessary background and platform from which to conduct future research. ... Read more

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This classic textbook now enters its forth edition - a distillation of decades of research and teaching experience in toxicology.Known all over the world after its translation into six languages,Lu's Basic Toxicology is a benchmark text - bringing clarity and insight into a rapidly evolving subject.

Noted for its concise yet broad coverage of the subject, this new edition includes new chapters on over-the counter preparations, lactation and occupational toxicology.In addition, it covers:
DT The action of chemicals that cause cancer, mutations, congenital malformations and organ or system specific effects;
DT Why chemical target specific organs and systems and how these effects are revealed by laboratory tests
DT The host and environmental factors that modify these effects
DT The effects of food additives, pesticides, metals, pollutants in air, water and soil, as well as toxicants encountered in workplaces
DT The procedures commonly used in assessing risk associated with these chemicals

The breadth of this book makes it ideal for students requiring an introduction to toxicology, whether those specializing in toxicology or those from other biomedical disciplines who need a clear and concise overview of the field.The inclusion of separate subject and chemical indexes also makes it a useful shelf reference for more experienced researchers. ... Read more

Customer Reviews (3)

Lu's Basic Toxicology
Excellent resource for a basic toxicolgy course in college.I read through each chapter for a more concise understanding because the lectures didn't do the subject justice like this book.

a good book for engineering major
Lu's basic toxicology is a very good choice when you what to learn some toxicology even though you have no sound chemisttry or biochemistry background. The authors use easy-understood words to explain the fundamentals of toxicology. After you read this book, you will have an overview of toxicological principles, such as professional terms, target organs, test methods as well as risk assesment.

Toxicology book
Item was as described, but shipping took more time than expected even when I paid for two-days shipping. ... Read more

Product Description
This exciting book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book.
This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security.

Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles.Will include the most agent-specific information on the market.

Includes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source.Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers time.


The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan.He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book.


Covers risk to humans, animals and the environment equally.Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with.

... Read more

Product Description
Since the publicaation of the first edition of Introduction to Toxicology,toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing. ... Read more

Customer Reviews (5)

Introduction to Toxicology
Received used copies of this book.They were in great condition and it is an excellent book.

Introduction to Toxicology, Third Edition
The book was in great coniditon. It had no writing or highlighting in the book as was advertised. The crease wasn't too bad either. Overall I was very happy with the item.

great intro guide
easy to understand, interesting topics, classic case studies. Overall, a comprehensive guide for basic toxicology

TIMBRELL'S TOXICOLOGY IS A WINNER
This book is suitable for all undergraduates on either Pharmacology or Toxicology- single or joint honours.The wording is simple;his message, short and sharp. The content is not too dense, and, unlike the othertextbooks, does not assume that the student has already acquired anauthoritative grasp of the underlying principles- a step-by-step approachis Professor Timbrell's style, which makes this book a very effective readbefore moving on to the more advanced texts, of which there is no shortageof in the library.It is possible to read the whole book in a week so itmakes a very effective companion for a quick revision of the lecture notesfor those of us who left it till the last minute!

TIMBRELL'S TOXICOLOGY IS A WINNER
This book is suitable for all undergraduates on either Pharmacology or Toxicology- single or joint honours.The wording is simple;his message, short and sharp. The content is not too dense, and, unlike the othertextbooks, does not assume that the student has already acquired anauthoritative grasp of the underlying principles- a step-by-step approachis Professor Timbrell's style, which makes this book a very effective readbefore moving on to the more advanced texts, of which there is no shortageof in the library.It is possible to read the whole book in a week so itmakes a very effective companion for a quick revision of the lecture notesfor those of us who left it till the last minute! ... Read more

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In the unique vignette format of the Pearls Series, this book presents a variety of problems that challenge emergency physicians and toxicologists in everyday practice. For each patient, the author presents the case scenario, physical findings, lab data, and a clinical photo, and the reader is challenged to formulate a diagnosis and a treatment strategy. The next page reveals the diagnosis, discusses the condition, and leaves the reader with several "pearls of wisdom" distilled from the case. ... Read more

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A fully updated and expanded edition of the bestselling guide on toxicology and its practical application

The field of toxicology has grown enormously since Industrial Toxicology: Safety and Health Applications in the Workplace was first published in 1985. And while the original edition was hugely popular among occupational health professionals, the time is ripe to address toxic agents not only in the industrial setting but also in the environment at large. Renamed Principles of Toxicology: Environmental and Industrial Applications, this new edition provides health protection professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the science of toxicology in both the occupational and environmental setting. Through contributions from leading experts in diverse fields, Principles of Toxicology, Second Edition features:
* Clear explanations of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems
* Coverage of occupational medicine and epidemiological issues
* The manifestation of toxic agents such as metals, pesticides, organic solvents, and natural toxins
* Special emphasis on the evaluation and control of toxic hazards
* Specific case histories on applying risk assessment methods in the modern workplace
* Ample figures, references, and a comprehensive glossary of toxicological terms ... Read more

Customer Reviews (1)

Lots of Useful Information
I bought this for my master's degree in industrial toxicology and almost all the topics covered at various points in the degree program are also covered in this book.Very useful tool for a degree in toxicology. ... Read more