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This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.

Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching.

New to the Fourth Edition:

• reorganized sections that cover basic principles followed by sections on different types of toxicity
• extensive use of examples throughout and numerous explanatory diagrams
• new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more
• questions with answers for each chapter for review and self-checking
• expanded and updated chapter bibliographies

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The Hospital For Sick Children, Toronto, Canada. Reference for clinicians interested in learning the teratogenic risks associated with environmental factors pregnant women are exposed to. Discusses which chemicals and proven to be teratogenic, as well as programs and options for pregnant women wishing to prevent birth defects. ... Read more

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This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards.
The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies. ... Read more

Customer Reviews (1)

An Educational Asset To The Field Of Aquatic Toxicology.
This textbook is literally a constructivepiece of scientific genius. Rand is perhaps one of the most knowledgable and most well respectedauthorities on Aquatic Toxicology and its many subdisciplines.

Afterpersuing through the first few chapters of this wonderfully writtenscientific text, one becomes very interested and more hungry for knowledgedealing with this subject.Unlike many other novels of this nature, thisone is very unique in that it gives the read a clear and very indepthpicture of Aquatic Toxicology and its impacts on the environment as awhole.

This text deals with aquatic toxicology from an environmentalpollution aspect dealing with manmade and natural chemical toxicants. Italso deals with the ecotoxicity affects of man-made pesticides when aquaticorganisms are involved in the bioecologicall food-chain.

In short one cansoon surmise that this text is an ideal educational asset for all who aredesiring a more comprehensive background and informative session in thefield of aquatic toxicology and its subdivision.It is superbly writtenand it details every single aspect of toxicological studies dealing withaquatic organisms in their environmental setting. ... Read more

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A bold new novel about the intersection of art, love, fame, and money from the acclaimed author of Dogeaters.

Jessica Hagedorn's edgy and entertaining new novel centers on the lives of two women who are neighbors in Manhattan's West Village. Mimi Smith is a filmmaker of low-budget slasher movies in search of new material. Her neighbor Eleanor Delacroix is a legendary writer of erotic fiction, now nearing eighty and addicted to cocaine and gin. Their personal and artistic lives begin to collide in unexpected ways as Eleanor grieves over the recent death of her live-in lover, the renowned painter Yvonne Wilder, and as Mimi deals with the challenges presented by her newly sober brother Carmelo; her drug-dealing boyfriend, who has mysteriously disappeared; and her wayward fourteen-year-old daughter, Violet. Looming over all these characters is the ghost of Agnes-an "illegal" and cousin of Mimi's who might have been murdered by her New Jersey employers. Toxicology is a dark yet playful exploration of money, desire, mortality, and the connection between creativity and self-destruction. ... Read more

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Food and Nutritional Toxicology provides a broad overview of the chemicals in food that have the potential to produce adverse health effects. The book covers the impact on human health of food containing environmental contaminants or natural toxicants, food additives, the migration of chemicals from packaging materials into foods, and the persistence of feed and food contaminants in food products. Chapters address the adverse effects of nutrient excesses, the impact of contaminants on nutrient utilization, metabolism of food toxicants, and the relationship of the body's biologic defense mechanisms to such toxicants. The book includes discussions on the risk determination process, food safety regulation, and the current status of the regulatory processes.Presenting the general principles of toxicology, this authoritative reference enhances the understanding of foodborne intoxications, infections, and diseases linked to foods. This in-depth study establishes a solid background in the principles and prevention of foodborne disease and the regulation of food safety. ... Read more

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Written by two experienced toxicology lecturers, Principles of Toxicology provides a broad-based yet in-depth introduction to this diverse subject. Comprehensive and easy-to-read, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular; physiological; and ecological and environmental. This revised second edition expands the coverage of the book while keeping the organizational format that made the first edition a bestseller. It also includes a series of brief case studies illustrating the application of toxicological principles to current issues of interest.

Each and every chapter has been revised, several have been significantly rewritten, and three are entirely new. This new edition retains the extensive cross-referencing system that links all sections and enhances the integration of material. It also includes an appendix of selected toxicants that describes chemical structure and category of use. These features combine to make finding specific information quick and easy. The highly readable format and uniform, consistent presentation of information will make this the most used reference on your shelf.

See what's new in the second edition: ... Read more

Customer Reviews (1)

A good begining text on toxicology
The text covers the major modern toxins, the method of action
and the biochemistry involved.
It also has a good reference appendix at the end that lists the toxins and their formulas with information about them.
As a reference for most people this book will be useful. ... Read more

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Schering-Plough Research Institute, Lafayette, NJ. Reviews various roles of genetic toxicology in human cancer risk assessment conducted by the U.S. and worldwide regulatory agencies. Discusses hazard identification, dose-response relationship, exposure assessment, and current practices of risk characterization. ... Read more

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Part of a long-established work on the field of occupational health. New subjects covered include hazardous wastes, man-made fibres, asbestos management in buildings and the safety and health effects of visual display terminals. ... Read more

Customer Reviews (1)

The Quintessential IH Reference
This series of books is the ultimate reference for industrial hygienists. While the sheer size of Patty's is daunting, it should be on every IH's bookshelf. If you need to know anything about the toxicology of a chemical or other workplace health hazards, chances are it's in Patty's. ... Read more

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This introductory text addresses the principles and mechanisms of toxicology as applied to environmentally-encountered toxic agents. Each chapter concludes with review questions that may be used for student self-testing and topics covered include dose response, hazards and risk assessment, determination of toxicity, pesticides, metals, plastics, organic solvents, environmental carcinogens, teratogens and mutagens. ... Read more

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Simply Outstanding And A Credit To Environmental Toxicology
After thoroughly perusing the pages of this textbook, it became clearly that the author, W. W. Hughes,touches on every topic and subtopicassociated with the discipline of Environmental Toxicology.

Unlike othertextbooks dealing with the same scientific discipline,Hughes does notappear to be unitalented or uniknowledgable when dealing with thediscipline of environmental toxicology. Rather, Hughes shows that he isvery knowledgable aboutthisdiscipline as well as its many subareas andtopics.This textbook touches on everyarea and related subarea ofenvironmental toxicology from organ toxicity and specificty tothe finercomponents of a detailed and scientifically adequate riskassessment.

Moreover, the author breaks down the various classes ofenvironmental pesticides for the reader in terms of names, biochemicalclass,solubility in water, and their Modes of Actions on terrestrials,aquatic, and invertebrate species.

This textbook is a must for anystudent, instructor, government biologist/chemist/toxicologist, orindustrialist desiring a more indepth and perhaps more scientific knowledgeabout the components which are used in the discipline of environmentaltoxicology.

Hughes makes sure this textbook stands out as an informativescience novel from an environmental point of view. It is a must-readtextbook that will definitely hold the reader's interest for a long periodof time. ... Read more

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This volume, closely related to MILS-6, deals mainly with metal (loid)-alkyl derivatives but also with the rarer aryl compounds. Most of these (commonly toxic) compounds are formed in the environment by microorganisms, but some anthropogenic input occurs as well.

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A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals

This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:
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An introduction to toxicology methods and an explanation of computational methods
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In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels
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Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena
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Chapters written by leading international experts
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Figures that illustrate computational models and references for further information

This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development. ... Read more

Customer Reviews (1)

Great Reference For Safety & Health Professionals!
I have used this book as a text for a university Toxicology course for Safety Engineering Technology.It is a wonderful guide to the scientific basis of toxicology in the workplace.It is a level above the basicinformation and would be a wonderful reference for the safety professionalwho needs to solve problems and needs to determine when to bring aspecialist into the worksite.It covers the applied (rather thantheoretical) science, toxic agents and their manifestations, and evaluationand control of hazards in industrial workplaces. ... Read more

Product Description
The Encyclopedia of Toxicology provides a comprehensive collection of concise and readable explanations of basic principles in toxicology and the potential hazards of chemicals. Written by highly qualified contributors and containing a broad selection of topics, the Encyclopedia of Toxicology is of value to both toxicologists and non-toxicologists, including physicians, attorneys, regulators, safety managers, and environmental engineers-anyone whose work involves the health and safety issues of common and uncommon substances. The Encyclopedia of Toxicology plays a critical role at the intermediate level by offering more detail than a dictionary while remaining accessible to the generalist in risk assessment, regulation, and consulting. The Encyclopedia includes entries related to research and clinical toxicology, risk assessment, ecotoxicology, epidemiology, radiation, noise, information resources, organizations, and education. With more than 750 entries, extensive cross-references, a detailed index, and numerousreferences to primary and secondary literature, the Encyclopedia will be an indispensable resource.

Key Features
* Provides an excellent selection of topics with more than 750 entries
* Organizes information in a highly structured format for easy reference
* Addresses basic, critical, and controversial elements in toxicology
* Overviews numerous key concepts and summarizes the hazardous properties of hundreds of chemicals
* Includes a detailed index and numerous cross references to primary and secondary literature
* Contains individual entries for both concepts and compounds--each chemical and metal has its own entry rather than being discussed briefly in a larger entry
* Provides extensive coverage of regulatory issues ... Read more

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Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health.This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds.

* Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter
* New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more ... Read more

Customer Reviews (1)

A must have reference handbook for Toxicologists and Regulatory Scientists
This book is recommended for both regulatory scientists and toxicologists dealing with metals exposures.The first 16 chapters cover fundamental concepts in metals toxicology and provide good coverage of factors important in health risk assessment.These preliminary chapters detail for the reader the myriad of issues that need to be taken into account when assessing metals and environmental data while drawing on relevant literature to illustrate points being made.Detailed reviews of individual metals are provided in subsequent chapters and it is invaluable having such in-depth coverage in a single volume.It would appear that some chapters were initially written a couple of years prior to publication so that the most recent information is not always included, but this is to be expected in such a publication.This handbook is highly recommended for anyone dealing with the toxicology of metals and is a must have for toxicologists involved in the assessment of environmental data.

Visit the Elsevier Internet site for a more detailed description of the handbooks content. ... Read more

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This updated edition of the classic, best-selling textbook -- including new chapters on methods validation, benzodiazepines, and GHB -- is ideal for the classroom and the reference shelf. Since the publication of the first edition in 1999, Principles of Forensic Toxicology has been used extensively for teaching students taking a one-semester course in forensic toxicology. It has also proven to be an invaluable reference for laboratorians.

The first section provides an introduction to postmortem forensic toxicology, human performance forensic toxicology, forensic drug testing, and pharmacokinetics and pharmacodynamics.

The second section is devoted to analytical principles, including both theory and applications. Methodologies covered include specimen preparation, spectrophotometry, chromatography, immunoassay, mass spectrometry, and methods validation.

The third section covers commonly encountered analytes, including alcohol, benzodiazepines, GHB, miscellaneous central nervous system depressants, opioids, cocaine, marijuana, amphetamines/sympathomimetic amines, hallucinogens, anticonvulsants, antiarrhythmics, antidepressants, neuroleptics, carbon monoxide/cyanide, inhalants, and metals. ... Read more

Customer Reviews (3)

Fast shipping
I really appreciated that it only took a few days for the book to arrive.

Great transaction
Product was exactly what I wanted and was looking for. Delivered promptly and in the described condition. Thanks for the quick and painless transaction.

Great service!
The product came in before the shipping estimate, and also before my class began.Thank you for prompt and definative service. ... Read more

Product Description
Environmental-friendliness, issues of public health, and the pros and cons of genetically-modified crops all receive regular coverage in the world's media. This, in turn, has led to increased questioning and investigation of chemical pesticides.Stenersen's concise introduction to chemical pesticides describes these compounds according to their biochemical mode of action, such as whether they are enzyme inhibitors, receptor ligands, or free radical generators. Chemical Pesticides provides answers to why pesticides are toxic to the target organism, how resistance develops, why pesticides are toxic to some organisms and not others. The book also discusses legal matters and concerns as well as potential environmental problems. ... Read more

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Behavioural ecotoxicology is an emerging field dealing with the effects of environmental pollutants on the behaviour of animals. Behavioural techniques derived from experimental psychology, behavioural pharmacology and neurotoxicology are applied to detect and characterise changes in animals living in the environment exposed to various pollutants. Behavioural effects are then interpreted in an ecological context considering the long-term relevance of these changes at both the individual and population level.

... Read more

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AstraZeneca Central Toxicology Laboratory, Macclesfield, UK. Focuses on the molecular regulation of apoptosis with emphasis on toxicant action. Addresses cell survival signalling and its perturbation. Relates data to the brain, immune system, reproductive organs, kidney, and liver. For clinicians and researchers. Expanded-outline format. ... Read more