Neglecting actuator saturations on both amplitude and dynamics can be source of undesirable or even catastrophic behavior for the closed-loop system (such as loosing closed-loop stability).

Such actuator saturations have also been blamed as one of several unfortunate mishaps leading to the 1986 Chernobyl nuclear power plant disaster. For these reasons, the study of the control problem (its structure, performance and stability analysis) for systems subject to both amplitude and rate actuator or sensor saturations as typical constraints has received the attention of many researchers in the last years.

The different techniques described throughout the book are particularly attractive for industrial applications not only in aeronautical or space domains but also in the context of biological systems domain. Such methods are well suited for the development of tools that help engineers to solve analysis and synthesis problems in the context of control systems with input and output constraints

In this context, biology systems need appropriate analysis tools due to their structure and hierarchy, complexity and environment interference, and we believe that these aspects may generate interesting research topics in control area. Indeed, several works, raising the potential impact of control developments to bring some beginning of answers in the context of biological systems, have been published in the recent years.

The idea of this book was conceived in the context mentioned above with the objective to help in claiming many of the problems for control researchers, starting discussions and opening interactive debates between the control and biology communities, and, finally, to alert graduate students to the many interesting ideas at the frontier between control feedback theory and biology.