81. The Laboratory Of Professor David E. Housman to human disease phenotypes. Genetic Marker Home Page. Lab Members. Please send commentsand suggestions regarding this home page to hmangenomics-www@mit.edu http://web.mit.edu/hman-genomics/www/

The Laboratory of Professor David E. Housman Center for Cancer Research Massachusetts Institute of Technology 77 Massachusetts Avenue, E17-543 Cambridge, MA 02139 ph: (617) 253-3013 fax: (617) 253-5202 General outline of our research activity: Identification and characterization of mammalian genes involved in diseases and development, Development and implementation of strategies for efficient mapping of mammalian genomes, and Utilization of mouse genetics to develop useful models for understanding the genetic contribution to human disease phenotypes. Genetic Marker Home Page Lab Members Publications Related Links Please send comments and suggestions regarding this home page to: hman-genomics-www@mit.edu Last modified March 2000

82. Genome Index Page - Actionbioscience.org biodiversity. environment. human genome. biotechnology. evolution. new frontiers.education. biodiversity. environment. genomics. biotechnology. evolution. new frontiers. http://www.actionbioscience.org/genomic/

home search email this page updates signup ... education issues in genomics indicates "educator resources" section at end of article Genetic information and privacy "Does Genetic Research Threaten Our Civil Liberties?" by Philip Bereano, Ph.D. "For Sale: Iceland's Genetic History" by Oksana Hlodan Ethics of DNA patenting "DNA Patents Create Monopolies on Living Organisms" from Council for Responsible Genetics Applications of genomic mapping "Species: Comparing Their Genome" from the Howard Hughes Medical Institute "Ethical Issues in Pharmacogenetics" by Carol Isaacson Barash, Ph.D. "The Genetics of Autism" by Michael J. Dougherty, Ph.D. New frontiers "Evolutionary Biology: Technology for the 21st Century"

83. The Institute For Genomic Research Primary research interests are in structural, functional and comparative analysis of genomes and gene Category Science Biology Genetics Organizations...... of the next four organisms for development of functional genomics reagents Mycobacterium Genomesequence of the human malaria parasite Plasmodium falciparum. http://www.tigr.org/

News New Mobile Bioscience Lab To Help Schools Keep Pace With Fast-Moving Research The nation's newest and largest mobile laboratory, the MdBioLab, will be launched in early February to help Maryland high schools enhance their bioscience education programs. TIGR has partnered with MdBio, Inc., and the University of Maryland Biotechnology Institute to create this innovative non-profit project. Press Release PFGRC Adds Four Pathogens For Year Two The Pathogen Functional Genomics Resource Center and The National Institute of Allergy and Infectious Disease announce the selection of the next four organisms for development of functional genomics reagents: Mycobacterium tuberculosis, Plasmodium falciparum, Neisseria gonorrhoeae, and the Chlamydia family. Rice Genome Sequence Announced By International Public Consortium An international sequencing consortium that includes TIGR announced today that scientists have completed the assembly of an advanced, high-quality draft genome sequence of rice and made that data freely available. The sequence is an important new tool for agricultural and nutritional research involving one of the world's most important crops. Press Release More TIGR News >> Genome News Network March 7 to March 21, 2003

84. Structural Genomics At BNL BNL is independently taking a structural genomics approach to gain structural informationabout human proteins that are involved in sensing and repairing DNA http://proteome.bnl.gov/

Structural Genomics at BNL Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The aim, ultimately, is to build a body of structural information that will facilitate prediction of a reasonable structure and potential function for almost any protein from knowledge of its coding sequence. Such information will be essential for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. BNL is a member of the New York Structural Genomics Research Consortium ( NYSGRC ), which is supported by the Protein Structure Initiative of the National Institute of General Medical Sciences (NIGMS) to be a Pilot Structural Genomics Center. Procedures are being developed for high-throughput x-ray crystallography of proteins expressed from cloned genomic or cDNA. Initial targets include a variety of yeast proteins, proteins associated with human disease, and proteins of human pathogens. Protein targets and progress toward structure determination will be posted on the NYSGRC web site. BNL is independently taking a structural genomics approach to gain structural information about human proteins that are involved in sensing and repairing DNA damage. This work is supported by the Office of Biological and Environmental Research of the Department of Energy. Protein targets and progress toward structure determination will be posted on this site in the following tables:

85. Genomics, Society & Human Health genomics Society and human Health is a groundbreaking opportunity for researchersand students, from as far a field as molecular biology, medicine, computer http://www.gshh.uwa.edu.au/

Welcome G enomics Society and Human Health is a ground-breaking opportunity for researchers and students, from as far a field as molecular biology, medicine, computer science, philosophy, law and public health, to work together with the people of Western Australia to explore the implications of new genetic knowledge for our way of life in the Twenty First Century. The program is centred on five themes: Understanding Advances in Genetics; New Frontiers in Medicine; Bioinformatics and Population Health; Social and Ethical Implications; and a Future for Society. These activities are supported by The University of Western Australia Institute of Advanced Studies. Winners of the Design-A-Gene Web Page WA Human Genetic Research Forum Professor D'Arcy Holman's introduction (Video) Part one Part two Part three Those videos are RAM files which require RealPlayer Basic to play. RealPlayer Basic is available free from www.real.com EVENTS MEDIA THEMES * Advances in Genetics * New Frontiers in Medicine Population Health ... The University of Western Australia Unauthorised duplication or modification of this page and its contents is prohibited.

86. HGMP-RC Fugu Genomics Project The Fugu genomics Group has already scanned in excess of 1000 cosmids. genomic lociin depth, focusing on regions sharing synteny with human chromosomes 11p13 http://fugu.hgmp.mrc.ac.uk/

MRC HGMP-RC The Fugu Genomics Project DRAFT SEQUENCE OF FUGU GENOME PUBLICLY AVAILABLE Fugu assembly release 2 - 17th May 2002 The UK MRC funds the Fugu Genomics Group at the HGMP-RC , as part of its commitment to comparative mapping and sequencing of vertebrate genomes. The group, headed by Greg Elgar, is involved in a number of projects geared towards understanding sequence data generated by the human genome project. Fugu rubripes (the Japanese puffer fish) is particularly suited to this kind of analysis because whilst its 400Mb genome is eight times smaller than human's, it has a similar repertoire of genes. These genome characteristics along with the large evolutionary distance between bony fish and mammals make Fugu a useful tool for studying gene evolution. See Elgar et al for further details. Please use the links in the navigation bars at the bottom of this webpage to access areas of the website. The Fugu Genomics Group has already scanned in excess of 1000 cosmids . Current work involves constructing large BAC contigs to examine particular genomic loci in depth, focusing on regions sharing synteny with human chromosomes 11p13, 20q12 and 6p21.3 (MHC). Data from these projects will involve the construction of a BAC database and will become available when accepted for publication. The Fugu Genomics Group also has a commitment to providing support for other researchers working on Fugu and this includes provision of resources and technical support.

87. Stanford Genomic Resources Provides links to various systematic analysis projects, resources, laboratories, and departments at Category Science Biology Genetics Eukaryotic...... Gene Ontology (GO) Consortium. Stanford genomics Breast Cancer Consortium Portal.human Radiation Hybrid Map Server. SaccharomycesGenome Deletion Project. http://genome-www.stanford.edu/

Stanford Genomic Resources This page provides links to various systematic analysis projects, resources, laboratories, and departments at Stanford University . It is maintained by the Saccharomyces Genome Database within the School of Medicine Database Resources Saccharomyces Genome Database Stanford Microarray Database PharmGKB ... Database) Stanford Genome Centers Stanford Human Genome Center (SHGC) Stanford Genome Technology Center Stanford Genomic Projects Stanford Functional Genomics Facility (SFGF) Gene Ontology (GO) Consortium Stanford Genomics Breast Cancer Consortium Portal Human Radiation Hybrid Map Server ... Yeast Genetic Footprinting Published Datasets (Stanford) S.cerevisiae C. elegans Human All organisms Software Resources Microarray Software Genomic Research Departments Genetics Biological Sciences Biochemistry Developmental Biology Mirrored Resources GeneCards v2.26u1 VectorDB WebMiner New Items Alter O, et al. (2003) Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms. Proc Natl Acad Sci USA 100(6):3351-3356 Higgins JP, et al. (2003) Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol 162(3):925-32 Whitney AR, et al. (2003) Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci U S A 100(4):1896-901 Bohen SP, et al. (2003) Variation in gene expression patterns in follicular lymphoma and the response to rituximab. Proc Natl Acad Sci U S A 100(4):1926-30 ... Enter here for previous Web Supplements Organism-limited sets are also available from the

88. Wellcome Trust Centre For Human Genetics - Core Genomics genomics Home. Sequenom. Microarray Facility. human 6p Deletions and Mouse Models.Mutation Detection. EBV Transformation Service. Sequencing. ABI 3700. ABI Matrices. http://www.well.ox.ac.uk/core-genotyping/

Genomics Home Sequenom Microarray Facility Human 6p Deletions and Mouse Models ... vacancies Core Genomics Head of Department Dr. Ioannis Ragoussis Aaron Abbott Dr. Helen Butler Gerovie Davidson ... vacancies This page updated: Friday, March 7, 2003

89. NCGR Homepage Develop bioinformatics and computational biology tools to support genetic analysis and discovery .Category Science Biology Eukaryotic Animal Mammal human...... and enable discovery. Primary research areas include genomics, biochemicalpathways and gene expression. SOFTWARE/TECHNOLOGY NCGR http://www.ncgr.org/

Programs Software Events About ... Search NOTE: On 20 March 2003, NCGR web sites will be offline during network maintenance between 9PM and 3AM, MST (GMT-7). We apologize for any inconvenience this may cause. SCIENTIFIC PROGRAMS In collaboration with users worldwide, NCGR creates biological databases and analytical tools to accelerate and enable discovery. Primary research areas include genomics, biochemical pathways and gene expression. SOFTWARE/TECHNOLOGY NCGR offers a variety of software tools that facilitate the access, integration, and analysis of different biological data types. Our tools provide scientists with a framework for accelerating discovery and understanding biological processes. PathDB Software Version 2.0. Now Available The latest version of NCGR's GUI based Pathway Analysis tool is now available for local installation and client download. New job openings Take a look at the exciting new career opportunities

90. 2003 GRC On Human Genetics & Genomics human Genetics genomics August 38, 2003 Colby College Waterville,ME. Chair Aravinda Chakravarti Vice Chair Eric Green. TOPICS http://www.grc.uri.edu/programs/2003/humangen.htm

August 3-8, 2003 Colby College Waterville, ME Chair: Aravinda Chakravarti Vice Chair: Eric Green TOPICS A. Chakravarti /E. Lander/ E. Eichler/ E. Green) Functional Dissection of the Human Genome K. Davies /C. Burge/T. Gingeras/H. Dietz/E. Rubin) Genome and Human Evolution E. Eichler /B. Trask/A. Sidow/P. Green/W.-H. Li) Mechanisms of Genomic Disease B. Trask /J. Lupski/B. Morrow/D. Albertson/M. Bedell) Molecular and Functional Variation D. Altshuler / D. Nickerson/D. Bentley/ A. Chakravarti /P.-Y. Kwok) Molecular Genetic Epidemiology D. Nickerson /D. Cutler/N. Cox/A. Doyle) Gene Identification in Complex Disease H. Willard /S. Antonarakis/D. Altshuler/E. Boerwinkle/M. Justice) J. Lupski /H. Willard /J. Lee/K. Davies) Disussion Leaders are in Bold Last Updated: 12/04/02 by Jeff Carroll

91. GeneTrove || Genomics Backgrounder - The Human Genome genomics Backgrounder. The human Genome. The information necessary forbuilding and maintaining life, from simple bacteria to remarkably http://www.genetrove.com/humGen.html

Genomics Backgrounder The Human Genome Many laboratories in the U.S., funded by the Human Genome Project (HGP), as well as many private companies, are performing sequencing of the human genome. Special issues of Science (Feb. 16, 2001) and Nature (Feb. 15, 2001) contain the working draft of the human genome sequence. The Nature publication includes the description and initial analysis of the sequence as generated by the Human Genome Project and is in the public domain. The Science publication describes sequences generated by the biotechnology company Celera Genomics .The sequence reported by Celera contains between 26,500-30,000 genes, which represents approximately 95% of the entire genome. This sequence is applicable to everyone, because all humans share the same basic set of genes and genomic regulatory regions that control the development and maintenance of their biological structures and processes. It is anticipated that a high-quality sequence of the human genome will be available by the end of 2003. Efforts of the genomics industry have resulted in a massive increase in both the amount and rate of accumulation of information over the last 3-5 years. Some highlights are:

92. Human Genome Epidemiology Network Club for human Genome Epidemiology Network, What's new with HuGE Net, Case Studies,Fact Sheets, Reviews, Feed Back, Evaluating HuGE Studies, genomics and Disease http://www.cdc.gov/genomics/hugenet/default.htm

W elcome to HuGENet™, a global collaboration of individuals and organizations who develop and communicate epidemiologic information on the human genome. Researchers are studying genetic variation to: Develop population-specific prevalence data on human gene variants Develop epidemiologic data on the association between genetic variation and diseases in different populations Develop quantitative population-based data on gene-environment interaction Determine population impact of genetic tests and services The results of these studies will lead to the use of genetic information to prevent disease and improve health. about us site search privacy last updated March 13, 2003

93. Human Genome Project Information News about this Department of Energy project. Includes abstracts on the legal, ethical and social issues. is DOE's next step in genomicsbuilding on data and resources from the human Genome Project, the Microbial Genome http://www.ornl.gov/TechResources/Human_Genome/home.html

The Human Genome Program of the U.S. Department of Energy funds this suite of Web sites. Gene Gateway tools for exploring the sequence The Genomes to Life program is DOE's next step in genomicsbuilding on data and resources from the Human Genome Project, the Microbial Genome Program, and systems biology to accelerate understanding of dynamic living systems. Celebrating 50 years of the discovery of the double helix DNA structure and the anticipated completion of the Human Genome Project Welcome! Explore this site for information about the U.S. and worldwide Human Genome Project. B egun in 1990, the U.S. Human Genome Project is a 13-year effort coordinated by the Department of Energy and the National Institutes of Health. The project originally was planned to last 15 years, but effective resource and technological advances have accelerated the expected completion date to 2003. Project goals are to identify all the approximately 30,000 genes in human DNA

94. The Wellcome Trust Sanger Institute Genome research centre furthering the knowledge of genetics through largescale sequencing and analysis Category Science Biology Genetics Research Centers...... human, Mouse, Zebrafish, Microbes, Protozoans, C.elegans, S.pombe, C.briggsae, X.tropicalisGenomics Genetics Cancer Genome Project, human Genetics, Mouse, C http://www.sanger.ac.uk/

Information Teams Faculty People ... Advertised Jobs 18th Mar 2003 More Essential network maintenance On Saturday the 22nd March between 07:00-19:00 GMT Ensembl will be unavailable and Sanger services will be greatly reduced ... 14th Mar 2003 More AceDB version 4.9p released The AceDB team are pleased to announce the release of a new Development version of AceDB. ... 4th Mar 2003 More The Sanger Institute is pleased to announce the availability of release 5 of Artemis and release 2 of ACT. ... 3rd Mar 2003 More Ensembl version 11 released Ensembl is pleased to announce a total of nine species with new data and updated schema for metazoan genomes. ... Finished Sequence: 1,654,917,538 bases (18-Mar-2003, 05:16 PM) Detailed Statistics Sanger Institute Site Search Contact us

95. Mutation Research Genomics, A Section Of Mutation Research. Covers the nature and consequences of genome variations in humans and appropriate model systems, focusing on experimental approaches, instrumentation, and informatics technologies. http://www.elsevier.com/inca/publications/store/6/0/0/0/9/7/index.htt

Home Search What's New Electronic Services ... Links Mutation Research Genomics, a section of Mutation Research. Journal Information Description Bibliographic and Ordering Information Authors and Editors Why Publish with Elsevier Science? Guide for Authors Help and FAQ Contents Services Tables of Contents Keyword Index Author Index ContentsDirect ... Free Sample Copy News/Related Websites Mutation Research Genomics Related Info Last update: 17 Mar 2003

96. Gene Amplification Intl Consultants in genomics and bioinformatics, specifically acquired genetic disorders due to exposure of humans living near uncontrolled hazardous waste sites. http://www.geneamplificationintl.com/

Gene Amplification Intl Environmental Consulting Agency Home Gene Amplificaion International Welcome to the "twenty nineth" of a series of environmental updates. This environmental update is taken from "Hazardous Waste-Associated Acquired Genetic Disorders". G. McKinstry. European Journal of Human Genetics, Vol. 9, Supplement 1, May 2001, page 326 and P1154 (poster) presented at the 10th International Congress of Human Genetics (ICHG) meeting, May 15-19, 2001, Vienna, Austria. Environmental updates are also, provided at this site, highlighting these and other environmental-related issues. These updates can be easily downloaded to most computer printers. **Side Comment below: Taken from The Scientist 12[2]:1, Jan. 19, 1998 (http://www.the-scientist.com/yr1998/jan/steinberg_p1_980119.html). **"The National Institute of Environmental Health Sciences, for example is trumpeting a plan to identify polymorphisms that render some people more vulnerable to pollutants and elements like lead and iron. L. Carl Barrett, scientific director of the institutes division of intramural research , says the Environmental Genome Project could cost $60 million over five years. Basic parameters, such as the number and identity of candidate genes, however, have yet to be established." **At the time of this posting (06/01), the information contained within the side comment was 3 yrs. old, publication date Jan. 1998.

97. B200 Human Genome Lectures Molecular Biology and the human Genome Project. Chapters 3, 4, 5 and 15of human genetics the molecular revolution by Edwin McConkey, pub. http://www.ucl.ac.uk/~ucbhjow/b200/b200.html

Molecular Biology and the Human Genome Project These are the last three lectures of the Biology B200 course, given by Dr Jonathan Wolfe Chapters 3, 4, 5 and 15 of Human genetics: the molecular revolution by Edwin McConkey, pub. Jones and Bartlett, 1993 are recommended reading. An excellent (though slightly out of date) web site to visit for relevant information is The US Department of Energy's Primer of Molecular Genetics . (The Department of Energy is a big mover in the Genome World.) Table of Contents Molecular Biology and the Human Genome Project Introduction Cloning cDNA clones ... Sequencing Introduction The last thirty years have seen the study of the human genome grow from a minority academic interest into a mega-industry. During this time it has ceased to be solely an academic province but has become the object of study of the major pharmaceutical companies, for example, in the US and UK SmithKline Beecham are very active in the field of human genome research. This is a link to their publicity . In addition research has moved out of small laboratories and into a few heavily funded genome factories (for want of a better word). The principal UK effort is at the Sanger Centre in Cambridgeshire.

98. JAMA -- Page Not Found 2001;28622802288 ABSTRACT FULL TEXT PDF SPECIAL COMMUNICATIONS The Anatomyof the human Genome A Neo-Vesalian Basis for Medicine in the 21st Century http://jama.ama-assn.org/issues/v286n18/toc.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

99. LLNL Human Genome Center Undertake sequencing of genomic regions containing DNA repair genes and human chromosome 19. Features Category Science Biology Eukaryotic Animal Mammal human...... on highthroughput sequencing, shotgun sequencing technology development, and functionalgenomics. regions containing DNA repair genes and human chromosome 19. http://www-bio.llnl.gov/bbrp/genome/genome.html

LLNL Human Genome Center General description of the Human Genome Center Maps of Human Chromosome 19 Genomic sequencing Informatics ... LLNL Human Genome Center Personnel < with contact information Jobs listing Link to the DOE Joint Genome Institute Homepage In the past two years, the goals of the Human Genome Center have undergone a dramatic evolution. This change is the result of several factors both intrinsic and extrinsic to the Human Genome Initiative. They include: 1) the successful completion of the first phase goal of the Center, namely a high-resolution, sequence-ready map of human chromosome 19; 2) advances in DNA sequencing that allowed us to accelerate scaling this operation; 3) the development of a strategic plan for the Biology and Biotechnology Research Program which integrates our resources and strengths in genomics with programs in DNA repair, individual susceptibility, structural biology, and microbial biotechnology; and 4) the formation of a Joint Genome Institute for the Department of Energy with its three Genome Centers at Livermore, Berkeley, and Los Alamos as anchors. In addition to genomic sequence, over 50 complementary DNA clones (cDNAs) from genes on human chromosome 19 were fully sequenced and submitted to public sequence databases. We have expanded the basis of the LLNL-based I.M.A.G.E. Consortium, an effort to characterize the transcribed human genome, through interactions with numerous collaborators (in particular, Washington University - Merck) such that the clone collection is now the largest public collection of sequenced cDNA clones, with over 500,000 arrayed clones, over 500,000 sequences in public databases, and over 15,000 mapped cDNAs.

100. Genetics, Genomics, And The Law: September 27-28, 2002 Home The Institute for Genome Sciences and Policy Duke University School of Law Duke University http://www.law.duke.edu/conference/gelp/

Home The Institute for Genome Sciences and Policy Duke University School of Law Duke University Home The Institute for Genome Sciences and Policy Duke University School of Law Duke University

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