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         Alexander Disease:     more books (100)
  1. Treatise on the diseases of women: For the use of students and practititioners by Alexander J. C Skene, 1889
  2. Schaffer's Diseases of the Newborn by Mary E. Avery, Alexander J. Schaffer, et all 1984-01
  3. A treatise on indigestion and its consequences,: Called nervous and bilious complaints; with observations on the organic diseases, in which they sometimes terminate by Alexander Philip Wilson Philip, 1823
  4. The Official Parent's Sourcebook on Alexander Disease: Updated Directory for the Internet Age by Icon Health Publications, 2003-12
  5. Alexander disease: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Dawn, MS, CGC Cardeiro, 2005
  6. Intermarriage: Or, The mode in which, and the causes why, beauty, health and intellect, result from certain unions, and deformity, disease and insanity, ... anthropological works of Alexander Walker) by Alexander Walker, 1844
  7. Alexander Disease - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker, 2007-07-19
  8. An experimental enquiry concerning the causes which have generally been said to produce putrid diseases. By William Alexander, M.D. by William Alexander, 2010-05-27
  9. Non-Neoplastic Diseases of the Central Nervous System (Atlas of Nontumor Pathology, First Series Fascicle) by David N., M.D. Louis, Matthew P., M.D., Ph.D. Frosch, et all 2010-05-20
  10. Phylogeny and disease association of Shiga toxin-producing Escherichia coli O91.(DISPATCHES)(Report): An article from: Emerging Infectious Diseases by Alexander Mellmann, Angelika Fruth, et all 2009-09-01
  11. Novel Mycobacterium tuberculosis complex pathogen, M. mungi.(DISPATCHES)(Report): An article from: Emerging Infectious Diseases by Kathleen A. Alexander, Pete N. Laver, et all 2010-08-01
  12. Influenza (H5N1) viruses in poultry, Russian Federation, 2005-2006.(RESEARCH)(Clinical report): An article from: Emerging Infectious Diseases by Aleksandr S. Lipatov, Vasily A. Evseenko, et all 2007-04-01
  13. Hemoplasma infection in HIV-positive patient, Brazil.(DISPATCHES): An article from: Emerging Infectious Diseases by Andrea Pires dos Santos, Rodrigo Pires dos Santos, et all 2008-12-01
  14. Hantavirus infections in humans and animals, China.(PERSPECTIVE): An article from: Emerging Infectious Diseases by Yong-Zhen Zhang, Yang Zou, et all 2010-08-01

41. Brain Work This Week
Genetic Basis of alexander disease Discovered. Scientists have identified thegene responsible for the rare childhood brain disorder alexander disease.
http://www.dana.org/books/press/bwtw/bwtw_0101-1.cfm
Volume 2, Number 1 - 01/05/01
Stimulating Growth in Damaged Adult Neurons Spinal cord regeneration-the regrowth and repair of damaged nerve fibers-is the Holy Grail quest of neuroscience. Researchers worldwide have explored a multitude of methods, with varying degrees of success. The major hurdles to regeneration are that the body has built-in inhibitory factors that repress nerve growth, and older nerve cells lose the growth capacity found in young neurons. Pate Skene and colleagues at Duke University Medical Center report in the January issue of Nature Neuroscience that they have identified two growth-associated proteins that when expressed together may help overcome these obstacles and stimulate new growth. The research team studied dorsal root ganglian neurons, which have both a central axon projecting up the spinal cord and an additional axon branch that projects through a peripheral nerve. Scientists know that peripheral nerves can regrow after damage, but damage to the peripheral nerve also causes the adjacent spinal cord axon to begin growth as well. The team concluded that certain genes are turned on after damage that allows this regrowth. They identified two proteins, known as CAP-23 and GAP-43, which are normally found at the growing tip (growth cone) of embryonic axons. Using the dorsal root ganglian nerves taken from genetically engineered mice, the researchers found that when these two proteins are expressed together, they activate growth activity into a nerve graft placed at the site of the lesion. This raises the possibility that these proteins may be useful in initiating nerve regeneration in patients with spinal cord injuries, perhaps in combination with therapies to neutralize the inhibitory environment of the adult central nervous system.

42. Press Release
As a member of a consortium of researchers looking into the rare brain conditionalexander disease, his Durham team is to receive $0.5m of the $4m total award.
http://www.dur.ac.uk/pr.office/02-91 top award for Durham Scientist.htm
Pr/brief/02-91 16 December 2002
Top award for Durham Scientist
The award of a prestigious research grant to Cell Biologist, Professor Roy Quinlan demonstrates the University of Durham's growing international reputation in Biomedical Sciences. Professor Quinlan has the rare distinction of being a non-US national to be included in an award from the US National Institute of Health. As a member of a consortium of researchers looking into the rare brain condition Alexander Disease, his Durham team is to receive $0.5m of the $4m total award. Sir Kenneth Calman, Vice-Chancellor of the University, said: "The University is tremendously proud to have people of world-class quality at the heart of its research community. We congratulate Professor Quinlan on this achievement and wish his team continued success in their work." It was Professor Quinlan's particular expertise in cell and structural biology that was important to the consortium. The project will make important contributions to one of the last great frontiers of modern science - understanding the human brain. Professor Quinlan has several research programmes that are investigating those components that give form and function to cells - namely the skeleton of the cell, called the cytoskeleton. In Alexander Disease, brain function is lost because this structural support is lost. The project will yield important new insights into the brain and how it is made and organised as an important step to treat degenerative brain diseases.

43. Nature Publishing Group
1 report 10 spontaneous mutations in the gene encoding the astrocytespecific protein,glial fibrillary acid protein (GFAP), in people with alexander disease.
http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v27/n1/full/ng0101_1

44. Index Of Figures And Tables
article. Mutations in GFAP, encoding glial fibrillary acidic protein,are associated with alexander disease Michael Brenner et al.
http://www.nature.com/ng/journal/v27/n1/fig_tab/ng0101_117_ft.html
To return to the article, close this browser window. To toggle between the article and the figure, click on the browser window containing the article.
Mutations in GFAP , encoding glial fibrillary acidic protein, are associated with Alexander disease
Michael Brenner et al.
Nature Genetics

doi:10.1038/83679
Figures
Figure 1:
GFAP mutations in Alexander disease patients characterized by DNA sequencing.
Figure 2:
Detection of mutations by restriction endonuclease digestion.
Figure 3:
Location of mutations in GFAP associated with Alexander disease in relation to protein domain structure of intermediate filaments.
Tables
Table 1:
Characteristics of patients with Alexander disease and associated GFAP mutations To return to the article, close this browser window. To toggle between the article and the figure, click on the browser window containing the article.

45. UAB MRRC
Genetic Basis for alexander disease This image shows some cultured astrocytes thathave been stained with a fluorescent antibody that reveals the presence of
http://www.mrrc.uab.edu/
Meet Our Director
Our Mission and Primary Objectives

Civitan International Research Center
and Chairman of the UAB Department of Neurobiolog is Director of the UAB MRRC.
(1) to increase scientific knowledge about basic brain development, particularly factors related to intellectual functioning, mental retardation (MR), and developmental disabilities (DD);
(2) to develop and test the efficacy of preventive interventions; and
(3) to ameliorate the personal, familial, and societal consequences of mental retardation and developmental disabilities through effective treatment strategies. Primary Objectives of Our Research More than 40 investigators from 14 basic science and clinical departments will participate in our education, research and service efforts. Our main objectives include the following: (1) to conduct programmatic research that will advance understanding the etiologies of developmental disabilities and to develop and test strategies to prevent and ameliorate mental retardation and developmental disabilities.  Six key interdisciplinary research programs (see above) have been identified as the most promising areas for concentration of research endeavors that will directly benefit from MRRC core supports, affording exceptional opportunities for multidisciplinary collaboration and scientific advances;

46. [Pathology Graduate Program] James E. Goldman, MD, PhD
We are also studying alexander disease, a leukodystrophy in which the braindoes not myelinate properly and astrocytes accumulate massive amounts of
http://pathology.cpmc.columbia.edu/pbio0010.html
Graduate and Research Programs in Pathobiology
Research Programs and Faculty

Our lab has been tracing cell lineages in the developing mammalian CNS to study the origins of neurons and glia from immature neuroectodermal cells. Using recombinant retroviruses to transfer genes into progenitor cells, we have followed the migration and differentiation of immature cells of germinal zones in vivo and have determined time- and location-specific patterns of glial development. We are examining what roles environmental vs. lineage-controlled factors play in specifying cell fates. We are particularly interested in how progenitors migrate through the developing brain, focusing on molecular mechanisms that regulate the direction, the beginning and the cessation of migration. Our lab is also starting to examine these same type of mechanisms as they apply to glial tumor migration through the brain.
Selected publications:
  • Gensert, J.M., and Goldman, J.E. Remyelination by endogenous progenitors in the adult rat CNS. Neuron Messing, A., Head, M.W., Galles, K., Galbreath, E.J., Goldman, J.E., and Brenner, M. Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice.

47. Cleveland Clinic Health System - Health Information
Search Results The following information is available for the topic alexander disease.Please select one. Care Treatment. , alexander disease. New Search.
http://www.cchs.net/health/getcontents.asp?DocID=do-query&TopicId=1272

48. Searchalot Directory For Leukodystrophy
Stroke. alexander disease Information sheet compiled by NINDS, theNational Institute of Neurological Disorders and Stroke. Devoted
http://www.searchalot.com/Top/Health/ConditionsandDiseases/NeurologicalDisorders
Home Search News Email Greetings Weather ... Global All the Internet About AltaVista AOL Search Ask Jeeves BBC Search BBC News Business Dictionary Discovery Health Dogpile CheckDomain CNN Corbis eBay Education World Employment Encyclopedia Encarta Excite Fast Search FindLaw FirstGov Google Google Groups Infomine iWon Librarians Index Looksmart Lycos Metacrawler Microsoft Northern Light Open Directory SearchEdu SearchGov Shareware Teoma Thesaurus Thunderstone WayBackMachine Webshots WiseNut Yahoo! Yahoo! Auctions Yahoo! News Yahooligans Zeal Sponsored Links Top Health Conditions and Diseases Neurological Disorders ... Demyelinating Diseases : Leukodystrophy Related Web Sites
  • Call Again Soon - Directed at making life better for people affected by Leukodystrophy and those who know and love them.
  • United Leukodystrophy Foundation - Nonprofit, voluntary health organization dedicated to providing patients and their families with information about their disease and assistance in their health.
  • Leukodystrophy - CHORUS document on the different types of Leukodystrophy. A little technical.
  • Aicardi-Goutieres Syndrome - News, descriptions, contacts, and other information concerning this leukodystrophy.

49. Florida State University College Of Medicine Digital Library
Resources; alexander disease Clinical Resources; alexander diseasePatient/Family Resources; Alkali Burns Clinical Resources; Allergic
http://fsumed-dl.slis.ua.edu/alpha-index/aa-alpha-individ/a-page.htm
Digital Library Alphabetic Browse
All Digital Library Resource Topics Beginning with "A"
See also:

50. Albee Messing Profile
in astrocyte development and reaction to injury in the central nervous system, andthe role of GFAP mutations in the pathogenesis of alexander disease, and 2
http://www.cmb.wisc.edu/profiles/MessingAlbee.html
Albee Messing
Title: Professor
Department: Pathobiological Sciences
School/College: School of Veterinary Medicine Address:
715 Waisman Center
1500 Highland Avenue
Madison, WI 53705 Phone: (608) 263-9191 or
Email: messing@waisman.wisc.edu
Website:
http://www.vetmed.wisc.edu/

pbs/messing.html
Research Areas:
Molecular Basis of Human Disease
Research Description:
Research in my laboratory is directed at understanding developmental and pathologic aspects of neuronal and glial cell biology in the nervous system of the mouse. Our main strategies involve genetic manipulation of glial gene expression using transgenic techniques, and gene targeting in embryonic stem cells to generate mutant strains of mice. Current projects address a variety of issues such as regulation of gene expression, cellular interactions during development, ion channels as regulators of excitability and differentiation, and mechanisms of neurodegenerative and demyelinating diseases. Most of our effort is directed at the following projects:
1) the molecular and cellular biology of intermediate filaments, particularly glial fibrillary acidic protein (GFAP), in astrocyte development and reaction to injury in the central nervous system, and the role of GFAP mutations in the pathogenesis of Alexander disease, and

51. Peripheral Nervous System Diseases
Links to information about peripheral nervous system diseases by Cliniweb International.Category Health Conditions and Diseases Peripheral Nervous System...... Diseases All Review Therapy Diagnosis; alexander disease Med. Coll.of Wisconsin; Chronic Immune Polyneuropathies Demyelinating
http://www.ohsu.edu/cliniweb/C10/C10.772.html
Peripheral Nervous System Diseases
Back to previous level

52. Silver Hill Hospital Digital Library
Clinical Resources by Topic Metabolic Disorders. alexander diseaseClinical Resources. alexander disease Patient/Family Resources.
http://silverhillhospital-dl.slis.ua.edu/clinical/metabolism/inborn/lipid/leukod
Clinical Resources by Topic: Metabolic Disorders
Alexander Disease Clinical Resources
Pediatrics Radiology Genetics Clinical Guidelines ... Miscellaneous Resources See also:

53. Central Nervous System Diseases
alexander disease MCW Health Link (US); An 8 years old boy .(Alexanderdisease) G Shah; MRI images - RefIndia; alexander disease
http://www.mic.ki.se/Diseases/c10.228.html
search help staff
Central Nervous System Diseases
Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider.

54. The Journal : Back Issues
C Warren Olanow. alexander disease GFAPmutations unify young andold Summary Full Text PDF. Albee Messing, Michael Brenner.
http://neurology.thelancet.com/journal/vol002/iss0002/contents
The Journal
Info for Authors
Profile
Help
Feedback The Journal Current Issue Back Issues Contents in full The leading edge ... The last word
Search Journal Register Subscribe Log in
Jobs
Awards and Announcements Conferences Press Services ... Contents in full Volume 002, Number 0002 01 February 2003
Born to be wild
In this months' Last word, John McCrone looks at the insights into neurodevelopment gained from the mysterious case of Amala and Kamala, two girls who spent their early years in the company of wolves.
The leading edge The leading edge Full Text PDF Newsdesk Newsdesk News in brief... News in brief... News in brief... News in brief... [ Full Text PDF Another set back for fetal transplants for Parkinson's disease [ Full Text PDF Richard Robinson Fourth gene for PD identified [ Full Text PDF James Butcher Ironing out the wrinkles in the botulinum toxin intracellular pathway [ Full Text PDF Ivan Oransky Calm down, it's not cannabis... [ Full Text PDF Kathryn Senior New mechanism for HIV infection of neurons discovered [ Full Text PDF Adrian Burton Long-term mapping of dendritic spines now possible [ Full Text PDF James Butcher ''Search and destroy'' stem cells [ Full Text PDF Helen Pilcher Cortical organisation after SCI [ Full Text PDF Rebecca Love MyLifeBits: holding on to the present to preserve the past [ Full Text PDF Marilynn Larkin Reflection and Reaction Reflection and Reaction Dietary vitamin E and Parkinson's disease: something to chew on [ Summary Full Text PDF C Warren Olanow Alexander disease: GFAPmutations unify young and old [ Summary Full Text PDF Albee Messing, Michael Brenner

55. Alexander's Disease
alexander'S disease. DEFINITION A neurodegenerative disorder characterized by degeneration of CNS white matter and
http://www.icondata.com/health/pedbase/files/ALEXANDE.HTM
  • Pediatric Database (PEDBASE)
  • Discipline: CNS
  • Last Updated: 5/22/94
    ALEXANDER'S DISEASE
    DEFINITION:
    A neurodegenerative disorder characterized by degeneration of CNS white matter and specific CNS pathological findings.
    EPIDEMIOLOGY:
    • incidence: rare
    • age of onset:
      • newborn to adulthood (depends on the Form)
    • risk factors:
      • sporadic
      PATHOGENESIS:
      1. Background
      • unknown etiology but thought to involve dysfunctional astrocytes
      PATHOLOGY:
      1. Rosenthal Fibres
      • refractile eosinophilic hyaline bodies found within the cytoplasm of astrocytes particularly in the subpial, subependymal, and perivascular regions
      • required for definite diagnosis but not pathognomonic as seen in other disorders as well, i.e., Neurofibromatosis, MS
      TYPES:
      Type I: Infantile Form
      Type II: Juvenile Form
      Type III: Adult Form
      CLINICAL FEATURES:
      1. Type I - Infantile Form
      • onset: mean of 6 months but can range from shortly after birth to 2 years of age
      • most common of the 3 variants and most are male
      • death in 2nd to 3rd years of age
      1. Neurological Manifestations
  • 56. Alexander's Disease : A Case Report Of A Biopsy Proven Case - M. Tatke, A. Sharm
    Volume 47 Issue 4 1999 SHORT REPORTS VOL474 alexander's disease A Case Report of a Biopsy Proven Case M. Tatke, A. Sharma Department of Pathology, G.B. Pant Hospital, New Delhi-110002, India. Keywords alexander's disease, Histopathology.
    http://www.neurologyindia.com/vol47-4/1194fl.shtml
    Neurology India Volume 47 Issue 4 1999 SHORT REPORTS VOL47-4 Alexander's Disease : A Case Report of a Biopsy Proven Case
    M. Tatke, A. Sharma
    Department of Pathology, G.B. Pant Hospital, New Delhi-110002, India.
    Keywords : Alexander's disease, Histopathology.
    Summary : A case of infantile onset Alexander's disease in a two and a half year old male child is presented, who had progressively increasing macrencephaly since birth. A frontal lobe biopsy revealed collections of Rosenthal fibres in the subpial and perivascular areas with diffuse dysmyelination and presence of reactive astrocytes. The Rosenthal fibres were immunoreactive for glial fibrillary acidic protein and ubiquitin. Electron microscopic examination showed the Rosenthal fibres as intra-astrocytic and extracellular granular osmiphilic collections. Introduction
    Alexander's disease (or leucodystrophy) is characterised by macrencephaly, frequently associated with hydrocephalus, extensive proliferation of reactive astrocytes and formation of Rosenthal fibres by these cells, which are seen intracellularly and extracellularly, predominantly in the perivascular, subependymal and subpial regions. The presentation may be in the infantile, juvenile or adult forms.

    57. Managing Pig Health, Treating Swine And Hog Diseases.
    Practical manual providing detailed information on pigs, hogs, swine. This 600+ page book, written by Mike Muirhead and Tom alexander is written in an easily understandable format and is aimed at everyone involved in swine production, from the farmer to the professional. Web site gives book contents and has an order form.
    http://www.managingpighealth.com
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    58. Index.page
    A 2yr old native american boy suffering from a rare immune deficiency. This site chronicles his disease and ongoing treatment through a bone marrow transplant.
    http://www.geocities.com/prayers4jared/
    Prayers for Jared Updates about Jared and his family
    Last updated

    August 17, 2002
    The Jared Alexander Fund
    C/O Sterling Savings Bank 111 N Wall St.
    Spokane, WA 99201 Juliana's Page Thank You for your prayers and/or donations Jared in June Read a Spokesman-Review article about Jared printed on December 5, 2000 Jared Alexander is a cheerful and active 22-month-old boy. Unfortunately, he cannot go anywhere in public. We have to be very careful about who comes to our house. He cannot be around large groups of people including family gatherings, because he is so vulnerable to getting sick. Jared has an unknown form of an immune deficiency in the category of SCIDS (severe combined immune deficiency syndrone.) Read a Spokesman- Review article about Jared printed on April 22, 2001 Jared in October At the end of September 2000, Jared went into the hospital. He was there for a month and spent some of that time on life support. He had pneumocystis carinii, among other infections, and could not breathe on his own so he ended up on a ventilator. Fortunately, he lived through this infection. However, he is at great risk of getting them again. Next time the infection could be fatal. Juliana in June The only thing that has a chance of helping Jared avoid further infections is a bone marrow transplant. Although every patient is different, the cost of that alone, not including living expenses, is $200,000 to $250,000. Jared is very lucky, his 5 year old sister is a perfect bone marrow match. She can be the donor. We have come to the determination that a bone marrow transplant, although risky, is the best chance of survival. It has the possibility of giving him an immune system. It is also very important for Jared to do this as soon as possible due to the severity of his condition and the time of year that is upon us.

    59. Chronic Fatigue Syndrome And The Alexander Technique
    How this centuryold method of releasing harmful stress can be of benefit to a patient with this disease.
    http://www.alexandertechnique.com/articles/chronicfatigue
    Chronic Fatigue Syndrome and the Alexander Technique by Martin Finnegan What exactly is Chronic Fatigue Syndrome?* Sometimes referred to as ME or Myalgic Encephalomyelitis, it is a term that describes a chronic, debilitating disorder that affects the immune and central nervous system. Typical of its symptoms are a profound fatigue, totally out of proportion to a person's physical activity and independent of mood, plus a range of other symptoms that can affect any organ of the body. The causes of CFS are unknown. Indeed there appear to be any number of apparent causes and in many cases the onset seems to be linked to a stress to the immune system such as an acute infection, especially viral in nature. After the stress or virus has run its course the symptoms do not abate as you would expect but set in, becoming chronic and are often associated with profound fatigue and feelings of general malaise. Western medicine advocates rest, counseling, adjusting lifestyle and support as the best approach to treating CFS and this is all good advice. The problem, it seems to me is one of perception. The orthodox point of view perceives CFS as a thing. It is my opinion that CFS is not a thing at all, which is the reason that no cause and no diagnosis can be found. It is a process. A process of a human system running down, in a variety of ways, to such a point that it can't function properly anymore. In my own experience of CFS, it was exactly that and the solution was not to attempt to 'fix' a part of my body but to address the whole of 'me' and my life, in all its various aspects - physical, mental, emotional and spiritual. And the new model that I followed worked.

    60. PedLynx
    AEROMONAS ENTERITIS AGENESIS OF THE CORPUS CALLOSUM AGENESIS OF THE CEREBELLAR VERMISAICARDI SYNDROME ALAGILLE SYNDROME alexander'S disease ALLERGIC disease
    http://www.icondata.com/health/pedbase/pedlynx.htm
    The Pediatric Database (PEDBASE) contains descriptions of over 550 childhood illnesses and has been on the Internet since November 15, 1995. Beginning in November of 1996, new diseases will be added and revisions made to existing files. Information on each disorder in this Database has been obtained from at least 3 sources including Nelson Textbook of Pediatrics (14th and 15th editions), the Birth Defects Encyclopedia (1990 and 1994 editions) and from at least one other source (journal articles, review articles, textbooks). One may download the entire Database as Shareware . An editable Registered version is also available through the author. AARSKOG SYNDROME
    AASE SYNDROME

    ABETALIPOPROTEINEMIA

    ACATALASEMIA
    ...
    ZELLWEGER'S SYNDROME

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