1. NINDS Alpers' Disease Information Page Alpersí Disease factsheet http://www.ninds.nih.gov/health_and_medical/disorders/alpersdisease_doc.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Alpers' Disease Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Alpers' Disease Information Page Synonym(s): Progressive Sclerosing Poliodystrophy Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Alpers' Disease? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Alpers' Disease? Alpers' disease is a rare, progressive neurodegenerative disease of the brain that occurs in infants and children. It is an autosomal recessive disorder that is sometimes seen in siblings. First signs of the disease, which include intractable seizures and failure to meet meaningful developmental milestones, usually occur in infancy. Primary symptoms of the disease are developmental delay, progressive mental retardation, hypotonia (low muscle tone), spasticity (stiffness of the limbs), and dementia. Seizures may include epilepsia partialis continua, a type of seizure that consists of repeated myoclonic (muscle) jerks. Optic atrophy may also occur, often leading to blindness. And, although physical signs of chronic liver dysfunction may not be present, many patients suffer liver impairment leading to liver failure. While some researchers believe that Alpers' disease is caused by an underlying metabolic defect, no consistent defect has been identified.

2. Alpers Disease An article about Alpers' disease, including the alternate names, symptoms and statistics.Category Health Conditions and Diseases Alpers......alpers disease alpers disease, formally known as Alpers Progressive InfantilePoliodystrophy, is a progressive neurodegenerative disease. http://www.cs.jmu.edu/common/projects/mtDNA/alpersdisease.html

Alpers Disease Alpers Disease, formally known as Alpers Progressive Infantile Poliodystrophy, is a progressive neurodegenerative disease. It is also known as Christensen-Krabbe Disease. The symptoms initially manifest via convulsions. Over time, the symptoms grow to include dementia, spasticity, and monoclonus. The final symptom the patient usually experiences is status epilepticus (Ford, 1951). Following the initial convulsions, neuronal degeneration begins to occur. The degeneration results in the formation of spongiform tissue. Alpers is also linked to massive liver failures (Catherine, 1999). Back

3. Demyelinating Diseases alpers disease, formally known as Alpers Progressive Infantile Poliodystrophy, is a progressive neurodegenerative disease. It is also known as ChristensenKrabbe Disease. The symptoms initially manifest via convulsions. http://www.mic.ki.se/Diseases/c10.314.html

search help staff Demyelinating Diseases Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Demyelinating Diseases The Myelin Project [the Odone family et al. ] - Washington DC (US) Brief Synopses of White Matter Disease: demyelinating , and White Matter Disease: dysmyelinating - CHORUS, Med College of Wisconsin (US) Diffuse Cerebral Sclerosis of Schilder About Alpers disease - NINDS Alpers disease information - James Madison Univ. (US) Canavan Disease About Canavan Disease - NTSAD (US) Canavan Disease - Univ of Pittsburgh (US) The Canavan Research Foundation - (US) Canavan Foundation Online Multiple Sclerosis About Multiple Sclerosis - Merck Manual, Home Edition Multiple Sclerosis: Current Status and Strategies for the Future - NAP 2001 (US) The International Multiple Sclerosis Support Foundation J Sumption ], and the MS-Library - Int'l MS Support Foundation Nat'l Multiple Sclerosis Society including an extensive Source Book - (US) MS Crossroads - Multiple Sclerosis Connections Alt.Support.Mult-Sclerosis

4. Alpers Disease A brief description of Alpers' disease, links to further resources and support groups.Category Health Conditions and Diseases Alpers......Alper's disease PubMed Medline search on Alper's disease Alper's Diseasefactsheet National Institute for Neurological Disorders and Stroke. http://www.ion.ucl.ac.uk/library/patient/alper.htm

Alper's disease Medline NLM definition : Diffuse progressive degeneration of the white matter of the brain, accompanied by mental deterioration, severe motor disturbances, and early death. PubMed Medline search on Alper's disease Alper's Disease factsheet: National Institute for Neurological Disorders and Stroke Support Groups Children's Mitochondrial Disease Information Network Email: paulmitogroup@netcentral.co.uk This website gives information on all mitochondrial diseases. United Mitochondrial Disease Foundation P.O. Box 1151 Monroeville, PA 15146-1151 Phone: (412) 793-8077 FAX: (412) 793-6477 Email: umdf@nb.net Aims to promote research for cures and treatments of mitochondrial diseases and to provide support to affected families. Up-to-date website with an extensive list of links to other resources, email and chat groups for people with mitochondrial diseases

5. NORD - Alpers Disease A brief description along with alternate name, followed by a list of resources for further information. http://www.stepstn.com/cgi-win/nord.exe?proc=GetDocument&rectype=0&recnu

6. Alpers 1 Pr alpers disease (Alpers Progressive Infantile Poliodystrophy or ChristensenKrabbeDisease). Progressive neurodegenerative disease. http://www.cs.jmu.edu/common/projects/mtDNA/Alpers 1 Pr.html

Alpers Disease (Alpers Progressive Infantile Poliodystrophy or Christensen-Krabbe Disease) Progressive neurodegenerative disease SYMPTOMS : convulsions, epiliptic seizures, neuronal degeneration (result in spongiform tissue), dementia, spasticity, massive liver failures, and monoclonus Only been 13 cases reported since 1931 Could be a result of the disease masking itself as something else, such as childhood jaundice or liver failure Next

7. United Mitochondrial Disease Foundation - Medical Article List By Subject The UMDF Medical Article List. Subject alpers disease (Progressive Infantile Poliodystrophy) http://www.umdf.org/data/query/alpers.htm

The UMDF Medical Article List Subject: Alpers Disease (Progressive Infantile Poliodystrophy) Back to the Subject List United Mitochondrial Disease Foundation We welcome any suggested additions to our list. Last updated: 26-Jun-98 REFERENCE FORMAT: Author Lastname; Firstname; Article Number; Article Title; Journal or Book; Year; Volume; Page Numbers Frydman ; M ; 1997* ; Alpers progressive infantile neuronal poliodystrophy: an acute neonatal form with findings of the fetal akinesia syndrome. ; American Journal of Medical Genetics ; 1993 ; 47(1) ; 31-6 Montine ; TJ ; 3814 ; Alpers' syndrome presenting with seizures and multiple stroke-like episodes in a 17-year-old male. ; Clin Neuropathol ; 1995 ; 14(6) ; 322-326 Narkewicz ; MR ; 2004 ; Liver involvement in Alpers disease. ; Journal of Pediatrics ; 1991 ; 119(2) ; 260-7 Wilson ; DC ; 1998* ; Progressive neuronal degeneration of childhood (Alpers syndrome) with hepatic cirrhosis. ; European Journal of Pediatrics ; 1993 ; 152(3) ; 260-2 Worle ; H ; 6380 ; Progressive cerebral degeneration of childhood with liver disease (Alpers Huttenlocher disease) with cytochrome oxidase deficiency presenting with epilepsia partialis continua as the first clinical manifestation. ; Clin Neuropathol ; 1998 ; 17(2) ; 63-8

8. NORD - National Organization For Rare Disorders, Inc. alpers disease. Copyright 1989, 1996, 1999, 2000 Synonyms of alpers diseaseAlpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Alpers Diseas

9. NORD - National Organization For Rare Disorders, Inc. Del Castillo Syndrome Aicardi Syndrome Alagille Syndrome Albinism Alexander DiseaseAlkaptonuria Allan Herndon Syndrome Alopecia Areata alpers disease Alpha1 http://www.rarediseases.org/search/rdblist.html

Search NORD's Databases NORD maintains three searchable databases and an alphabetical index of disease names. Index of Rare Diseases The A-to-Z of Rare Diseases Rare Disease Database Read about more than 1,100 rare diseases. View sample report Organizational Database Find a support group or other source of help. Orphan Drug Designation Database Find out about new and experimental orphan products. Database Subscriptions Subscriptions provide complete access to NORD's databases at libraries, schools, universities, and hospitals. NORD's Washington Office Read about events on Capitol Hill, funding for rare-disease research, and other topics of interest from NORD's office in Washington, DC. 5 Oxoprolinuria ACTH Deficiency AIDS (Acquired Immune Deficiency Syndrome) AIDS Dysmorphic Syndrome ... HOME Last modified Sunday, February 02, 2003

10. Prion Review: Alpers Disease Translate this page Síndrome de Alpers. Conjunto de enfermedades crónicas degenerativas delSNC de niños y recien nacidos. Poco frecuentes. Su neuropatología http://www.bio.vu.nl/thb/users/ingeborg/PrionAlper.html

CJD Se ha transmitido sin dificultad a hamsters mediante inoculaciones intracerebrales, pero no se ha logrado la transferencia a cerdos. Prion Home Page

11. Health Library - Alpers Disease alpers disease. Synonyms Disorder Subdivisions General Discussion Resources AlpersDisease is a progressive neurologic disorder that begins during childhood. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

12. 1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso information. NORD alpers disease A brief description along with alternatename, followed by a list of resources for further information. http://www.1uphealth.com/links/neurodegenerative-diseases-alpers.html

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Neurodegenerative Diseases : Alpers' Description Sites About com Symptoms, diagnosis, and treatment of Alpers' disease. Information on research, community outreach and support. Alpers' Disease Information sheet compiled by NINDS. Alpers' Progressive Infantile Poliodystophy Features listed for this disorder. Institute of Neurology A brief description of Alpers' disease, links to further resources and support groups. James Madison University An article about Alpers' disease, including the alternate names, symptoms and statistics. MedicineNet.com An Alpers' disease article with some general information. NORD - Alpers Disease A brief description along with alternate name, followed by a list of resources for further information. Readers Digest Health General information about Alpers' disease including the alternate names.

13. Alpers' Disease only one click For Medical Professionals only. Alpers' disease,,Print this article, (Bernard Jacob Alpers, 20th century, American http://www.amershamhealth.com/medcyclopaedia/Volume VI 1/Alpers disease.html

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Alpers' disease, (Bernard Jacob Alpers, 20th century, American neurologist), (also called progressive cerebral poliodystrophy), very rare mitochondrial encephalopathy (see mitochondrial diseases ) characterized by predominant involvement of the grey matter and liver. It manifests in the first years of life as intractable seizures and developmental delay. CT shows a low density area, mainly occipital and posterior temporal, involving both grey and white matter. GS The Encyclopaedia of Medical Imaging Volume VI:1 Welcome to Medcyclopaedia. This site is open to a public audience, still we want to know a little more about our visitors. Please tick off the boxes that match your profile. Do you live in Europe?

14. Mitochondrial Disease red fibres). Kearns Sayre disease. alpers disease. Menkes disease.GS The Encyclopaedia of Medical Imaging Volume VI1. Disclaimer Legal http://www.amershamhealth.com/medcyclopaedia/Volume VI 1/mitochondrial disease.h

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Mitochondrial disease, a group of conditions responsible for various types of neurodegenerative disorders, together with peroxisomal disorder and lysosomal disease Mitochondria are DNA-containing organelles, located in the cytoplasm of the cell; their main role is synthesis of adenosine triphosphate, ATP, the main source of energy for the cell. They produce numerous enzyme, mainly involved in the oxidative respiratory cycle (Krebs cycle). Deficiency of these enzymes cause various types of diseases with multiorgan involvement, including the white or grey matter of the brain, or both. Some of the most common and better defined mitochodrial encephalopathies are listed below: Leigh disease (subacute necrotizing encephalomyelopathy) MELAS (mitochondrial encephalomyelopathy, lactic acidosis and stroke-like episodes)

15. University Of Miami School Of Medicine - Glossary - Alpers Disease Medical Dictionary. alpers disease. A continuous seizure (status epilepticus)is often the final event. alpers disease is due to more than one cause. http://www.med.miami.edu/patients/glossary/art.asp?articlekey=8929

16. Alpers Disease alpers disease. This article submitted by on 5/3/98. Email AddressDoes anyone have any info on alpers dissease. We were given this http://neuro-www.mgh.harvard.edu/forum/MitochondrialDis.F/5.3.981.57PMalpersdise

alpers disease This article submitted by on 5/3/98. Email Address: Does anyone have any info on alpers dissease. We were given this as a possible diagnosis for my 2 yr old son but no tesets have been done. The other possible diagnosis was myopathy w/ lactic acidosis and sideroblastic anemia. We tested for angelmans and although it came back negative they are still talking about it. From what little I've read about alpers it sounds pretty bad. I would like to hear from any one. thanks Next Article Previous Article Return to Neurological Disorder Topic Menu Here is a list of responses that have been posted regarding this article... My 6yr. old daughter has Alpers (7/17/99) 2:55 PM My 6yr. old daughter has Alpers (6/27/99) 11:49 PM My Boyfriends Cousin (3/22/99) 5:27 AM My Boyfriend Cousin (3/22/99) 5:25 AM ... anon (1/15/99) 6:15 PM If you want to post a completely new article on any topic you like, click here. If you would like to post a direct response to this article, fill out this form completely... Response Title: Name: Email: Remember that your Name and Email Address are optional...you don't have to enter them! You can remain completely anonymous if you like by leaving these fields empty.

17. Birth Disorder Information Directory - A alpers disease (Alpers Progressive Sclerosing Poliodystrophy, Diffuse CerebralDegeneration in Infancy, Poliodystrophia Cerebri Progressiva/Progressive http://www.bdid.com/defectag.htm

HOME Ag-Am Aganglionosis Total Intestinal Aganglionosis total intestinal AGANGLIONOSIS, TOTAL INTESTINAL Aganthia with Holoprosencephaly and Situs Inversus Aganthia holoprosencephaly situs inversus AGNATHIA-HOLOPROSENCEPHALY Agammaglobulinemia List of Sites Agenesis of the Cerebellar Vermis List of Sites Agenesis of the Corpus Callosum List of Sites Related Books Aglossia Adactylia (Oromandibular Limb Hypoplasia) Aglossia adactylia AGLOSSIA-ADACTYLIA Also see Hanhart Syndrome Agnathia -Holoprosencephaly See Holoprosencephaly-Agnathia Agyria-Pachygyria Type I See Miller-Dieker (Lissencephaly) Syndrome Aicardi Syndrome List of Sites Aicardi-Goutieres Syndrome (Encephalopathy-Basal Ganglia Calcification) Aicardi-Goutieres syndrome Encephalopathy, Familial Infantile, with Calcification of Basal Ganglia and Chronic Cerebrospinal Fluid Lymphocytosis Related Books Cutis verticis gyrata thyroid aplasia mental retardation ... CUTIS VERTICIS GYRATA, THYROID APLASIA, AND MENTAL RETARDATION Aksu Stockhausen Syndrome (Branchial Arch Defects) branchial arch defects Al-Awadi Farag Teebi Syndrome (Primary Hypogonadism with Partial Alopecia) Al awadi farag teebi syndrome HYPOGONADISM, PRIMARY, AND PARTIAL ALOPECIA

18. Birth Disorder Information Directory - P Poliodystrophia Cerebri Progressiva See alpers disease. Poliosis See WhiteForelock. Polycystic Kidney Disease (PKD) List of Sites. Polydactyly http://www.bdid.com/defectp.htm

HOME P P-4 Deletion Syndrome A nationally recognized not-for-profit pre-school and therapeutic center for children with and without developmental delays ages 18 months to five years p47-PHOX, Deficiency of See Granulomatous Disease, Chronic, Autosomal Cytochrome-b-Positive Form, Type I p67-PHOX, Deficiency of See Granulomatous Disease, Chronic, Autosomal Cytochrome-b-Positive Form, Type II Pachydermopreiostosis (Hypertrophic Osteoarthropathy, Primary or Idiopathic) PACHYDERMOPERIOSTOSIS; PDP Pachyonychia Congenita See Jadassohn Lewandowsky Syndrome Pagod Syndrome See Kennerknecht Sorgo Oberhoffer Syndrome Pagon Bird Detter Syndrome (Anemia Sideroblastic Spinocerebellar Ataxia) Anemia sideroblastic spinocerebellar ataxia ANEMIA, SIDEROBLASTIC, AND SPINOCEREBELLAR ATAXIA; ASAT Pagon Syndrome See Walker Warburg Syndrome Pallister Syndrome See Schinzel Syndrome Pallister Hall Syndrome (Hypothalamic Hamartoblastoma, Hypopituitarism, Imperperforate Anus, and Postaxial Polydactyly) Pallister Hall syndrome:early diagnosis and natural history PALLISTER-HALL SYNDROME; PHS Also see McKusick Kaufman Syndrome Pallister Killian Syndrome V-KI-RAS2 KIRSTEN RAT SARCOMA 2 VIRAL ONCOGENE HOMOLOG; KRAS2

19. Mioti: Medical Condition Condition alpers disease. NINDS Alpers' Disease Information Page. NORD AlpersDisease. Information from the National Organization for Rare Disorders. http://www.mioti.com/cat/condition/condition.asp?Cat=AlpersDisease

20. Alpers alpers disease. Home HotLines Resources Printed Guide Child Carefor the '90's Links. © 1997 ABC F Press. MoreInfo@ChildHealthInfo.com. http://www.childhealthinfo.com/alpers.htm

ALPERS DISEASE [Home] [Printed Guide] [Child Care for the '90's] [Links] ... MoreInfo@ChildHealthInfo.com

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