41. The AIDS Epidemic In San Francisco: The Medical Response, 1981-1984, Vol. VI hairy leukoplakia. Recognizing Leukoplakia in Gay Men. The cases were verysmall in number at this time. The Naming of hairy leukoplakia HL. http://sunsite.berkeley.edu:2020/dynaweb/teiproj/oh/science/aids6/@Generic__Book

Expand Search The AIDS Epidemic in San Francisco: The Medical Response, 1981-1984, Vol. VI Deborah Greenspan II The Aids Epidemic Hairy Leukoplakia Hairy Leukoplakia Recognizing Leukoplakia in Gay Men D. Greenspan During this time I was seeing and managing patients with oral candidiasis. I was also seeing patients who had white patches in the mouth that were not responding to antifungal therapy. We didn't have a lot of "antifungals" actually in the late seventies and early eighties. That's the time when new antifungals like Mycelex and Ketochorazole were being tested and evaluated for use. Hughes Now, the white patches were synonymous with leukoplakia? That was the diagnosis? D. Greenspan A non-removable white patch in the mouth is called a leukoplakia. Leukoplakia simply means white patch, and the difference between a leukoplakia and pseudomembranous candidiasis is that pseudomembranous candidiasis is a removable white patch and leukoplakia is a non-removable white patch. Some of these leukoplakias may represent dysplasia, atypia, or early squamous cell carcinoma. And in 1980 and 1981, I saw people with white lesions on the tongue that were thought to be due to candida that in fact didn't respond to antifungal therapy, and therefore we biopsied them, because you need to biopsy white patches to find out what they are, to make sure that there is no dysplasia or carcinoma. The biopsies found slightly unusual appearances in the epithelium, that these were lesions that had no evidence of dysplasia or atypia, no evidence of candida, but nevertheless were a hyperkeratosis. We saw several cases

42. The AIDS Epidemic In San Francisco: The Medical Response, 1981-1984, Vol. VI Significance of hairy leukoplakia. And then as I said, above all, providingcare. Because apart from hairy leukoplakia, lots of other problems came. http://sunsite.berkeley.edu:2020/dynaweb/teiproj/oh/science/aids6/@Generic__Book

Expand Search The AIDS Epidemic in San Francisco: The Medical Response, 1981-1984, Vol. VI Deborah Greenspan II The Aids Epidemic Significance of Hairy Leukoplakia Significance of Hairy Leukoplakia D. Greenspan We found that hairy leukoplakia was very significant; it was evidence of an immunosuppression; it was consistent with falling CD4 count; it was consistent with increasing anergy to sensitivity testing; it was significant because of the development of an AIDS diagnosis out of an opportunistic infection or Kaposi's sarcoma. And therefore understanding it and then teaching people to recognize it was a very important part of this disease. And then as I said, above all, providing care. Because apart from hairy leukoplakia, lots of other problems came. We had troublesome candidiasis, nasty aphous ulcers, a very aggressive form of periodontal disease. Hairy leukoplakia was often the first thing the patients recognized. We know now, looking back, that it's one of the early markers of failing immune competence, so we know now why we saw it and why it was one of the first things we recognized, and why some of the other problems which we've now been seeing we didn't see in the early stages, in the beginning, because people hadn't been infected long enough. CDC Includes HP in the Case Definition of HIV Infection Hughes Hairy leukoplakia was indeed eventually incorporated in the CDC case definition eventually, was it not?

43. Oral Hairy Leukoplakia First Previous Next Last Index Home Text. Slide 33 of 53. http://faculty-web.at.nwu.edu/nuds/ettlin/senior/98-white1-dw/sld033.htm

44. Hairy Leukoplakia First Previous Next Last Index Home Text. Slide 15 of 57. http://faculty-web.at.nwu.edu/nuds/ettlin/palate/sld015.htm

45. Hairy Leukoplakia Resources On The Internet hairy leukoplakia. Forum on HIV and Oral Health Information resources on hairyleukoplakia (HK) and other oral conditions, including FAQs, from The Body. http://www.healthcyclopedia.com/hairy_leukoplakia.html

Home Health Conditions by Category ... Contact Us Hairy Leukoplakia Health News Search millions of published articles for news on Hairy Leukoplakia The eLibrary newspaper and magazine archive contains articles from current and back issues of hundreds of publications, including: Modern Medicine Aging The Ardell Wellness Report HealthFacts The Journal of Environmental Health Medical Post Medical Update Men's Health and the National Women's Health Report Note: To access the full text of articles, sign up for a seven-day no-risk free trial subscription to eLibrary. Web Directory Web Links: Forum on HIV and Oral Health - Information resources on hairy leukoplakia (HK) and other oral conditions, including FAQs, from The Body. The Web Directory section is adapted from the Open Directory Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor

46. INFODONT - Hairy Leukoplakia About INFODONT INFODONT ELECTIVES Contact AUTHOR(S) CUSTODIAN(S) HAIRYLEUKOPLAKIA. This type of leukoplakia was first described in 1984. http://www.od.mah.se/depts/webodont/hairy.html

About INFODONT INFODONT ELECTIVES Contact AUTHOR(S) - CUSTODIAN(S) HAIRY LEUKOPLAKIA This type of leukoplakia was first described in 1984. It is associated with the Epstein-Barr virus . The lesions have a typically corrugated surface, and they have most often been reported from the posterior tongue margins (I1), and - with increased frequency - in HIV positive and AIDS patients. They should always be further investigated with the aim to trace their pathogenesis. The histopathological changes in the surface epithelium of hairy leukoplakia normally accord well with the clinical appearance of the lesion (I2). BKGS REFERENCES: AUTHOR(S) TEXTBOOK REFBASE IMGBASE

47. Welcome To Medifocus! For more information call 1800-965-30025. Oral hairy leukoplakia, XL626. Oralhairy leukoplakia Updated Regularly. The Medifocus Guide Advantage. http://www.medifocuslegal.com/guide_detail.asp?gid=XL626&a=a

48. Oral Hairy Leukoplakia Is Not A Specific Sign Of HIV Infection But Related To Im Oral hairy leukoplakia is not a specific sign of HIV infection but related to immunosuppressionin general. J Oral Pathol Med 1989182831. Julkaisutiedot. http://www.uku.fi/wwwdata/julkaisutoiminta/julkaisut/1989/8900472.html

Julkaisu Reference Syrjänen S, Laine P, Niemelä M, Happonen RP. Oral hairy leukoplakia is not a specific sign of HIV infection but related to immunosuppression in general. J Oral Pathol Med Julkaisutiedot Julkaisutyyppi: Alkuperäisartikkeli. Kansainvälinen. Publication data Publication type: Original scientific article. International. Tekijät Contributors Kuopion yliopisto Kliinisen patologian ja oikeuslääketieteen laitos Suupatologian, röntgenologian ja oikeushammaslääketieteen laitos University of Kuopio Department of Pathology and Forensic Medicine Department of Oral Pathology, Roentgenology and Forensic Odontology Julkaisutietokanta Publications Data Base

49. Deborah Greenspan, BDS, DSc, Biosketch Greenspan, D., Greenspan, JS, Hearst, NG, Pan, LZ, Conant, MA, Abrams, DI, Hollander,H., and Levy, JA Relation of oral hairy leukoplakia to infection with http://cc.ucsf.edu/people/greenspan_deborah.html

Deborah Greenspan, BDS, DSc Clinical Professor, Stomatology; and Clinical Director, Oral AIDS Center, UCSF Member, UCSF Comprehensive Cancer Center mail: Box 0422, UCSF San Francisco, CA 94143-0422 phone: fax: e-mail: dgre@itsa.ucsf.edu University of London, BDS, 1964, Dentistry University of California San Francisco, Certificate, 1978, Oral Medicine University of London, Dsc (Med), 1991, Oral Medicine Private Practice, London, England Lecturer in Oral Biology and Preventive Dentistry, UCSF Fellow of the National Cancer Institute, Department of Oral Medicine and Hospital Dentistry, UCSF Visiting Lecturer, UCSF Assistant Clinical Professor, Oral Medicine, UCSF Associate Clinical Professor, Oral Medicine, Department of Stomatology, UCSF Clinical Professor, Oral Medicine, Department of Stomatology, UCSF Clinical Director, Oral AIDS Center, UCSF American Cancer Society Fellow, 1978 Faculty Member, OKU, 1984 Fellow, American College of Dentists, 1988

50. John S. Greenspan, PhD, Biosketch Oral hairy leukoplakia after a decade. Sequence variation of latent membrane protein1 of EpsteinBarr virus strains associated with hairy leukoplakia. http://cc.ucsf.edu/people/greenspan_john.html

John S. Greenspan, PhD Chair, Stomatology, School of Dentistry; and Professor, Pathology, School of Medicine, UCSF Program Member, UCSF Comprehensive Cancer Center mail: Box 0422, UCSF San Francisco, CA 94143-0422 phone: fax: e-mail: greenspanj@dentistry.ucsf.edu Royal Free Hospital Medical School, London, BSc(1st class Honors), 1959, Anatomy Royal Dental School, London, BDS (Honors), 1963, Dentistry Royal Postgraduate Medical School, London, PhD, 1967, Experimental Pathology Royal College of Pathologists, MRCPath, 1971, Oral Pathology Royal College of Pathologists, FRCPath, 1983, Oral Pathology Fellow, Histochemistry, Royal Postgraduate Medical School, London Assistant Lecturer, Oral Pathology, Royal Dental Hospital School of Dental Surgery Lecturer, Oral Pathology, Royal Dental Hospital School of Dental Surgery Senior Lecturer, Oral Pathology, Royal Dental Hospital School of Dental Surgery Fellow, Pathology, St. George's Hospital Medical School, London

51. HIV Guidelines. New York State Department Of Health AIDS Institute: Oral Health TOP OF PAGE. B. hairy leukoplakia. Hairy deterioration. hairy leukoplakiainvolving other mucosal surfaces also has been reported. http://www.hivguidelines.org/public_html/CENTER/clinical-guidelines/adult_hiv_gu

HOME SITE MAP ARCHIVES Clinical Guidelines ... Search this site This option available for PC users only. CRITERIA FOR THE MEDICAL CARE OF ADULTS WITH HIV INFECTION ORAL HEALTH COMPLICATIONS IN THE HIV-INFECTED PATIENT Published March 2001 * Text taken from the NYSDOH AI booklet - "Criteria for the Medical Care of Adults with HIV Infection" Download printer friendly version of this document (Requires Adobe Acrobat) Download printer friendly version of the NYSDOH AI Tables and Recommendations for this document (Requires Adobe Acrobat) I. The Oral Examination II. Medications and Oral Health ... Further Reading Oral health care is a critical component of comprehensive HIV medical management. Development of oral pathology is frequently associated with an underlying progression of HIV-disease status. A thorough soft-tissue examination may reveal pathology associated with dysphagia or odynophagia. Dental problems can result in or exacerbate nutritional problems. In addition, psychosocial and quality-of-life issues frequently are associated with the condition of the oral cavity and the dentition.

52. HAIRY LEUKOPLAKIA (Search FastHealth.com) HAIRY LEUKOPLAKIA Dictionary FastHealth Email This! hairy leukoplakia n a conditionthat affects the mouth and esp. the edges of the tongue, is http://www.fasthealth.com/dictionary/h/hairy_leukoplakia.php

Dictionary FastHealth Email This! hairy leukoplakia n oral hairy leukoplakia FastNurse Drug Search Hospital Search ... Dead Links

53. National AIDS Treatment Information Project: Mouth And Throat Problems problems in HIV disease include oral candidiasis, herpes simplex virus (HSV) infection,hairy leukoplakia, gingivitis and periodontal disease, Kaposi's sarcoma http://www.natip.org/mouth.html

RETURN TO INDEX SPANISH TRANSLATION Mouth and Throat Problems What are mouth and throat problems? What type occur in HIV disease? What are the symptoms and signs of mouth and throat problems? How are they evaluated? ... How are mouth and throat problems managed? What are mouth and throat problems? The mouth and throat are the entry point of the digestive tract, where food is initially processed. The tongue is important for tasting food to make sure it is appetizing, the salivary glands for starting the digestive process, the teeth for grinding food, and the esophagus for moving it from the mouth to the stomach. Mouth and throat problems often lead to decreased oral intake and, if persistent or severe, can result in dehydration or malnutrition. What type occur in HIV disease? Mouth and throat problems are sometimes the first signs of HIV disease ( Table 1 ). Many become more frequent or bothersome as the immune system gets weaker. The most common mouth and throat problems in HIV disease include oral candidiasis herpes simplex virus (HSV) infection hairy leukoplakia gingivitis and periodontal disease Kaposi's sarcoma (KS) , and aphthous ulcers ("canker sores") What are the symptoms and signs of mouth and throat problems?

54. Oral Manifestations Of HIV hairy leukoplakia. hairy leukoplakia (advanced) lateral border of tongue; Hairyleukoplakia (H E stain), vacuolated cells associated with Epstein-Barr virus; http://edcenter.med.cornell.edu/Pathophysiology_Cases/HIV/Oral_Manifestations/Or

Oral Manifestations of HIV Infection by Dr. Richard B. Roberts Herpes Simplex Crusted vesiculo-ulcerative papules of the vermillion border Herpes simplex (chronic) , one month's duration Hairy Leukoplakia Hairy leukoplakia (advanced) - lateral border of tongue , vacuolated cells associated with Epstein-Barr virus Hairy leukoplakia (PAS stain) , glycogen positive Candidiasis Candida (oral thrush) Candida glossitis : Whitish removable moist plaques - tongue ... (oral thrush) , chronic in late symptomatic stage of HIV infection Squamous cell carcinoma- non-removable, indurated plaques Kaposi's Sarcoma Kaposi's sarcoma (early) , maxillary palate Kaposi's sarcoma (advanced) , maxillary palate Comments or Suggestions? E-mail edweb@mail.med.cornell.edu Last modified February 16, 1999

55. Oral Manifestations Of HIV Infection Author(s)/Editor(s) Candidiasis vs hairy leukoplakia in HIV Infection HIV, Saliva, and SalivaryGlands 15. Mucosal Immunity to HIV1 in Infected Women 16. http://www.quintpub.com/display_detail.php3?psku=B2869

56. Online Dermatology Image Library Dermatlas Dermatology oral hairy leukoplakia,immunodeficiency,dermatology image,Humanimmunodeficiency virus infection,Epstein-Bar virus infection, acquired http://dermatlas.med.jhmi.edu/derm/result.cfm?BodySite=60

57. Online Dermatology Image Library Dermatlas Dermatology white sponge nevus,pachonychia congenita,oral hairy leukoplakia,onycholysis,mucocele,leukokeratosis,keratosispilaris,hyperpigmentation http://dermatlas.med.jhmi.edu/derm/result.cfm?Category=10

58. Oral Manifestations Of HIV - New Treatments, February 5, 2003 in HIV infection, with up to 15% of all HIVinfected patients being affected HIV,apthous ulcers, candidiasis, Kaposi's sarcoma, hairy leukoplakia, AIDS, mouth http://www.medical-library.org/journals2a/oral_manifestations_hiv.htm

This page has moved. Click here to view. Oral Complications of HIV Infection Oral Fungal Lesions Candidiasis Oral candidiasis is very prevalent in HIV infection, with up to 15% of all HIV-infected patients being affected HIV, apthous ulcers, candidiasis, Kaposi's sarcoma, hairy leukoplakia, AIDS, mouth, oral. Oral candidiasis occurs more frequently as the CD4 count falls below 400 cells/µL. Candida albicans is the most frequent cause of oral candidal infections. Manifestations of Oral Candidiasis Pseudomembranous candidiasis , also called thrush, is characterized by white or creamy HIV, apthous ulcers, candidiasis, Kaposi's sarcoma, hairy leukoplakia, AIDS, mouth, oral plaques on the oral mucosa; plaques can be removed, often revealing a bleeding surface. Erythematous candidiasis appears as a flat red lesion that may be found on the hard or HIV, apthous ulcers, candidiasis, Kaposi's sarcoma, hairy leukoplakia, AIDS, mouth, oral HIV, apthous ulcers, candidiasis, kaposi's sarcoma, hairy leukoplakia, AIDS, mouth pain soft palate, dorsal surface of the tongue, or on other mucosal locations. Angular cheilitis may present as cracking, Oral HIV Apthous ulcers candidiasis kaposi's sarcoma hairy leukoplakia Oral HIV Apthous ulcers candidiasis kaposi's sarcoma hairy leukoplakia Oral HIV Apthous ulcers candidiasis kaposi's sarcoma hairy leukoplakia Oral HIV apthous ulcers, candidiasis, kaposi's sarcoma, hairy leukoplakia, AIDS, mouth pain

59. Oral Complications Of HIV Infection - New Treatments, February 5, 2003 We have shown that both oral candidiasis and hairy leukoplakia predict the developmentof AIDS in HIVinfected patients independently of hairy leukoplakia. http://www.medical-library.org/journals2a/Oral_HIV.htm

This page has moved. Click here to view page. Oral Complications of HIV Infection Oral lesions often occur in HIV and are reflections of reduced immune function manifested as oral opportunistic conditions, which are often the earliest clinical features of HIV infection. Some, in the presence of known HIV infection, are highly predictive of the ultimate development of the full syndrome, whereas others represent the Oral lesions seen in association with HIV infection are classified in Table 12-1, and our general approach to the diagnosis and management of oral HIV disease is summarized in Table 12-2. Standardized definitions and Candidiasis The pseudomembranous form of oral candidiasis (thrush) was described in the first group of AIDS patients and is a harbinger of the full-blown syndrome in HIV-seropositive individuals. We have shown that both oral candidiasis and hairy leukoplakia predict the development of AIDS in HIV-infected patients independently of Table 12-1. Oral Lesions in HIV Infection Fungal Candidiasis Pseudomembranous Erythematous Angular cheilitis Hyperplastic Histoplasmosis Geotrichosis Cryptococcosis Aspergillosis Bacterial HIV-associated gingivitis HIV-associated periodontitis Necrotizing stomatitis Mycobacterium avium complex Klebsiella stomatitis Bacillary angiomatosis Viral Herpes simplex Herpes zoster Cytomegalovirus ulcers Hairy leukoplakia Warts Neoplastic Kaposi's sarcoma Non-Hodgkin's lymphoma Squamous cell carcinoma (?)

60. Infectious Disease News: Oral Manifestations Of Viral Infections More Pronounced Oral hairy leukoplakia. Oral hairy leukoplakia is a white lesion of thetongue that Greenspan and his colleagues first discovered in 1981. http://www.infectiousdiseasenews.com/199707/oral.asp

Oral manifestations of viral infections more pronounced in immunosuppressed by Bob Kronemyer July 1997 "The mouth is the mirror of the body. But often it is overlooked," said John S. Greenspan, DDS, PhD, professor and chair of the department of stomatology and director of the Oral AIDS Center at the School of Dentistry, University and California San Francisco. "Diseases due to viruses in the mouth are quite common in the general, otherwise healthy, population," said Greenspan at the annual meeting of the American Academy of Dermatology here. The occurrence is greater among immunosuppressed people, though. "In the context of HIV infection and other forms of immunosuppression, such as kidney transplant patients, there is an increase in the frequency of these oral viral lesions." Moreover, these diseases often manifest differently in the immunosuppressed population. "Even new lesions have been seen," noted Greenspan. Oral hairy leukoplakia Oral hairy leukoplakia is a marker for immunosuppresion.

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