1. IgA Nephropathy From NIDDK a description of this disease along with some further resources.Category Health Conditions and Diseases Glomerular iga nephropathy......iga nephropathy is a kidney disorder caused by deposits of the protein immunoglobulinA (IgA) inside the glomeruli (filters) within the kidney. http://www.niddk.nih.gov/health/kidney/summary/iganeph/iganeph.htm

Also see: Glomerular Diseases IgA nephropathy is a kidney disorder caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli (the singular form is glomerulus ) normally filter wastes and excess water from the blood and send them to the bladder as urine. The IgA protein prevents this filtering process, leading to blood and protein in the urine and swelling in the hands and feet. This chronic kidney disease may progress over a period of 10 to 20 years. If this disorder leads to end-stage renal disease, the patient must go on dialysis or receive a kidney transplant. The IgA protein is a normal part of the body's system to protect against disease (the immune system). We do not know what causes IgA deposits in the glomeruli. But, since IgA nephropathy may run in families, genetic factors probably contribute to the disease. Kidney disease usually cannot be cured. Once the tiny filtering units are damaged, they cannot be repaired. Treatment focuses on slowing the progression of the disease and preventing complications. One complication is high blood pressure, which further damages glomeruli. Some patients may benefit from limiting protein in their diet to reduce the buildup of waste in the blood. Patients with IgA nephropathy often have high cholesterol. Reducing cholesterolthrough diet, medication, or bothappears to help slow the progression of IgA nephropathy.

2. IGA Nephropathy, The Transplant A personal story of Darryl who had this disease. From the beginning, to the diagnosis, the kidney transplant and the update. http://www.geocities.com/albertja_48446

var PUpage="76001073"; var PUprop="geocities"; WELCOME TO The Albert's HOMEPAGE Smile, God loves you. IGA NEPHROPATHY The Transplant Contents Introduction The Beginning The Diagnose The Transplant ... The Parents Introduction Hello. If you have been diagnosed with the disease of IGA Nephropathy or want to know our story, please continue to read our homepage, and we hope it is beneficial for you. This is our story about our son, Darryl. By telling our story, we feel that God is directing us to give you comfort, peace, and contact and for us this is uplifting. Our story will start at the beginning, then the diagnose, the transplant, the update, and finally the parents. The Beginning In 1995 Darryl started his first year of college at Michigan State University (MSU). During the fall of 1997 at a plasma donation center, his urine was tested at a high protein count. It was around an eight count. He felt fine and was physically active. Again and again, he went back to the plasma center and still the protein in his urine was a high count. The center would not draw his plasma. The Diagnose After blood labs, ultra sound, and a kidney biopsy, our son was diagnosed with a kidney disease, IGA Nephropathy, March 1998. The nephrologist told us that our son had 48% kidney function. During this revelation, his creatinine was 2.1. Any creatinine level above 1.5 is possibly a kidney problem. Then, he was 22 years old. My husband, Darryl, and I sat there stunned. Usually, IGA is caused by some kind of respiratory infection. Our son did not have any kind of respiratory onset; although, in 1996 and 1997, Michigan State University had a meningitis epidemic. The doctor started him on prednisone and blood pressure medicine to maintain his kidneys and his high blood pressure. After six weeks, the nephrologist made us all an appointment with the Nephrology Department at the University of Michigan Medical Center, Ann Arbor, Michigan. Our son's girlfriend, Eileen, went with us, too. She and her family were great supporters.

3. Nephrology - IgA Nephropathy An article about iga nephropathy.Category Health Conditions and Diseases Glomerular iga nephropathy......Nephrology. iga nephropathy. A number of features typify the presentationof iga nephropathy. Hematuria is a presenting sign in 95% of cases. http://www.mc.vanderbilt.edu/peds/pidl/nephro/iganeph.htm

PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Nephrology IgA NEPHROPATHY IgA nephropathy or Berger's disease is a clinical/pathological entity defined by the presence of macroscopic or microscopic hematuria and mesangial IgA deposits. The disease is found throughout the world but is most prevalent in Japan, Australia, Southeast Asia, and Southern Europe. In the U.S. the incidence is approximately 4% of all renal biopsies but may be as high as 45% of biopsies in Japan. It is not a benign illness as once believed, with up to 25% of patients ultimately developing renal failure. The pathogenesis of the disease remains unknown. Findings on renal biopsy are characteristic. In all patients, IgA is present and is deposited mainly in the mesangium of the glomerular tuft. Other immunoglobulins and complement, especially C3, are often found in a mesangial pattern. Light microscopy frequently reveals a focal lesion, present in some but not all glomeruli. Electron microscopy will show a nodular electron dense deposit in either a subepithelial or subendothelial pattern. In large series of IgA nephropathy in children, end stage renal disease occurs in 5- 10%. Some clinical features have been correlated with a more rapid decline in renal function. These include male sex, older age at onset, absence of recurrent gross hematuria as a presenting complaint, and hypertension at the time of biopsy. In addition the histologic picture on renal biopsy correlates with outcome. Minimal glomerular abnormalities, pure mesangial proliferation, and focal or segmental change are associated with little change in renal function. Proliferative glomerulonephritis and crescents are associated with the high likelihood of progressive renal disease.

4. IgA Nephropathy iga nephropathy. Primary iga nephropathy is an autoimmune kidney disease marked by IgA glomerulonephritis due to the http://www.aarda.org/page21a.html

IgA Nephropathy Primary IgA nephropathy is an autoimmune kidney disease marked by IgA glomerulonephritis due to the glomerular immune deposit formation in the kidney. IgA nephropathy usually occurs in adolescents or young adults between the ages of 15 and 35. Males are affected two or three times more often than females. It occurs significantly more often in native Americans than in any other ethnic group tested. It is more prevalent in Caucasians than in Afro-Americans, and it is one of the leading causes of acute nephritis in young people in the United States, Europe, and Japan. One study of young men in the military showed an annual occurrence of 94 cases of IgA nephropathy out of 100,000 male inductees. For more information on IgA nephropathy or other autoimmune disorders, please click on the request information icon below. Information provided at this web site is of a general nature and is not intended to take the place of a physician's adivice It is vital that persons diagnosed with, or suspected of having, an autoimmune disease consult with their physician or with the appropriate division at a major teaching hospital, to assure proper evaluation, treatment and interpretation of information contained on this site.

5. IgA Nephropathy A detailed look at iga nephropathy, the occurrences and symptoms, pathology and treatment. http://www.outlinemed.com/demo/nephrol/11648.htm

IgA Nephropathy A. Occurrence and Symptoms See outline "Chronic Renal Failure" Symptoms Hypertension Polyuria of long duration Hematuria with red blood cell casts Male : Female ratio of 3:1 Urine protein levels (normal 150-200mg/day filtered) See outline "Nephrotic Syndrome" Over time, incidence of true nephrotic syndrome increases Renal failure develops in ~30% of patients 5-25 years after diagnosis of idiopathic type Worldwide idiopathic IgA nephropathy is most common cause of chronic renal failure B. Pathology See outline "Renal Pathology" Glomerular increased cellularity, increased pink material in mesangeum Mesangeal proliferation and infalmmation (glomerulonephritis) Mesangial IgA deposition demonstration by immunofluorescence Likely has an immune component, antibody associated disease (B cell dysfunction) C. IgA Renal Deposition Diseases See outline "Renal Deposition Disease" Idiopathic IgA Nephropathy Henoch-Schšnlein Purpura (HSP) Systemic Lupus Erythematosus (SLE) See outline "Lupus Nephritis" May be seen in multiple myeloma with IgA gammopathy This list represents a differential diagnosis for IgA deposition in kidney D. Treatment of IgA Nephropathy

6. Virtual Hospital: Glomerulonephritis: IgA Nephropathy Contains a brief history of the discovery of the disease with photos of morphologic features. http://www.vh.org/Providers/Textbooks/GN/05IgANeph.html

For Providers Glomerulonephritis: Antibody Mediated Injury IgA Nephropathy Donna J. Lager, M.D. Peer Review Status: Internally Peer Reviewed IgA nephropathy, first descibed in 1968, is the most common form of primary glomerulonephritis in the world. It is an antibody-mediated glomerular disease in which the immune deposits localize to the mesangium. It is not certain whether the deposits form in situ or from circulating immune complexes. Patients with IgA nephropathy usually present with one of three syndromes: Macroscopic hematuria concurrent with an upper respiratory infection; so-called synpharyngitic hematuria. Asymptomatic microscopic hematuria and variable proteinuria. Henoch-Schonlein purpura is the systemic form of the disease process causing IgA nephropathy, and occurs more frequently in children than adults. Patients with Henoch-Schonlein purpura manifest skin, joint and intestinal involvement. A less common presentation is with the nephrotic syndrome. These patients may have advanced disease or normal renal function. In the latter case, the light microscopic features are of minimal change disease but with intense mesangial staining for IgA. A. Morphologic Features

7. Urology Disorders - Immunoglobulin A (IgA) Nephropathy - Methodist Health Care S A description of iga nephropathy along with a look at the causes, symptoms and treatment. http://www.methodisthealth.com/urogen/iganeph.htm

Urology Disorders Home La Urologia - Los Trastornos Genitourinarios (en español) La Salud de la Próstata (en español) Clinical Services Urology Institute at The Methodist Hospital Methodist Diagnostic Hospital Methodist Sugar Land Hospital ... Newsletters! Immunoglobulin A (IgA) Nephropathy What is IgA nephropathy? IgA nephropathy is a chronic kidney disease that may progress over a period of 10 to 20 years, and can lead to end-stage renal disease. It is caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli normally filter waste and excess water from the blood and send them to the bladder as urine. However, the IgA protein prevents this filtering process. This may lead to the following: blood and protein in the urine swelling in the hands and feet What causes IgA nephropathy? The IgA protein is a normal part of the body's immune system. It is unknown what causes IgA deposits in the glomeruli, however, in more than half of families, IgA nephropathy is inherited by an autosomal dominant gene. Autosomal dominant inheritance means that

8. MEDLINEplus Medical Encyclopedia: IgA Nephropathy (Berger’s Disease) iga nephropathy also known as berger's disease, a look at what it is, causes, incidence and risk factors. http://www.nlm.nih.gov/medlineplus/ency/article/000466.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z IgA nephropathy (Berger’s disease) Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Male urinary system Alternative names Return to top Nephropathy - IgA; Berger's disease Definition Return to top A kidney disorder characterized by blood in the urine ; caused by inflammation of the internal kidney structures and deposits of IgA antibodies in the kidney mesangial tissue. Causes, incidence, and risk factors Return to top IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis. Inflammation of the renal glomeruli occurs, and there are IgA (a type of antibody ) deposits in the kidney. The disorder can appear as acute , rapidly progressive, or chronic glomerulonephritis ; or as visible or microscopic hematuria blood in the urine Berger's disease usually is discovered after one or more episodes of dark or bloody urine in a person with no other symptoms of kidney disorder. Bloody urine may begin during or soon after a respiratory infection.

9. The Australian Kidney Foundation iga nephropathy, what it is, diagnosis, causes, the course of the disease, follow up and treatment. http://www.kidney.org.au/renal_resources/fact_sheets/iga_nephropathy.asp

Glomerulonephritis is the commonest cause of kidney damage and failure of kidney function which may result in the need for dialysis(artificial kidney treatment) and/or a kidney transplant. There are many different types of glomerulonephritis but IgA Nephropathy is the most common type in Australia. It is found more often in males than females. About 10-30%of people with IgA Nephropathy have progressive deterioration of kidney function leading to what is called irreversible or end stage kidney (renal)failure. In Australia, 11% of all patients on dialysis have IgA Nephropathy. While IgA Nephropathy occurs in all age groups, it is usually diagnosed before the age of 30 years. It is common in children but the peak incidence is between 15-25 years. Usually, the passage of blood in the urine (macroscopichaematuria) making it coffee or tea coloured, is one of the signs for which the person sees a doctor. This is usually associated with a sore throat or respiratory infection or diarrhoea and vomiting, and may occur again in association with such infections. In some people who may have very few symptoms of severe illness, the only clue may be the finding of blood cells or protein or both (these are referred to as haematuria and proteinuria) in the urine on a routine urine test (urinalysis). The final diagnosis of IgA Nephropathy can be made only by a kidney biopsy- after a local anaesthetic, a sample of kidney tissue is removed by a needle and then examined under a microscope.

10. IGA Nephropathy, The Transplant If you have been diagnosed with iga nephropathy or want to know our son Darryl'sstory, please continue to read our homepage. Gardening. Michigan. http://www.geocities.com/albertja_48446/thirdpage.html

var PUpage="76001073"; var PUprop="geocities"; Gardening Michigan Michigan is a great place to live and raise a family. Because of a temperate climate, Michigan residents can grow beautiful vegetable and flower gardens. My husband is a planting maniac; however, he does grow beautiful flowers and scrumptious vegetables. He has found that organic gardening is a solution to growing plants. Plants are healthier and tastier. All food scraps from our kitchen are dumped into an organic bucket that sits in the garage and then placed in our gardens. Sometimes, grass clippings from our lawn are placed in our gardens to feed and mulch. Occasionally, grass clippings remain on our lawn which feeds our grass as fertilizer. Gardening, flowers or vegetables, provides exercise, peace, accomplishment, and a closer relationship to God. I am a gardener's companion, and we grew the best dahlias this year 2000. Our columbines and Veronica sage in June 2000 By the middle of July 2000, our flower garden was lush with Asiatic lilies, day lilies, tick seeds, Russian sage, zinnias, and etcetera. Finally, I have some very nice pictures from our 2002 gardening. This is a new daylilie for us, which I named rose. My 35mm surprised me this year or I surprised myself!

11. IgA Nephropathy Support Group Complete iga nephropathy information from the patient's perspective, with medicaladvisory board overseer, peer support discussion groups in both English and http://www.igan.ca/

var TlxPgNm='index'; These links will take you to the website's main sections: About us Advisory Board IgA Nephropathy Notebook Renal Failure Notebook ... Help support this site IgA Nephropathy Support Group Forums and information for IgAN patients and their families, from initial diagnosis to dialysis and transplant IgA Nephropathy is also known as: Berger's Disease , IgA nephritis and IgA glomerulonephritis Contact information Contact us Search this site or WWW This is the home of the IgA Nephropathy Support Group , a large and active international discussion forum, currently hosted on Yahoo! Groups. We cover IgA nephropathy (IgAN), or Berger's Disease, from initial diagnosis to end-stage renal failure, dialysis and beyond. Go directly to our Yahoo Group (over 600 members) Go directly to our web-based message board forums (registration not necessary, but allows access to private messaging etc.) Please use this website as a source of information, but always check with your doctor first. Note that the purpose is to supplement the information provided by your doctor. As such, this is not a scientific research site, and we do not provide references, even though the information provided is as factual and current as possible, and is based on current medical practice. See our full at the bottom of this page.

12. IgA Nephropathy Notebook iga nephropathy Support Group Home iga nephropathy Notebook This is a basic primerabout IgAN things that you should know once you have suspected IgAN or http://www.igan.ca/id46.htm

var TlxPgNm='id46'; Website main sections: About us Advisory Board IgA Nephropathy Notebook Renal Failure Notebook Hypertension Notebook IgAN Discussion Groups IgAN Glossary ... Help support this site IgA Nephropathy Support Group Home IgA Nephropathy Notebook This is a basic primer about IgAN - things that you should know once you have suspected IgAN or have been diagnosed with it. It is based on our experience with real questions, asked by real patients on our peer-support discussion group. Table of Contents What is IgAN? History of IgAN How it presents Types of IgAN ... Personal stories

13. IGAN Information. iga nephropathy. - Protocol for Diagnosis. - Booklet http://www.igan.net/

14. Renal Pathology In many parts of the world, iga nephropathy is the most common form of glomerulonephritis a disease that damages the tiny filtering units of the kidney, called glomeruli. http://www-medlib.med.utah.edu/WebPath/RENAHTML/RENAL095.html

This is Berger's disease, or IgA nephropathy. The IgA is deposited mainly in mesangium, which then increases mesangial cellularity as shown at the arrow. Patients with IgA nephropathy usually present with hematuria.

15. Nephrology - IgA Nephropathy Causes of iga nephropathy, written by Ari Kostadaras, MD. Looks at the pathology, presenting symptoms, diagnosis and etiology. http://www.kidneydoctor.com/iga.htm

PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Nephrology IgA NEPHROPATHY IgA nephropathy or Berger's disease is a clinical/pathological entity defined by the presence of macroscopic or microscopic hematuria and mesangial IgA deposits. The disease is found throughout the world but is most prevalent in Japan, Australia, Southeast Asia, and Southern Europe. In the U.S. the incidence is approximately 4% of all renal biopsies but may be as high as 45% of biopsies in Japan. It is not a benign illness as once believed, with up to 25% of patients ultimately developing renal failure. The pathogenesis of the disease remains unknown. Findings on renal biopsy are characteristic. In all patients, IgA is present and is deposited mainly in the mesangium of the glomerular tuft. Other immunoglobulins and complement, especially C3, are often found in a mesangial pattern. Light microscopy frequently reveals a focal lesion, present in some but not all glomeruli. Electron microscopy will show a nodular electron dense deposit in either a subepithelial or subendothelial pattern. In large series of IgA nephropathy in children, end stage renal disease occurs in 5- 10%. Some clinical features have been correlated with a more rapid decline in renal function. These include male sex, older age at onset, absence of recurrent gross hematuria as a presenting complaint, and hypertension at the time of biopsy. In addition the histologic picture on renal biopsy correlates with outcome. Minimal glomerular abnormalities, pure mesangial proliferation, and focal or segmental change are associated with little change in renal function. Proliferative glomerulonephritis and crescents are associated with the high likelihood of progressive renal disease.

16. Virtual Hospital: Glomerulonephritis: IgA Nephropathy iga nephropathy. Donna iga nephropathy, first descibed in 1968, is themost common form of primary glomerulonephritis in the world. It http://www.vh.org/adult/provider/pathology/GN/05IgANeph.html

For Providers Glomerulonephritis: Antibody Mediated Injury IgA Nephropathy Donna J. Lager, M.D. Peer Review Status: Internally Peer Reviewed IgA nephropathy, first descibed in 1968, is the most common form of primary glomerulonephritis in the world. It is an antibody-mediated glomerular disease in which the immune deposits localize to the mesangium. It is not certain whether the deposits form in situ or from circulating immune complexes. Patients with IgA nephropathy usually present with one of three syndromes: Macroscopic hematuria concurrent with an upper respiratory infection; so-called synpharyngitic hematuria. Asymptomatic microscopic hematuria and variable proteinuria. Henoch-Schonlein purpura is the systemic form of the disease process causing IgA nephropathy, and occurs more frequently in children than adults. Patients with Henoch-Schonlein purpura manifest skin, joint and intestinal involvement. A less common presentation is with the nephrotic syndrome. These patients may have advanced disease or normal renal function. In the latter case, the light microscopic features are of minimal change disease but with intense mesangial staining for IgA. A. Morphologic Features

17. IgA NEPHROPATHY iga nephropathy In many parts of the world, iga nephropathy is the most common formof glomerulonephritis a disease that damages the tiny filtering units of http://www.kidney.org/general/atoz/content/iganephropathy.html

IgA Nephropathy In many parts of the world, IgA nephropathy is the most common form of glomerulonephritis - a disease that damages the tiny filtering units of the kidney, called glomeruli. The damage caused by IgA nephropathy results from abnormal deposits of a protein called "IgA" in the glomeruli. One of the kidney's most important jobs is to filter toxic waste products from the blood, and the glomeruli play a key role in this process. As more glomeruli are damaged by the IgA protein, the kidney progressively loses its ability to clear wastes from the body. In some patients with IgA nephropathy, this loss of kidney function progresses to chronic kidney failure, which requires dialysis treatment or a kidney transplant to maintain life. IgA Nephropathy is sometimes called "Berger's Disease," because a French physician named Berger was one of the first to describe the disease. What are the signs and symptoms of IgA nephropathy? The most common sign is blood in the urine. The amount of blood may be so small that it is only visible with the aid of a microscope. Another common sign is swelling of the feet. As loss of kidney function progresses, symptoms may include pain in the back below the ribs, increased need to urinate (especially at night), fatigue, nausea, swelling of hands and feet, and high blood pressure.

18. IgA Nephropathy - Urological Disorders Health Guide Immunoglobulin A (IgA) Nephropathy. What is iga nephropathy? blood and proteinin the urine; swelling in the hands and feet. What causes iga nephropathy? http://www.umm.edu/urology-info/iganeph.htm

Urological Disorders Urogenital Disorders... Analgesic Nephropathy Cystocele ... Site Index Related Resources Within UMM Urology Urological Disorders Immunoglobulin A (IgA) Nephropathy What is IgA nephropathy? IgA nephropathy is a chronic kidney disease that may progress over a period of 10 to 20 years, and can lead to end-stage renal disease. It is caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli normally filter waste and excess water from the blood and send them to the bladder as urine, however, the IgA protein prevents this filtering process. This may lead to: blood and protein in the urine swelling in the hands and feet What causes IgA nephropathy? The IgA protein is a normal part of the body's immune system. It is unknown what causes IgA deposits in the glomeruli. Genetic factors may be a cause. How is IgA nephropathy often treated? Treatment focuses on slowing the progression of the disease and preventing complications, such as high blood pressure, which further damages glomeruli. A treatment recommendation will be made after careful review of your condition and symptoms. Treatment options may include: diet modification cholesterol reduction medication Home Health Info Our Physicians Our Services ... Make Appt.

19. IgA Nephropathy Urology. Immunoglobulin A (IgA) Nephropathy. What is iga nephropathy? What causesiga nephropathy? The IgA protein is a normal part of the body's immune system. http://www.mcghealthcare.org/urology/iganeph/iganeph.htm

MCG Health System Phone Numbers: (706) 721-CARE 1-800-736-CARE Request an Appointment Online Urology Immunoglobulin A (IgA) Nephropathy What is IgA nephropathy? IgA nephropathy is a chronic kidney disease that may progress over a period of 10 to 20 years, and can lead to end-stage renal disease. It is caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli normally filter waste and excess water from the blood and send them to the bladder as urine, however, the IgA protein prevents this filtering process. This may lead to: blood and protein in the urine swelling in the hands and feet What causes IgA nephropathy? The IgA protein is a normal part of the body's immune system. It is unknown what causes IgA deposits in the glomeruli. Genetic factors may be a cause. How is IgA nephropathy often treated? Specific treatment for IgA nephropathy will be determined by your physician based on: your age, overall health, and medical history

20. IgA Nephropathy iga nephropathy Guide picks. iga nephropathy Foundation Site offers comprehensiveinformation, news, email list, physician referrals, and personal stories. http://rarediseases.about.com/cs/iganephropathy/

zfp=-1 About Rare/Orphan Diseases Search in this topic on About on the Web in Products Web Hosting Rare/Orphan Diseases with Mary Kugler Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects BUYER'S GUIDE Before You Buy Top Picks Sites for Online Specialty Shopping ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement IgA Nephropathy Guide picks A form of kidney disease (glomerulonephritis) caused by abnormal deposits of a protein (IgA). Also called Berger's disease. Feature article Feature article about IgA nephropathy, it diagnosis, and treatments, from the About.com Guide to Rare/Orphan Diseases. IgA Nephropathy Foundation Site offers comprehensive information, news, email list, physician referrals, and personal stories. National Kidney Foundation: IgA Nephropathy Information about the disorder. The Foundation also offers support and education for all kidney disorders. NIDDK: IgA Nephropathy Concise information from the National Kidney and Urologic Diseases Information Clearinghouse (U.S.). MEDLINEplus: IgA Nephropathy Concise information on the disorder from the National Library of Medicine (U.S.).

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