21. Autoimmune Kidney Disease Autoimmune Kidney Disease. iga nephropathy. Related Resources. Thisis true for iga nephropathy. It is not a disease that is routinely http://rarediseases.about.com/library/weekly/aa042002a.htm

zfp=-1 About Rare/Orphan Diseases Search in this topic on About on the Web in Products Web Hosting Rare/Orphan Diseases with Mary Kugler Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects BUYER'S GUIDE Before You Buy Top Picks Sites for Online Specialty Shopping ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement Autoimmune Kidney Disease IgA nephropathy Related Resources Internet links on IgA nephropathy Internet links on other kidney diseases Elsewhere on the Web IgA Nephropathy Foundation IgA nephropathy discussion group Mary Kugler, MSN, RN,C Guide to Rare/Orphan Diseases April 20, 2002 Kidney disease is a sneaky thing. There may be no symptoms at all for a long time while it is developing. This means that unfortunately, many people never realize they have a kidney problem until a symptom such as back pain or blood in the urine appears. This is true for IgA nephropathy. It is not a disease that is routinely tested for in many countries (such as the United States), and although it seems to run in families, it can occur in anyone and not be associated with any other disease. What is it?

22. IgA Nephropathy iga nephropathy James V. Donadio, MD, and Joseph P. Grande, MD, Ph.D. Causesand Genetic Factors. The cause of primary iga nephropathy is unknown. http://www.medical-journals.com/real2a.htm

UK Europe Asia Medical Law ... Home MEDICAL PROGRESS NEJM Volume 347:738-748 September 5, 2002 Number 10 IgA Nephropathy James V. Donadio, M.D., and Joseph P. Grande, M.D., Ph.D. IgA nephropathy is a relatively newly recognized disease, first described by Berger and Hinglais in 1968. It is now generally known to be the most common form of primary glomerulonephritis throughout the world. Primary IgA nephropathy is an immune-complex–mediated glomerulonephritis defined immunohistologically by the presence of glomerular IgA deposits accompanied by a variety of histopathologic lesions. Although primary IgA nephropathy receives the most attention, many other diseases are also associated with glomerular IgA deposits ( Table 1 ). The most common of these is Schönlein–Henoch purpura. This condition may indeed be indistinguishable from primary IgA nephropathy and may represent a systemic form of the disease process. View this table: [in this window] [in a new window] Table 1. Diseases Associated with Glomerular Deposition of IgA.

23. Moderately Proteinuric IgA Nephropathy In The Young Moderately Proteinuric iga nephropathy in the Young. iga nephropathy(IgAN) is one of the most common glomerular diseases worldwide. http://www.iospress.nl/site/html/boek-187670111.html

Moderately Proteinuric IgA Nephropathy in the Young Volume 44 Biomedical and Health Research Edited by: L. Peruzzi and R. Coppo 2000, 134 pp., hardcover ISBN: Price: IgA Nephropathy (IgAN) is one of the most common glomerular diseases world-wide. Its natural history is consistent with a clinical onset in the first decades of life. Clinical indicators of poor prognosis are proteinuria and hypertension. Angiotensin-converting enzyme-inhibitors (ACE-I) are a promising treatment, since Angiotensin II plays a key role in glomerular hypertension and permselectivity and modulates mesangial and tubular cell functions. This Concerned Action was designed to evaluate the effect of ACE-I (benazepril 0.2 mg/Kg) versus placebo in young IgAN patients ( 1g/day 50 ml/min/1.73m2). Activity and chronicity indexes are evaluated on renal biopsies together with the spatial distribution of IgA and C3 deposits by confocal microscopy. Ambulatory blood pressure measurements allow the identification of medium-high pressure levels. Enrolled patients are investigated for factors modulating the disease progression, including genetic predictors (gene polymorphism of HLA, IgA switch region, ACE, AT1 receptor, adducin, complement factors) and immunologic parameters (aberrantly glycosylated and macromolecular IgA in serum and cytokine urinary excretion).” IOS Press Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands

24. IgA Nephropathy Pathogenesis of iga nephropathy. The pathogenesis of iga nephropathy, the mostcommon form of glomerulonephritis in the world, is still largely unknown. http://www.lifespan.org/nephrology/research/patho.html

Pathogenesis of IgA Nephropathy Abdalla Rifai, Ph.D The pathogenesis of IgA nephropathy, the most common form of glomerulonephritis in the world, is still largely unknown. Utilizing an experimental model of IgA immune complex-mediated nephropathy, our laboratory is focused on elucidating in vivo the cellular and molecular mechanisms that are associated with glomerular IgA immune deposits. Identification of the early molecular events induced by glomerular IgA deposition includes establishing a profile of proinflammatory cytokines, chemokines and growth factors that initiate renal tissue injury. In addition, differential expression of extracellular matrix genes involved in the progressive stages of renal fibrosis is being characterized in a chronic model of this disease. This approach promises to provide an opportunity to develop rational therapies for IgA nephropathy. Home Search News Find a Physician ... Site Map Web site design by Lifespan By using this website, you accept the terms of our user agreement . Please read it.

25. IgA Nephropathy iga nephropathy. from EdREN, the website of the Renal Unit of the RoyalInfirmary of Edinburgh. What is iga nephropathy? iga nephropathy http://renux.dmed.ed.ac.uk/EdREN/EdRenINFObits/IgALong.html

26. EMedicine - IgA Nephropathy : Article By Richard Neiberger, MD, PhD iga nephropathy In 1968, Berger and Hinglais described idiopathic immunoglobulinA (IgA) nephropathy (IgAN) (often termed Berger nephropathy), which now is http://www.emedicine.com/ped/topic228.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Nephrology IgA Nephropathy Last Updated: April 25, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: IgAN, immunoglobulin A nephropathy, focal glomerulonephritis, Berger focal glomerulonephritis, Berger's focal glomerulonephritis, Berger nephropathy, Berger’s nephropathy AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Richard Neiberger, MD, PhD , Director of Pediatric Renal Stone Disease Clinic, Associate Professor, Department of Pediatrics, University of Florida and Shands Hospital Coauthor(s): Mohammad Ilyas, MD, FAAP , Assistant Professor of Pediatrics, University of Florida College of Medicine; Consulting Staff, Department of Pediatrics, Section of Nephrology, Children's Primary Care Center at Shands Jacksonville Richard Neiberger, MD, PhD, is a member of the following medical societies: American Academy of Pediatrics American Federation for Medical Research American Medical Association American Society of Nephrology ... Southern Society for Pediatric Research , and Southwest Pediatric Nephrology Study Group Editor(s): Deogracias Pena, MD

27. EMedicine - IgA Nephropathy : Article By Mona Brake, MD iga nephropathy The pathology of immunoglobulin A (IgA) nephropathy, first describedby Berger and Hinglais in 1968, is characterized by predominant IgA http://www.emedicine.com/med/topic886.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Nephrology IgA Nephropathy Last Updated: February 6, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: immunoglobulin A nephropathy, Berger disease, mesangial glomerulonephritis, mesangial proliferative glomerulonephritis, Berger’s disease, glomerular mesangium, mucosal immune system, end-stage renal disease, ESRD, acute renal failure, chronic renal insufficiency, glomerular lesions, Henoch-Schönlein purpura, HSP, systemic lupus erythematosus, hepatitis, dermatitis herpetiformis, ankylosing spondylitis, episodic gross hematuria, persistent microscopic hematuria, synpharyngitic nephritis, Haemophilus parainfluenzae, H parainfluenzae, rapidly progressive glomerulonephritis, RPGN, renal transplantation, renal transplants, kidney transplantation, kidney transplants AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Mona Brake, MD

28. IgA Nephropathy iga nephropathy. Immunoglobulins are type of proteins that provides thebody strength to fight against infections. Causes of iga nephropathy. http://www.kidneyindia.com/iga.htm

29. 1Up Health > IgA Nephropathy (Berger's Disease) > Causes, Incidence, And Risk Fa Comprehesive information on iga nephropathy (Berger's disease) (Berger's disease,Nephropathy IgA). Berger's disease, Nephropathy - IgA. Definition http://www.1uphealth.com/health/iga_nephropathy_bergers_disease_info.html

1Up Health IgA nephropathy (Berger's disease) Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health IgA nephropathy (Berger's disease) Information IgA nephropathy (Berger's disease) Causes, Incidence, and Risk Factors Alternative names : Berger's disease, Nephropathy - IgA Definition : A kidney disorder characterized by blood in the urine ; caused by inflammation of the internal kidney structures and deposits of IgA antibodies in the kidney mesangial tissue. Causes, Incidence, and Risk Factors IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis. Inflammation of the renal glomeruli occurs, and there are IgA (a type of antibody ) deposits in the kidney. The disorder can appear as acute , rapidly progressive, or chronic glomerulonephritis ; or as visible or microscopic hematuria blood in the urine Berger's disease usually is discovered after one or more episodes of dark or bloody urine in a person with no other symptoms of kidney disorder. Bloody urine may begin during or soon after a respiratory infection.

30. Atlas Of Renal Pathology No. 4 iga nephropathy. iga nephropathy with minimal increase in mesangial matrixand cells (normal is less than or equal to 3 cells/mesangial area). http://ajkd.wbsaunders.com/atlas/31/4/atlas31_4.htm

ATLAS OF RENAL PATHOLOGY Each month the Atlas of Renal Pathology presents a compilation of figures on a specific pathologic entity. You should read the Terms and Conditions of Use before using this site. If you agree to the terms, you may download the figures to create your own personal, noncommercial library of images or to create slides for teaching purposes. To view a larger version of each figure, select View larger version below each figure. To make a slide, select download slide-quality image file . Download times may be somewhat lengthy. For tips on preparing slides from the files, please see Downloading Images for Slide Preparation IgA Nephropathy Pathology Editor: Agnes Fogo, MD Medical Photographer: Brent Weedman With Assistance From the National Kidney Foundation's cyberNephrology TM Team: Kim Solez, MD, Director; Joseph DeAlmeida, Computer Engineer; and Brenda Kalynchuk, Administrative Assistant View larger version Download slide-quality image Fig 1A. IgA nephropathy with minimal increase in mesangial matrix and cells (normal is less than or equal to 3 cells/mesangial area). The diagnosis must rely on additional immunofluorescence and electron microscopic studies ([A] periodic acid-Schiff, original magnification x200; [B] Jones' silver stain, original magnification x400). View larger version Download slide-quality image Fig 1B.

31. NIH Guide: PROGRESSION OF RENAL DISEASE: IgA NEPHROPATHY IN CHILDREN AND YOUNG A Full Text DK94-014 PROGRESSION OF RENAL DISEASE iga nephropathy IN CHILDREN ANDYOUNG ADULTS NIH GUIDE, Volume 23, Number 1, January 7, 1994 RFA DK-94-014 http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-94-014.html

Return to RFAs Index Return to NIH Guide Main Index Department of Health and Human Services National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892

32. IGA Nephropathy Articles, Support Groups, And Resources iga nephropathy articles, support groups, and resources for patientsfrom Med Help International (www.medhelp.org). iga nephropathy. http://www.medhelp.org/HealthTopics/IGA_Nephropathy.html

[Health Topics A-Z] A B C D ... Z IGA Nephropathy Medical Glossary: IGA NEPHROPATHY Ask The Doctor Forums Kidney Dysfunction (Urology Forum) Support Groups: IgA Nephropathy Support Network [Med Help Home] [Library Search] [Medical Forums] ... [Patient Network] Revised: 3/30/2003

33. IGA NEPHROPATHY iga nephropathy This is a form of glomerulonephritis that results fromthe deposition of circulating IgA antibody in the kidney tissues. http://www.medhelp.org/glossary2/new/GLS_2617.HTM

IGA NEPHROPATHY - This is a form of glomerulonephritis that results from the deposition of circulating IgA antibody in the kidney tissues. Inflammation of the glomerulus (glomerulonephritis) is the result. This condition may present as acute glomerulonephritis chronic glomerulonephritis, or rapidly progressive glomerulonephritis . Berger's is usually detected in an individual with one or two bouts of bloody urine (usually begins during or soon after a respiratory infection ) and no other symptoms of renal disease. Only rarely, will Berger's disease permanently affect kidney function and progress to chronic renal failure . This renal disorder more commonly affects males in the 16-40 age group. Med Help Home Search Ask the Doctor Patient Network The medical glossary has been made possible by a generous donation from:

34. Alveolar Hemorrhage In IgA Nephropathy Treated With Plasmapheresis Alveolar Hemorrhage in iga nephropathy Treated With Plasmapheresis. Findingswere consistent with HenochSchönlein syndrome or iga nephropathy. http://www.sma.org/smj/97feb16.htm

Alveolar Hemorrhage in IgA Nephropathy Treated With Plasmapheresis BEKELE AFESSA, MD, RANDY G. COWART, MD, and STEVEN M. KOENIG, MD, Belleville, Ill ABSTRACT: A 66-year-old man had diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis due to IgA nephropathy. The diffuse alveolar hemorrhage resolved after high-dose corticosteroid therapy, and renal function improved after plasmapheresis. This response suggests an adjunctive role for plasmapheresis in the treatment of patients presenting this rare clinical picture. CASE REPORT Laboratory tests were done 1 month before and on the day of admission (Table). Erythrocyte sedimentation rate was normal. Cultures of blood, urine, and sputum were negative for organisms. Arterial blood gas measurements showed pH 7.38, PaO2 63.5 mm Hg, and PaCO2 38.3 mm Hg. Urinalysis showed pH 5 and protein 500 mg/dL; red blood cells too numerous to count; 20 to 25 white blood cells per high-power field; and many granular, few hyaline, and occasional red blood cell casts. Chest roentgenography revealed diffuse, bilateral, symmetrical alveolar infiltrates. Echocardiography and renal ultrasonography were unremarkable. Left maxillary sinus wall thickening was seen on sinus roentgenograms. On pulmonary function testing, spirometry and lung volumes were normal but carbon monoxide diffusion capacity (DLCO) was 132% of the predicted value. DISCUSSION References 1. Travis WD, Colby TV, Lombard C, et al: A clinicopathologic study of 34 cases of diffuse pulmonary hemorrhage with lung biopsy confirmation.

35. HealthlinkUSA IgA Nephropathy (Berger's Disease) Links Try it, you'll love it! AhHa. Click here for page 1 of iga nephropathy (Berger'sDisease) information from the HealthlinkUSA directory. Save on Drugs Here. http://www.healthlinkusa.com/554ent.htm

36. IgA Nephropathy (Berger's Disease); Treatment, Prevention, Cure iga nephropathy (Berger's Disease)Search information from many of thebest iga nephropathy (Berger's Disease) health sites. Quickly http://www.healthlinkusa.com/content/554.html

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37. Kidney Transplantation For Patients With IgA Nephropathy Kidney transplantation for patients with iga nephropathy. Questionwas submitted by Giovanni Mauro, MD on 11/30/95. Question A http://www.transweb.org/qa/askarchive/answers9511/transplantationinIGAGNFR.html

Kidney transplantation for patients with IgA nephropathy Question was submitted by: Giovanni Mauro, MD on 11/30/95. Question: A good friend of mine has been diagnosed of Berger's IG A glomerulonephritis when she was 8. Her conditions worsened at the end of 1994. Now she has chronic uremia, and she is under daily peritoneal dialysis from March 1995. The doctors said that there are small possibilities of transplantation because the disease can affect the new kidney too. A Medline search showed us that in this disease the survival of the transplanted kidney can reach 66%. We would like to have an expert opinion about this case. She is 32, 44 kg, high blood pressure. We can give any further needed infos, lab findings, etc. Thank you very much for your assistance. Answer: Physicians in the United States do not hesitate to transplant individuals with IgA Nephropathy. The incidence of clinically relevant recurrence is certainly accepted as less than 10%. Alan Leichtman, MD (transplant nephrologist), University of Michigan List of Questions and Answers TransWeb

38. 4th Glomerulonephritis-Workshop: IgA-Nephropathy, Abstracts W. Schoeppe iga nephropathy epidemiology. (Nieren Hochdruckkrh 1994 (23)538 - 540). T. Risler, N. Braun Clinical course of iga nephropathy. http://www.uni-tuebingen.de/uni/kmp/tusem4_e.htm

Weiter Heim 4th Glomerulonephritis-Workshop: IgA-Nephropathy W. Schoeppe: IgA nephropathy - epidemiology (Nieren Hochdruckkrh 1994 (23) 538 - 540). After Berger's first report on a nosological entity of recurrent hematuria and proteinuria together with mesangial IgA-depositions increasing information exists in the literature to correlate the disease with further etiological, epidemiological and prognostic characteristics. 1.5 to 35 % of patients with renal biopsy show IgA nephropathy reaching peaks in Japan and France compared to low frequencies in Northern America (USA + Canada). Finding of IgA deposits is frequently related to infections of the respiratory tract. Key words: Mesangial IgA deposits - etiological and epidemiological factors. M. Rambausek, A. Schwarzbeck, E. Ritz: Pathophysiology of mesangial IgA glomerulonephritis (Nieren Hochdruckkrh 1994 (23) 541 - 547). In patients with mesangial IgA glomerulonephritis impaired activity of suppressor-inducer T-cells, decreased suppressor T-cell activity and a hyperactivity of T-helper cells is found. This results in increased production of IgA and IgA-immune-complexes. It is suspected that oral tolerance is also disturbed in IgA-nephropathy. The familial occurrence and deviations in allele frequencies of certain HLA-subtypes, complement components and of immunoglobulin genes point to a genetic predisposition for IgA nephropathy. It is presently unknown how IgA immune complexes result in glomerular mesangial damage. Key words: Mesangial IgA glomerulonephritis - Pathophysiology.

39. Member Sign In Response to reader´s question Was a predonation donor kidney biopsy absolutelyindicated in this donor who was found to have iga nephropathy after the fact? http://www.medscape.com/viewarticle/443809

If you are having trouble logging in: In order to use Medscape, your browser must be set to accept "cookies." To find out how to adjust your browser settings, please click here Log In Username Password Forgot your password? Not a Member? Register Now for free access to: MEDLINE (Optimized for Physicians) 200+ Free CME Courses 25 Medical Specialty Sites 100+ Medical Journals Conference Coverage Daily Medical News About Medscape Help WebMD Health

40. Treatment Of Biopsy-Proven IgA Nephropathy At what degree of urinary protein excretion would you consider treating biopsyproveniga nephropathy with corticosteroids and alkylating agents? http://www.medscape.com/viewarticle/444445

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