61. Small Group Session 21 are contrasting a person with McArdle's glycogen storage disease (deficiency in musclephosphorylase) and one with Hers disease (deficiency in mcardles normal http://education.hsc.wvu.edu/human_function/courses/biochem/sm_group/sg21_answer

Small Group Session 21 Dr. Lisa Salati This web page in printable format Web page wth questions Reference: Lipid tutorial in SOLE - referenced in "self-study" questions below (look for "LIPID" link under "courses") Lipid Digestion Lecture People with Cystic Fibrosis fail to secrete sufficient amounts of pancreatic enzymes into their gastrointestinal tract. To digest and absorb food they must consume pills containing large amounts of these enzymes every time they eat. Describe what would happen if a high-fat meal was consumed without taking the pills (this happens in small children due to getting into food without a parent's supervision or the babysitter forgets to give the pills). In your answer include a description of the fate of triacylglycerol, phospholipid and cholesterol ester in the lipid droplet, the emulsion droplet, and the mixed micelle. Would any lipid enter the intestinal cell? Answer: The triacylglycerols, phospholipids, and cholesterol esters in the diet would remain as such in the absence of pancreatic enzymes. Thus, you would still see the lipid droplet containing these undigested lipids. The emulsion droplet would still form because bile secretion is still present so the bile salts, the driving force for this droplet would still form. Cholesterol esters and triacylglycerols would be in the core of the emulsion droplet and the phospholipids would be in the periphery with the bile acids. The mixed micelle would not form and lipid would not enter the cell. The result in elimination of all dietary lipid including fat soluble vitamins in the stool. This is called steatorrhea.

62. Winds Of Change He petitioned me for himself and the other mcardles to be granted the Isle Incantor,Kindling McTaff has recently been suffering from a rare disease that has http://www.bears.org.uk/lair/winds.htm

Winds of Change (by Mephisto McSnaga) When: October 21, 1100 Location: Stormbulls Barn/Tavern, Cudbright, South West Caledonia The evening got off to a good start as Teran (Chuffy) McYokel, acting Clan Chieftain of the mighty Clan McYokel welcomed all comers to the Stormbulls Barn, now converted into a tavern. Formerly the training facilities of the elite military forces of Caledonia (read: Lunatics with no magic), now a reputable drinking establishment (read: Shrine for drunken Lunatics). And a fine tavern it was, bedecked with its famous shield wall and the glorious queens' banners. The turnout was excellent with around 120 people turning up to celebrate the end of the foamorri war. The event was attended by representatives of many factions, many who themselves had aided in the defence of Caledonia. As none of the 3 queens were available, it was down to myself as Laird Provost to receive visiting dignataries. I had the great pleasure of once again meeting Lady Morven, Ambassador from the Wolves who introduced me to a noble friend as well as their High Incantor and High Healer, both delightful ladies. Morven explained to me that the White Hand, who had previously been attacking the Wolves in all manner of different ways had been banished by a group of people known as the Hyperborians, an ancient people, possibly even the original people to walk the northern lands of the Heartlands. They followed one calling himself their great leader who was referred to as the Serpent King. They live in the land of Vanya (if any Wolf is reading this, please correct any errors here) which is becoming increasingly uninhabitable due to advancing ice caps. They disappeared at the same time making it very clear that they would be back to reclaim their rightful land.

63. Metabolske Forstyrrelser (E70-E90) E71.0, Maple syrup urine disease . Sykdom med forstyrrelse i leucin, isoleucin,valin og alloisoleucinmetabolismen. Hers'. - mcardles. - Pompes. - Tauris. http://www.odont.uio.no/allmennodontologi-voksen/ICD10SOK/icd10/KIV_8.htm

Metabolske forstyrrelser (E70-E90) Ekskl: 5-a-reduktasemangel ( androgent resistens-syndrom ( Ehlers-Danlos syndrom ( hemolytiske anemier som skyldes enzymforstyrrelser ( Marfans syndrom ( medfødt binyrebarkhyperplasi ( Forstyrrelser i metabolismen av aromatiske aminosyrer Klassisk fenylketonuri Føllings sykdom Andre hyperfenylalaninemier Forstyrrelse i tyrosinmetabolismen Alkaptonuri Hypertyrosinemi Okronose Tyrosinemi Tyrosinose Albinisme Albinisme: - okulokutan - okulær Syndrom: - Chediak(-Steinbrinck)-Higashis - Cross' - Hermansky-Pudlaks Andre spesifiserte forstyrrelser i metabolismen av aromatiske aminosyrer Forstyrrelser i: - histidinmetabolismen - tryptofanmetabolismen Uspesifisert forstyrrelse i metabolismen av aromatisk aminosyre Forstyrrelse i metabolismen av grenede aminosyrer og fettsyrer "Maple syrup urine disease" Sykdom med forstyrrelse i leucin, isoleucin, valin og alloisoleucin-metabolismen Andre forstyrrelser i metabolismen av grenede aminosyrer Hyperleucin-isoleucinemi Hypervalinemi Isovalerinacidemi Metylmalonacidemi Propionacidemi Uspesifisert forstyrrelse i metabolismen av grenede aminosyrer Forstyrrelse i metabolismen av fettsyrer Adrenoleukodystrofi [Addison-Schilder] Mangel på carnitinpalmityltransferase i muskel Ekskl: Refsums sykdom ( Schilders sykdom ( Zellwegers syndrom ( Andre forstyrrelser i aminosyremetabolismen Ekskl: forstyrrelse i metabolismen av: - aromatiske aminosyrer ( - fettsyrer ( - grenede aminosyrer ( - purin og pyrimidin ( unormale funn uten diagnose (

64. ~Nicole's Place~ I am seeing a chiropracter right now to help ease the pain and he is looking up infoon mcardles' disease (what I have) to see what 'natural' supplements might http://nickkiwick.blogspot.com/

get rid of this ad advertise here ~Nicole's Place~ Friday, March 21, 2003 ( 2:31 PM ) Nicole Well, I am enjoying my spring break from school... It's more like a 'brain rest' lol Funny thing is, is that my kids go on their spring break when I go back... oh well. I am having trouble posting on my sister soup for some odd reason and so I figured I would test here and see if I have any problems posting. Sierra is sick and home from school for the 2nd day in a row:( She was vomiting and had diarrhea. It's going around. I am not sick though:) Had some nice calls out in service this week and was really enjoying my time to go out. Nice thing is when I do go back to school it will be at night, so I can go out in the day for service more. Well, I'm gonna post and see if this works. Monday, March 03, 2003 ( 9:56 AM ) Nicole Hi there everyone! It's been quite a long time since coming here, but I suppose I needed to get with it...LOL:) It was funny what you said Retta about dating your post! LOL I guess I have not been here in quite some time eh? he he I am still pluggin away at school and it's got me pretty tied up, especially with meetings and family. I am going to do a special thing they have going on at our hall called the star system. The two star is when you split aux hrs between two people, three is between three people, and four is four people sharing time. I am going to split mine with my son Matthew because I am not sure I will be able to do it all myself and plus that will help him too:)

65. Council Minutes For April/May 2001 M504 SPECIAL MEETING OF THE COMMITTEE *M505 FOOT AND MOUTH disease *M506 DECLARATIONS JDillon, Heap, Hilyer,s Hindle, Hurst, Jabbar and mcardles *N APOLOGIES http://www.oldham.gov.uk/minutes/co_apmay01/TOC.html

The original Microsoft Word file for all of the minutes listed is also available here "Council minutes for April/May 2001" Table Of Contents *H PLANNING COMMITTEE *P PRESENT: Councillor Dugdale (Chair) *N APOLOGIES: Councillors J Dillon, McInnes, Siddall and Uddin *M88 MINUTES ... *A The original Microsoft Word file containing all of the minutes listed is also available here

66. Leavey Family History - Chapter 7 - William Leavey And Mary Casey time when he was four and quite a tall boy- developed a bone disease in his oneside ( I later met them again when I lived in Mudgee) and the mcardles on the http://www.fbe.unsw.edu.au/staff/stephen.peter/leaveyhistory/text/chapter7.htm

Chapter 7 William Leavey and Mary Casey by Sr Carmel Leavey OP October 1998 William James Leavey was the youngest son and second youngest child of the six children of Thomas and Elizabeth Leavey. He was born on September 10, 1888 at Cavan Park Katunga near Cobram in Victoria. The family seems to have been very happy one and he certainly appreciated the good things of Cavan Park . Even in older age, he would often refer to his childhood and the good times they all had together. As a child he was full of fun according to the family and he continued to have a great sense of humour and a marvellous fund of stories and poems. With his older siblings, he went to the local Primary school at Naring, which he always called Sandmount, perhaps because it was on the Sandmount Road. While the girls continued their education at "finishing school" in Melbourne, the boys of the family seemed not to have proceeded further with formal education, though Cavan Park was well supplied with books and the grandparents were great readers according to Julia Brady. We have to remember, of course, that we are speaking about the 1890's when there were very few high schools anywhere and when, thanks to the Sisters, girls' boarding schools were far more plentiful than those for boys. Good friends, the Dixons, who lived nearby, took an interest in the two younger boys and had them taught Book Keeping. To the end my father retained a very alert mind and was very quick at Mathematics. With his brothers, William belonged to the Muckatah Football Club and played regularly in local Australian Rules competitions. According to Jack Parnell, they were very good players and could have played in Melbourne. Early in his life he found an interest in horses, a love which he also retained to the end; he had been to the Randwick races on the day he died: October 14,1961. He was interested in trotting as well, a sport no doubt encouraged by his elder brother Edward, who owned and trained trotters, winning the Richmond Cup in 1920. Dad also retained a lively interest in politics and was remarkably well informed on political issues.

67. McArdle's Disease Resources Information, resources, and contacts for those affected by this disease or any of the glycogen storage Category Health Conditions and diseases Genetic Disorders McArdle s...... Type V please see my links page. This site is the result of 10 yearsspent searching for information about McArdle's disease. Most http://members.aol.com/itsgumby/

links page. This site is the result of 10 years spent searching for information about McArdle's Disease. Most of the information I managed to find through those years turned out to be either confusing, misleading or of little use to anyone outside the scientific community. With this site, I hope to provide the "good stuff" - information you can use to help yourself and, in most cases, your physician to find the treatment and support that is available. Within these pages you will find everything you need to contact the people places that have the most useful information about McArdle's - those who have it and those who treat it. Hopefully, this site will also help to clear up some of the confusion that surrounds this disease. You may find that much of the information you were given is out of date. Most of all, after your visit here you will know that you are not alone. If that is the only bit of information you take with you then this site has served its purpose. E-Mail

68. WWW Bichemistry Resources degenerative arthritis. A defect in the metabolic pathway of branchedchain amino acids causes maple syrup urine disease. In addition http://www.nwhealth.edu/suplemen/biochem1/biochres.htm

Biochemistry Resources Amino Acids Carbohydrates Proteins Lipids ... Metabolic Cycles Many of the following sites require the CHIME browser plugin which you can download for free from MDL Information Systems . It has already been installed on computers here at the school. Some of the tutorials use SCHOCKWAVE or AUTHORWARE and you will need the free players from Macromedia to view them. Let me know if you have a link you think I should add. tfrick@nwhealth.edu AMINO ACIDS Tutorial Aids Amino Acid Matching Game (uses JAVA) Amino Acid Quiz (uses CHIME) Virtual Biochemistry Lab (uses SHOCKWAVE) Clinical Biochemistry A number of serious disorders are caused by improper amino acid metabolism. In class we discussed phenylketonuria which results from the inability to convert phenylalanine into tyrosine. Alkaptonuria , the first inborn metabolic error to be recognized, is another disorder of the phenylalanine/tyrosine metabolic pathway. It results in the excretion of black pigments in the urine. These pigments also accumulate in tissues, especially collagen, which causes ochronosis which can result in degenerative arthritis. A defect in the metabolic pathway of branched chain amino acids causes

69. HFI Qualifications activity intensities and habits bodyweight more than 20% above optimal, thyroiddisease, diabetes or glucose intolerance, mcardles syndrome, hypoglyceamia. http://www.hfigroup.com/acsmsyllabus.htm

KNOWLEDGE SKILLS AND ABILITIES (KSAs) books section of this web site and look under the ACSM Preparatory Text for ACSM Workshops and Exams category. ACSM EXERCISE LEADER SM (Fitness Instructor) AND ACSM HEALTH / FITNESS INSTRUCTOR SM (Personal Trainer) Functional Anatomy and Biomechanics Exercise Physiology Human Development and Aging Pathophysiology/Risk Factors ... Programme Administration/Management Functional Anatomy and Biomechanics EXERCISE LEADER (FITNESS INSTRUCTOR) (EL ) 1-11, HEALTH / FITNESS INSTRUCTOR (PERSONAL TRAINER) (HFI) 1-15 1. Describe the basic structures of bone, skeletal muscle, and connective tissues. 2. Describe the basic anatomy of the heart, cardiovasacular system, and respiratory system. 3. Identify the major bones and muscles and their actions. Major muscles include, but not limited to: trapezius, pectoralis major, latissimus dorsi, biceps, triceps, abdominal, erector spinae, gluteus maximus, quadriceps, hamstrings and gastrocnemius. 4. Define the following terms: supination, pronation, flexion, extension, adduction, abduction, hyperextension, rotation and circumduction.

70. Solicitors content= asbestos,injury,claim,accident,industrial disease,compensation,solicitors McArdlesSolicitorslaw firm providing legal services and professional advi http://legal-directory.net/links/solicitors.html

The UK Accident, Personal Injury and Legal Resource Centre Solicitors Home Page ThemeIndex Solicitors Gordons Cranswick is one of Yorkshire's largest firms of solicitors, and represents a very wide range of businesses from growing one person enterprises through to large publicly quoted organisations, ... http://www.gordonscranswick.co.uk We have been advising our clients for more than 20 years, principally in the areas of BR Residential Conveyancing BR Family Law BR Residential Conveyancing and Property Law BR Employment Law BR Accid... http://www.winterssolicitors.co.uk Singletons Solicitors Susan Singleton Solicitor, Principal Singletons, Solicitors The Ridge South View Road Pinner, Middlesex, HA5 3YD UK Regulated by the Law Society of England and Wales and subject... http://www.singlelaw.com Brar and Co Solicitors are a Commercial Firm of Solicitors specialising in Immigration, Property Sales, Personal Injury, Family and Matrimonial matters.... http://www.brar.co.uk Friendly Law Firm based in Chesterfield Derbyshire but happy to represent clients throughout uk... http://www.bowen-johnsons.co.uk

71. Re: Would Like Info On Epifacial is Dr Bitters, in New England it is Claire mcardles's staff at http://www.healthboards.com/cosmetic-surgery/4814.html

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72. Neuromuscular Conditions. Leuko Dystrophy. Limb Girdle Muscular Dystrophy. Manifesting Carriers. McArdlesdisease. Mini Core disease. Mitochondrial disease. Multicore disease. http://www.monaghanhospital.com/conditions/no/neurcond.htm

Neuromuscular Conditions Neuromuscular conditions are characterised by loss of muscle strength, as progressive muscle wasting or nerve deterioration occurs. Most of these conditions are genetic in origin. They can affect men, women and children, at any age and any racial group. There are very few drugs to ease management and there are no cures at present. The different types of neuromuscular conditions There are over 58 different types of neuromuscular conditions. The main ones are listed below: Acid Maltase Deficiency. Becker Muscular Dystrophy. Benign Congenital Hypotonia. Carnit Palmityltransferase Deficiency. Carnitine Deficiency. Central Core Disease. Charcot Marie Tooth Disease. Chondrodystrophic Myotonia (Schwartz-Jampel). Chronic Inflammatory Demyelinating Peripheral Neuropathy (CIDP). Congenital Myotonic Dsytrophy. Congenital Muscular Dystrophy Myopathy. Dejerine Sottas Syndrome. Dermatomyositis. Distal Muscular Dystrophy. Duchenne Muscular Dsytrophy. Eaton Lambert Myasth Syndrome. Emery-Dreifuss. Eosinophilic Myositis.

73. Untitled Document Stress Research. 13, 4, 597-612. 56.­ Hughson AVM, Cooper AF, mcardles CS. http://www.sepsiquiatria.org/sepsiquiatria/html/informacion_sociedad/manual/a7n6

6.PSICOONCOLOGIA E PSICOINDUCCION CANCER PSICOCONSECUENCIAS -tratamientis -Terminalidad -Supervivencia PSICOINDUCCION A. Riesgo celular: paso de protooncogenes a oncogenes. Investigaciones experimentales en animales Dentro de las investigaciones prospectivas (realizadas en personas sanas, valorando la incidencia de cáncer en revisiones hechas al cabo de 10-15 años), Hagnell (1966) (19) observó que las personas que presentaron cáncer habían sido calificadas inicialmente como poseedoras de una personalidad "subestable", descrita como "cálida, cordial, concreta, pesada, industriosa, interesada en la gente, sociable, con tendencia a las interrelaciones sociales e inhibición". Los resultados de Thomas (1979), Grossarth (1983), Graves (1986), etc. (5), reafirman en el paciente canceroso una mayor supresión de las emociones (especialmente de la agresividad) y más sucesos estresantes vividos con desesperación-depresión, y observan una menor intimidad afectiva con los padres en la infancia. PSICOINDUCCION ONCOVINCULADA -Autoagresividad Por tanto, no hay evidencia clara de que la depresión clínica (en sentido psiquiátrico) sea un factor de riesgo para el cáncer, aunque si parece existir un "estado de aflicción leve crónica", similar a ella (24). Tal vez las reacciones depresivas o "estados de aflicción" (en sentido de desánimo, desesperanza y desvalimiento) sean la manifestación de un estilo de afrontamiento insuficiente para salir adelante ante los estreses vitales.

74. Neuromuscular Center - Conditions (Glycolytic Defects: Myophosphorylase Deficien glycogenosis type V; McArdle's disease) source Ronald G. Haller, MD A diet rich inprotein and adequate in carbohydrate is recommended for McArdle's disease. http://ieemphd.com/nmc/myophosphorylase_deficiency.htm

Glycolytic Defects Myophosphorylase Deficiency Phosphofructokinase Deficiency Phosphoglycerate Mutase Phosphoglycerate Kinase ... Glycogen NOS Myophosphorylase Deficiency (glycogenosis type V; McArdle's Disease) source: Ronald G. Haller, MD McArdle's patients experience lifelong premature exertional fatigue and are subject to exertional muscle pain, contractures, and rhabdomyolysis when muscle energy demands exceed supply. Later in life, McArdle's patients may develop fixed weakness. A diet rich in protein and adequate in carbohydrate is recommended for McArdle's disease. Protein requirements are increased by the ongoing muscle injury and increased muscle regeneration that are typical of this condition. Also, amino acids provide a potential alternative oxidative fuel for skeletal muscle. When combined with a program of regular exercise, a high-protein diet was found to improve exercise capacity significantly. Dietary carbohydrate sufficient to maintain hepatic glycogen stores is desirable, because glucose utilization and hepatic glycogenolysis are increased during exercise in McArdle's disease. The immediate effect of a carbohydrate meal may be to reduce exercise capacity, owing to homeostatic mechanisms that maintain blood glucose in a narrow range and the corresponding reduction in plasma fatty acids levels. Intravenous glucose raises blood glucose levels, increases glucose transport into muscle, and augments exercise capacity, but it is useful primarily in a hospital. Glucagon increases hepatic glycogenolysis and may improve exercise capacity in the short term, but indications for chronic treatment are unproven.

75. Case 130 --Neuropathology Case Case 130 Chronic Myalgias After Exercise Contributed by David Lacomis, MD* and Michael J. Giuliani, MD* University of Pittsburgh School of Medicine, Departments of Neurology* and Pathology (Neuropathology) http://path.upmc.edu/cases/case130.html

Case 130 Chronic Myalgias After Exercise Contributed by David Lacomis, MD Published on line in January 1998 PATIENT HISTORY: A 48-year-old woman was referred for evaluation of myalgias. She had muscle problems dating to childhood. She tired easily and was unable to keep up with her peers in athletic events. Shortly after beginning to exercise, she experienced weakness and a burning sensation in her muscles. She could not complete assigned running tasks in the allotted time and frequently became nauseated and sometimes vomited after running. She was labeled as a "slacker" because of this behavior. No cola-colored urine was noted during these events. Symptoms improved with rest; however, she also developed myalgias at rest as an adult. Over the past few years, she developed fixed proximal weakness manifest as difficulty combing her hair and climbing stairs, and she had difficulty peddling a bicycle. The myalgias and fatigue interfered with her ability to work in a packaging plant. She also had difficulty sleeping that improved with amitriptyline administration. Previous neurologic evaluations disclosed elevated creatine kinase (CK) levels (two to three times normal) on several occasions. An electromyogram (EMG) of limb muscles was normal. A deltoid muscle biopsy specimen, which was evaluated at a referral center, was interpreted as showing type II muscle fiber atrophy and non-specific changes suggestive of myopathy including subsarcolemmal red staining with Gomori trichrome. Electron microscopy revealed focal collections of both enlarged mitochondria and glycogen. Serologic testing for connective tissue diseases was negative. The thyroid stimulating hormone was minimally elevated.

76. AGSD - UK Site - Type V (c) Dr Ros Quinlivan FRCPCH FRCP. April 200 Neuromuscular Physician, McArdlesDisease Clinic, Robert Jones and Agnes Hunt Hospital, Oswestery, UK. http://www.agsd.org.uk/home/type5.asp

LOW GRAPHICS VERSION HELP Registered Charity No. 327841 Home Email How we can help Join ... About us Mon Mar 31 Send to a friend Printer Friendly Version Glycogen Storage Disease Type V (muscle glycogen phosphorylase deficiency, McArdle disease) McArdle's disease (Glycogen Storage Disease Type V or GSD V) is a rare metabolic myopathy involving the glycolytic pathway. Affected patients are unable to produce myophosphorylase, the enzyme involved in the phosphorolytic cleavage of glycogen to glucose-1-6- phosphate and glucose during anaerobic exercise. The consequence is exercise-induced myalgia and fatigue. The disorder affects all skeletal muscle, a frequently ignored fact by health workers, which results in significant disability. McArdle's disease is a rare metabolic muscle disorder, first described in 1951. The disorder is also known as Glycogen Storage Disease Type V or Phosphorylase Deficiency. Individuals born with McArdle's disease are unable to produce an enzyme known as myophosphorylase, which is important for creating a fuel source for exercise. There are two types of exercise: 1. Aerobic exercise, such as: jogging, cycling and walking.

77. Traduci http://www.unict.it/medint/nutrizione.htm

HOME SOMMARIO Infezioni batteriche e micosi Malattie da virus ... Storia della medicina BIBLIOTECA VIRTUALE ON-LINE MALATTIE NUTRIZIONALI E DISMETABOLICHE web editor: Guglielmo M.Trovato Istituto di Medicina Interna e Terapia Medica - Università di Catania - In questa sezione di biblioteca virtuale sono censiti siti con caratteristiche assai diverse: testi, collezioni di immagini, video didattici etc. Per una traduzione on-line si può attivare il traduttore di ALTAVISTA , su cui bisogna riportare, dopo averlo selezionato, il testo che interessa (seleziona col mouse, copia, incolla sul traduttore elettronico, traduci) FDA Center for - (US) IUNS - via Monash (AU) The Nutrition Navigator (rating guide) at Tufts University USDA Nutrient Database for Standard Reference, rel 12

78. Ask Jeeves: Search Results For "Cure For Laziness" Search the Web for Related Searches http://webster.directhit.com/webster/search.aspx?qry=Cure For Laziness

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