21. BehaveNet® Clinical Capsule™: Neuroleptic Malignant Syndrome DSMIV DSM-IV-TR neuroleptic malignant syndrome. A medication coma.neuroleptic malignant syndrome Information Service. Reprinted http://www.behavenet.com/capsules/disorders/nms.htm

BehaveNet DSM-IV DSM-IV-TR : Neuroleptic Malignant Syndrome A medication-induced movement disorder , this potentially fatal syndrome associated with neuroleptic drugs used in the treatment of mental disorders is characterized by severe muscle rigidity, fever, sweating, hypertension, and delirium sometimes progressing to coma. Neuroleptic Malignant Syndrome Information Service Reprinted with permission from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. American Psychiatric Association Books and Other Media: Follow the hypertext link to purchase items online. Neuroleptic Malignant Syndrome - A Clinical Approach Hardcover 1991 Lazarus, Arthur, et al The Neuroleptic Malignant Syndrome and Related Conditions (Clinical Practice, No 6) Hardcover 1989 -"This book provides new insights on this often misdiagnosed and sometimes fatal complication of antipsychotic drug therapy." http://www.behavenet.com/capsules Request New Term BehaveNet®

22. Neuroleptic Malignant Syndrome neuroleptic malignant syndrome. Rare syndrome associated with use of antipsychoticsMain features Muscular rigidity. Pyrexia. Altered consciousness. http://www.mds.qmw.ac.uk/statgen/dcurtis/lectures/nms1.html

Neuroleptic malignant syndrome Rare syndrome associated with use of antipsychotics Main features: Muscular rigidity Pyrexia Altered consciousness Autonomic instability But clinical picture is variable and exact boundaries of condition are unclear nms2.html

23. Neuroleptic Malignant Syndrome (2) neuroleptic malignant syndrome (2). NMS is due to disturbance of dopaminetransmission Occurs with all antidopaminergic agents (anti http://www.mds.qmw.ac.uk/statgen/dcurtis/lectures/nms2.html

Neuroleptic malignant syndrome (2) NMS is due to disturbance of dopamine transmission Occurs with all anti-dopaminergic agents (anti-emetics as well as anti-psychotics) Can occur with withdrawal of dopaminergic drugs used to treat Parkinson's disease Occurs with atypical antipsychotics, including clozapine, although presentation may be less typical In NMS pyrexia is due to: Muscular contraction occurring as an extrapyramidal side effect Central disturbance of temperature control nms1.html nms3.html

24. Neuroleptic Malignant Syndrome Articles, Support Groups, And Resources neuroleptic malignant syndrome articles, support groups, and resourcesfor patients from Med Help International (www.medhelp.org). http://www.medhelp.org/HealthTopics/Neuroleptic_Malignant_Syndrome.html

[Health Topics A-Z] A B C D ... Z Neuroleptic Malignant Syndrome Medical Glossary: NEUROLEPTIC MALIGNANT SYNDROME [Med Help Home] [Library Search] [Medical Forums] ... [Patient Network] Revised: 3/30/2003

25. NEUROLEPTIC MALIGNANT SYNDROME neuroleptic malignant syndrome This describes the combination of catatonic rigidity,stupor, unstable blood pressure, fever, profuse sweating, sweating, and http://www.medhelp.org/glossary2/new/GLS_3312.HTM

NEUROLEPTIC MALIGNANT SYNDROME - This describes the combination of catatonic rigidity, stupor , unstable blood pressure fever , profuse sweating, sweating, and incontinence as a reaction to antipsychotic agents ( phenothiazines ) in therapeutic doses. Med Help Home Search Ask the Doctor Patient Network The medical glossary has been made possible by a generous donation from:

26. Health Library - Neuroleptic Malignant Syndrome neuroleptic malignant syndrome. Synonyms Disorder Subdivisions GeneralDiscussion Resources National Organization for Rare Disorders. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

27. Member Sign In neuroleptic malignant syndrome (NMS) is best defined as a form of druginducedhyperthermia. Classic neuroleptic malignant syndrome (NMS) was diagnosed. http://www.medscape.com/viewarticle/449736

If you are having trouble logging in: In order to use Medscape, your browser must be set to accept "cookies." To find out how to adjust your browser settings, please click here Log In Username Password Forgot your password? Not a Member? Register Now for free access to: MEDLINE (Optimized for Physicians) 200+ Free CME Courses 25 Medical Specialty Sites 100+ Medical Journals Conference Coverage Daily Medical News About Medscape Help WebMD Health

28. Member Sign In Abstract and Introduction Case Report Discussion References. Atypical NeurolepticMalignant Syndrome Associated With Olanzapine from Pharmacotherapy http://www.medscape.com/viewarticle/434458

If you are having trouble logging in: In order to use Medscape, your browser must be set to accept "cookies." To find out how to adjust your browser settings, please click here Log In Username Password Forgot your password? Not a Member? Register Now for free access to: MEDLINE (Optimized for Physicians) 200+ Free CME Courses 25 Medical Specialty Sites 100+ Medical Journals Conference Coverage Daily Medical News About Medscape Help WebMD Health

29. Health Library - Neuroleptic Malignant Syndrome neuroleptic malignant syndrome. Synonyms Disorder Subdivisions GeneralDiscussion Resources National Organization for Rare Disorders. http://www.laurushealth.com/library/healthguide/illnessconditions/topic.asp?hwid

30. HKMJ - Abstract neuroleptic malignant syndrome induced by droperidol. A case of droperiodolinducedneuroleptic malignant syndrome during anaesthesia is presented. http://www.hkmj.org.hk/hkmj/abstracts/v7n1/101.htm

Surf HKMJ by: Please select keyword search: Vol. 1 to 5 keyword search: Vol. 6 to 8 volume theme supplements Search the latest HKMJ: Neuroleptic malignant syndrome induced by droperidol PC So Department of Anaesthesiology, North District Hospital, 9 Po Kin Road, Sheung Shui, New Territories, Hong Kong A case of droperiodol-induced neuroleptic malignant syndrome during anaesthesia is presented. An 86-year-old male underwent spinal anaesthesia for open reduction and internal fixation of a trochanteric hip fracture. He received droperidol 5 mg intravenously for sedation towards the end of surgery. He subsequently became very drowsy and experienced marked muscle rigidity and autonomic instability. He became febrile postoperatively. The clinical syndrome resolved after 12 hours. When using droperidol in anaesthesia or intensive careespecially when large doses are giventhe development of neuroleptic malignant syndrome should be suspected if the patient becomes febrile and has muscle rigidity and autonomic instability. HKMJ 2001;7(1):101-3

31. Neuroleptic Malignant Syndrome neuroleptic malignant syndrome. The diagnosis of neuroleptic malignantsyndrome should be suspected in any patient who develops unexplained http://www.egora.fr/Tox-In/TOXIANGL/SYNDROME/MALNEURO.HTM

32. Arch Gen Psychiatry -- Page Not Found 56;101102, January 1999, Olanzapine-Induced neuroleptic malignant syndrome, PierreR. Burkhard, MD; Francois JG Vingerhoets, MD; Christel Alberque, MD http://archpsyc.ama-assn.org/issues/v56n1/ffull/ylt0199-3.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

33. Neuroleptic Malignant Syndrome Lawsuit News Find Trial Lawyers InjuryBoard News neuroleptic malignant syndrome Find trial lawyers and attorneyswith experience in lawsuits involving neuroleptic malignant syndrome. http://www.injuryboard.com/lvlthreeInjury.cfm/hurl/fstli=5/secli=18/trdli=50

Airbags Airlines Avandia Baycol / Cerivastatin ... Injuries Neuroleptic Malignant Syndrome If you or a family member has been injured, Contact an Attorney today. Just fill out InjuryBoard.com's On-line Questionnaire and have an attorney evaluate your case - free of charge. Ask an Attorney Neuroleptic Malignant Syndrome (NMS) is a potentially fatal complex that is associated with the use of nearly all antipsychotic drugs. Symptoms of NMS include, but are not limited to, acute kidney failure , body temperature in excess of 106ï¾° (hyperpyrexia), rigid muscles, irregular pulse or blood pressure , rapid heart beat ( tachycardia ), and irregular heartbeat. What do I do Now? As with many personal injury claims, time is critical. Contact an attorney today to protect your rights. An Injuryboard sponsor will: Help you with the merits of your case.

34. IPCS INTOX: Neuroleptic Malignant Syndrome neuroleptic malignant syndrome DEFINITION. A lifethreatening idiosyncraticreaction characterised by muscle rigidity and hyperthermia http://www.intox.org/pagesource/treatment/english/neurolepticmanlignant.htm

NEUROLEPTIC MALIGNANT SYNDROME DEFINITION A life-threatening idiosyncratic reaction characterised by muscle rigidity and hyperthermia, related to acute dopamine depletion, either from the use of neuroleptic drugs or of dopamine antagonists, or the withdrawal of dopamine agonists. TOXIC CAUSES Exposure to therapeutic doses of potent neuroleptic drugs (eg, haloperidol, fluphenazine) or the sudden cessation of dopamine agonists such as amantidine. Reported risk factors include dehydration and the concurrent use of lithium and tricyclic antidepressants. CLINICAL FEATURES Extreme hyperpyrexia, lead-pipe muscular rigidity, autonomic dysfunction (tachycardia, elevated or fluctuating blood pressure), sweating, tachypnoea, respiratory failure, altered mental status (confusion, delirium, stupor and coma), extrapyramidal signs (e.g. cogwheel hypertonia). Acute myoglobinuric renal failure may occur. The condition is fatal in up to 12 % of cases. DIFFERENTIAL DIAGNOSIS Anticholinergic poisoning Catatonia CNS infections CNS mass lesions Ethanol or sedative-hypnotic drug withdrawal Extrapyramidal symptoms with fever Heat-stroke (environmental or exertional) Malignant hyperthermia Metal fume fever Psychiatric disorders Septicaemia Strychnine poisoning Thyroid storm Tetanus Tetany RELEVANT INVESTIGATIONS Laboratory tests are generally non-specific, but may be used to exclude alternative diagnoses.

35. The Universal Field Hypothesis Of Catatonia And Neuroleptic Malignant Syndrome The Universal Field Hypothesis of Catatonia and neuroleptic malignant syndrome. ByBrendan T. Carroll, MD. The neuroleptic malignant syndrome. J Clin Psychiatry. http://www.medicalbroadcast.com/CMEReviews/catatonia/CNS700_Carroll.html

The Universal Field Hypothesis of Catatonia and Neuroleptic Malignant Syndrome By Brendan T. Carroll, MD CNS Spectrums Abstract Catatonia and neuroleptic malignant syndrome (NMS) are uncommon disorders that can be life-threatening. Many researchers consider them as clinically divergent entities; however, they share similar and overlapping literature on causative agents, phenomenology, and treatment response. This hypothesis considers both disorders as a single entity that result from variable combinations of the following: 1) g-aminobutyric acid (GABA) hypoactivity at the GABAA receptor; 2) dopamine hypoactivity at the D receptor; 3) serotonin hyperactivity at the 5-HT receptor and hypoactivity at the 5-HT receptor; and 4) glutamate hypoactivity at the N-methyl-d-aspartate (NDMA) receptor. In this paper, evidence to support this hypothesis is limited to retrospective human studies of catatonia and NMS. The four components of the hypothesis are: 1) GABAA agonists have been shown to alleviate catatonia and NMS; 2) D antagonism is proportional to the relative likelihood of NMS and catatonia; 3) 5-HT

36. Psychiatric Times neuroleptic malignant syndrome Best Treated as Catatonia. by Max Fink, MD Chicago;May 17. NMSIS (2000), neuroleptic malignant syndrome Information Service. http://www.psychiatrictimes.com/p001128.html

37. NeurolepticMS neuroleptic malignant syndrome. neuroleptic malignant syndrome isa life threatening side effect of any antipsychotic drug but is http://www.psyweb.com/Diction/nms.html

38. Counteract Side Effects Dentrium ( Danrolene ) is used to counter act neuroleptic malignant syndrome( NMS .). Inderal ( Propranolol )is used to counter act Akathisia. http://www.psyweb.com/Drughtm/otherdrug.html

39. Neuroleptic Malignant Syndrome : A Review Of 12 Cases* The summary for this Bihari page contains characters that cannot be correctly displayed in this language/character set. http://www.mahidol.ac.th/mahidol/ra/rapc/v4123.html

Neuroleptic Malignant Syndrome : ¡ÒÈÖ¡ÉÒÂé͹ËÅѧ㹼Ùé»èÇ 12 Ò ¡ÒÈÖ¡ÉÒ㹻Ѩ¨ØºÑ¹ ¾ºÇèÒÍѵҵÒÂŴŧ¨Ò¡éÍÂÅÐ 25 ¡è͹»Õ 1984 àËÅ×Í éÍÂÅÐ 11.6 㹪èǧ»Õ 1984-19873,16 áÅШҡ¡ÒÈÖ¡ÉÒẺ prospective â´Â Rosebush áÅÐ Stewart ã¹»Õ 1989 äÁ辺ÇèÒÁÕ¡ÒµÒÂà¡Ô´¢Öé¹17 «Öè§ÍÒ¨áÊ´§¶Ö§¡Ò·Õèá¾·Âìä´éµÐ˹ѡÁÒ¡¢Öé¹ ÇÔ¹Ô¨©ÑÂä´éàçÇ¢Öé¹ ÊÒÁÒ¶ËÂØ´ÂÒáÅÐÑ¡ÉÒä´éàçÇ¢Öé¹3,17 ´Ñ§¹Ñ鹡ÒÈÖ¡ÉÒ¹ÕéÁըش»Ðʧ¤ìà¾×èÍÈÖ¡ÉÒ´ÙÅѡɳеèÒ§ æ ¢Í§¼Ùé»èÇ NMS ã¹à×èͧÍÒ¡Ò ¡Ò´Óà¹Ô¹â¤ ÂÒ·Õèà¡ÕèÂÇ¢éͧ à¾×èÍãËéä´éµÐ˹ѡáÅÐÊÒÁÒ¶ÇÔ¹Ô¨©ÑÂã¹ÐÂÐá¡à¾×èÍÑ¡ÉÒä´é·Ñ¹ áÅÐÊÒÁҶŴÍѵҡҵÒÂä´é ÈÖ¡ÉÒÂé͹ËÅѧ¨Ò¡àǪÐàºÕ¹¼Ùé»èÇ·ÕèÁÒѺ¡ÒÑ¡ÉÒã¹â§¾ÂÒºÒÅʧ¢ÅÒ¹¤Ô¹·ì áÅÐä´éѺ¡ÒÇÔ¹Ô¨©ÑÂÇèÒà»ç¹ neuroleptic malignant syndrome µÑé§áµèÇѹ·Õè 1 ¸Ñ¹ÇÒ¤Á 2530 ¶Ö§ 30 àÁÉÒ¹ 2537 ÁÕ¼Ùé»èÇ NMS 㹡ÒÈÖ¡ÉÒ¹Õé¨Ó¹Ç¹ 12 Ò à»ç¹ªÒ 8 Ò ˭ԧ 4 Ò ÍÒÂصÑé§áµè 15 ¶Ö§ 69 »Õ (à©ÅÕè 37.2 »Õ, SD 17.4 »Õ) â¤Ë×ÍÀÒÇзÕèà»ç¹ÍÂÙèÁÕ bipolar disorder 4 Ò (éÍÂÅÐ 33.3) schizophrenia 3 Ò (éÍÂÅÐ 25) psychosis 2 Ò (éÍÂÅÐ 16.6) major depression 1 Ò (éÍÂÅÐ 8.3) substance use disorder 1 Ò áÅÐ simple phobia 1 Ò (´Ñ§µÒÒ§·Õè 1) ÍÒ¡ÒáÅÐÍÒ¡ÒáÊ´§·Õèà¡Ô´¢Öé¹·Ø¡ÒÂÁÕä¢éÊÙ§ â´ÂÍسËÀÙÁÔÊÙ§ÊØ´ 38.2-40.9 c (à©ÅÕè 39.25 c, SD 0.92 c), ¡ÅéÒÁà¹×éÍá¢ç§à¡ç§ дѺ¢Í§¡ÒÙéÊÖ¡µÑÇà»ÅÕè¹á»Å§ â´ÂÁÕä´éµÑé§áµè mutism, drowsy, stuporous, confusion ¨¹¶Ö§ coma ÁÕÍҡҢͧкº»ÐÊÒ·ÍѵºÒÅỻǹ â´ÂÁÕªÕ¾¨à¾ÔèÁ¢Öé¹·Ø¡Ò ¤ÇÒÁ´Ñ¹âÅËÔµäÁ褧·Õè 10 Ò (éÍÂÅÐ 83.3) ËÒÂã¨àçÇ 11 Ò (éÍÂÅÐ 91.6) à˧×èÍÍÍ¡ 7 Ò (éÍÂÅÐ 58.3) ¡ÅÑé¹»ÑÊÊÒÇÐäÁèä´é 8 Ò (éÍÂÅÐ 66.6) (´Ñ§áÊ´§ã¹µÒÒ§·Õè 3) ¹Í¡¨Ò¡¹ÕéÂѧ¾ºÍÒ¡ÒÍ×è¹ æ èÇÁ´éÇ àªè¹ cogwheel rigidity, Á×ÍÊÑè¹ ¡Å×¹ÅÓºÒ¡ occulogiric crisis, retrocollis, trismus, opisthotonos, choreiform movement, dyskinetic movement, ªÑ¡ áÅм×è¹·Õè¼ÔÇ˹ѧ

40. AIDS And Neuroleptic Malignant Syndrome colleagues report on what they believe to be the first three reported cases in peoplewith AIDSRelated Dementia of neuroleptic malignant syndrome caused by http://www.aegis.com/news/ads/1988/AD880018.html

"AIDS and Neuroleptic Malignant Syndrome" Lancet (12/24-31/88) Vol. 2, No. 4826/4827, P. 1488 Breitbart, William, et al. Abstract: William Breitbart of Memorial Sloan-Kettering Cancer Center and Cornell Medical College and his colleagues report on what they believe to be the first three reported cases in people with AIDS-Related Dementia of neuroleptic malignant syndrome caused by the dopamine-blocking effects of potent neuroleptic drugs. In all three patients, symptoms of the syndrome appeared following the administration of oral haloperidol. Cessation of the drug and the addition of other drugs resolved the problems. Although researchers have recommended low-dose haloperidol for the management of organic mental disorders in AIDS patients, such patients may have increased susceptibility to the dopamine-blocking effects of potent neuroleptics, Breitbart and colleagues report. Boehringer Ingelheim iMetrikus, Inc. , the National Library of Medicine , and donations from users like you. Always watch for outdated information. This article first appeared in 1988. This material is designed to support, not replace, the relationship that exists between you and your doctor. Feedback/Contact Us

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