41. HHMI News: Progress In Search For Genetic Trigger Of Pancreatic Cancer Progress in Search for Genetic Trigger of pancreatic cancer, “Fromthese data, it became clear that four generations ago one man http://www.hhmi.org/news/kruglyak.html

RESEARCH NEWS RESEARCH NEWS GRANT ANNOUNCEMENTS SCIENCE EDUCATION NEWS INSTITUTE NEWS ... HHMI HOME ALSO OF INTEREST Blood Vessels Trigger Development of the Pancreas Tracking Down the Cause of an Inherited Leukemia Loss of Tumor Suppressor Gene Triggers Colon Cancer Download this story in Acrobat PDF format. (requires Acrobat Reader Progress in Search for Genetic Trigger of Pancreatic Cancer “From these data, it became clear that four generations ago one man with this inherited locus passed the gene it contained on to five of his six sons, all of whom died of pancreatic cancer, but not before they passed it on to future generations," said HHMI investigator Leonid Kruglyak. Researchers are reporting progress in the search for a gene mutation that triggers pancreatic cancer, the fifth leading cause of cancer death in the United States. Genetic studies of a family that has a long history of pancreatic cancer have led researchers to a region of chromosome 4 that is the likely location of a gene mutation that causes cancer in members of this family. Pancreatic cancer is difficult to detect, spreads quickly, and kills almost all affected patients within six months of diagnosis. Of an estimated 29,200 cases of pancreatic cancer diagnosed each year in the United States, 28,900 patients succumb to the disease, usually within four to six months of diagnosis.

42. ACS :: What Is Pancreatic Cancer? What Is pancreatic cancer? Ampullary cancers are included together with pancreaticcancer in this document because treatments are very similar. http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_what_is_pancreatic_cancer_3

Home Community Get Involved Donate ... Search GetRandomImage("headerImage", "jpg", 121, 77, 30); My Planner Register Sign In Cancer Reference Information ... Cancer Drug Guide What Is Pancreatic Cancer? The Normal Pancreas The pancreas is a gland located behind the stomach. It is shaped a little bit like a fish with a wide head, a tapering body, and a narrow pointed tail. It is about six inches long but less than 2 inches wide, and extends horizontally across the abdomen. The head of the pancreas is located on the right side of the abdomen, behind the junction of the stomach and the duodenum (the first part of the small intestine). The body of the pancreas is located behind the stomach and the tail of the pancreas is on the left side of the abdomen next to the spleen. Think of the pancreas as two separate glands found inside the same organ: exocrine and endocrine. Exocrine glands release into ducts; endocrine glands release into the bloodstream. Over 95% of the cells in the pancreas form exocrine glands and ducts. The exocrine glands produce pancreatic juice, which contains enzymes that break down fats, proteins, and carbohydrates in the food you eat so the nutrients can be absorbed by the small intestine. The exocrine ducts carry this pancreatic juice to the common bile duct and eventually to the small intestine. A small percentage of the cells in the pancreas are endocrine cells. These cells are arranged in small clusters called islets (or islets of Langerhans). The islets release two hormones, insulin and glucagon, that are important in controlling the amount of sugar in the blood.

43. ACS :: What Are The Risk Factors For Pancreatic Cancer? What Are the Risk Factors for pancreatic cancer? Cigarette Smoking Therisk of developing pancreatic cancer is increased among smokers. http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_f

44. Pancreatic Cancer Resources - Make A Difference! pancreatic cancer Awareness was established in 1999 in honor of our friendBarbara Decker who died March 17, 2000. pancreatic cancer Awareness. http://deckerfund.tripod.com/

Get Five DVDs for $.49 each. Join now. Tell me when this page is updated Note: All ads appearing at top of pages are embedded by Tripod and are not generating revenue for this site. Pancreatic Cancer Awareness Our mission is to provide excellent, extensive online resources for pancreatic cancer patients, patient advocates, friends and family members, and medical professionals - thereby also achieving the goal of expanding awareness horizons. This is the People Mover train. You can help. Make a difference today. Information about Evening with the Stars Next Page of the PCA site Online resources More Online resources ... Memorial Page New Cases in 2001 The American Cancer Society estimates that 29,200 Americans will be diagnosed with cancer of the pancreas. Deaths An estimated 28,900 Americans have died of pancreatic cancer in 2001, according to the ACS. Over 187,000 people worldwide will die of pancreatic cancer this year. About 2 out of 10 patients with cancer of the pancreas will live at least one year after the cancer is found, but only a very few will survive for five years. (The five-year survival rate is only 4%.) Rank Pancreatic cancer is the eleventh most common cancer and the fourth leading cause of cancer death in men and in women.

45. Pancreatic Cancer - Overview, Risk Factors & Symptoms - OncologyChannel.com pancreatic cancer is the fifth leading cause of cancerrelated death, therisk of contracting this cancer increases for a number of reasons. http://www.oncologychannel.com/pancreaticcancer/

Home Search SiteMap Ask the Dr. ... Medical Store advertisement advertisement PANCREATIC CANCER Overview Risk Factors Symptoms Diagnosis ... Prevention CONDITIONS Adrenal Cancer AIDS Related Lymphoma Bladder Cancer Brain Cancer Breast Cancer Carcinoid Malignancy ... Classification of Cancer Colorectal Cancer Cytopenia Endometrial Cancer Esophageal Cancer ... Lymphoma- Hodgkin's Disease Lymphoma- Non-Hodgkin's Melanoma Non-Melanoma Skin Cancer Ovarian Cancer Pain Pancreatic Cancer Prostate Cancer ... Urethral Cancer RESOURCES HealthProfiler Education Links Questions to Ask Your Physician Self Help Videos ABOUT US Healthcommunities.com Pressroom Testimonials The pancreas is an organ of the digestive system. It is located near the stomach and small intestine. It has two major jobs or functions. First, the exocrine pancreas makes enzymes that help in the digestion of food products. Second, the endocrine pancreas produces several hormones that have diverse functions. Cancers of the pancreas can occur in the exocrine pancreas (classic pancreatic adenocarcinomas) or can occur in the endocrine pancreas. This section will discuss exocrine pancreatic carcinoma. Risk Factors The risk of developing cancer of the pancreas is usually low before the age of 40, but the risk subsequently increases sharply, with most people diagnosed between their sixties and eighties. Risk factors for the development of this disease include environmental factors, medical/surgical factors, genetic factors, and occupational exposures.

46. Pancreatic Cancer, Progress Review Groups (PRGS), Office Of Science Planning And pancreatic cancer is disproportionately underrepresented in both clinicaland basic research compared with other cancer sites. Several http://prg.nci.nih.gov/pancreatic/default.html

From Pancreatic Cancer: An Agenda for Action The Report of the Pancreatic Cancer Progress Review Group Strategic Plan for Addressing PRG Recommendations Pancreatic Cancer U.S. Racial/Ethnic Cancer Patterns Cancer Information for Patients and Health Professionals Cancer Clinical Trials Last updated 02.12.02 (smz)

47. HON - News : Faulty Gene May Contribute To Pancreatic Cancer Resources from HONselect. Faulty Gene May Contribute to pancreatic cancerSame gene mutations have been tied to breast, ovarian cancer http://www.hon.ch/News/HSN/511619.html

HON News - 300 medical topics and themes Themes: A B C ... I J K L M N ... P Q R S T U ... W X Y Z Browse archive: Mar Feb Jan Dec ... Sep Other news for: Pancreatic Neoplasms Genetics Resources from HONselect Faulty Gene May Contribute to Pancreatic Cancer Same gene mutations have been tied to breast, ovarian cancer By Kathleen Doheny HealthScoutNews Reporter TUESDAY, Feb. 4 (HealthScoutNews) Mutations in the BRCA2 gene, already known to increase the risk of breast and ovarian cancers, may also make people susceptible to a hereditary form of pancreatic cancer, German researchers conclude. Their findings echo those of previous studies. "We have found mutations which are likely to explain in a subgroup of families with pancreatic cancer cases why the disease occurs," says Dr. Stephan A. Hahn, a professor of oncology at the Knappschaftskrankenhaus University of Bochum in Bochum, Germany. Hahn is also co-author of the new study, which appears in the Feb. 5 issue of the Journal of the National Cancer Institute Hahn and his colleagues identified 26 European families with at least two first-degree relatives a sister or father, for instance with pancreatic cancer. After testing them, the researchers found that 19 percent of the families had at least one member who had either a mutation or a variant of BRCA2. While the new research confirms findings in previous studies, including one done by Johns Hopkins University researchers, Hahn says the study population for his study is broader.

48. Pancreatic Cancer Treatment statement for Health professionals. pancreatic cancer. Getthis document via a secure connection Stage I pancreatic cancer. http://www.meb.uni-bonn.de/cancer.gov/CDR0000062951.html

Treatment statement for Health professionals Pancreatic Cancer Get this document via a secure connection General Information Cellular Classification Stage Information ... Changes to this Summary (02/19/2003) General Information Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.) Carcinoma of the pancreas has markedly increased in incidence over the past several decades, and ranks as the fourth leading cause of cancer death in the United States. Despite the high mortality rate associated with pancreatic cancer, its etiology is poorly understood. [ ] Cancer of the exocrine pancreas is rarely curable and has an overall survival rate of less than 4%. [ ][Level of evidence: 3iA] Improvements in imaging technology, including spiral computed tomographic scans, magnetic resonance imaging scans, positron emission tomographic scans, endoscopic ultrasound examination, and laparoscopic staging can aid in the diagnosis and the identification of patients with disease that is not amenable to resection. [ ] In a case series of 228 patients, positive peritoneal cytology had a positive predictive value of 94%, specificity of 98%, and sensitivity of 25% for determining unresectability. [

49. Study Shows Obesity Can Increase Risk Of Pancreatic Cancer pancreatic cancer is a killer. Study shows obesity can increase risk of pancreaticcancer Weight loss, exercise urged as preventive measures. http://www.researchmatters.harvard.edu/story.php?article_id=189

50. Ask NOAH About: Types Of Cancer New York Online Access to Health CancerNet National Cancer InstituteCategory Health Child Health Circumcision Medical Views...... Tumor) Hypopharyngeal Cancer (See Head and Neck Cancers ) Intraocular Melanoma (SeeEye Cancers ) Islet Cell Cancer (See pancreatic cancer ) Kaposi's Sarcoma http://www.noah-health.org/english/illness/cancer/cantypes.html

Ask NOAH About: Cancer Types of Cancer A B C E ... Women's Cancers Return to Main Cancer Page Types of Cancer Adrenal Cancer (See also Pheochromocytoma Adrenal Cancer - Urology Forum Adrenal Cancer - Johns Hopkins Oncology Center Adrenocortical Carcinoma: Treatment - National Cancer Institute (also in Spanish AIDS-Related Lymphoma (See Also Kaposi's Sarcoma AIDS-Related Lymphoma: Treatment - National Cancer Institute (also in Spanish AIDS-Related Lymphoma - Lymphoma Information Network Anal Cancer Bladder Cancer Bladder Cancer: Detailed Guide - American Cancer Society Bladder Cancer: What Every Man and Woman Should Know - Urology Institute, Dallas TX How is Bladder Cancer Diagnosed? - American Cancer Society What are the Risk Factors for Bladder Cancer - American Cancer Society ... What You Need to Know About Bladder Cancer - National Cancer Institute Treatment Bladder Cancer: Treatment - National Cancer Institute (also in Spanish How is Bladder Cancer Treated? - American Foundation for Urologic Disease How is Bladder Cancer Treated? - American Cancer Society Bladder Cancer: Treatment Decision Tools - American Cancer Society (requires registration Clinical Trials Bladder Neoplasms - ClinicalTrials.gov

51. Www.PANCREAS.org A New Susceptibility Locus for Autosomal Dominant pancreatic cancer Mapsto Chromosome 4q3234 By MA Eberle, R Pfutzer, KL Pogue-Geile, MP. http://www.pancreas.org/

Figure: This is a 3D reconstruction of the pancreas and related structures form a patient. The contrast in color reflects different densities of the structures. To identify the structures labeled A-F, move your pointer over the image. NEW! IAP Guidelines for the Surgical Management of Acute Pancreatitis November 8-9, 2003 Fourth International Symposium on Inherited Diseases of the Pancreas A satellite symposium of the American Pancreatic Association Annual Meeting, sponsored by the Midwest Mutlicenter Pancreatic Study Group (USA) to be held at the The Westin River North in Chicago, Illinois. Click here for more information or contact Randall Brand MD at rbrand@enh.org A New Susceptibility Locus for Autosomal Dominant Pancreatic Cancer Maps to Chromosome 4q32-34 By MA Eberle, R Pfutzer, KL Pogue-Geile, MP. Bronner, D Crispin, M Kimmey, R Duerr, L Kruglyak, DC Whitcomb, TA Brentnall Click here to read the press release Special Issue of Pancreatology Now Available!

52. The National Pancreas Foundation - Homepage Mission includes supporting pancreas diseases research and providing information and services to those Category Health Conditions and Diseases Digestive Disorders Pancreas...... A non profit organization, the NPF was founded by two families whose lives havebeen forever changed by the devastation of pancreatic cancer and chronic http://www.pancreasfoundation.org/

Search Our Site: Contributor's Choice Member of the United Way unitedway.org This Page is best viewed in 800 x 600 using the latest version of: Internet Explorer Winter, 2003 What's New Thanks to the hard work and incredible hours donated by Doug Price and Mark Bishop www.markbishop.com , we are pleased to announce the ability to donate to the National Pancreas Foundation online by credit card. "We have wanted this capability for sometime to eliminate paperwork and streamline the donation process, and thanks to two tireless volunteers, Doug and Mark, it has come to fruition," says Co-President Jane Holt To donate by credit card, visit the Donations section of the website. It is a very simple walk through process and one can print the confirmation for their records. Of course, the National Pancreas Foundation will continue to send a formal acknowledgement to the donor for their tax records. We have new low-fat recipes from Cooking Light Magazine . These new additions as well as other great recipes can be found in our Recipes section.

53. Recent Advances In Combined-Modality Treatment Of Pancreatic Cancer Recent Advances in CombinedModality Treatment of pancreatic cancer CME AuthorsJohanna Chock Bendell, MD; David P. Ryan, MD; Christopher G. Willett, MD http://www.medscape.com/viewprogram/2210

Focus On... ADHD ALLHAT Alzheimer's Disease Anthrax Asthma Biologic Therapies Bipolar Disorder Breast Cancer Depression Erectile Dysfunction Genital Herpes GERD Geriatric Care Heart Failure Heart Failure: CRT Hepatitis C HIPAA Home Defib in SCA Hyperlipidemia IBS InfluenZone Insulin Pump Tx Kidney Disease Menopause Micro Complications Multiple Sclerosis Osteoporosis Ovarian Cancer Pain Management Pancreatic Cancer Patient Safety Rheum Arthritis Schizophrenia Secondary Anemia Serious Mental Ill Sports Medicine UTI-Zone Weight Management Related Topics Health Diversity Hospice Care Medical Privacy Welcome, March 31, 2003 Recent Advances in Combined-Modality Treatment of Pancreatic Cancer CME Authors: Johanna Chock Bendell, MD; David P. Ryan, MD; Christopher G. Willett, MD Disclosures Release Date: January 28, 2003 Valid for credit through January 28, 2004 Credit Hours Available Physicians - up to 1.0 AMA PRA category 1 credit(s) Contents of This CME Activity Recent Advances in Combined-Modality Treatment of Pancreatic Cancer Introduction Definition and Staging Combined Radiation Therapy and Chemotherapy: Overview of Randomized Trials Combined Radiation Therapy and Chemotherapy: Alterations in Radiation Therapy Combined Radiation Therapy and Chemotherapy: Alterations in Chemotherapy Palliative Role of Chemoradiation Future Directions in Therapy References Post Test and Evaluation The material presented here does not reflect the views of Medical Education Collaborative, Medscape or the companies providing unrestricted educational grants. These materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified health care professional should be consulted before using any therapeutic product discussed. All readers and continuing education participants should verify all information and data before treating patients or employing any therapies described in this continuing medical education activity.

54. Applied Biosystems - BioBeat - Pancreatic Cancer Gene Researchers Locate First Susceptibility Gene Specific for PancreaticCancer. by Michael D. O'Neill. Genetic analysis of a large, multi http://www.appliedbiosystems.com/biobeat/pancreatic_cancer/

Products MSDS Store BioBeat Subscribe Contact Breakthroughs ... Awards Researchers Locate First Susceptibility Gene Specific for Pancreatic Cancer by Michael D. O'Neill Genetic analysis of a large, multi-generational family (Family X) displaying an unusual, early-onset form of hereditary pancreatic cancer has allowed researchers to localize the first susceptibility gene specific for pancreatic cancer to a region of chromosome 4. The use of genetic analysis technology from Applied Biosystems, including the , and , was instrumental in enabling this historic advance. American Journal of Human Genetics Pancreatic cancer is a particularly lethal form of cancer that is rarely detected before it is far advanced and that kills almost all its victims very rapidly. An estimated 29,200 new cases of pancreatic cancer are diagnosed each year in the United States, and approximately 28,900 (98.9%) of the affected individuals will die of the disease, usually within six months of diagnosis. The disease has even struck close to a member of the research team. Dr. Kruglyak had a cousin who died of pancreatic cancer and the scientist dedicated his work in this study to the memory of this cousin.

55. Cancer - Pancreatic Cancer - Methodist Health Care System, Houston, Texas pancreatic cancer What is pancreatic cancer? What are the symptoms of pancreatic cancer?The following are the other most common symptoms of pancreatic cancer. http://www.methodisthealth.com/cancer/pancreas.htm

Cancer Home Page Clinical Services The Methodist Hospital Methodist Diagnostic Hospital San Jacinto Methodist Hospital Cancer Center ... Visiting Nurse Assn Cancer Types Bile Duct Bladder Bone Brain ... Vulvar Cancer Information What is Cancer? Screening Guidelines Symptoms Risk Factors ... Schedule an Appointment Pancreatic Cancer What is pancreatic cancer? Pancreatic cancer is the fourth most common cancer in men and women in the US, according to the American Cancer Society. The majority of pancreatic cancer cases occur in people 50 years of age or older. There are several types of pancreatic cancers, including: adenocarcinoma of the pancreas cystadenocarcinoma Some noncancerous tumors in the pancreas include: insulinoma gastrinoma glucagonoma What are the symptoms of pancreatic cancer? The following are the other most common symptoms of pancreatic cancer. However, each individual may experience symptoms differently. Symptoms may include: pain in the upper abdomen poor appetite weight loss jaundice indigestion nausea vomiting diarrhea fatigue The symptoms of pancreatic cancer may resemble other conditions or medical problems. Consult a physician for diagnosis.

56. Molecular Cancer Full Text Invasion And Metastasis In Review Invasion and metastasis in pancreatic cancer Shereen Keleg , Peter Büchler, Roman Ludwig , Markus W Büchler and Helmut Friess University of Heidelberg http://www.molecular-cancer.com/content/2/1/14

57. Molecular Cancer Review Invasion and metastasis in pancreatic cancer Shereen Keleg et al MolecularCancer 2003 214 (22 January 2003) Abstract Provisional PDF. http://www.molecular-cancer.com/start.asp

58. Pancreas Cancer FAQs What you should know about pancreatic cancer? Posted 02/13/2003 pancreatic cancerVaccine An educational animation by Helen MacFarlane The Whipple Procedure. http://pathology2.jhu.edu/pancreas/

Frequently Asked Questions: What is the Pancreas? What is Pancreatic Cancer (PC)? What may cause Pancreatic Cancer? Is Pancreatic Cancer hereditary? ... What should we expect during the final stages? Click here for... other Hopkins Pathology Specialties We subscribe to the HONcode principles of the Health On the Net Foundation This site is supported by generous educational grants from the Vesalius Trust No two patients with pancreas cancer are identical. The appropriate treatment of individual cases varies greatly depending on the patient's medical and surgical history. The information expressed in this Web page is not medical advice. It is meant only to educate health care professionals and patients about the current status of treatment and research at Hopkins. Before making any medical decisions, patients are advised to consult with their personal physicians.

59. Pancreas Cancer FAQs 2) What exactly is pancreatic cancer? What is Cancer? cancer, A malignanttumor (a malignant neoplasm.). What is pancreatic cancer? http://pathology2.jhu.edu/pancreas/pc_overview.cfm

The Pancreas Pancreatic Cancer Causes of PC Heredity ... Pain Management 2) What exactly is pancreatic cancer? What is Cancer? The word cancer is derived from the Latin word for crab because it grabs onto something and will not let go. The term cancer refers to a new growth which will invade surrounding tissues, metastasize (spread to other organs) and may eventually lead to the patient's death if untreated. We often hear about cancer from friends and family and in the news. The terms tumor and cancer are sometimes used synonymously which can be misleading. A tumor is not necessarily a cancer. The word tumor simply refers to a mass. For example, a collection of pus is by definition a tumor. A cancer is a particularly threatening type of tumor. It is helpful to keep these distinctions clear when discussing a possible cancer diagnosis. neoplasm- An abnormal new growth of tissue that grows more rapidly than normal cells and will continue to grow if not treated. These growths will compete with normal cells for nutrients. This is a non-specific term that can refer to benign or malignant growths. A synonym for tumor. tumor- The more commonly used term for a neoplasm. The word tumor simply refers to a mass. This is a general term that can refer to benign or malignant growths.

60. Pancreatic Cancer These resources related to pancreatic cancer provide information and news about pancreaticcancer treatments, tests, statistics and other information hepful to http://cancer.about.com/cs/pancreaticcancer/

zfp=-1 About Cancer Search in this topic on About on the Web in Products Web Hosting Cancer with Erin Breitenbach Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects ESSENTIALS Top 10 Cancer Risks New Cancer Drugs Approved By The FDA 3 Ways to Reduce Your Cancer Risk ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement Pancreatic Cancer Guide picks These resources related to pancreatic cancer provide information and news about pancreatic cancer treatments, tests, statistics and other information hepful to the patient or survivor and his/her family and friends. NCI's Pancreatic Cancer Resources This site from the National Cancer Institute provides a wealth of information on pancreatic cancer including statistics, treatment options, clinical trials, testing, and coping issues. Pancreatic Cancer Overview This site provides information about what pancreatic cancer is as well as its causes and risk factors. Also provided is information about pancreatic cancer statistics, detection, staging, treatment, and more. FAQ's About Pancreatic Cancer This site answers questions about the nature of pancreatic cancer, how it is diagnosed, tested, and treated, nutritional issues, and what happens after treatment.

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